Phosphodiesterases in neuronal function (Homo sapiens)

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1324PKAGuanylat cyclases (GC)(soluble)glutamergic neuron Dopamine receptor D1nucleus accumbens/caudate-putamenA2Asynaptic gapnAChR (nicotine alpha 7 receptor)frontal cortexPDEsLegendrelease of neurotransmitters into synaptic gapbindingstimulationinhibitionmainly responsibleAMPA receptorNMDA receptornucleusGRIN2BNOS1PDE1CGRIN1PDE6ACyclic GMPPDE3BNitric oxidePDE?PDE11ACHRNA7ADCY3PDE9AGUCY1A3PKAPDE8APDE7ARolipramPDE6BPDE6GPKGADCY8ADCY5PDE3AADCY7ADCY2GUCY1A2GRIN2CPDE2AGRIN2DCalciumPDE4BDopamineCaMKPDEADORA2ADARPP-32PDE8BSildenafilPDE1ACREBGRIA1PDE6HADCY9ADCY10ADCY6PDE3BPDE4APDE3ACaffeinePDE4CGMPPDE6DPDE10APDE7BGUCY1B3GUCY1B2L-GlutamatePDE5APDE12ADCY1PDE4DPDE5ACilostazolDRD2DRD1GRIN2APDE1BAMPPDE6CADCY4Cyclic AMPL-GlutamateL-GlutamateCyclic AMPDopamineneuron dopamergic neuron from substantianigra pars compacta (SNc)and/or ventral tegmental areaDopaminePDE10APDE4DPDE1BPDE4DL-GlutamateDopaminePKADRD2GRIN1GRIN2DGRIN2CGRIN2AGRIN2BAMPAspiny neuronD1 direct pathwayspiny neuron D2 indirect pathwaystriatal interneuronGMPCyclic GMPGUCY1A3GUCY1A2GUCY1B2GUCY1B3GMPCyclic GMPPDE1BnucleusCREBPKGAMPAGRIN1GRIN2DGRIN2CGRIN2AGRIN2BDRD1nucleusCREBPKGGUCY1A2GUCY1B3GUCY1A3GUCY1B2GRIN2AGRIN2CGRIN1GRIN2BGRIN2DDRD1DRD2Dopamine receptor D2GRIA1ADORA2AGUCY1B2GUCY1A3GUCY1B3GUCY1A2Adenylat cyclases (AC)PDE1BPDE10APDE4DADCY2ADCY1AMPCyclic AMPADCY2ADCY1AMPADCY2ADCY1DARPP-32PKAADCY2ADCY1AMPCyclic AMPPKADARPP-32


Description

Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

Quality Tags

Ontology Terms

 

Bibliography

  1. Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle LP, Blokland A, Prickaerts J; ''''; , PubMed Europe PMC Scholia
  2. Kitabchi AE, Wilson DB, Sharma RK.; ''Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE).''; vBiochem Biophys Res Commun. , 1971 PubMed Europe PMC Scholia
  3. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, Kimura Y, Ikeda Y, Shiku H, Nishikawa M.; ''Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.''; Life Sci. , 1997 PubMed Europe PMC Scholia
  4. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, Deschepper CF, Petrof BJ, Des Rosiers C.; ''Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.''; Proc Natl Acad Sci U S A., 2008 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
107160view14:24, 17 September 2019MaintBotChEBI identifier normalization
106137view12:03, 16 August 2019MaintBotHMDB identifier normalization
105135view12:00, 10 July 2019EgonwFixed the identifier for L-glutamate (a more accurate record)
96808view11:35, 9 April 2018Fehrhartfixed data node annotation
96231view13:22, 1 March 2018FehrhartOntology Term : 'attention deficit hyperactivity disorder' added !
96230view13:22, 1 March 2018FehrhartOntology Term : 'obsessive-compulsive disorder' added !
96229view13:22, 1 March 2018FehrhartOntology Term : 'Gilles de la Tourette syndrome' added !
96228view13:22, 1 March 2018FehrhartOntology Term : 'Huntington's disease' added !
96227view13:21, 1 March 2018FehrhartOntology Term : 'Parkinson's disease' added !
96226view13:21, 1 March 2018FehrhartOntology Term : 'schizophrenia' added !
96225view13:20, 1 March 2018FehrhartOntology Term : 'Alzheimer's disease' added !
96224view13:19, 1 March 2018FehrhartOntology Term : 'glutamate signaling pathway' added !
96223view13:19, 1 March 2018FehrhartOntology Term : 'dopamine signaling pathway' added !
96222view13:18, 1 March 2018FehrhartOntology Term : 'neuron-to-neuron signaling pathways' added !
96221view13:18, 1 March 2018FehrhartOntology Term : 'neuron' added !
96220view13:17, 1 March 2018Fehrhartwork in progress
96219view11:02, 1 March 2018Fehrhartwork in progress
96218view10:15, 1 March 2018FehrhartModified title
96216view15:31, 28 February 2018Fehrhartwork in progress
96215view15:00, 28 February 2018Fehrhartwork in progress
96214view14:21, 28 February 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADCY10GeneProductENSG00000143199 (Ensembl)
ADCY1GeneProductENSG00000164742 (Ensembl)
ADCY2GeneProductENSG00000078295 (Ensembl)
ADCY3GeneProductENSG00000138031 (Ensembl)
ADCY4GeneProductENSG00000129467 (Ensembl)
ADCY5GeneProductENSG00000173175 (Ensembl)
ADCY6GeneProductENSG00000174233 (Ensembl)
ADCY7GeneProductENSG00000121281 (Ensembl)
ADCY8GeneProductENSG00000155897 (Ensembl)
ADCY9GeneProductENSG00000162104 (Ensembl)
ADORA2AGeneProductENSG00000128271 (Ensembl)
AMPAGeneProductENSG00000155511 (Ensembl)
AMPMetaboliteHMDB03540 (HMDB)
CHRNA7GeneProductENSG00000175344 (Ensembl)
CREBGeneProductENSG00000118260 (Ensembl)
CaMK GeneProduct
CaffeineMetaboliteHMDB01847 (HMDB)
CalciumMetaboliteHMDB00464 (HMDB)
CilostazolMetaboliteHMDB15297 (HMDB)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
DARPP-32GeneProductENSG00000131771 (Ensembl)
DRD1GeneProductENSG00000184845 (Ensembl)
DRD2GeneProductENSG00000149295 (Ensembl)
DopamineMetaboliteHMDB00073 (HMDB)
GMPMetaboliteHMDB0001397 (HMDB)
GRIA1GeneProductENSG00000155511 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2DGeneProductENSG00000105464 (Ensembl)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
NOS1GeneProductENSG00000089250 (Ensembl)
Nitric oxideMetaboliteHMDB03378 (HMDB)
PDEGeneProduct
PDE10AGeneProductENSG00000112541 (Ensembl)
PDE11AGeneProductENSG00000128655 (Ensembl)
PDE12GeneProductENSG00000174840 (Ensembl)
PDE1AGeneProductENSG00000115252 (Ensembl)
PDE1BGeneProductENSG00000123360 (Ensembl)
PDE1CGeneProductENSG00000154678 (Ensembl)
PDE2AGeneProductENSG00000186642 (Ensembl)
PDE3AGeneProductENSG00000172572 (Ensembl)
PDE3BGeneProductENSG00000152270 (Ensembl)
PDE4AGeneProductENSG00000065989 (Ensembl)
PDE4BGeneProductENSG00000184588 (Ensembl)
PDE4CGeneProductENSG00000105650 (Ensembl)
PDE4DGeneProductENSG00000113448
PDE4DGeneProductENSG00000113448 (Ensembl)
PDE5AGeneProductENSG00000138735 (Ensembl)
PDE6AGeneProductENSG00000132915 (Ensembl)
PDE6BGeneProductENSG00000133256 (Ensembl)
PDE6CGeneProductENSG00000095464 (Ensembl)
PDE6DGeneProductENSG00000156973 (Ensembl)
PDE6GGeneProductENSG00000185527 (Ensembl)
PDE6HGeneProductENSG00000139053 (Ensembl)
PDE7AGeneProductENSG00000205268 (Ensembl)
PDE7BGeneProductENSG00000171408 (Ensembl)
PDE8AGeneProductENSG00000073417 (Ensembl)
PDE8BGeneProductENSG00000113231 (Ensembl)
PDE9AGeneProductENSG00000160191 (Ensembl)
PDE?GeneProduct
PKAGeneProduct
PKGGeneProduct
RolipramMetabolite104872 (ChEBI)
SildenafilMetaboliteHMDB05039 (HMDB)

Annotated Interactions

No annotated interactions

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