IL-4 Signaling Pathway (Homo sapiens)

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Molecule in the pathwayCY -> PMDNUExtracellularDesumoylationCY -> PMMethylationInhibitionCY -> PMCytoplasmDemethylationCY -> PMECPlasma membraneGOPalmitoylationReaction through unknown mechanisms/moleculesDDEndoplasmic reticulumDLigandUbiquitinationAccession Number: NetPath 16AutophosphorylationEndosomeDeubiquitinationAcetylationDActivationDephosphorylationMolecular associationPhosphorylationENProteins in a complex interactionTranslocationControlCY -> NUProteolytic cleavageMitochondrionERMTDSumoylationGolgi apparatusDPMCY -> NURecruitmentCYEnzyme complexDNucleus(Protein-protein interaction)ReceptorDeacetylationDGlycosylationPRKCDIRS1NFKB1PRKCIJAK2AKT1NFKB1SPI1PIK3R1PTPN6ATF2IL2RGPIK3R2IL4JAK2RASA1MAPK3STAT6MAPK1SRCPRKCIMAPK14PRKD3TYK2PTPN11PRKCZPIK3CDJAK1MAPK11IL4NCF1PTK2IL13RA1SOCS5SOCS1FYNMAPK14ADRBK2Gene SymbolPIK3CADOK2STAMIL4RBCL2L1EP300STAT6BADPRKCZPLCG1STAT1ETS1LCKSOCS3SOS1INPP5DCBLJAK3STAT5ACREBBPHMGA1HIST2H3CJAK1IL4RSTAT6RPS6KB1ELK1STAT6FESSHC1IRS2CXCR4GRB2PRKD3STAT6RELAPRKCDPAWR


Interleukin-4 belongs to the IL-2 family of cytokines, which includes IL-2, IL-7, IL-9, IL-15 and IL-21. It signals through 2 different receptor complexes; Receptor complex 1 comprises of IL-4 receptor alpha (IL4RA) and the common gamma chain (γc), Receptor complex 2 comprises of IL4RA and IL-13 receptor alpha1. IL-4 stimulates the JAK/STAT and MAPK signaling modules. Source: NetPath


GenMAPP notes 
NetPath 16 - IL-4 Signaling Pathway

NetPath ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks

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Ontology Terms



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110790view17:32, 5 June 2020Joops05Modified title
108325view21:04, 6 December 2019L DupuisConverted interactions to graphical lines in legend
89828view12:06, 6 October 2016MkutmonModified description
79978view13:37, 29 April 2015Zarirepalced NEW ID for NCOA3
78576view14:50, 7 January 2015MaintBotadded missing graphIds
78053view13:03, 23 November 2014EgonwReplaced label Entrez Genes identifiers by their numeric IDs.
74009view15:25, 19 March 2014Joppe014connected lines
70016view01:50, 12 July 2013AlexanderPicoModified title
69985view21:32, 11 July 2013MaintBotupdated to 2013 schema
67378view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-4 signaling pathway' added !
63211view20:58, 8 May 2013MaintBotUpdating gpml version
48437view14:33, 24 May 2012NetPathModified description
45367view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45131view00:50, 7 October 2011AlexanderPicofixed db refs
44846view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44625view18:04, 22 September 2011Khanspersadded description
44624view18:03, 22 September 2011KhanspersUpdating content to NetSlim
44108view20:32, 24 August 2011KhanspersReverted to version '23:21, 1 March 2011' by Khanspers
44024view22:52, 22 August 2011KhanspersAdded category
44023view22:51, 22 August 2011KhanspersModified description
44022view22:49, 22 August 2011KhanspersUpdating pathway from NetSlim
41099view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35643view21:32, 12 February 2010KhanspersModified description
28126view19:19, 27 January 2009KhanspersCapitalized Pathway in name
21514view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
8176view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
7708view16:11, 18 December 2007MaintBotfixed category names
7247view12:41, 4 November 2007MaintBotAdded categories to GPML
6337view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-4_NetPath_16]]

External references


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NameTypeDatabase referenceComment
ADRBK2GeneProduct157 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ETS1GeneProduct2113 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
Gene SymbolGeneProduct
HIST2H3CGeneProduct126961 (Entrez Gene)
HMGA1GeneProduct3159 (Entrez Gene)
IL13RA1GeneProduct3597 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL4RGeneProduct3566 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NCF1GeneProduct4687 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PAWRGeneProduct5074 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD3GeneProduct23683 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOCS5GeneProduct9655 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

No annotated interactions
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