Oxidative Stress (Homo sapiens)
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Stress-regulated
MAP kinase
Inhibition of oxidases
Induction of
antioxidant genes
Reactive Oxygen Species
Repression
Immediate-early
gene induction
TF inhibition
Repression of ROS-
producing systems
Adaptive response
Activation
TF activation
HMOX1
FOS
NFKB1
MT1X
NOX4
TXNRD1
MAOA
GPX3
MAPK10
NFE2L2
SP1
MAPK14
GCLC
CYBA
CYP1A1
TXNRD2
JUNB
SOD3
GSTT2
GSR
NFIX
TXN2
CAT
SOD2
MGST1
UGT1A6
NQO1
SOD1
XDH
GPX1
Description
No description
Comments
GenMAPP notes
Adapted from Biochem J 1999 Sep 15;342 Pt 3:481-96 Morel Y, Barouki R. Repression of gene expression by oxidative stress. Biochem J 1999 Sep 15;342 Pt 3:481-96
GenMAPP remarks
Adapted from rat by GenMAPP.org
Quality Tags
Ontology Terms
Saving...
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Bibliography
Morel Y, Barouki R; ''Repression of gene expression by oxidative stress.''; Biochem J, 1999
PubMed
Europe PMC
Scholia
History
View all...
Compare
Revision
Action
Time
User
Comment
106567
view
21:14, 6 September 2019
Khanspers
Modified description
105772
view
19:39, 15 August 2019
Khanspers
Modified description
102225
view
21:08, 11 December 2018
Khanspers
fixed interaction and added missing xrefs
98125
view
13:53, 24 July 2018
Hhhwschmidt
Polishing
98124
view
13:48, 24 July 2018
Hhhwschmidt
Added NOX1, 2, 3, 5.
98123
view
13:37, 24 July 2018
Hhhwschmidt
Moved NOX4 from being a target of ROS to being a source of ROS
94131
view
09:25, 23 August 2017
Xuyongdeng
78546
view
10:30, 7 January 2015
MaintBot
added missing graphIds
77658
view
05:20, 3 October 2014
Egonw
Gave 'Reactive Oxygen Species' a ChEBI ID.
69029
view
17:50, 8 July 2013
MaintBot
Updated to 2013 gpml schema
59210
view
19:50, 22 February 2013
MaintBot
Updated Ensembl and UniProt data source
45296
view
19:19, 7 October 2011
Khanspers
Modified description
45295
view
19:17, 7 October 2011
Khanspers
Modified description
45293
view
19:15, 7 October 2011
Khanspers
removed old comment
45288
view
19:14, 7 October 2011
Khanspers
added lit ref
45283
view
19:09, 7 October 2011
Khanspers
Ontology Term : 'oxidative stress response pathways' added !
45145
view
01:15, 7 October 2011
AlexanderPico
fixed db ref
42904
view
17:22, 19 May 2011
MartijnVanIersel
Turn improper complexes into groups
41211
view
23:44, 1 March 2011
MaintBot
Removed redundant pathway information and comments
38774
view
23:47, 23 September 2010
AlexanderPico
38772
view
23:46, 23 September 2010
AlexanderPico
38771
view
23:46, 23 September 2010
AlexanderPico
Specify description
38459
view
07:32, 15 September 2010
Kodlips
Periodical save, work in progress
32425
view
17:10, 15 August 2009
MaintBot
Fixed text labels
32084
view
13:40, 14 August 2009
MaintBot
Fixed group labels
21540
view
11:32, 14 November 2008
MaintBot
[[Pathway:Homo sapiens:Oxidative Stress]] moved to [[Pathway:WP408]]: Moved to stable identifier
15413
view
23:17, 27 May 2008
Khanspers
connectors fix
14770
view
00:53, 24 May 2008
Khanspers
Added connectors, increased label size
14768
view
00:51, 24 May 2008
Khanspers
added connectors
12959
view
10:56, 17 May 2008
MaintBot
Sticky edges patch by Sjoerd
8318
view
13:46, 7 January 2008
MaintBot
[[Pathway:Human:Oxidative Stress]] moved to [[Pathway:Homo sapiens:Oxidative Stress]]: Renaming species
7777
view
16:17, 18 December 2007
MaintBot
fixed category names
7482
view
12:42, 4 November 2007
MaintBot
Added categories to GPML
19531
view
22:18, 22 May 2007
I.Reyes
gpml file for [[Human:Oxidative_Stress]]
6360
view
22:18, 22 May 2007
N.Reyes
gpml file for [[Human:Oxidative_Stress]]
External references
DataNodes
View all...
Name
Type
Database reference
Comment
CAT
GeneProduct
847 (Entrez Gene)
CYBA
GeneProduct
1535 (Entrez Gene)
Probe set ID: u18729
CYP1A1
GeneProduct
1543 (Entrez Gene)
FOS
GeneProduct
2353 (Entrez Gene)
GCLC
GeneProduct
2729 (Entrez Gene)
GPX1
GeneProduct
2876 (Entrez Gene)
GPX3
GeneProduct
2878 (Entrez Gene)
GSR
GeneProduct
2936 (Entrez Gene)
GSTT2
GeneProduct
2953 (Entrez Gene)
HMOX1
GeneProduct
3162 (Entrez Gene)
JUNB
GeneProduct
3726 (Entrez Gene)
MAOA
GeneProduct
4128 (Entrez Gene)
MAPK10
GeneProduct
5602 (Entrez Gene)
MAPK14
GeneProduct
1432 (Entrez Gene)
MGST1
GeneProduct
4257 (Entrez Gene)
MT1X
GeneProduct
4501 (Entrez Gene)
NFE2L2
GeneProduct
ENSG00000116044 (Ensembl Human)
NFIX
GeneProduct
4784 (Entrez Gene)
NFKB1
GeneProduct
4790 (Entrez Gene)
NOX4
GeneProduct
50507 (Entrez Gene)
NQO1
GeneProduct
1728 (Entrez Gene)
SOD1
GeneProduct
6647 (Entrez Gene)
SOD2
GeneProduct
6648 (Entrez Gene)
SOD3
GeneProduct
6649 (Entrez Gene)
SP1
GeneProduct
6667 (Entrez Gene)
TXN2
GeneProduct
25828 (Entrez Gene)
TXNRD1
GeneProduct
7296 (Entrez Gene)
TXNRD2
GeneProduct
10587 (Entrez Gene)
UGT1A6
GeneProduct
54578 (Entrez Gene)
XDH
GeneProduct
7498 (Entrez Gene)
Annotated Interactions
No annotated interactions
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