IL-4 Signaling Pathway (Homo sapiens)

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Description

Quality Tags

Ontology Terms

Bibliography

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History

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Compare	Revision	Action	Time	User	Comment
	110790	view	17:32, 5 June 2020	Joops05	Modified title
	108325	view	21:04, 6 December 2019	L Dupuis	Converted interactions to graphical lines in legend
	89828	view	12:06, 6 October 2016	Mkutmon	Modified description
	79978	view	13:37, 29 April 2015	Zari	repalced NEW ID for NCOA3
	78576	view	14:50, 7 January 2015	MaintBot	added missing graphIds
	78053	view	13:03, 23 November 2014	Egonw	Replaced label Entrez Genes identifiers by their numeric IDs.
	74009	view	15:25, 19 March 2014	Joppe014	connected lines
	70016	view	01:50, 12 July 2013	AlexanderPico	Modified title
	69985	view	21:32, 11 July 2013	MaintBot	updated to 2013 schema
	67378	view	10:44, 26 June 2013	Christine Chichester	Ontology Term : 'interleukin-4 signaling pathway' added !
	63211	view	20:58, 8 May 2013	MaintBot	Updating gpml version
	48437	view	14:33, 24 May 2012	NetPath	Modified description
	45367	view	20:59, 7 October 2011	AlexanderPico	Ontology Term : 'DOID:8406' removed !
	45131	view	00:50, 7 October 2011	AlexanderPico	fixed db refs
	44846	view	09:47, 6 October 2011	MartijnVanIersel	Ontology Term : 'Interleukin mediated signaling pathway' added !
	44625	view	18:04, 22 September 2011	Khanspers	added description
	44624	view	18:03, 22 September 2011	Khanspers	Updating content to NetSlim
	44108	view	20:32, 24 August 2011	Khanspers	Reverted to version '23:21, 1 March 2011' by Khanspers
	44024	view	22:52, 22 August 2011	Khanspers	Added category
	44023	view	22:51, 22 August 2011	Khanspers	Modified description
	44022	view	22:49, 22 August 2011	Khanspers	Updating pathway from NetSlim
	41099	view	23:21, 1 March 2011	MaintBot	Removed redundant pathway information and comments
	35643	view	21:32, 12 February 2010	Khanspers	Modified description
	28126	view	19:19, 27 January 2009	Khanspers	Capitalized Pathway in name
	21514	view	11:32, 14 November 2008	MaintBot	[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
	8176	view	13:46, 7 January 2008	MaintBot	[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
	7708	view	16:11, 18 December 2007	MaintBot	fixed category names
	7247	view	12:41, 4 November 2007	MaintBot	Added categories to GPML
	6337	view	22:18, 22 May 2007	A.Pandey	gpml file for [[Human:IL-4_NetPath_16]]

External references

DataNodes

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Name	Type	Database reference	Comment
AKT1	GeneProduct	207 (Entrez Gene)
ATF2	GeneProduct	1386 (Entrez Gene)
BAD	GeneProduct	572 (Entrez Gene)
BIRC5	Rna	332 (Entrez Gene)
CBL	GeneProduct	867
CEBPA	GeneProduct	1050 (Entrez Gene)
CEBPB	GeneProduct	1051 (Entrez Gene)
CHUK	GeneProduct	1147 (Entrez Gene)
DOK2	GeneProduct	9046 (Entrez Gene)
ELK1	GeneProduct	2002 (Entrez Gene)
EP300	GeneProduct	2033 (Entrez Gene)
FES	GeneProduct	2242 (Entrez Gene)
FOS	Rna	2353 (Entrez Gene)
GAB2	GeneProduct	9846
GATA3	Rna	2625 (Entrez Gene)
GRB2	GeneProduct	2885 (Entrez Gene)
HRH1	Rna	3269 (Entrez Gene)
IKBKB	GeneProduct	3551 (Entrez Gene)
IL2RG	GeneProduct	3561 (Entrez Gene)	IL-4 induces the formation of a complex consisting of IL-4 receptor alpha and common gamma chain.
IL4	GeneProduct	3565
IL4R	GeneProduct	3566 (Entrez Gene)
INPP5D	GeneProduct	3635 (Entrez Gene)
IRS1	GeneProduct	3667 (Entrez Gene)
IRS2	GeneProduct	8660 (Entrez Gene)
JAK1	GeneProduct	3716 (Entrez Gene)
JAK2	GeneProduct	3717
JAK3	GeneProduct	3718 (Entrez Gene)
Ligand	GeneProduct	7040 (Entrez Gene)
MAPK11	GeneProduct	5600 (Entrez Gene)
MAPK14	GeneProduct	1432
MAPK1	GeneProduct	5594 (Entrez Gene)
MAPK3	GeneProduct	5595 (Entrez Gene)
NCOA3	GeneProduct	8262 (Entrez Gene)
NFIL3	Rna	4783 (Entrez Gene)
NFKB1	GeneProduct	4790 (Entrez Gene)
NFKBIA	GeneProduct	4792 (Entrez Gene)
PIK3CA	GeneProduct	5290 (Entrez Gene)
PIK3CD	GeneProduct	5293 (Entrez Gene)	IL-4 induces the interaction of PIK3CD,PIK3CA with PIK3R1,PIK3R2 in human neutrophils.
PIK3R1	GeneProduct	5295 (Entrez Gene)
PIK3R2	GeneProduct	5296 (Entrez Gene)
PRKCZ	GeneProduct	3716 (Entrez Gene)
PTPN11	GeneProduct	5781 (Entrez Gene)
PTPN6	GeneProduct	5777 (Entrez Gene)
Protein	Protein	5894 (Entrez Gene)
Protein	Protein
RASA1	GeneProduct	9046 (Entrez Gene)	IL-4 stimulation leads to tyrosine phosphorylation of DOK2 and subsequent interaction of DOK2 with N-terminal SH2 domain of RASA1 in 32D cells.
RELA	GeneProduct	5970 (Entrez Gene)
RELA	GeneProduct	2353 (Entrez Gene)
RPS6KB1	GeneProduct
Receptor	GeneProduct	7040 (Entrez Gene)
SHC1	GeneProduct	6464 (Entrez Gene)
SOCS1	GeneProduct	8651 (Entrez Gene)
SOCS3	GeneProduct	9021 (Entrez Gene)
SOCS5	GeneProduct	9655
SOS1	GeneProduct	6654 (Entrez Gene)
STAT1	GeneProduct	6772 (Entrez Gene)
STAT3	GeneProduct	6774 (Entrez Gene)
STAT5A	GeneProduct	STAT5A (Entrez Gene)
STAT5B	GeneProduct	STAT5B (Entrez Gene)
STAT6	GeneProduct	6778
STAT6	GeneProduct	6778 (Entrez Gene)
STAT6	GeneProduct	6778 (Entrez Gene)
TYK2	GeneProduct	7297 (Entrez Gene)
mRNA	Protein

Annotated Interactions

No annotated interactions