PPAR Signaling Pathway (Danio rerio)

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Liver / Skeletal muscleNucleuspltpacadlunsaturated fatty acidspparabVLDLChylomicronangpt14slc27a1b9-cis-Retinoic acidslc27a1asaturated fatty acidseicosanoidGluconeogenesisscdcd36zgc:101540Clofibrateslc27a6apoa1aacox3slc27a4thiazolidinedionesfabp3Adipocyokinesignaling pathwayNSAIDsVLDLChylomicronfabp2fabp7bfabp6fabp7afabp1aSkeletal muscle / AdipocyteAdipocyteunsaturated fatty acidsunsaturated fatty acids9-cis-Retinoic acid9-cis-Retinoic acidNSAIDseicosanoidrxrgapparabrxrgapparabrxrgafads2cyp7a1cyp8b1nr1h3cyp27a1.4dbifabp1afabp3slc27a1acd36lplacsbg1acs14bacsbg2acs14aacs11bacs15acs11aacs13bacs16acs13aslc27a4slc27a1bsi:dkey-91i10.3cyp27a1.2scdbehhadhcpt1aacpt1abcpt2acaa1scp2aLipid transportLipogenesisCholesterol metabolismFatty acid transportFatty acid oxidationacox1acadmLipidmetabolismplin2adipoqaadipoqbsorbs1Adipocyte differentiationilkpdpk1bsi:ch211-202a12.4 ubbubcpck1Cell survivalUbiquitinationpck2aqp7zgc:172295LigandTransciption factorTarget gene


Description

Peroxisome proliferator-activated receptors (PPARs) are nuclear hormone receptors that are activated by fatty acids and their derivatives. PPAR has three subtypes (PPARalpha, beta/delta, and gamma) showing different expression patterns in vertebrates. Each of them is encoded in a separate gene and binds fatty acids and eicosanoids. PPARalpha plays a role in the clearance of circulating or cellular lipids via the regulation of gene expression involved in lipid metabolism in liver and skeletal muscle. PPARbeta/delta is involved in lipid oxidation and cell proliferation. PPARgamma promotes adipocyte differentiation to enhance blood glucose uptake. Source: KEGG (http://www.genome.jp/dbget-bin/www_bget?pathway+dre03320)

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Ontology Terms

 

Bibliography

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  1. Lehrke M, Lazar MA; ''The many faces of PPARgamma.''; Cell, 2005 PubMed Europe PMC
  2. Takahashi N, Goto T, Kusudo T, Moriyama T, Kawada T; ''[The structures and functions of peroxisome proliferator-activated receptors (PPARs)].''; Nihon Rinsho, 2005 PubMed Europe PMC
  3. Mandard S, Müller M, Kersten S; ''Peroxisome proliferator-activated receptor alpha target genes.''; Cell Mol Life Sci, 2004 PubMed Europe PMC
  4. Hauner H; ''The mode of action of thiazolidinediones.''; Diabetes Metab Res Rev, 2002 PubMed Europe PMC
  5. Inoue H; ''[Endogenous ligands for PPARs].''; Nihon Rinsho, 2005 PubMed Europe PMC
  6. Feige JN, Gelman L, Michalik L, Desvergne B, Wahli W; ''From molecular action to physiological outputs: peroxisome proliferator-activated receptors are nuclear receptors at the crossroads of key cellular functions.''; Prog Lipid Res, 2006 PubMed Europe PMC
  7. Fujii H; ''[PPARs-mediated intracellular signal transduction].''; Nihon Rinsho, 2005 PubMed Europe PMC
  8. Desvergne B, Wahli W; ''Peroxisome proliferator-activated receptors: nuclear control of metabolism.''; Endocr Rev, 1999 PubMed Europe PMC
  9. Savage DB; ''PPAR gamma as a metabolic regulator: insights from genomics and pharmacology.''; Expert Rev Mol Med, 2005 PubMed Europe PMC
  10. Desvergne B, Michalik L, Wahli W; ''Transcriptional regulation of metabolism.''; Physiol Rev, 2006 PubMed Europe PMC
  11. Semple RK, Chatterjee VK, O'Rahilly S; ''PPAR gamma and human metabolic disease.''; J Clin Invest, 2006 PubMed Europe PMC
  12. Takada I, Kato S; ''[PPARs target genes].''; Nihon Rinsho, 2005 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106086view11:59, 16 August 2019MaintBotHMDB identifier normalization
93200view17:07, 2 August 2017Khanspersfixed unconnected
93149view23:07, 31 July 2017Khanspersfixed interaction
93067view17:03, 27 July 2017Khanspersfixed interaction
93039view22:52, 26 July 2017KhanspersOntology Term : 'PW:0001356' removed !
93038view22:52, 26 July 2017KhanspersOntology Term : 'peroxisome proliferator-activated receptor signaling pathway' added !
93037view22:52, 26 July 2017KhanspersOntology Term : 'altered peroxisome proliferator-activated receptor signaling pathway' added !
93036view22:52, 26 July 2017KhanspersAdded lit refs
93035view22:44, 26 July 2017KhanspersModified description
93034view22:43, 26 July 2017KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
9-cis-Retinoic acidMetaboliteHMDB02369 (HMDB)
Adipocyokine signaling pathwayPathway
ClofibrateMetaboliteHMDB14774 (HMDB)
GluconeogenesisPathwayWP1356 (WikiPathways)
NSAIDsMetaboliteCHEBI:35475 (ChEBI)
VLDL ChylomicronMetaboliteCHEBI:6495 (ChEBI)
acaa1GeneProductZDB-GENE-040704-48 (ZFIN)
acadlGeneProductZDB-GENE-040426-771 (ZFIN)
acadmGeneProductZDB-GENE-040426-1945 (ZFIN)
acox1GeneProductZDB-GENE-041010-219 (ZFIN)
acox3GeneProductZDB-GENE-040426-2163 (ZFIN)
acs11aGeneProductZDB-GENE-050809-115 (ZFIN)
acs11bGeneProductZDB-GENE-040801-88 (ZFIN)
acs13aGeneProductZDB-GENE-050420-181 (ZFIN)
acs13bGeneProductZDB-GENE-030131-492 (ZFIN)
acs14aGeneProductZDB-GENE-040426-1565 (ZFIN)
acs14bGeneProductZDB-GENE-030131-6493 (ZFIN)
acs15GeneProductZDB-GENE-040912-169 (ZFIN)
acs16GeneProductZDB-GENE-030131-6776 (ZFIN)
acsbg1GeneProductZDB-GENE-110914-219 (ZFIN)
acsbg2GeneProductZDB-GENE-030131-7099 (ZFIN)
adipoqaGeneProductZDB-GENE-080423-2 (ZFIN)
adipoqbGeneProductZDB-GENE-060825-220 (ZFIN)
angpt14GeneProductZDB-GENE-041111-222 (ZFIN)
apoa1aGeneProductZDB-GENE-990415-14 (ZFIN)
aqp7GeneProductZDB-GENE-030131-6461 (ZFIN)
cd36GeneProductZDB-GENE-040718-55 (ZFIN)
cpt1aaGeneProductZDB-GENE-060503-925 (ZFIN)
cpt1abGeneProductZDB-GENE-030131-3250 (ZFIN)
cpt2GeneProductZDB-GENE-030131-6719 (ZFIN)
cyp27a1.2GeneProductZDB-GENE-081104-511 (ZFIN)
cyp27a1.4GeneProductZDB-GENE-030131-1060 (ZFIN)
cyp7a1GeneProductZDB-GENE-040426-1296 (ZFIN)
cyp8b1GeneProductZDB-GENE-040808-53 (ZFIN)
dbiGeneProductZDB-GENE-040426-1861 (ZFIN)
ehhadhGeneProductZDB-GENE-040426-2581 (ZFIN)
eicosanoidMetaboliteCHEBI:23899 (ChEBI)
fabp1aGeneProductZDB-GENE-020318-3 (ZFIN)
fabp2GeneProductZDB-GENE-991019-5 (ZFIN)
fabp3GeneProductZDB-GENE-020318-2 (ZFIN)
fabp6GeneProductZDB-GENE-040625-49 (ZFIN)
fabp7aGeneProductZDB-GENE-000627-1 (ZFIN)
fabp7bGeneProductZDB-GENE-040614-4 (ZFIN)
fads2GeneProductZDB-GENE-011212-1 (ZFIN)
ilkGeneProductZDB-GENE-040426-1435 (ZFIN)
lplGeneProductZDB-GENE-990415-139 (ZFIN)
nr1h3GeneProductZDB-GENE-050410-7 (ZFIN)
pck1GeneProductZDB-GENE-030909-11 (ZFIN)
pck2GeneProductZDB-GENE-040426-2266 (ZFIN)
pdpk1bGeneProductZDB-GENE-040426-1820 (ZFIN)
plin2GeneProductZDB-GENE-050913-12 (ZFIN)
pltpGeneProductZDB-GENE-040801-22 (ZFIN)
pparabGeneProductZDB-GENE-990415-211 (ZFIN)
rxrgaGeneProductZDB-GENE-980526-36 (ZFIN)
saturated fatty acidsMetaboliteCHEBI:26607 (ChEBI)
scdGeneProductZDB-GENE-031106-3 (ZFIN)
scdbGeneProductZDB-GENE-050522-12 (ZFIN)
scp2aGeneProductZDB-GENE-040426-1846 (ZFIN)
si:ch211-202a12.4 GeneProductZDB-GENE-030131-8486 (ZFIN)
si:dkey-91i10.3GeneProductZDB-GENE-081105-124 (ZFIN)
slc27a1aGeneProductZDB-GENE-050320-112 (ZFIN)
slc27a1bGeneProductZDB-GENE-061013-672 (ZFIN)
slc27a4GeneProductZDB-GENE-050417-248 (ZFIN)
slc27a6GeneProductZDB-GENE-060825-27 (ZFIN)
sorbs1GeneProductZDB-GENE-090313-168 (ZFIN)
thiazolidinedionesMetaboliteCHEBI:50864 (ChEBI) Should be thiazolidine derivative
ubbGeneProductZDB-GENE-050411-10 (ZFIN)
ubcGeneProductZDB-GENE-061110-88 (ZFIN)
unsaturated fatty acidsMetaboliteCHEBI:27208 (ChEBI)
zgc:101540GeneProductZDB-GENE-041212-67 (ZFIN)
zgc:172295GeneProductZDB-GENE-080204-72 (ZFIN)

Annotated Interactions

No annotated interactions

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