Phosphodiesterases in neuronal function (Homo sapiens)

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1nucleusNAc/CPUsynaptic gapneuron frontal cortexLegendrelease of neurotransmitters into synaptic gapbindingstimulationinhibitionCyclic AMPCyclic GMPGRIN2DGCGRIN1CREBCaMKL-GlutamateAC GRIN2APDE10AGRIN2BPKAPDE?PDE1BGRIN2CDopamineCalciumDRD1ADORA2APDE4DD2AMPAPKGDARPP-32L-GlutamateL-GlutamateCyclic AMPDopamineneuron neuron DopaminePDE10APDE4DPDE1BPDE4DL-GlutamateDopaminePKAD2GRIN1GRIN2DGRIN2CGRIN2AGRIN2BAMPA


Description

Phosphodiesterases are enzymes which break phosphodiester bonds and play an importan role in signaling pathways, especially in second messenger pathways which involve cyclic AMP or GMP.

Quality Tags

Ontology Terms

 

Bibliography

  1. Heckman PR, van Duinen MA, Bollen EP, Nishi A, Wennogle LP, Blokland A, Prickaerts J; ''''; , PubMed Europe PMC
  2. Kitabchi AE, Wilson DB, Sharma RK.; ''Steroidogenesis in isolated adrenal cells of rat. II. Effect of caffeine on ACTH and cyclic nucleotide-induced steroidogenesis and its relation to cyclic nucleotide phosphodiesterase (PDE).''; vBiochem Biophys Res Commun. , 1971 PubMed Europe PMC
  3. Minami N, Suzuki Y, Yamamoto M, Kihira H, Imai E, Wada H, Kimura Y, Ikeda Y, Shiku H, Nishikawa M.; ''Inhibition of shear stress-induced platelet aggregation by cilostazol, a specific inhibitor of cGMP-inhibited phosphodiesterase, in vitro and ex vivo.''; Life Sci. , 1997 PubMed Europe PMC
  4. Khairallah M, Khairallah RJ, Young ME, Allen BG, Gillis MA, Danialou G, Deschepper CF, Petrof BJ, Des Rosiers C.; ''Sildenafil and cardiomyocyte-specific cGMP signaling prevent cardiomyopathic changes associated with dystrophin deficiency.''; Proc Natl Acad Sci U S A., 2008 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
107160view14:24, 17 September 2019MaintBotChEBI identifier normalization
106137view12:03, 16 August 2019MaintBotHMDB identifier normalization
105135view12:00, 10 July 2019EgonwFixed the identifier for L-glutamate (a more accurate record)
96808view11:35, 9 April 2018Fehrhartfixed data node annotation
96231view13:22, 1 March 2018FehrhartOntology Term : 'attention deficit hyperactivity disorder' added !
96230view13:22, 1 March 2018FehrhartOntology Term : 'obsessive-compulsive disorder' added !
96229view13:22, 1 March 2018FehrhartOntology Term : 'Gilles de la Tourette syndrome' added !
96228view13:22, 1 March 2018FehrhartOntology Term : 'Huntington's disease' added !
96227view13:21, 1 March 2018FehrhartOntology Term : 'Parkinson's disease' added !
96226view13:21, 1 March 2018FehrhartOntology Term : 'schizophrenia' added !
96225view13:20, 1 March 2018FehrhartOntology Term : 'Alzheimer's disease' added !
96224view13:19, 1 March 2018FehrhartOntology Term : 'glutamate signaling pathway' added !
96223view13:19, 1 March 2018FehrhartOntology Term : 'dopamine signaling pathway' added !
96222view13:18, 1 March 2018FehrhartOntology Term : 'neuron-to-neuron signaling pathways' added !
96221view13:18, 1 March 2018FehrhartOntology Term : 'neuron' added !
96220view13:17, 1 March 2018Fehrhartwork in progress
96219view11:02, 1 March 2018Fehrhartwork in progress
96218view10:15, 1 March 2018FehrhartModified title
96216view15:31, 28 February 2018Fehrhartwork in progress
96215view15:00, 28 February 2018Fehrhartwork in progress
96214view14:21, 28 February 2018FehrhartNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AC GeneProduct
ADORA2AGeneProductENSG00000128271
AMPAGeneProductENSG00000155511
CREBGeneProductENSG00000118260
CaMK GeneProduct
CalciumMetaboliteHMDB00464 (HMDB)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Cyclic GMPMetaboliteHMDB01314 (HMDB)
D2GeneProductENSG00000149295
DARPP-32GeneProductENSG00000131771
DRD1GeneProductENSG00000184845
DopamineMetaboliteHMDB00073 (HMDB)
GCGeneProduct
GRIN1GeneProductENSG00000176884
GRIN2AGeneProductENSG00000183454
GRIN2BGeneProductENSG00000273079
GRIN2CGeneProductENSG00000161509
GRIN2DGeneProductENSG00000105464
L-GlutamateMetaboliteHMDB60475 (HMDB)
PDE10AGeneProductENSG00000112541
PDE1BGeneProductENSG00000123360
PDE4DGeneProductENSG00000113448
PDE?GeneProduct
PKAGeneProduct
PKGGeneProduct

Annotated Interactions

No annotated interactions

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