NO/cGMP/PKG mediated Neuroprotection (Homo sapiens)

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Endothelial Cell B SubunitsNatriuretric PeptidesCNG Cation ChannelsNeuronNF-kBNMDAR: Ligand ComplexNucleussGCCAMK IIA SubunitsMicrogliaMitochondrialPermeabilityTransitionPoreNR2 SubunitsNR1 SubunitNMDA ReceptorCalmodulinMitochondrionSmall SolublesNR1 Interacting ProteinsCell DepolarizationTBHNADPGUCY1A2CAMK2GGRIN1IL-1BCytochrome CAKAP9ApoptosisGTPcAMPGUCY1A3NADPHGRIN2ANPR1CAMK2DCNGB1CAMK2BCaspase CascadeNFKBIAIFN-GammacGMPL-ArginineCa2+ACTN2CNGA1DLG4CAMK2ACa2+TSPOiNOSCNGA3Mg2+K+PKG2TNF-aAMPXIAPeNOSL-GlutamateCASP9NEFLGRIN2DPDE3GRIN2BO2ANPGRIN2CCNGA2NFKB1BCL2BNPCa2+Cyclophilin DPDE2nNOSCREB1GUCY1B2NFKB3CNGA4GUCY1B3CNGB3CALM1LPSNOL-CitrullineO2L-ArginineNADPHTBHNADPL-CitrullineNOACTN2DLG4NR2 Interacting ProteinsCalmodulinCa2+CALM1O2L-ArginineNADPHTBHNADPL-CitrullineNONOSmall SolublesK+Ca2+BADSmall SolublesK+Ca2+Small SolublesK+Ca2+Mitochondrial DepolarizationCytochrome C


Description

NO/cGMP/PKG Neuroprotection. Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

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CompareRevisionActionTimeUserComment
107157view14:24, 17 September 2019MaintBotChEBI identifier normalization
106656view21:17, 12 September 2019KhanspersModified description
105657view05:15, 10 August 2019KhanspersModified description
96448view09:26, 15 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
96378view06:46, 11 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
92677view11:02, 28 June 2017SauerThorbenOntology Term : 'signaling pathway involving second messengers' added !
92676view11:01, 28 June 2017SauerThorbenOntology Term : 'signaling pathway' added !
92675view11:01, 28 June 2017SauerThorbenOntology Term : 'neuron' added !
92674view11:01, 28 June 2017SauerThorbenOntology Term : 'neural cell' added !
92673view11:01, 28 June 2017SauerThorbenOntology Term : 'dementia' added !
92672view09:59, 28 June 2017SauerThorbenModified title
92671view09:57, 28 June 2017SauerThorbenNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ACTN2GeneProductENSG00000077522 (Ensembl)
AKAP9GeneProductENSG00000127914 (Ensembl)
AMPMetaboliteCHEBI:16027 (ChEBI)
ANPGeneProductENSG00000175206 (Ensembl)
Apoptosis
BADGeneProductENSG00000002330 (Ensembl)
BCL2GeneProductENSG00000171791 (Ensembl)
BNP GeneProductENSG00000120937 (Ensembl)
CALM1GeneProductENSG00000198668 (Ensembl)
CAMK2AGeneProductENSG00000070808 (Ensembl)
CAMK2BGeneProductENSG00000058404 (Ensembl)
CAMK2DGeneProductENSG00000145349 (Ensembl)
CAMK2GGeneProductENSG00000148660 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CNGA1GeneProductENSG00000198515 (Ensembl)
CNGA2GeneProductENSG00000183862 (Ensembl)
CNGA3GeneProductENSG00000144191 (Ensembl)
CNGA4GeneProductENSG00000132259 (Ensembl)
CNGB1GeneProductENSG00000070729 (Ensembl)
CNGB3GeneProductENSG00000170289 (Ensembl)
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteCHEBI:29108 (ChEBI)
Caspase Cascade
Cyclophilin DGeneProductENSG00000171497 (Ensembl)
Cytochrome CGeneProductENSG00000172115 (Ensembl)
DLG4GeneProductENSG00000132535 (Ensembl)
GRIN1GeneProductENSG00000176884 (Ensembl)
GRIN2AGeneProductENSG00000183454 (Ensembl)
GRIN2BGeneProductENSG00000273079 (Ensembl)
GRIN2CGeneProductENSG00000161509 (Ensembl)
GRIN2D GeneProductENSG00000105464 (Ensembl)
GTPMetaboliteCHEBI:37565 (ChEBI)
GUCY1A2GeneProductENSG00000152402 (Ensembl)
GUCY1A3GeneProductENSG00000164116 (Ensembl)
GUCY1B2GeneProductENSG00000123201 (Ensembl)
GUCY1B3GeneProductENSG00000061918 (Ensembl)
IFN-GammaProteinENSG00000111537 (Ensembl)
IL-1BProteinENSG00000125538 (Ensembl)
K+MetaboliteCHEBI:29103 (ChEBI)
L-ArginineMetaboliteCHEBI:16467 (ChEBI)
L-CitrullineMetaboliteCHEBI:16349 (ChEBI)
L-GlutamateMetaboliteCHEBI:16015 (ChEBI)
LPSCHEBI:89981 (ChEBI)
Mg2+MetaboliteCHEBI:18420 (ChEBI)
NADP MetaboliteCHEBI:18009 (ChEBI)
NADPHMetaboliteCHEBI:16474 (ChEBI)
NEFLGeneProductENSG00000277586 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NFKB3GeneProductENSG00000173039 (Ensembl)
NFKBIAGeneProductENSG00000100906 (Ensembl)
NOMetaboliteCHEBI:16480 (ChEBI)
NPR1GeneProductENSG00000169418 (Ensembl)
O2MetaboliteCHEBI:29372 (ChEBI)
PDE2GeneProductENSG00000186642 (Ensembl)
PDE3GeneProductENSG00000172572 (Ensembl)
PKG2GeneProductENSG00000138669 (Ensembl)
TBHMetaboliteCHEBI:64090 (ChEBI)
TNF-a ProteinENSG00000232810 (Ensembl)
TSPOGeneProductENSG00000100300 (Ensembl)
XIAPGeneProductENSG00000101966 (Ensembl)
cAMPMetaboliteCHEBI:17489 (ChEBI)
cGMPMetaboliteCHEBI:16356 (ChEBI)
eNOSGeneProductENSG00000164867 (Ensembl)
iNOSGeneProductENSG00000007171 (Ensembl)
nNOSGeneProductENSG00000089250 (Ensembl)

Annotated Interactions

No annotated interactions

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