mRNA, protein, and metabolite inducation pathway by cyclosporin A (Homo sapiens)

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Making a figure from the 2013 paper machine readable.

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Ontology Terms



  1. Wilmes A, Limonciel A, Aschauer L, Moenks K, Bielow C, Leonard MO, Hamon J, Carpi D, Ruzek S, Handler A, Schmal O, Herrgen K, Bellwon P, Burek C, Truisi GL, Hewitt P, Di Consiglio E, Testai E, Blaauboer BJ, Guillou C, Huber CG, Lukas A, Pfaller W, Mueller SO, Bois FY, Dekant W, Jennings P; ''Application of integrated transcriptomic, proteomic and metabolomic profiling for the delineation of mechanisms of drug induced cell stress.''; J Proteomics, 2013 PubMed Europe PMC Scholia


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106206view12:10, 16 August 2019MaintBotHMDB identifier normalization
96732view08:07, 1 April 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
94203view20:58, 25 August 2017DeSlAnnotated metabolite nodes with missing IDs.
92352view07:26, 29 May 2017FehrhartAdded some annotations
91623view18:35, 24 March 2017Khanspersconnected one interaction
91027view22:56, 22 December 2016EgonwMore content of the figure.
91002view12:46, 20 December 2016ElisaAll lines are connected
90927view16:27, 18 December 2016EgonwOntology Term : 'xenobiotic metabolic pathway' added !
90926view16:19, 18 December 2016EgonwModified description
90925view16:17, 18 December 2016EgonwModified title
90924view16:15, 18 December 2016EgonwNew pathway

External references


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NameTypeDatabase referenceComment
ATF4GeneProductENSG00000128272 (Ensembl)
ATF4ProteinQ96AQ3 (Uniprot-TrEMBL)
KEAP1ProteinENSG00000079999 (Ensembl)
L-IsoleucineMetaboliteCHEBI:17191 (ChEBI)
L-ValineMetaboliteCHEBI:6321 (ChEBI)
L-alanineMetaboliteCHEBI:16977 (ChEBI)
L-asparagineMetaboliteCHEBI:17196 (ChEBI)
L-glutamineMetaboliteCHEBI:18050 (ChEBI)
L-leucineMetaboliteCHEBI:15603 (ChEBI)
L-threonineMetaboliteCHEBI:16857 (ChEBI)
L-tryptophanMetaboliteCHEBI:21407 (ChEBI)
L-tyrosineMetaboliteCHEBI:17895 (ChEBI)
Nrf2ProteinQ16236 (Uniprot-TrEMBL)
ROSMetaboliteQ424361 (Wikidata)
SLC1A5GeneProductENSG00000105281 (Ensembl)
SLC3A2GeneProductENSG00000168003 (Ensembl)
SLC7A5GeneProductENSG00000103257 (Ensembl)

Annotated Interactions

No annotated interactions

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