Endometrial cancer (Homo sapiens)

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1-5, 7-10610LegendNucleusFree beta-cateninCell survivalActivating mutationType I endometrialadenocarcinomap53 Signaling PathwayFOSERBB Signaling PathwayAdherens junctionEGFPIP3MAPK SignalingPathwayEGFRGRB2SOS1SOS2HRASKRASNRASARAFBRAFRAF1MAP2K1PPMAP2K2PPMAPK1MAPK3PPPPELK1PPPPTENPIK3CAPIK3CBPIK3CDPIK3R1PIK3R2PIK3R3PDPK1ILKAKT1PAKT2PAKT3PFOXO3PPPBADPPPPCASP9PPPPI3K-Akt Signaling PathwayCDH1CTNNB1CTNNA1CTNNA2CTNNA3AXIN1AXIN2APCAPC2GSK3BCTNNB1PCTNNB1Wnt Signaling PathwayTCF7LEF1TCF7L1TCF7L2CCND1MYCCell growth and proliferationProliferationType II serous adenocarcinomaERBB2Cell CycleUncontrolled proliferationIncreased survivalGenomic instabilityBAXCDKN1ADDB2GADD45AGADD45BGADD45GBAK1POLKDNA damageTP53Inactivating mutationType I endometrialadenocarcinomaType I endometrialadenocarcinomaFGFR2FGF1FGF2FGFR1FGFR31010


Description

Endometrial cancer (EC) is the most common gynecological malignancy and the fourth most common malignancy in women in the developed world after breast, colorectal and lung cancer. Two types of endometrial carcinoma are distinguished with respect to biology and clinical course. Type-I carcinoma is related to hyperestrogenism by association with endometrial hyperplasia, frequent expression of estrogen and progesterone receptors and younger age, whereas type-II carcinoma is unrelated to estrogen, associated with atrophic endometrium, frequent lack of estrogen and progesterone receptors and older age. The morphologic differences in these cancers are mirrored in their molecular genetic profile with type I showing defects in DNA-mismatch repair and mutations in PTEN, K-ras, and beta-catenin, and type II showing aneuploidy, p53 mutations, and her2/neu amplification.

Pathway was modeled after KEGG Endometrial Cancer pathway (http://www.genome.jp/dbget-bin/www_bget?pathway+hsa05213)

Phosphorylation information collected from PhosphoSitePlus (https://www.phosphosite.org)

Quality Tags

Ontology Terms

 

Bibliography

  1. Winterhoff B, Konecny GE; ''Targeting fibroblast growth factor pathways in endometrial cancer.''; Curr Probl Cancer, 2017 PubMed Europe PMC
  2. Buza N, Roque DM, Santin AD; ''HER2/neu in Endometrial Cancer: A Promising Therapeutic Target With Diagnostic Challenges.''; Arch Pathol Lab Med, 2014 PubMed Europe PMC
  3. Hipskind RA, Rao VN, Mueller CG, Reddy ES, Nordheim A; ''Ets-related protein Elk-1 is homologous to the c-fos regulatory factor p62TCF.''; Nature, 1991 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106779view13:25, 17 September 2019MaintBotHMDB identifier normalization
106402view21:32, 28 August 2019KhanspersModified description
105446view04:56, 8 August 2019KhanspersModified description
105335view00:08, 1 August 2019Khanspersupdated layout, added drugs
105007view04:57, 28 June 2019KhanspersModified description
103782view20:28, 5 April 2019Khanspersmoved lit ref from state to parent node
103771view01:02, 5 April 2019Khanspersupdated ERBB2 amplification status and legend
97135view21:34, 30 April 2018Khanspersupdated lit refs and added cell type
95371view16:29, 10 December 2017Khanspersadded FGFR drug targeting
95023view23:46, 1 November 2017KhanspersAdded FGFR signaling, updated signaling through ERBB2
94899view19:39, 12 October 2017Khanspersmoved comment from node to state
94811view00:45, 6 October 2017AlexanderPicoOntology Term : 'endometrial cancer pathway' added !
94810view00:44, 6 October 2017AlexanderPicoOntology Term : 'disease pathway' added !
94809view00:44, 6 October 2017AlexanderPicoUpdated layout, labels and lines connecting to non-datanodes
94800view23:25, 5 October 2017Khansperslayout change - move Type I part to the left
94778view21:23, 5 October 2017AlexanderPicoAdded 5 more FOXO3 PTMs
94777view19:49, 5 October 2017Khanspersadditional phosphosites
94776view19:42, 5 October 2017KhanspersOntology Term : 'epithelial cell of uterus' added !
94775view19:41, 5 October 2017KhanspersOntology Term : 'endometrial cancer' added !
94774view19:41, 5 October 2017KhanspersModified description
94773view19:39, 5 October 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
AKT1GeneProductENSG00000142208 (Ensembl)
AKT2GeneProductENSG00000105221 (Ensembl)
AKT3GeneProductENSG00000117020 (Ensembl)
APC2GeneProductENSG00000115266 (Ensembl)
APCGeneProductENSG00000134982 (Ensembl)
ARAFGeneProductENSG00000078061 (Ensembl)
AXIN1GeneProductENSG00000103126 (Ensembl)
AXIN2GeneProductENSG00000168646 (Ensembl)
Adherens junctionPathway
BADGeneProductENSG00000002330 (Ensembl)
BAK1GeneProductENSG00000030110 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
BRAFGeneProductENSG00000157764 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CCND1GeneProductENSG00000110092 (Ensembl)
CDH1GeneProductENSG00000039068 (Ensembl)
CDKN1AGeneProductENSG00000124762 (Ensembl)
CTNNA1GeneProductENSG00000044115 (Ensembl)
CTNNA2GeneProductENSG00000066032 (Ensembl)
CTNNA3GeneProductENSG00000183230 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell CyclePathwayWP179 (WikiPathways)
DDB2GeneProductENSG00000134574 (Ensembl)
EGFGeneProductENSG00000138798 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
ELK1GeneProductENSG00000126767 (Ensembl)
ERBB Signaling PathwayPathwayWP673 (WikiPathways)
ERBB2GeneProductENSG00000141736 (Ensembl)
FGF1GeneProductENSG00000113578 (Ensembl)
FGF2GeneProductENSG00000138685 (Ensembl)
FGFR1GeneProductENSG00000077782 (Ensembl)
FGFR2GeneProductENSG00000066468 (Ensembl)
FGFR3GeneProductENSG00000068078 (Ensembl)
FOSGeneProductENSG00000170345 (Ensembl)
FOXO3GeneProductENSG00000118689 (Ensembl)
GADD45AGeneProductENSG00000116717 (Ensembl)
GADD45BGeneProductENSG00000099860 (Ensembl)
GADD45GGeneProductENSG00000130222 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GSK3BGeneProductENSG00000082701 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
ILKGeneProductENSG00000166333 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
LEF1GeneProductENSG00000138795 (Ensembl)
MAP2K1GeneProductENSG00000169032 (Ensembl)
MAP2K2GeneProductENSG00000126934 (Ensembl)
MAPK Signaling PathwayPathwayWP382 (WikiPathways)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK3GeneProductENSG00000102882 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PDPK1GeneProductENSG00000140992 (Ensembl)
PI3K-Akt Signaling PathwayPathwayWP3932 (WikiPathways)
PIK3CAGeneProductENSG00000121879 (Ensembl)
PIK3CBGeneProductENSG00000051382 (Ensembl)
PIK3CDGeneProductENSG00000171608 (Ensembl)
PIK3R1GeneProductENSG00000145675 (Ensembl)
PIK3R2GeneProductENSG00000105647 (Ensembl)
PIK3R3GeneProductENSG00000117461 (Ensembl)
PIP3MetaboliteHMDB04249 (HMDB)
POLKGeneProductENSG00000122008 (Ensembl)
PTENGeneProductENSG00000171862 (Ensembl)
RAF1GeneProductENSG00000132155 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SOS2GeneProductENSG00000100485 (Ensembl)
TCF7GeneProductENSG00000081059 (Ensembl)
TCF7L1GeneProductENSG00000152284 (Ensembl)
TCF7L2GeneProductENSG00000148737 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
Wnt Signaling PathwayPathwayWP428 (WikiPathways)
p53 Signaling PathwayPathway

Annotated Interactions

No annotated interactions

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