Cell Cycle and Cell Division (Saccharomyces cerevisiae)

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Second messengersignaling pathway+pMaintenance) Complex+p-p+plow+p+pUBA (E1)MBFAPC/Cyclosome+pM+pAPCUbiquitin mediated proteolysisCondensinUBC (E2)+pSBFDNASpre-RC+plow+pG2ORC (OrigninDNA biosynthesisG1MCBSpindle checkpoint+pAPCARSPheromone(mating signal)eUnattached kinetochoresSTARTDNA damage checkpointsMCM (Mini-ChromosomeDNA26SProteasome+pMAPK signalingpathwaySCF (E3)-pORC+pS-phaseproteinseSCBRecognition Complex)high+pCondensinMCMNutrientsDNA+p2Skp1Pds1Mec3Mcm6Bub1Cdc4Cak1Cdh1Chk1Pho4Brn1Hsl1Bub3Cdc28PhosphateMad1Swi5Apc5Orc1Orc3Hus1Mad3Mad2Cdc28Rad1Cks1Dam1Apc8Apc11Mec1Mbp1Cdc28Gin4Cdc16Esc5Tup1Mih1Pho80Crt1Rad9Pho85Byr4Sic1Rad26Mps1Cdc20Cdc53Cdc53Tem1Bub2Cdc34Pho85Dbf4Cdc23Cdc7Doc1Pho2Clb3Cdc5Cdc6Sic1Mob1Swe1Cdc46Cdc15Cln3Mik1Uba1Esp1Dbf2Dcd1Sco1Cyclic AMPMcm2Far1Cdc53Fus3Dbf20Ssn6Loc7Rad25Apc1Pds1Apc9Mcm3Swi6Rad9Orc2Rad53Cdc54Apc2Swi6Cln1Scc2Smc4Cdc34Cdc47Rad9Cdc27Rad17Cdc5Cdc45Smc2Skp1Pcl1Cdc26Rad24Orc4Orc6Pho81Swi4Ycg1Hsl7Skp1Clb1Clb5Met30Grr1Lte1Cdc34Rad24Pho5Cdc14Cdc28Cdc28Orc5Apc41


Description

(From http://en.wikipedia.org/wiki/Cell_cycle) The cell cycle is the series of events that takes place in a cell leading to its division and duplication (replication). Regulation of the cell cycle involves processes crucial to the survival of a cell, including the detection and repair of genetic damage as well as the prevention of uncontrolled cell division. Two key classes of regulatory molecules, cyclins and cyclin-dependent kinases (CDKs), determine a cell's progress through the cell cycle.

Comments

GenMAPP notes 
Adapted from: http://www.genome.ad.jp/kegg/pathway/sce/sce04110.html

Quality Tags

Ontology Terms

 

Bibliography

  1. Kang J, Yu H; ''Kinase signaling in the spindle checkpoint.''; J Biol Chem, 2009 PubMed Europe PMC Scholia
  2. Taylor SS; ''Chromosome segregation: dual control ensures fidelity.''; Curr Biol, 1999 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
107024view13:48, 17 September 2019MaintBotHMDB identifier normalization
97053view15:16, 26 April 2018AdoBioInfoFixed unconnected lines. For free. *Godsplan by Drake starts playing*
89528view11:04, 16 September 2016Mkutmonontology tag fix
89487view13:39, 15 September 2016Mkutmonremove space from ontology term id
78393view10:25, 7 January 2015MaintBotadded missing graphIds
76251view22:37, 23 June 2014Khanspersconnected lines, added states, general cleanup
71351view18:02, 17 October 2013MaintBotAutomated update of data sources
70079view09:51, 12 July 2013Mkutmonfixed unconnected lines
69871view17:49, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69659view20:39, 8 July 2013MaintBotUpdated to 2013 gpml schema
67105view10:07, 26 June 2013Christine ChichesterOntology Term : 'cell cycle pathway, mitotic' added !
62698view23:08, 1 May 2013MaintBotUpdated UniProt data source
60654view10:02, 25 March 2013StephanieWiddisonOne of the two bub1's should probably be bub3. Added litrefs.
41898view04:53, 2 March 2011MaintBotRemoved redundant pathway information and comments
35394view09:43, 12 February 2010MartijnVanIerselConnected right half
35386view09:28, 12 February 2010MartijnVanIerselConnected lines (left half)
35385view09:27, 12 February 2010MartijnVanIerselPeriodical save, work in progress
35368view09:15, 12 February 2010MartijnVanIerselModified description
21554view11:32, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Cell Cycle KEGG]] moved to [[Pathway:WP414]]: Moved to stable identifier
12668view07:57, 17 May 2008MaintBotautomated metabolite conversion
8537view14:02, 7 January 2008MaintBotAdded to category $category
19400view14:02, 7 January 2008BruceConklinUploaded new pathway
8535view14:02, 7 January 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
Apc11GeneProductS000002166 (SGD)
Apc1GeneProductS000005116 (SGD)
Apc2GeneProductS000004117 (SGD)
Apc4GeneProductS000002525 (SGD)
Apc5GeneProductS000005775 (SGD)
Apc8GeneProduct
Apc9GeneProductS000004092 (SGD)
Brn1GeneProductS000000193 (SGD)
Bub1GeneProductS000003420 (SGD)
Bub2GeneProductS000004659 (SGD)
Bub3GeneProductS000005552 (SGD)
Byr4GeneProductS000003814 (SGD)
Cak1GeneProductS000001865 (SGD)
Cdc14GeneProductS000001924 (SGD)
Cdc15GeneProductS000000072 (SGD)
Cdc16GeneProductS000001505 (SGD)
Cdc20GeneProductS000003084 (SGD)
Cdc23GeneProductS000001209 (SGD)
Cdc26GeneProductS000001932 (SGD)
Cdc27GeneProductS000000180 (SGD)
Cdc28GeneProductS000000364 (SGD)
Cdc34GeneProductS000002461 (SGD)
Cdc45GeneProductS000004093 (SGD)
Cdc46GeneProductS000004264 (SGD)
Cdc47GeneProductS000000406 (SGD)
Cdc4GeneProductS000001885 (SGD)
Cdc53GeneProductS000002290 (SGD)
Cdc54GeneProductS000006223 (SGD)
Cdc5GeneProductS000004603 (SGD)
Cdc6GeneProductS000003730 (SGD)
Cdc7GeneProductS000002175 (SGD)
Cdh1GeneProductS000002971 (SGD)
Chk1GeneProductS000000478 (SGD)
Cks1GeneProductS000000339 (SGD)
Clb1GeneProductS000003340 (SGD)
Clb3GeneProductS000002314 (SGD)
Clb5GeneProductS000006324 (SGD)
Cln1GeneProductS000004812 (SGD)
Cln3GeneProductS000000038 (SGD)
Crt1GeneProductS000003746 (SGD)
Cyclic AMPMetaboliteHMDB00058 (HMDB)
Dam1GeneProductS000003345 (SGD)
Dbf20GeneProductS000006315 (SGD)
Dbf2GeneProductS000003324 (SGD)
Dbf4GeneProductS000002459 (SGD)
Dcd1GeneProductS000006115 (SGD)
Doc1GeneProductS000003209 (SGD)
Esc5GeneProductS000003612 (SGD)
Esp1GeneProductS000003330 (SGD)
Far1GeneProductS000003693 (SGD)
Fus3GeneProductS000000112 (SGD)
Gin4GeneProductS000002915 (SGD)
Grr1GeneProductS000003850 (SGD)
Hsl1GeneProductS000001584 (SGD)
Hsl7GeneProductS000000337 (SGD)
Hus1GeneProductS000005424 (SGD)
Loc7GeneProductS000004262 (SGD)
Lte1GeneProductS000000022 (SGD)
Mad1GeneProductS000003054 (SGD)
Mad2GeneProductS000003567 (SGD)
Mad3GeneProductS000003550 (SGD)
Mbp1GeneProductS000002214 (SGD)
Mcm2GeneProductS000000119 (SGD)
Mcm3GeneProductS000000758 (SGD)
Mcm6GeneProductS000003169 (SGD)
Mec1GeneProductS000000340 (SGD)
Mec3GeneProductS000004279 (SGD)
Met30GeneProductS000001308 (SGD)
Mih1GeneProductS000004639 (SGD)
Mik1GeneProduct
Mob1GeneProductS000001368 (SGD)
Mps1GeneProductS000002186 (SGD)
Orc1GeneProductS000004530 (SGD)
Orc2GeneProductS000000264 (SGD)
Orc3GeneProductS000003927 (SGD)
Orc4GeneProductS000006366 (SGD)
Orc5GeneProductS000005205 (SGD)
Orc6GeneProductS000001160 (SGD)
Pcl1GeneProductS000005233 (SGD)
Pds1GeneProductS000002520 (SGD)
Pho2GeneProductS000002264 (SGD)
Pho4GeneProductS000001930 (SGD)
Pho5GeneProductS000000297 (SGD)
Pho80GeneProductS000005361 (SGD)
Pho81GeneProductS000003465 (SGD)
Pho85GeneProductS000005952 (SGD)
Phosphate14265-44-2 (CAS)
Rad17GeneProductS000005895 (SGD)
Rad1GeneProductS000005943 (SGD)
Rad24GeneProductS000000975 (SGD)
Rad25GeneProductS000001405 (SGD)
Rad26GeneProductS000003796 (SGD)
Rad53GeneProductS000006074 (SGD)
Rad9GeneProductS000002625 (SGD)
Scc2GeneProductS000002588 (SGD)
Sco1GeneProductS000000241 (SGD)
Sic1GeneProductS000004069 (SGD)
Skp1GeneProductS000002736 (SGD)
Smc2GeneProductS000001927 (SGD)
Smc4GeneProductS000004076 (SGD)
Ssn6GeneProductS000000316 (SGD)
Swe1GeneProductS000003723 (SGD)
Swi4GeneProductS000000913 (SGD)
Swi5GeneProductS000002553 (SGD)
Swi6GeneProductS000004172 (SGD)
Tem1GeneProductS000004529 (SGD)
Tup1GeneProductS000000680 (SGD)
Uba1GeneProductS000001693 (SGD)
Ycg1GeneProductS000002733 (SGD)

Annotated Interactions

No annotated interactions
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