Ethanol metabolism resulting in production of ROS by CYP2E1 (Mus musculus)

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1NucleusPPSIStressors converted by CYP2E1ROSAREPKCζ siRNA2-Difluoromethoxy-2,2-difluoroaceticacidPromoterSP600125siRNANfe2l2Mafgchlorzoxazonetrifluoroacetic acidOxidative Stress (mus musculus)acetaminophenethanolEnfluranestaurosporinefluorideProtein kinase CisofluranemethoxyfluraneHalothaneCyp2e1Sp1Map2k1MafkMap2k2NAPQIMaffDiallyl sulfide6-hydroxychlorzoxazoneMapk8SevofluraneVitamin CU0126acetaldehydePSp1Cyp2e1Cyp2e1Nfe2l2SubstrateOutcome metabolitefluoridefluoride


Description

Metabolism of Ethanol resulting in production of ROS by CYP2E1. Also includes a list of other CYP2E1 substrates and their metabolite outcomes. This pathway is also available for rat and human.

Quality Tags

Ontology Terms

 

Bibliography

  1. Jin M, Ande A, Kumar A, Kumar S; ''Regulation of cytochrome P450 2e1 expression by ethanol: role of oxidative stress-mediated pkc/jnk/sp1 pathway.''; Cell Death Dis, 2013 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106892view13:36, 17 September 2019MaintBotHMDB identifier normalization
104891view14:23, 23 June 2019EgonwReplaced a secondary ChEBI identifiers with a primary identifier.
98060view07:55, 13 July 2018Fehrhartlayout
97870view12:02, 12 June 2018Marvin M2Modified description
97839view07:25, 10 June 2018EgonwOntology Term : 'xenobiotic metabolic pathway' added !
97299view08:40, 8 May 2018AdoBioInfoConnected ze unconnected line
97143view12:44, 1 May 2018AdoBioInfoAdded pathway node (WP412)
97093view08:52, 27 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
97036view14:48, 26 April 2018AdoBioInfoLine was unconnected, however, it was time for change. Change is good. So now the line is connected. Noice.
97013view12:11, 26 April 2018AdoBioInfoChanged remaining human genes into mouse genes.
97012view09:41, 26 April 2018AdoBioInfoAttached some loose links.
97011view09:40, 26 April 2018AdoBioInfoNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
6-hydroxychlorzoxazoneMetaboliteHMDB60998 (HMDB)
Cyp2e1GeneProductENSMUSG00000025479 (Ensembl)
Diallyl sulfideMetaboliteCHEBI:4489 (ChEBI)
EnfluraneMetaboliteHMDB14373 (HMDB)
HalothaneMetaboliteCHEBI:5615 (ChEBI)
MaffGeneProductENSMUSG00000042622 (Ensembl)
MafgGeneProductENSMUSG00000051510 (Ensembl)
MafkGeneProductENSMUSG00000018143 (Ensembl)
Map2k1GeneProductENSMUSG00000004936 (Ensembl)
Map2k2GeneProductENSMUSG00000035027 (Ensembl)
Mapk8GeneProductENSMUSG00000021936 (Ensembl)
NAPQIMetaboliteCHEBI:29132 (ChEBI)
Nfe2l2GeneProductENSMUSG00000015839 (Ensembl)
Oxidative Stress (mus musculus)PathwayWP412 (WikiPathways)
Protein kinase CProteinQ1MX41 (Uniprot-TrEMBL)
SevofluraneMetaboliteCHEBI:9130 (ChEBI)
Sp1GeneProductENSMUSG00000001280 (Ensembl)
U0126MetaboliteCHEBI:64208 (ChEBI)
Vitamin CMetaboliteCHEBI:38290 (ChEBI)
acetaldehydeMetaboliteCHEBI:15343 (ChEBI)
acetaminophenMetaboliteCHEBI:46195 (ChEBI)
chlorzoxazoneMetaboliteCHEBI:3655 (ChEBI)
ethanolMetaboliteCHEBI:16236 (ChEBI)
fluorideMetaboliteCHEBI:17051 (ChEBI)
isofluraneMetaboliteCHEBI:6015 (ChEBI)
methoxyfluraneMetaboliteCHEBI:6843 (ChEBI)
staurosporineMetaboliteCHEBI:57491 (ChEBI)
trifluoroacetic acidMetaboliteCHEBI:45892 (ChEBI)

Annotated Interactions

No annotated interactions

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