mRNA, protein, and metabolite inducation pathway by cyclosporin A (Homo sapiens)

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1cysteineROSglutathionereductaseL-leucineSLC3A2Nrf2ATF4L-IsoleucinePiSLC7A5SLC1A5L-tyrosineL-ValineL-tryptophanL-threonineL-alanineL-glutamineL-asparagineSLC3A2SLC7A5SLC1A5KEAP1KEAP1ATF4glutamate cysteineligase catalytic subunitglutamate cysteineligase modifier subunitglutamate cysteineligase modifier subunitglutamate cysteineligase modifier subunitADPSLC7A11SLC3A2SLC7A11L-cysteine


Exposure to cyclosporin A triggers a cascade of changes in expression and abundance of various mRNAs, proteins, and metabolites, which can be measured experimentally.

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Ontology Terms



  1. Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, Hamon J, Carpi D, Ruzek S, Handler A, Schmal O, Herrgen K, Bellwon P, Burek C, Truisi GL, Hewitt P, Di Consiglio E, Testai E, Blaauboer BJ, Guillou C, Huber CG, Lukas A, Pfaller W, Mueller SO, Bois FY, Dekant W, Jennings P; ''Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.''; J Proteomics, 2013 PubMed Europe PMC Scholia


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106206view12:10, 16 August 2019MaintBotHMDB identifier normalization
96732view08:07, 1 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94203view20:58, 25 August 2017DeSlAnnotated metabolite nodes with missing IDs.
92352view07:26, 29 May 2017FehrhartAdded some annotations
91623view18:35, 24 March 2017Khanspersconnected one interaction
91027view22:56, 22 December 2016EgonwMore content of the figure.
91002view12:46, 20 December 2016ElisaAll lines are connected
90927view16:27, 18 December 2016EgonwOntology Term : 'xenobiotic metabolic pathway' added !
90926view16:19, 18 December 2016EgonwModified description
90925view16:17, 18 December 2016EgonwModified title
90924view16:15, 18 December 2016EgonwNew pathway

External references


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NameTypeDatabase referenceComment
ADPMetaboliteHMDB01341 (HMDB)
ATF4GeneProductENSG00000128272 (Ensembl)
ATF4ProteinQ96AQ3 (Uniprot-TrEMBL)
KEAP1ProteinENSG00000079999 (Ensembl)
L-IsoleucineMetaboliteCHEBI:17191 (ChEBI)
L-ValineMetaboliteCHEBI:6321 (ChEBI)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-asparagineMetaboliteCHEBI:17196 (ChEBI)
L-cysteineMetaboliteHMDB00574 (HMDB)
L-glutamineMetaboliteCHEBI:18050 (ChEBI)
L-leucineMetaboliteCHEBI:15603 (ChEBI)
L-threonineMetaboliteCHEBI:16857 (ChEBI)
L-tryptophanMetaboliteCHEBI:21407 (ChEBI)
L-tyrosineMetaboliteCHEBI:17895 (ChEBI)
Nrf2ProteinQ16236 (Uniprot-TrEMBL)
ROSMetaboliteQ424361 (Wikidata)
SLC1A5GeneProductENSG00000105281 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A11GeneProductENSG00000151012 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)
glutamate cysteine ligase catalytic subunitRna
glutamate cysteine ligase modifier subunitRna
glutathione reductaseRna

Annotated Interactions

No annotated interactions

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