One carbon metabolism and related pathways (Homo sapiens)

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Oxidative stress enzymesH2OH2O2Bile acid biosynthesisPLD15-oxoprolineL-CysteineL-MethioninePEMTDimethylglycineSHMT13-SulfinoalanineCBSLCHDHCDP-EthanolamineGlycineMAT2AHomocysteine5,10-Methenyltetrahydrofolic acidBAATGPX5BHMT10-formyldihydrofolateCSADCTHGlutamateSarcosineTYMSHypotaurineSHMT2GPX2O-PhosphoethanolamineCholineCEPT1S-AdenosylmethionineDMGDHPCYT1BSOD2S-AdenosylhomocysteineGPX6DNMT3ASOD1TaurineNADPL-SerineGSSNADPHGPX3CDO1DHFR2DNM1SARDHL-SerinePhosphatidylethanolaminePhosphatidylcholinesgamma-GlutamylcysteineCHPT1Taurochenodesoxycholic acidGSRMAT1AGCLCCHKAGPX1AHCYL1ETNK2GCLMSOD3MTHFRTotal PhospholipidsGlutathione (GSH)Phosphocholine5-Methyltetrahydrofolic acidL-CystathionineGAD2Glutathione disulfide (GSSG)Folic acidBHMT2GPX7PCYT2EthanolamineGPX4GAD1CHKBBetaineTaurocholic acidMTRPCYT1ACDP-cholineGlycineGNMTETNK1Tetrahydrofolic acid2-oxobutanoate(S)-2-Aminobutanoategamma-L-Glutamyl-L-2-aminobutyrateOphthalmateBCAT1AGXT2GCLCGSSBCAT2GCLM


Description

This pathway shows the carbon metabolism over grey and related pathways around it. Source KEGG. This pathway is part the CPTAC Assay Portal.

Comments

HomologyMapper 
This pathway was inferred from Mus musculus pathway WP1770_96326 with a 100.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. ''''; https://www.genome.jp/dbget-bin/www_bget?pathway+mmu00270,

History

View all...
CompareRevisionActionTimeUserComment
107153view14:23, 17 September 2019MaintBotChEBI identifier normalization
106513view21:00, 5 September 2019Khanspersconnected interactions
106512view20:55, 5 September 2019KhanspersModified description
106511view20:54, 5 September 2019Khanspersadded reference
106213view12:10, 16 August 2019MaintBotHMDB identifier normalization
105765view19:36, 15 August 2019KhanspersModified description
105764view19:34, 15 August 2019KhanspersModified description
102896view10:25, 27 January 2019EgonwReplaced two PubChem SID with CID identifiers.
96353view17:03, 9 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96327view09:30, 8 March 2018MkutmonUpdated homology conversion
96235view13:30, 1 March 2018DeSlModified description
96234view13:30, 1 March 2018DeSlRemoved licence number and last modified part.
94312view12:05, 1 September 2017Marvin M2Connected unconnected lines
94206view21:13, 25 August 2017DeSlAdded ID for phosphocholine
93078view09:01, 28 July 2017ElisaFixed unconnected interactions (added anchors to lines)
93018view09:37, 25 July 2017DeSlAdded small sidebrach from L-Cystationine to Ophthalmate.
91096view01:13, 4 January 2017Khanspersconnected interactions
90808view18:21, 14 December 2016KhanspersOntology Term : 'folate mediated one-carbon metabolic pathway' added !
90807view18:20, 14 December 2016KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2-AminobutanoateMetaboliteCHEBI:35619 (ChEBI)
10-formyldihydrofolateMetaboliteHMDB0006485 (HMDB)
2-oxobutanoateMetabolite16763 (ChEBI)
3-SulfinoalanineMetaboliteC00606 (KEGG Compound)
5,10-Methenyltetrahydrofolic acidMetaboliteC00445 (KEGG Compound)
5-Methyltetrahydrofolic acidMetaboliteC00440 (KEGG Compound)
5-oxoprolineMetaboliteC01879 (KEGG Compound)
AGXT2GeneProductENSG00000113492 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000089678
AHCYL1GeneProductENSG00000168710 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709
BAATGeneProductENSG00000136881 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012
BCAT1GeneProductENSG00000060982 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030268
BCAT2GeneProductENSG00000105552 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030826
BHMT2GeneProductENSG00000132840 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918
BHMTGeneProductENSG00000145692 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116
BetaineMetaboliteC00719 (KEGG Compound)
CBSLGeneProductENSG00000274276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411
CDO1GeneProductENSG00000129596 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583
CDP-EthanolamineMetaboliteC00570 (KEGG Compound)
CDP-cholineMetaboliteC00307 (KEGG Compound)
CEPT1GeneProductENSG00000134255 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712
CHDHGeneProductENSG00000016391 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865
CHKAGeneProductENSG00000110721 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660
CHKBGeneProductENSG00000100288 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651
CHPT1GeneProductENSG00000111666 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862
CSADGeneProductENSG00000139631 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277
CTHGeneProductENSG00000116761 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869
CholineMetaboliteC00114 (KEGG Compound)
DHFR2GeneProductENSG00000178700 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361
DMGDHGeneProductENSG00000132837 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129
DNM1GeneProductENSG00000106976 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429
DNMT3AGeneProductENSG00000119772 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435
DimethylglycineMetaboliteC01026 (KEGG Compound)
ETNK1GeneProductENSG00000139163 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320
ETNK2GeneProductENSG00000143845 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253
EthanolamineMetaboliteC00189 (KEGG Compound)
Folic acidMetaboliteC00504 (KEGG Compound)
GAD1GeneProductENSG00000128683 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415
GAD2GeneProductENSG00000136750 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417
GCLCGeneProductENSG00000001084 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032350
GCLMGeneProductENSG00000023909 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000028124
GNMTGeneProductENSG00000124713 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711
GPX1GeneProductENSG00000233276 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775
GPX2GeneProductENSG00000176153 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776
GPX3GeneProductENSG00000211445 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778
GPX4GeneProductENSG00000167468 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249
GPX5GeneProductENSG00000224586 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780
GPX6GeneProductENSG00000198704 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512
GPX7GeneProductENSG00000116157 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305
GSRGeneProductENSG00000104687 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782
GSSGeneProductENSG00000100983 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027610
GlutamateMetaboliteC00217 (KEGG Compound)
Glutathione (GSH)MetaboliteC00051 (KEGG Compound)
Glutathione disulfide (GSSG)MetaboliteC00127 (KEGG Compound)
GlycineMetaboliteC00037 (KEGG Compound)
HomocysteineMetaboliteC05330 (KEGG Compound)
HypotaurineMetaboliteC00519 (KEGG Compound)
L-CystathionineMetaboliteC02291 (KEGG Compound)
L-CysteineMetaboliteC00097 (KEGG Compound)
L-MethionineMetaboliteHMDB0000696 (HMDB)
L-SerineMetaboliteC00065 (KEGG Compound)
MAT1AGeneProductENSG00000151224 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720
MAT2AGeneProductENSG00000168906 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087
MTHFRGeneProductENSG00000177000 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769
MTRGeneProductENSG00000116984 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505
NADPMetaboliteC00006 (KEGG Compound)
NADPHMetaboliteC00005 (KEGG Compound)
O-PhosphoethanolamineMetaboliteC00346 (KEGG Compound)
OphthalmateMetabolite7018721 (PubChem-compound)
PCYT1AGeneProductENSG00000161217 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026
PCYT1BGeneProductENSG00000102230 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899
PCYT2GeneProductENSG00000185813 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671
PEMTGeneProductENSG00000133027 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18618
PLD1GeneProductENSG00000075651 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805
PhosphatidylcholinesMetabolite8002-43-5 (CAS)
PhosphatidylethanolamineMetaboliteC00350 (KEGG Compound)
PhosphocholineMetaboliteCHEBI:18132 (ChEBI)
S-AdenosylhomocysteineMetaboliteC00021 (KEGG Compound)
S-AdenosylmethionineMetaboliteC00019 (KEGG Compound)
SARDHGeneProductENSG00000123453 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166
SHMT1GeneProductENSG00000176974 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425
SHMT2GeneProductENSG00000182199 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037
SOD1GeneProductENSG00000142168 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655
SOD2GeneProductENSG00000112096 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656
SOD3GeneProductENSG00000109610 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657
SarcosineMetaboliteC00213 (KEGG Compound)
TYMSGeneProductENSG00000176890 (Ensembl) Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171
TaurineMetaboliteC00245 (KEGG Compound)
Taurochenodesoxycholic acidMetaboliteC05465 (KEGG Compound)
Taurocholic acidMetaboliteC05122 (KEGG Compound)
Tetrahydrofolic acidMetaboliteC00101 (KEGG Compound)
Total PhospholipidsMetabolite16247 (ChEBI)
gamma-GlutamylcysteineMetaboliteC00669 (KEGG Compound)
gamma-L-Glutamyl-L-2-aminobutyrateMetabolite7014903 (PubChem-compound)

Annotated Interactions

No annotated interactions
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