One carbon metabolism and related pathways (Homo sapiens)

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(Modified description)
Current revision (12:10, 16 August 2019) (view source)
(HMDB identifier normalization)
 
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3940 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3940 CPTAC Assay Portal].</Comment>
   <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway [http://wikipathways.org/instance/WP1770_r96326 WP1770_96326] with a 100.0% conversion rate.</Comment>
   <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway [http://wikipathways.org/instance/WP1770_r96326 WP1770_96326] with a 100.0% conversion rate.</Comment>
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   <DataNode TextLabel="S-Adenosylhomocysteine" GraphId="a1114" Type="Metabolite">
   <DataNode TextLabel="S-Adenosylhomocysteine" GraphId="a1114" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00021"/>
+
     <Xref Database="KEGG Compound" ID="C00021" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Total Phospholipids" GraphId="a2024" Type="Metabolite">
   <DataNode TextLabel="Total Phospholipids" GraphId="a2024" Type="Metabolite">
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     <Xref Database="ChEBI" ID="16247"/>
+
     <Xref Database="ChEBI" ID="16247" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Methionine" GraphId="a2be8" Type="Metabolite">
   <DataNode TextLabel="L-Methionine" GraphId="a2be8" Type="Metabolite">
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     <Xref Database="HMDB" ID="HMDB00696"/>
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     <Xref Database="HMDB" ID="HMDB0000696" />
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   </DataNode>
   <DataNode TextLabel="ETNK2" GraphId="a3b7f" Type="GeneProduct" GroupRef="a827f">
   <DataNode TextLabel="ETNK2" GraphId="a3b7f" Type="GeneProduct" GroupRef="a827f">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:214253</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000143845"/>
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     <Xref Database="Ensembl" ID="ENSG00000143845" />
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   </DataNode>
   <DataNode TextLabel="GPX5" GraphId="a794b" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX5" GraphId="a794b" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14780</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000224586" />
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   </DataNode>
   <DataNode TextLabel="SOD1" GraphId="aa37f" Type="GeneProduct" GroupRef="b0523">
   <DataNode TextLabel="SOD1" GraphId="aa37f" Type="GeneProduct" GroupRef="b0523">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20655</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000142168"/>
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     <Xref Database="Ensembl" ID="ENSG00000142168" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="3-Sulfinoalanine" GraphId="aaf8e" Type="Metabolite">
   <DataNode TextLabel="3-Sulfinoalanine" GraphId="aaf8e" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00606"/>
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     <Xref Database="KEGG Compound" ID="C00606" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Cysteine" GraphId="ab4d6" Type="Metabolite">
   <DataNode TextLabel="L-Cysteine" GraphId="ab4d6" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00097"/>
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     <Xref Database="KEGG Compound" ID="C00097" />
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   </DataNode>
   <DataNode TextLabel="CSAD" GraphId="ab995" Type="GeneProduct">
   <DataNode TextLabel="CSAD" GraphId="ab995" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:246277</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000139631"/>
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     <Xref Database="Ensembl" ID="ENSG00000139631" />
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   </DataNode>
   <DataNode TextLabel="CHPT1" GraphId="abec5" Type="GeneProduct">
   <DataNode TextLabel="CHPT1" GraphId="abec5" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:212862</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000111666"/>
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     <Xref Database="Ensembl" ID="ENSG00000111666" />
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   </DataNode>
   <DataNode TextLabel="NADP" GraphId="ac416" Type="Metabolite">
   <DataNode TextLabel="NADP" GraphId="ac416" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00006"/>
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     <Xref Database="KEGG Compound" ID="C00006" />
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   </DataNode>
   <DataNode TextLabel="Hypotaurine" GraphId="adf02" Type="Metabolite">
   <DataNode TextLabel="Hypotaurine" GraphId="adf02" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00519"/>
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     <Xref Database="KEGG Compound" ID="C00519" />
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   </DataNode>
   <DataNode TextLabel="Glutathione (GSH)" GraphId="b0348" Type="Metabolite">
   <DataNode TextLabel="Glutathione (GSH)" GraphId="b0348" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00051"/>
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     <Xref Database="KEGG Compound" ID="C00051" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="DHFR2" GraphId="b0493" Type="GeneProduct">
   <DataNode TextLabel="DHFR2" GraphId="b0493" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13361</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000178700"/>
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     <Xref Database="Ensembl" ID="ENSG00000178700" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Tetrahydrofolic acid" GraphId="b2917" Type="Metabolite">
   <DataNode TextLabel="Tetrahydrofolic acid" GraphId="b2917" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00101"/>
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     <Xref Database="KEGG Compound" ID="C00101" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PCYT1A" GraphId="b308b" Type="GeneProduct" GroupRef="aa34f">
   <DataNode TextLabel="PCYT1A" GraphId="b308b" Type="GeneProduct" GroupRef="aa34f">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13026</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000161217"/>
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     <Xref Database="Ensembl" ID="ENSG00000161217" />
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   </DataNode>
   <DataNode TextLabel="MAT2A" GraphId="b3972" Type="GeneProduct" GroupRef="ace75">
   <DataNode TextLabel="MAT2A" GraphId="b3972" Type="GeneProduct" GroupRef="ace75">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:232087</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000168906"/>
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     <Xref Database="Ensembl" ID="ENSG00000168906" />
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   </DataNode>
   <DataNode TextLabel="GSR" GraphId="b4f03" Type="GeneProduct">
   <DataNode TextLabel="GSR" GraphId="b4f03" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14782</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000104687"/>
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     <Xref Database="Ensembl" ID="ENSG00000104687" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Phosphocholine" GraphId="b6194" Type="Metabolite">
   <DataNode TextLabel="Phosphocholine" GraphId="b6194" Type="Metabolite">
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     <Xref Database="ChEBI" ID="CHEBI:18132"/>
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     <Xref Database="ChEBI" ID="CHEBI:18132" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PCYT1B" GraphId="b681e" Type="GeneProduct" GroupRef="aa34f">
   <DataNode TextLabel="PCYT1B" GraphId="b681e" Type="GeneProduct" GroupRef="aa34f">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:236899</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000102230"/>
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     <Xref Database="Ensembl" ID="ENSG00000102230" />
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   </DataNode>
   <DataNode TextLabel="Ethanolamine" GraphId="b8b78" Type="Metabolite">
   <DataNode TextLabel="Ethanolamine" GraphId="b8b78" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C00189"/>
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     <Xref Database="KEGG Compound" ID="C00189" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Taurocholic acid" GraphId="ba689" Type="Metabolite">
   <DataNode TextLabel="Taurocholic acid" GraphId="ba689" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C05122"/>
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     <Xref Database="KEGG Compound" ID="C05122" />
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   </DataNode>
   <DataNode TextLabel="ETNK1" GraphId="bb692" Type="GeneProduct" GroupRef="a827f">
   <DataNode TextLabel="ETNK1" GraphId="bb692" Type="GeneProduct" GroupRef="a827f">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75320</Comment>
-
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     <Xref Database="Ensembl" ID="ENSG00000139163"/>
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     <Xref Database="Ensembl" ID="ENSG00000139163" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glutathione disulfide (GSSG)" GraphId="bc24f" Type="Metabolite">
   <DataNode TextLabel="Glutathione disulfide (GSSG)" GraphId="bc24f" Type="Metabolite">
-
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     <Xref Database="KEGG Compound" ID="C00127"/>
+
     <Xref Database="KEGG Compound" ID="C00127" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5,10-Methenyltetrahydrofolic acid" GraphId="bd7d1" Type="Metabolite">
   <DataNode TextLabel="5,10-Methenyltetrahydrofolic acid" GraphId="bd7d1" Type="Metabolite">
-
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     <Xref Database="KEGG Compound" ID="C00445"/>
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     <Xref Database="KEGG Compound" ID="C00445" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CEPT1" GraphId="be9cc" Type="GeneProduct">
   <DataNode TextLabel="CEPT1" GraphId="be9cc" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:99712</Comment>
-
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     <Xref Database="Ensembl" ID="ENSG00000134255"/>
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     <Xref Database="Ensembl" ID="ENSG00000134255" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SOD3" GraphId="bed8c" Type="GeneProduct" GroupRef="b0523">
   <DataNode TextLabel="SOD3" GraphId="bed8c" Type="GeneProduct" GroupRef="b0523">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20657</Comment>
-
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     <Xref Database="Ensembl" ID="ENSG00000109610"/>
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     <Xref Database="Ensembl" ID="ENSG00000109610" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MAT1A" GraphId="bf8ee" Type="GeneProduct" GroupRef="ace75">
   <DataNode TextLabel="MAT1A" GraphId="bf8ee" Type="GeneProduct" GroupRef="ace75">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:11720</Comment>
-
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     <Graphics CenterX="623.9166666666666" CenterY="67.75000000000003" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000151224"/>
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     <Xref Database="Ensembl" ID="ENSG00000151224" />
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   </DataNode>
   <DataNode TextLabel="Taurochenodesoxycholic acid" GraphId="c0b74" Type="Metabolite">
   <DataNode TextLabel="Taurochenodesoxycholic acid" GraphId="c0b74" Type="Metabolite">
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     <Graphics CenterX="288.5" CenterY="838.1176470588226" Width="153.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C05465"/>
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     <Xref Database="KEGG Compound" ID="C05465" />
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   </DataNode>
   <DataNode TextLabel="GPX7" GraphId="c3448" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX7" GraphId="c3448" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:67305</Comment>
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     <Graphics CenterX="781.6666666666666" CenterY="843.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="781.6666666666666" CenterY="843.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000116157"/>
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     <Xref Database="Ensembl" ID="ENSG00000116157" />
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   </DataNode>
   <DataNode TextLabel="CTH" GraphId="c4c3d" Type="GeneProduct">
   <DataNode TextLabel="CTH" GraphId="c4c3d" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:107869</Comment>
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     <Graphics CenterX="462.51657940663154" CenterY="562.6359716661532" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="462.51657940663154" CenterY="562.6359716661532" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000116761"/>
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     <Xref Database="Ensembl" ID="ENSG00000116761" />
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   </DataNode>
   <DataNode TextLabel="Glutamate" GraphId="c524b" Type="Metabolite">
   <DataNode TextLabel="Glutamate" GraphId="c524b" Type="Metabolite">
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     <Graphics CenterX="687.0000000000001" CenterY="573.1176470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="687.0000000000001" CenterY="573.1176470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
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     <Xref Database="KEGG Compound" ID="C00217"/>
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     <Xref Database="KEGG Compound" ID="C00217" />
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   </DataNode>
   <DataNode TextLabel="CDP-choline" GraphId="c7224" Type="Metabolite">
   <DataNode TextLabel="CDP-choline" GraphId="c7224" Type="Metabolite">
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     <Graphics CenterX="1022.4166666666662" CenterY="388.25" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C00307"/>
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     <Xref Database="KEGG Compound" ID="C00307" />
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   </DataNode>
   <DataNode TextLabel="GSS" GraphId="c7e00" Type="GeneProduct">
   <DataNode TextLabel="GSS" GraphId="c7e00" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14854</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14854</Comment>
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     <Graphics CenterX="687.1666666666663" CenterY="712.6176470588225" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="687.1666666666663" CenterY="712.6176470588225" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000100983"/>
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     <Xref Database="Ensembl" ID="ENSG00000100983" />
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   </DataNode>
   <DataNode TextLabel="CHDH" GraphId="c8696" Type="GeneProduct">
   <DataNode TextLabel="CHDH" GraphId="c8696" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:218865</Comment>
-
     <Graphics CenterX="617.9999999999999" CenterY="398.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="617.9999999999999" CenterY="398.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Ensembl" ID="ENSG00000016391"/>
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     <Xref Database="Ensembl" ID="ENSG00000016391" />
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   </DataNode>
   <DataNode TextLabel="DNMT3A" GraphId="caebc" Type="GeneProduct" GroupRef="f48ae">
   <DataNode TextLabel="DNMT3A" GraphId="caebc" Type="GeneProduct" GroupRef="f48ae">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13435</Comment>
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     <Graphics CenterX="872.3333333333317" CenterY="161.4999999999998" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="872.3333333333317" CenterY="161.4999999999998" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000119772"/>
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     <Xref Database="Ensembl" ID="ENSG00000119772" />
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   </DataNode>
   <DataNode TextLabel="O-Phosphoethanolamine" GraphId="cb345" Type="Metabolite">
   <DataNode TextLabel="O-Phosphoethanolamine" GraphId="cb345" Type="Metabolite">
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     <Graphics CenterX="1022.4166666666662" CenterY="116.66666666666667" Width="128.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="1022.4166666666662" CenterY="116.66666666666667" Width="128.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
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     <Xref Database="KEGG Compound" ID="C00346"/>
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     <Xref Database="KEGG Compound" ID="C00346" />
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   </DataNode>
   <DataNode TextLabel="BHMT2" GraphId="cc188" Type="GeneProduct" GroupRef="a6355">
   <DataNode TextLabel="BHMT2" GraphId="cc188" Type="GeneProduct" GroupRef="a6355">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:64918</Comment>
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     <Graphics CenterX="505.8017719989076" CenterY="392.9129137407713" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="505.8017719989076" CenterY="392.9129137407713" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000132840"/>
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     <Xref Database="Ensembl" ID="ENSG00000132840" />
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   </DataNode>
   <DataNode TextLabel="Phosphatidylethanolamine" GraphId="cc24e" Type="Metabolite">
   <DataNode TextLabel="Phosphatidylethanolamine" GraphId="cc24e" Type="Metabolite">
-
     <Graphics CenterX="1022.708333333333" CenterY="213.66666666666666" Width="132.58333333333394" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C00350"/>
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     <Xref Database="KEGG Compound" ID="C00350" />
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   </DataNode>
   <DataNode TextLabel="MTHFR" GraphId="ce536" Type="GeneProduct">
   <DataNode TextLabel="MTHFR" GraphId="ce536" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:17769</Comment>
-
     <Graphics CenterX="696.3333333333329" CenterY="271.666666666667" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="696.3333333333329" CenterY="271.666666666667" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000177000"/>
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     <Xref Database="Ensembl" ID="ENSG00000177000" />
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   </DataNode>
   <DataNode TextLabel="DNM1" GraphId="ce7b6" Type="GeneProduct" GroupRef="f48ae">
   <DataNode TextLabel="DNM1" GraphId="ce7b6" Type="GeneProduct" GroupRef="f48ae">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:13429</Comment>
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     <Graphics CenterX="872.3333333333317" CenterY="143.50000000000009" Width="80.0" Height="18.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="872.3333333333317" CenterY="143.50000000000009" Width="80.0" Height="18.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000106976"/>
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     <Xref Database="Ensembl" ID="ENSG00000106976" />
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   </DataNode>
   <DataNode TextLabel="Dimethylglycine" GraphId="cf3a1" Type="Metabolite">
   <DataNode TextLabel="Dimethylglycine" GraphId="cf3a1" Type="Metabolite">
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     <Xref Database="KEGG Compound" ID="C01026"/>
+
     <Xref Database="KEGG Compound" ID="C01026" />
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   </DataNode>
   <DataNode TextLabel="Betaine" GraphId="cf56a" Type="Metabolite">
   <DataNode TextLabel="Betaine" GraphId="cf56a" Type="Metabolite">
-
     <Graphics CenterX="513.0000000000002" CenterY="435.00000000000017" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C00719"/>
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     <Xref Database="KEGG Compound" ID="C00719" />
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   </DataNode>
   <DataNode TextLabel="PLD1" GraphId="cfaaa" Type="GeneProduct">
   <DataNode TextLabel="PLD1" GraphId="cfaaa" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:18805</Comment>
-
     <Graphics CenterX="767.0" CenterY="386.5" Width="80.0" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="767.0" CenterY="386.5" Width="80.0" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000075651"/>
+
     <Xref Database="Ensembl" ID="ENSG00000075651" />
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   </DataNode>
   <DataNode TextLabel="SOD2" GraphId="d0d06" Type="GeneProduct" GroupRef="b0523">
   <DataNode TextLabel="SOD2" GraphId="d0d06" Type="GeneProduct" GroupRef="b0523">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20656</Comment>
-
     <Graphics CenterX="931.5833333333353" CenterY="777.4509803921555" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="931.5833333333353" CenterY="777.4509803921555" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000112096"/>
+
     <Xref Database="Ensembl" ID="ENSG00000112096" />
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   </DataNode>
   <DataNode TextLabel="GPX6" GraphId="d2a45" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX6" GraphId="d2a45" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:75512</Comment>
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     <Graphics CenterX="781.6666666666666" CenterY="823.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000198704"/>
+
     <Xref Database="Ensembl" ID="ENSG00000198704" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Phosphatidylcholines" GraphId="d337f" Type="Metabolite">
   <DataNode TextLabel="Phosphatidylcholines" GraphId="d337f" Type="Metabolite">
-
     <Graphics CenterX="1022.4166666666661" CenterY="345.4166666666667" Width="144.75" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="CAS" ID="8002-43-5"/>
+
     <Xref Database="CAS" ID="8002-43-5" />
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   </DataNode>
   <DataNode TextLabel="CHKB" GraphId="d4f50" Type="GeneProduct" GroupRef="b6a64">
   <DataNode TextLabel="CHKB" GraphId="d4f50" Type="GeneProduct" GroupRef="b6a64">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12651</Comment>
-
     <Graphics CenterX="868.3333333333334" CenterY="380.75000000000006" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="868.3333333333334" CenterY="380.75000000000006" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000100288"/>
+
     <Xref Database="Ensembl" ID="ENSG00000100288" />
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   </DataNode>
   <DataNode TextLabel="GAD1" GraphId="d554b" Type="GeneProduct" GroupRef="fccbd">
   <DataNode TextLabel="GAD1" GraphId="d554b" Type="GeneProduct" GroupRef="fccbd">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14415</Comment>
-
     <Graphics CenterX="256.33333333333417" CenterY="653.1176470588232" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000128683"/>
+
     <Xref Database="Ensembl" ID="ENSG00000128683" />
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   </DataNode>
   <DataNode TextLabel="CDO1" GraphId="d5bba" Type="GeneProduct">
   <DataNode TextLabel="CDO1" GraphId="d5bba" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12583</Comment>
-
     <Graphics CenterX="256.33333333333417" CenterY="618.5343137254893" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000129596"/>
+
     <Xref Database="Ensembl" ID="ENSG00000129596" />
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   </DataNode>
   <DataNode TextLabel="GAD2" GraphId="d5ff0" Type="GeneProduct" GroupRef="fccbd">
   <DataNode TextLabel="GAD2" GraphId="d5ff0" Type="GeneProduct" GroupRef="fccbd">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14417</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000136750"/>
+
     <Xref Database="Ensembl" ID="ENSG00000136750" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Serine" GraphId="d6762" Type="Metabolite">
   <DataNode TextLabel="L-Serine" GraphId="d6762" Type="Metabolite">
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     <Graphics CenterX="622.666666666666" CenterY="489.33333333333326" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C00065"/>
+
     <Xref Database="KEGG Compound" ID="C00065" />
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   </DataNode>
   <DataNode TextLabel="Taurine" GraphId="d6e5f" Type="Metabolite">
   <DataNode TextLabel="Taurine" GraphId="d6e5f" Type="Metabolite">
-
     <Graphics CenterX="373.25" CenterY="770.8676470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Xref Database="KEGG Compound" ID="C00245"/>
+
     <Xref Database="KEGG Compound" ID="C00245" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GNMT" GraphId="d7098" Type="GeneProduct">
   <DataNode TextLabel="GNMT" GraphId="d7098" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14711</Comment>
-
     <Graphics CenterX="869.9166666666667" CenterY="277.08333333333354" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="869.9166666666667" CenterY="277.08333333333354" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000124713"/>
+
     <Xref Database="Ensembl" ID="ENSG00000124713" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="NADPH" GraphId="d7507" Type="Metabolite">
   <DataNode TextLabel="NADPH" GraphId="d7507" Type="Metabolite">
-
     <Graphics CenterX="538.3333333333333" CenterY="802.7843137254886" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="KEGG Compound" ID="C00005"/>
+
     <Xref Database="KEGG Compound" ID="C00005" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="BHMT" GraphId="d7eef" Type="GeneProduct" GroupRef="a6355">
   <DataNode TextLabel="BHMT" GraphId="d7eef" Type="GeneProduct" GroupRef="a6355">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12116</Comment>
-
     <Graphics CenterX="505.8017719989076" CenterY="372.9129137407713" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="505.8017719989076" CenterY="372.9129137407713" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000145692"/>
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     <Xref Database="Ensembl" ID="ENSG00000145692" />
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   </DataNode>
   <DataNode TextLabel="SHMT1" GraphId="d8d2a" Type="GeneProduct" GroupRef="a9359">
   <DataNode TextLabel="SHMT1" GraphId="d8d2a" Type="GeneProduct" GroupRef="a9359">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:20425</Comment>
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     <Graphics CenterX="597.3333333333334" CenterY="161.99999999999991" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="597.3333333333334" CenterY="161.99999999999991" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000176974"/>
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     <Xref Database="Ensembl" ID="ENSG00000176974" />
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   </DataNode>
   <DataNode TextLabel="Sarcosine" GraphId="d8d5b" Type="Metabolite">
   <DataNode TextLabel="Sarcosine" GraphId="d8d5b" Type="Metabolite">
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     <Graphics CenterX="771.0000000000002" CenterY="337.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="771.0000000000002" CenterY="337.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
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     <Xref Database="KEGG Compound" ID="C00213"/>
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     <Xref Database="KEGG Compound" ID="C00213" />
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   </DataNode>
   <DataNode TextLabel="CDP-Ethanolamine" GraphId="daf14" Type="Metabolite">
   <DataNode TextLabel="CDP-Ethanolamine" GraphId="daf14" Type="Metabolite">
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     <Graphics CenterX="1022.4166666666662" CenterY="168.66666666666666" Width="122.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="1022.4166666666662" CenterY="168.66666666666666" Width="122.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
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     <Xref Database="KEGG Compound" ID="C00570"/>
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     <Xref Database="KEGG Compound" ID="C00570" />
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   </DataNode>
   <DataNode TextLabel="PCYT2" GraphId="dc876" Type="GeneProduct">
   <DataNode TextLabel="PCYT2" GraphId="dc876" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:68671</Comment>
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     <Graphics CenterX="1150.6666666666633" CenterY="138.16666666666674" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="1150.6666666666633" CenterY="138.16666666666674" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000185813"/>
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     <Xref Database="Ensembl" ID="ENSG00000185813" />
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   </DataNode>
   <DataNode TextLabel="SARDH" GraphId="dcc5a" Type="GeneProduct">
   <DataNode TextLabel="SARDH" GraphId="dcc5a" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:192166</Comment>
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     <Graphics CenterX="830.0000000000003" CenterY="233.16666666666694" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="830.0000000000003" CenterY="233.16666666666694" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000123453"/>
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     <Xref Database="Ensembl" ID="ENSG00000123453" />
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   </DataNode>
   <DataNode TextLabel="GPX4" GraphId="dea3b" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX4" GraphId="dea3b" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:625249</Comment>
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     <Graphics CenterX="781.6666666666666" CenterY="783.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="781.6666666666666" CenterY="783.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000167468"/>
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     <Xref Database="Ensembl" ID="ENSG00000167468" />
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   </DataNode>
   <DataNode TextLabel="GPX2" GraphId="dec7d" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX2" GraphId="dec7d" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14776</Comment>
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     <Graphics CenterX="781.6666666666666" CenterY="743.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="781.6666666666666" CenterY="743.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000176153"/>
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     <Xref Database="Ensembl" ID="ENSG00000176153" />
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   </DataNode>
   <DataNode TextLabel="GPX1" GraphId="df08d" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX1" GraphId="df08d" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14775</Comment>
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     <Graphics CenterX="781.6666666666666" CenterY="723.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="781.6666666666666" CenterY="723.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000233276"/>
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     <Xref Database="Ensembl" ID="ENSG00000233276" />
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   </DataNode>
   <DataNode TextLabel="MTR" GraphId="dfe81" Type="GeneProduct">
   <DataNode TextLabel="MTR" GraphId="dfe81" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:238505</Comment>
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     <Graphics CenterX="466.3333333333333" CenterY="259.83333333333314" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="466.3333333333333" CenterY="259.83333333333314" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000116984"/>
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     <Xref Database="Ensembl" ID="ENSG00000116984" />
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   </DataNode>
   <DataNode TextLabel="GCLM" GraphId="e2789" Type="GeneProduct">
   <DataNode TextLabel="GCLM" GraphId="e2789" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14630</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14630</Comment>
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     <Graphics CenterX="687.0000000000001" CenterY="601.1176470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="687.0000000000001" CenterY="601.1176470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000023909"/>
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     <Xref Database="Ensembl" ID="ENSG00000023909" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="10-formyldihydrofolate" GraphId="e288e" Type="Metabolite">
   <DataNode TextLabel="10-formyldihydrofolate" GraphId="e288e" Type="Metabolite">
-
     <Graphics CenterX="318.0" CenterY="164.0" Width="121.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="318.0" CenterY="164.0" Width="121.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
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     <Xref Database="HMDB" ID="HMDB06485"/>
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     <Xref Database="HMDB" ID="HMDB0006485" />
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   </DataNode>
   <DataNode TextLabel="GPX3" GraphId="e467b" Type="GeneProduct" GroupRef="d0df8">
   <DataNode TextLabel="GPX3" GraphId="e467b" Type="GeneProduct" GroupRef="d0df8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:14778</Comment>
-
     <Graphics CenterX="781.6666666666666" CenterY="763.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="781.6666666666666" CenterY="763.9509803921544" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000211445"/>
+
     <Xref Database="Ensembl" ID="ENSG00000211445" />
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   </DataNode>
   <DataNode TextLabel="AHCYL1" GraphId="e54c4" Type="GeneProduct">
   <DataNode TextLabel="AHCYL1" GraphId="e54c4" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:229709</Comment>
-
     <Graphics CenterX="645.9779969897597" CenterY="454.6611659141065" Width="80.0" Height="17.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="645.9779969897597" CenterY="454.6611659141065" Width="80.0" Height="17.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000168710"/>
+
     <Xref Database="Ensembl" ID="ENSG00000168710" />
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   </DataNode>
   <DataNode TextLabel="CBSL" GraphId="e6ae7" Type="GeneProduct">
   <DataNode TextLabel="CBSL" GraphId="e6ae7" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12411</Comment>
-
     <Graphics CenterX="434.0" CenterY="489.33333333333337" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="434.0" CenterY="489.33333333333337" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000274276"/>
+
     <Xref Database="Ensembl" ID="ENSG00000274276" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-oxoproline" GraphId="e7571" Type="Metabolite">
   <DataNode TextLabel="5-oxoproline" GraphId="e7571" Type="Metabolite">
-
     <Graphics CenterX="801.0" CenterY="573.1176470588226" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="KEGG Compound" ID="C01879"/>
+
     <Xref Database="KEGG Compound" ID="C01879" />
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   </DataNode>
   <DataNode TextLabel="DMGDH" GraphId="e78fe" Type="GeneProduct">
   <DataNode TextLabel="DMGDH" GraphId="e78fe" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:74129</Comment>
-
     <Graphics CenterX="642.6666666666665" CenterY="316.99999999999994" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="642.6666666666665" CenterY="316.99999999999994" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000132837"/>
+
     <Xref Database="Ensembl" ID="ENSG00000132837" />
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   </DataNode>
   <DataNode TextLabel="BAAT" GraphId="e7c8f" Type="GeneProduct">
   <DataNode TextLabel="BAAT" GraphId="e7c8f" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12012</Comment>
-
     <Graphics CenterX="371.00000000000006" CenterY="805.7843137254893" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="371.00000000000006" CenterY="805.7843137254893" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000136881"/>
+
     <Xref Database="Ensembl" ID="ENSG00000136881" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-Methyltetrahydrofolic acid" GraphId="e818f" Type="Metabolite">
   <DataNode TextLabel="5-Methyltetrahydrofolic acid" GraphId="e818f" Type="Metabolite">
-
     <Graphics CenterX="490.99999999999994" CenterY="290.0" Width="146.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="490.99999999999994" CenterY="290.0" Width="146.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
-
     <Xref Database="KEGG Compound" ID="C00440"/>
+
     <Xref Database="KEGG Compound" ID="C00440" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="L-Cystathionine" GraphId="e9676" Type="Metabolite">
   <DataNode TextLabel="L-Cystathionine" GraphId="e9676" Type="Metabolite">
-
     <Graphics CenterX="535.0" CenterY="524.7373847024302" Width="96.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="KEGG Compound" ID="C02291"/>
+
     <Xref Database="KEGG Compound" ID="C02291" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Folic acid" GraphId="ea4c0" Type="Metabolite">
   <DataNode TextLabel="Folic acid" GraphId="ea4c0" Type="Metabolite">
-
     <Graphics CenterX="318.0" CenterY="116.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="318.0" CenterY="116.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
-
     <Xref Database="KEGG Compound" ID="C00504"/>
+
     <Xref Database="KEGG Compound" ID="C00504" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="S-Adenosylmethionine" GraphId="ea735" Type="Metabolite">
   <DataNode TextLabel="S-Adenosylmethionine" GraphId="ea735" Type="Metabolite">
-
     <Graphics CenterX="720.0" CenterY="107.0" Width="112.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="720.0" CenterY="107.0" Width="112.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
-
     <Xref Database="KEGG Compound" ID="C00019"/>
+
     <Xref Database="KEGG Compound" ID="C00019" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Homocysteine" GraphId="ef2cc" Type="Metabolite">
   <DataNode TextLabel="Homocysteine" GraphId="ef2cc" Type="Metabolite">
-
     <Graphics CenterX="535.0" CenterY="468.0" Width="86.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="535.0" CenterY="468.0" Width="86.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
-
     <Xref Database="KEGG Compound" ID="C05330"/>
+
     <Xref Database="KEGG Compound" ID="C05330" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Glycine" GraphId="f247b" Type="Metabolite">
   <DataNode TextLabel="Glycine" GraphId="f247b" Type="Metabolite">
-
     <Graphics CenterX="771.0000000000002" CenterY="195.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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     <Graphics CenterX="771.0000000000002" CenterY="195.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff" />
-
     <Xref Database="KEGG Compound" ID="C00037"/>
+
     <Xref Database="KEGG Compound" ID="C00037" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SHMT2" GraphId="f36c4" Type="GeneProduct" GroupRef="a9359">
   <DataNode TextLabel="SHMT2" GraphId="f36c4" Type="GeneProduct" GroupRef="a9359">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:108037</Comment>
-
     <Graphics CenterX="597.3333333333334" CenterY="181.99999999999991" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="597.3333333333334" CenterY="181.99999999999991" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Ensembl" ID="ENSG00000182199"/>
+
     <Xref Database="Ensembl" ID="ENSG00000182199" />
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   </DataNode>
   <DataNode TextLabel="CHKA" GraphId="f4d34" Type="GeneProduct" GroupRef="b6a64">
   <DataNode TextLabel="CHKA" GraphId="f4d34" Type="GeneProduct" GroupRef="b6a64">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:12660</Comment>
-
     <Graphics CenterX="868.3333333333334" CenterY="399.00000000000006" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="868.3333333333334" CenterY="399.00000000000006" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Ensembl" ID="ENSG00000110721"/>
+
     <Xref Database="Ensembl" ID="ENSG00000110721" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Choline" GraphId="f5235" Type="Metabolite">
   <DataNode TextLabel="Choline" GraphId="f5235" Type="Metabolite">
-
     <Graphics CenterX="709.0" CenterY="434.3333333333335" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="KEGG Compound" ID="C00114"/>
+
     <Xref Database="KEGG Compound" ID="C00114" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TYMS" GraphId="f530e" Type="GeneProduct">
   <DataNode TextLabel="TYMS" GraphId="f530e" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = L:22171</Comment>
-
     <Graphics CenterX="340.16666666666663" CenterY="272.3333333333335" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Graphics CenterX="340.16666666666663" CenterY="272.3333333333335" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Ensembl" ID="ENSG00000176890"/>
+
     <Xref Database="Ensembl" ID="ENSG00000176890" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="gamma-Glutamylcysteine" GraphId="f8795" Type="Metabolite">
   <DataNode TextLabel="gamma-Glutamylcysteine" GraphId="f8795" Type="Metabolite">
-
     <Graphics CenterX="626.5" CenterY="685.1176470588226" Width="131.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" ShapeType="RoundedRectangle" Color="0000ff"/>
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-
     <Xref Database="KEGG Compound" ID="C00669"/>
+
     <Xref Database="KEGG Compound" ID="C00669" />
   </DataNode>
   </DataNode>
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Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106213view12:10, 16 August 2019MaintBotHMDB identifier normalization
105765view19:36, 15 August 2019KhanspersModified description
105764view19:34, 15 August 2019KhanspersModified description
102896view10:25, 27 January 2019EgonwReplaced two PubChem SID with CID identifiers.
96353view17:03, 9 March 2018EgonwConverted interactions to regular arrows, which were not mim:conversions.
96327view09:30, 8 March 2018MkutmonUpdated homology conversion
96235view13:30, 1 March 2018DeSlModified description
96234view13:30, 1 March 2018DeSlRemoved licence number and last modified part.
94312view12:05, 1 September 2017Marvin M2Connected unconnected lines
94206view21:13, 25 August 2017DeSlAdded ID for phosphocholine
93078view09:01, 28 July 2017ElisaFixed unconnected interactions (added anchors to lines)
93018view09:37, 25 July 2017DeSlAdded small sidebrach from L-Cystationine to Ophthalmate.
91096view01:13, 4 January 2017Khanspersconnected interactions
90808view18:21, 14 December 2016KhanspersOntology Term : 'folate mediated one-carbon metabolic pathway' added !
90807view18:20, 14 December 2016KhanspersNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/b/b8/WP3940_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/b/b8/WP3940_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106213)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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