Epithelial to mesenchymal transition in colorectal cancer (Homo sapiens)

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  1. Koyama M, Ito M, Nagai H, Emi M, Moriyama Y; ''Inactivation of both alleles of the DPC4/SMAD4 gene in advanced colorectal cancers: identification of seven novel somatic mutations in tumors from Japanese patients.''; Mutat Res, 1999 PubMed Europe PMC Scholia
  2. Vu T, Datta PK; ''Regulation of EMT in Colorectal Cancer: A Culprit in Metastasis.''; Cancers (Basel), 2017 PubMed Europe PMC Scholia
  3. De Bosscher K, Hill CS, Nicolás FJ; ''Molecular and functional consequences of Smad4 C-terminal missense mutations in colorectal tumour cells.''; Biochem J, 2004 PubMed Europe PMC Scholia
  4. Lu MH, Huang CC, Pan MR, Chen HH, Hung WC; ''Prospero homeobox 1 promotes epithelial-mesenchymal transition in colon cancer cells by inhibiting E-cadherin via miR-9.''; Clin Cancer Res, 2012 PubMed Europe PMC Scholia
  5. Neumann J, Zeindl-Eberhart E, Kirchner T, Jung A; ''Frequency and type of KRAS mutations in routine diagnostic analysis of metastatic colorectal cancer.''; Pathol Res Pract, 2009 PubMed Europe PMC Scholia
  6. Lamouille S, Xu J, Derynck R; ''Molecular mechanisms of epithelial-mesenchymal transition.''; Nat Rev Mol Cell Biol, 2014 PubMed Europe PMC Scholia
  7. Takagi Y, Kohmura H, Futamura M, Kida H, Tanemura H, Shimokawa K, Saji S; ''Somatic alterations of the DPC4 gene in human colorectal cancers in vivo.''; Gastroenterology, 1996 PubMed Europe PMC Scholia
  8. Li Q, Wu J, Wei P, Xu Y, Zhuo C, Wang Y, Li D, Cai S; ''Overexpression of forkhead Box C2 promotes tumor metastasis and indicates poor prognosis in colon cancer via regulating epithelial-mesenchymal transition.''; Am J Cancer Res, 2015 PubMed Europe PMC Scholia
  9. Abba M, Patil N, Rasheed K, Nelson LD, Mudduluru G, Leupold JH, Allgayer H; ''Unraveling the role of FOXQ1 in colorectal cancer metastasis.''; Mol Cancer Res, 2013 PubMed Europe PMC Scholia
  10. Zhang H, Meng F, Liu G, Zhang B, Zhu J, Wu F, Ethier SP, Miller F, Wu G; ''Forkhead transcription factor foxq1 promotes epithelial-mesenchymal transition and breast cancer metastasis.''; Cancer Res, 2011 PubMed Europe PMC Scholia
  11. Yang C, Chen H, Tan G, Gao W, Cheng L, Jiang X, Yu L, Tan Y; ''FOXM1 promotes the epithelial to mesenchymal transition by stimulating the transcription of Slug in human breast cancer.''; Cancer Lett, 2013 PubMed Europe PMC Scholia
  12. Amado RG, Wolf M, Peeters M, Van Cutsem E, Siena S, Freeman DJ, Juan T, Sikorski R, Suggs S, Radinsky R, Patterson SD, Chang DD; ''Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer.''; J Clin Oncol, 2008 PubMed Europe PMC Scholia
  13. Miyaki M, Kuroki T; ''Role of Smad4 (DPC4) inactivation in human cancer.''; Biochem Biophys Res Commun, 2003 PubMed Europe PMC Scholia
  14. Kranenburg O; ''Prometastatic NOTCH Signaling in Colon Cancer.''; Cancer Discov, 2015 PubMed Europe PMC Scholia
  15. Wang X, Wu F, Wang H, Duan X, Huang R, Tuersuntuoheti A, Su L, Yan S, Zhao Y, Lu Y, Li K, Yao J, Luo Z, Guo L, Liu J, Chen X, Hu H, Li X, Bao M, Bi X, Du B, Miao S, Cai J, Wang L, Zhou H, Ying J, Song W, Zhao H; ''PDCD6 cooperates with C-Raf to facilitate colorectal cancer progression via Raf/MEK/ERK activation.''; J Exp Clin Cancer Res, 2020 PubMed Europe PMC Scholia


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111457view23:37, 10 August 2020KhanspersAdded interaction between PDCD6 and RAF1
108129view10:28, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106393view21:28, 28 August 2019KhanspersModified description
105464view05:12, 8 August 2019KhanspersModified description
103784view20:45, 5 April 2019Khanspersunified node size and added lit refs for mutations
97604view12:00, 29 May 2018AMTanOntology Term : 'colon epithelial cell' added !
97583view22:40, 26 May 2018AlexanderPicoModified title
97138view22:02, 30 April 2018Khanspersadded cell label
97137view21:54, 30 April 2018KhanspersModified title
97006view23:30, 25 April 2018KhanspersModified title
96593view23:50, 22 March 2018KhanspersModified description
96592view23:17, 22 March 2018KhanspersOntology Term : 'disease of cellular proliferation' added !
96591view20:56, 22 March 2018KhanspersModified description
96590view20:45, 22 March 2018Khansperswork in progress
96586view16:45, 22 March 2018KhanspersOntology Term : 'colorectal cancer' added !
96585view04:27, 22 March 2018KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDH2GeneProductENSG00000170558 (Ensembl)
CDKL2GeneProductENSG00000138769 (Ensembl)
CRB3GeneProductENSG00000130545 (Ensembl)
CTDSP1GeneProductENSG00000144579 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
DLK1GeneProductENSG00000185559 (Ensembl)
DLL1GeneProductENSG00000198719 (Ensembl)
DLL3GeneProductENSG00000090932 (Ensembl)
DLL4GeneProductENSG00000128917 (Ensembl)
DSPGeneProductENSG00000096696 (Ensembl)
EEDGeneProductENSG00000074266 (Ensembl)
EIF5A2GeneProductENSG00000163577 (Ensembl)
EZH2GeneProductENSG00000106462 (Ensembl)
FMNL2GeneProductENSG00000157827 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
FOXC2GeneProductENSG00000176692 (Ensembl)
FOXM1GeneProductENSG00000111206 (Ensembl)
FOXQ1GeneProductENSG00000164379 (Ensembl)
GDF15GeneProductENSG00000130513 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HIF1AGeneProductENSG00000100644 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
ID1GeneProductENSG00000125968 (Ensembl)
ID2GeneProductENSG00000115738 (Ensembl)
ITGA5GeneProductENSG00000161638 (Ensembl)
JAG1GeneProductENSG00000101384 (Ensembl)
JAG2GeneProductENSG00000184916 (Ensembl)
JUPGeneProductENSG00000173801 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LATS2GeneProductENSG00000150457 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAP2K3GeneProductENSG00000034152 (Ensembl)
MAP2K4GeneProductENSG00000065559 (Ensembl)
MAP2K6GeneProductENSG00000108984 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MEF2DGeneProductENSG00000116604 (Ensembl)
MMP15GeneProductENSG00000102996 (Ensembl)
MMP2GeneProductENSG00000087245 (Ensembl)
MMP9GeneProductENSG00000100985 (Ensembl)
MPP5GeneProductENSG00000072415 (Ensembl)
NOTCH1GeneProductENSG00000148400 (Ensembl)
NOTCH2GeneProductENSG00000134250 (Ensembl)
NOTCH3GeneProductENSG00000074181 (Ensembl)
NOTCH4GeneProductENSG00000204301 (Ensembl)
NR2C2GeneProductENSG00000177463 (Ensembl)
NRP2GeneProductENSG00000118257 (Ensembl)
NUBPLGeneProductENSG00000151413 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PI3KGeneProductENSG00000166333 (Ensembl)
PKD1GeneProductENSG00000008710 (Ensembl)
PKP1GeneProductENSG00000081277 (Ensembl)
PKP2GeneProductENSG00000057294 (Ensembl)
PROX1GeneProductENSG00000117707 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
RBBP4GeneProductENSG00000162521 (Ensembl)
RBPJGeneProductENSG00000168214 (Ensembl)
SHC1GeneProductENSG00000160691 (Ensembl)
SMAD2GeneProductENSG00000175387 (Ensembl)
SMAD3GeneProductENSG00000166949 (Ensembl)
SMAD4GeneProductENSG00000141646 (Ensembl)
SNAI1GeneProductENSG00000124216 (Ensembl)
SNAI2GeneProductENSG00000019549 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
SPARCGeneProductENSG00000113140 (Ensembl)
STRAPGeneProductENSG00000023734 (Ensembl)
SUZ12GeneProductENSG00000178691 (Ensembl)
TGFB1GeneProductENSG00000105329 (Ensembl)
TGFB2GeneProductENSG00000092969 (Ensembl)
TGFB3GeneProductENSG00000119699 (Ensembl)
TGFBR1GeneProductENSG00000106799 (Ensembl)
TGFBR2GeneProductENSG00000163513 (Ensembl)
TJP1GeneProductENSG00000104067 (Ensembl)
TMPRSS4GeneProductENSG00000137648 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
TRAF6GeneProductENSG00000175104 (Ensembl)
TUSC3GeneProductENSG00000104723 (Ensembl)
TWIST1GeneProductENSG00000122691 (Ensembl)
TWIST2GeneProductENSG00000233608 (Ensembl)
Tyrosine kinase receptorsGeneProduct
VTNGeneProductENSG00000109072 (Ensembl)
ZEB1GeneProductENSG00000148516 (Ensembl)
ZEB2GeneProductENSG00000169554 (Ensembl)
pre-miR-9-2GeneProductENSG00000284447 (Ensembl)

Annotated Interactions

No annotated interactions

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