IL-4 Signaling Pathway (Homo sapiens)

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CY -> PMPhosphorylationDGlycosylationLigandControlDephosphorylationDGolgi apparatusPMMolecular associationCytoplasmCY -> NUEnzyme complexTranslocationPlasma membraneCY -> PMNucleusAutophosphorylationReaction through unknown mechanisms/moleculesMolecule in the pathwayDesumoylationEndosomeDCY -> PMECAcetylationActivationERDMTAccession Number: NetPath 16DeacetylationProteins in a complex interactionInhibitionProteolytic cleavageCY -> PMGOExtracellular(Protein-protein interaction)DDeubiquitinationRecruitmentDDemethylationCY -> NUENUbiquitinationNUReceptorDMitochondrionPalmitoylationCYMethylationDSumoylationEndoplasmic reticulumDSPI1STAT6JAK1IRS2PRKCIIL2RGPIK3CABCL2L1SOCS1MAPK11RPS6KB1STAT6NFKB1MAPK14SHC1SOCS5AKT1STAT5ARELAETS1MAPK14PTPN6IL4RIL13RA1EP300STAT6PTK2SOS1SRCBADPTPN11STAT6IL4RSTAT6ELK1IL4PRKCINFKB1TYK2PRKCDFESCXCR4IL4STAT1PIK3R1MAPK1HMGA1JAK2HIST2H3CLCKSOCS3STAMGene SymbolPRKD3PLCG1FYNPIK3CDPRKCZCREBBPINPP5DPIK3R2ATF2JAK1DOK2MAPK3ADRBK2PRKD3GRB2PRKCDIRS1JAK2PAWRNCF1PRKCZRASA1JAK3CBL


Description

No description

Comments

GenMAPP notes 
NetPath 16 - IL-4 Signaling Pathway

NetPath (http://www.netpath.org) is a collaborative project between PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and the Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the NetPath website until the pathway is published.

GenMAPP remarks 
http://www.netpath.org

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
110790view17:32, 5 June 2020Joops05Modified title
108325view21:04, 6 December 2019L DupuisConverted interactions to graphical lines in legend
89828view12:06, 6 October 2016MkutmonModified description
79978view13:37, 29 April 2015Zarirepalced NEW ID for NCOA3
78576view14:50, 7 January 2015MaintBotadded missing graphIds
78053view13:03, 23 November 2014EgonwReplaced label Entrez Genes identifiers by their numeric IDs.
74009view15:25, 19 March 2014Joppe014connected lines
70016view01:50, 12 July 2013AlexanderPicoModified title
69985view21:32, 11 July 2013MaintBotupdated to 2013 schema
67378view10:44, 26 June 2013Christine ChichesterOntology Term : 'interleukin-4 signaling pathway' added !
63211view20:58, 8 May 2013MaintBotUpdating gpml version
48437view14:33, 24 May 2012NetPathModified description
45367view20:59, 7 October 2011AlexanderPicoOntology Term : 'DOID:8406' removed !
45131view00:50, 7 October 2011AlexanderPicofixed db refs
44846view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44625view18:04, 22 September 2011Khanspersadded description
44624view18:03, 22 September 2011KhanspersUpdating content to NetSlim
44108view20:32, 24 August 2011KhanspersReverted to version '23:21, 1 March 2011' by Khanspers
44024view22:52, 22 August 2011KhanspersAdded category
44023view22:51, 22 August 2011KhanspersModified description
44022view22:49, 22 August 2011KhanspersUpdating pathway from NetSlim
41099view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35643view21:32, 12 February 2010KhanspersModified description
28126view19:19, 27 January 2009KhanspersCapitalized Pathway in name
21514view11:32, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-4 NetPath 16]] moved to [[Pathway:WP395]]: Moved to stable identifier
8176view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-4 NetPath 16]] moved to [[Pathway:Homo sapiens:IL-4 NetPath 16]]: Renaming species
7708view16:11, 18 December 2007MaintBotfixed category names
7247view12:41, 4 November 2007MaintBotAdded categories to GPML
6337view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-4_NetPath_16]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ADRBK2GeneProduct157 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
ATF2GeneProduct1386 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
CBLGeneProduct867 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CXCR4GeneProduct7852 (Entrez Gene)
DOK2GeneProduct9046 (Entrez Gene)
ELK1GeneProduct2002 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ETS1GeneProduct2113 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
Gene SymbolGeneProduct
HIST2H3CGeneProduct126961 (Entrez Gene)
HMGA1GeneProduct3159 (Entrez Gene)
IL13RA1GeneProduct3597 (Entrez Gene)
IL2RGGeneProduct3561 (Entrez Gene)
IL4GeneProduct3565 (Entrez Gene)
IL4RGeneProduct3566 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
IRS1GeneProduct3667 (Entrez Gene)
IRS2GeneProduct8660 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JAK3GeneProduct3718 (Entrez Gene)
LCKGeneProduct3932 (Entrez Gene)
MAPK11GeneProduct5600 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NCF1GeneProduct4687 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
PAWRGeneProduct5074 (Entrez Gene)
PIK3CAGeneProduct5290 (Entrez Gene)
PIK3CDGeneProduct5293 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD3GeneProduct23683 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PTPN6GeneProduct5777 (Entrez Gene)
RASA1GeneProduct5921 (Entrez Gene)
RELAGeneProduct5970 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS1GeneProduct8651 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOCS5GeneProduct9655 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
SPI1GeneProduct6688 (Entrez Gene)
SRCGeneProduct6714 (Entrez Gene)
STAMGeneProduct8027 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT5AGeneProduct6776 (Entrez Gene)
STAT6GeneProduct6778 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)

Annotated Interactions

No annotated interactions
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