Gastric ulcer formation (Homo sapiens)

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Helicobactor pyloriPTGS1Platelet aggregationMucosal blood flowGastric ulcerPTGS2FAAHNSAIDsNH4+Bicarbonate ionsSurfacantMucousMucosal defenceAngiogenesisCNR1Leukocyte adherencePhospholipaseLeukocyte activationCNR2


Description

Adverse Outcome Pathway (AOP) for Gastric ulcer formation, originating from the AOPXplorer app for Cytoscape. Also, this AOP is in development on aopwiki.org (https://aopwiki.org/aops/217)

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

CompareRevisionActionTimeUserComment
96742view06:03, 2 April 2018EgonwReplaced a secondary ChEBI identifier with a primary identifier.
93136view13:57, 31 July 2017Marvin M2Ontology Term : 'gastric ulcer' added !
93135view13:56, 31 July 2017Marvin M2Ontology Term : 'digestive system disease pathway' added !
93129view12:21, 31 July 2017Marvin M2New pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AngiogenesisPathwayWP1539 (WikiPathways)
Bicarbonate ionsMetaboliteCHEBI:17544 (ChEBI)
CNR1GeneProductENSG00000118432 (Ensembl)
CNR2GeneProductENSG00000188822 (Ensembl)
FAAHGeneProductENSG00000117480 (Ensembl)
Gastric ulcer
Helicobactor pylori
Leukocyte activation
Leukocyte adherence
Mucosal blood flow
Mucosal defence
Mucous
NH4+MetaboliteCHEBI:7435 (ChEBI)
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
PTGS1GeneProductENSG00000095303 (Ensembl)
PTGS2GeneProductENSG00000073756 (Ensembl)
Phospholipase
Platelet aggregationPathwayWP1884 (WikiPathways)
Surfacant

Annotated Interactions

No annotated interactions

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