Ethanol metabolism resulting in production of ROS by CYP2E1 (Rattus norvegicus)

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1NucleusSP600125PromotersiRNA2-Difluoromethoxy-2,2-difluoroaceticacidStressors converted by CYP2E1PPSIROSAREPKCζ siRNAMafkMaffSevofluraneMap2k2ethanolHalothaneacetaldehydetrifluoroacetic acidacetaminophenNfe2l26-hydroxychlorzoxazoneVitamin CisofluranefluorideCyp2e1NAPQIMapk8chlorzoxazoneU0126Protein kinase CMap2k1EnfluraneSp1methoxyfluraneMafgDiallyl sulfidestaurosporinePSp1Nfe2l2SubstrateOutcome metabolitefluoridefluorideCyp2e1Cyp2e1


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes.

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Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106992view13:45, 17 September 2019MaintBotHMDB identifier normalization
104896view15:37, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98052view05:54, 13 July 2018Fehrhartlayout
98051view05:52, 13 July 2018Fehrhartsome layout work
97871view12:02, 12 June 2018Marvin M2Modified description
97141view11:53, 1 May 2018AdoBioInfoNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
6-hydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
Cyp2e1GeneProductENSRNOG00000012458 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
MaffGeneProductENSRNOG00000012886 (Ensembl)
MafgGeneProductENSRNOG00000036697 (Ensembl)
MafkGeneProductENSRNOG00000001277 (Ensembl)
Map2k1GeneProductENSRNOG00000010176 (Ensembl)
Map2k2GeneProductENSRNOG00000020005 (Ensembl)
Mapk8GeneProductENSRNOG00000020155 (Ensembl)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSRNOG00000001548 (Ensembl)
Protein kinase CProteinA0A0G2K5Q0 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSRNOG00000014084 (Ensembl)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
fluorideMetaboliteCHEBI:17051 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
staurosporineMetaboliteCHEBI:57491 (ChEBI)
trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)

Annotated Interactions

No annotated interactions

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