Microglia Pathogen Phagocytosis Pathway (Homo sapiens)

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(HMDB identifier normalization)
Current revision (21:08, 12 September 2019) (view source)
(Modified description)
 
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This pathway was converted from the original human pathway to mouse.
This pathway was converted from the original human pathway to mouse.
-
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal].</Comment>
+
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3937 CPTAC Assay Portal]</Comment>
   <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate.</Comment>
   <Comment Source="HomologyMapper">This pathway was inferred from Mus musculus pathway "Microglia Pathogen Phagocytosis Pathway", WP3626 revision 87399, with a 94.0% conversion rate.</Comment>
   <BiopaxRef>f4f</BiopaxRef>
   <BiopaxRef>f4f</BiopaxRef>
-
   <Graphics BoardWidth="1112.0" BoardHeight="665.0" />
+
   <Graphics BoardWidth="1112.0" BoardHeight="665.0"/>
   <DataNode TextLabel="Oxygen" GraphId="a3593" Type="Metabolite">
   <DataNode TextLabel="Oxygen" GraphId="a3593" Type="Metabolite">
-
     <Graphics CenterX="880.0" CenterY="124.0" Width="46.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="880.0" CenterY="124.0" Width="46.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="HMDB" ID="HMDB0001377" />
+
     <Xref Database="HMDB" ID="HMDB0001377"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Pik3" GraphId="a6dc7" Type="GeneProduct">
   <DataNode TextLabel="Pik3" GraphId="a6dc7" Type="GeneProduct">
-
     <Graphics CenterX="576.0" CenterY="407.0" Width="36.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="009999" />
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     <Graphics CenterX="576.0" CenterY="407.0" Width="36.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="009999"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="IgG" GraphId="a8fda" Type="GeneProduct">
   <DataNode TextLabel="IgG" GraphId="a8fda" Type="GeneProduct">
-
     <Graphics CenterX="328.0" CenterY="118.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="328.0" CenterY="118.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="HCK" GraphId="aad71" Type="GeneProduct">
   <DataNode TextLabel="HCK" GraphId="aad71" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000003283</Comment>
-
     <Graphics CenterX="388.0" CenterY="309.0" Width="34.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="388.0" CenterY="309.0" Width="34.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000101336" />
+
     <Xref Database="Ensembl" ID="ENSG00000101336"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="C1QA" GraphId="adb3f" Type="GeneProduct" GroupRef="f05af">
   <DataNode TextLabel="C1QA" GraphId="adb3f" Type="GeneProduct" GroupRef="f05af">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036887</Comment>
-
     <Graphics CenterX="328.0" CenterY="40.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="328.0" CenterY="40.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000173372" />
+
     <Xref Database="Ensembl" ID="ENSG00000173372"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TYROBP" GraphId="c8356" Type="GeneProduct" GroupRef="ea93c">
   <DataNode TextLabel="TYROBP" GraphId="c8356" Type="GeneProduct" GroupRef="ea93c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030579</Comment>
-
     <Graphics CenterX="513.0" CenterY="233.0" Width="56.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="513.0" CenterY="233.0" Width="56.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000011600" />
+
     <Xref Database="Ensembl" ID="ENSG00000011600"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SYK" GraphId="c8803" Type="GeneProduct">
   <DataNode TextLabel="SYK" GraphId="c8803" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000021457</Comment>
-
     <Graphics CenterX="509.0" CenterY="315.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="509.0" CenterY="315.0" Width="44.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000165025" />
+
     <Xref Database="Ensembl" ID="ENSG00000165025"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIK3R1" GraphId="cfb94" Type="GeneProduct" GroupRef="bbc2b">
   <DataNode TextLabel="PIK3R1" GraphId="cfb94" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000041417</Comment>
-
     <Graphics CenterX="139.0" CenterY="204.0" Width="57.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="139.0" CenterY="204.0" Width="57.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000145675" />
+
     <Xref Database="Ensembl" ID="ENSG00000145675"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SIGLEC7" GraphId="d1d6d" Type="GeneProduct" GroupRef="c9cd3">
   <DataNode TextLabel="SIGLEC7" GraphId="d1d6d" Type="GeneProduct" GroupRef="c9cd3">
     <Comment>Siglece interacts with Ptpn6 according to BioGRID</Comment>
     <Comment>Siglece interacts with Ptpn6 according to BioGRID</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030474</Comment>
-
     <Graphics CenterX="284.5" CenterY="309.0" Width="53.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="284.5" CenterY="309.0" Width="53.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000168995" />
+
     <Xref Database="Ensembl" ID="ENSG00000168995"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TREM1" GraphId="d330a" Type="GeneProduct" GroupRef="f3006">
   <DataNode TextLabel="TREM1" GraphId="d330a" Type="GeneProduct" GroupRef="f3006">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042265</Comment>
-
     <Graphics CenterX="475.0" CenterY="173.0" Width="54.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="475.0" CenterY="173.0" Width="54.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000124731" />
+
     <Xref Database="Ensembl" ID="ENSG00000124731"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PIP2" GraphId="d7a56" Type="Metabolite">
   <DataNode TextLabel="PIP2" GraphId="d7a56" Type="Metabolite">
-
     <Graphics CenterX="621.5" CenterY="194.0" Width="41.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="621.5" CenterY="194.0" Width="41.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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     <Xref Database="Wikidata" ID="Q27088398" />
+
     <Xref Database="Wikidata" ID="Q27088398"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FCER1G" GraphId="d8a3d" Type="GeneProduct" GroupRef="ea93c">
   <DataNode TextLabel="FCER1G" GraphId="d8a3d" Type="GeneProduct" GroupRef="ea93c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000058715</Comment>
-
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     <Graphics CenterX="442.0" CenterY="233.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000158869" />
+
     <Xref Database="Ensembl" ID="ENSG00000158869"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FCGR1A" GraphId="f4098" Type="GeneProduct">
   <DataNode TextLabel="FCGR1A" GraphId="f4098" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015947</Comment>
-
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     <Graphics CenterX="400.0" CenterY="220.0" Width="52.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000150337" />
+
     <Xref Database="Ensembl" ID="ENSG00000150337"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ITGAM" GraphId="ffaf8" Type="GeneProduct" GroupRef="f82bd">
   <DataNode TextLabel="ITGAM" GraphId="ffaf8" Type="GeneProduct" GroupRef="f82bd">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030786</Comment>
-
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     <Graphics CenterX="542.5" CenterY="193.0" Width="53.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000169896" />
+
     <Xref Database="Ensembl" ID="ENSG00000169896"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="TREM2" GraphId="fa9da" Type="GeneProduct" GroupRef="f3006">
   <DataNode TextLabel="TREM2" GraphId="fa9da" Type="GeneProduct" GroupRef="f3006">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000023992</Comment>
-
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     <Graphics CenterX="475.0" CenterY="193.0" Width="54.0" Height="20.0" ZOrder="32769" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000095970" />
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     <Xref Database="Ensembl" ID="ENSG00000095970"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Trem3" GraphId="bef2c" Type="GeneProduct" GroupRef="f3006">
   <DataNode TextLabel="Trem3" GraphId="bef2c" Type="GeneProduct" GroupRef="f3006">
     <Comment Source="HomologyMapper">No homologues found for original id En:ENSMUSG00000041754</Comment>
     <Comment Source="HomologyMapper">No homologues found for original id En:ENSMUSG00000041754</Comment>
-
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     <Xref Database="" ID="" />
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     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ITGB2" GraphId="bbcb5" Type="GeneProduct" GroupRef="f82bd">
   <DataNode TextLabel="ITGB2" GraphId="bbcb5" Type="GeneProduct" GroupRef="f82bd">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000000290</Comment>
-
     <Graphics CenterX="542.5" CenterY="213.0" Width="53.0" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="542.5" CenterY="213.0" Width="53.0" Height="20.0" ZOrder="32771" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000160255" />
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     <Xref Database="Ensembl" ID="ENSG00000160255"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LYN" GraphId="be6a8" Type="GeneProduct">
   <DataNode TextLabel="LYN" GraphId="be6a8" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000042228</Comment>
-
     <Graphics CenterX="371.0" CenterY="268.0" Width="34.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="371.0" CenterY="268.0" Width="34.0" Height="20.0" ZOrder="32772" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000254087" />
+
     <Xref Database="Ensembl" ID="ENSG00000254087"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PTPN6" GraphId="f7fe2" Type="GeneProduct" GroupRef="c9cd3">
   <DataNode TextLabel="PTPN6" GraphId="f7fe2" Type="GeneProduct" GroupRef="c9cd3">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000004266</Comment>
-
     <Graphics CenterX="324.5" CenterY="336.0" Width="45.0" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="324.5" CenterY="336.0" Width="45.0" Height="20.0" ZOrder="32773" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000111679" />
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     <Xref Database="Ensembl" ID="ENSG00000111679"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PLCG2" GraphId="ef07b" Type="GeneProduct" GroupRef="b1008">
   <DataNode TextLabel="PLCG2" GraphId="ef07b" Type="GeneProduct" GroupRef="b1008">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034330</Comment>
-
     <Graphics CenterX="693.5" CenterY="235.0" Width="45.0" Height="22.0" ZOrder="32775" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="693.5" CenterY="235.0" Width="45.0" Height="22.0" ZOrder="32775" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000197943" />
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     <Xref Database="Ensembl" ID="ENSG00000197943"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="LAT" GraphId="bf6f2" Type="GeneProduct" GroupRef="b1008">
   <DataNode TextLabel="LAT" GraphId="bf6f2" Type="GeneProduct" GroupRef="b1008">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030742</Comment>
-
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     <Graphics CenterX="707.5" CenterY="214.0" Width="45.0" Height="20.0" ZOrder="32776" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000213658" />
+
     <Xref Database="Ensembl" ID="ENSG00000213658"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAC1" GraphId="e1720" Type="GeneProduct" GroupRef="d3138">
   <DataNode TextLabel="RAC1" GraphId="e1720" Type="GeneProduct" GroupRef="d3138">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment>
-
     <Graphics CenterX="753.5" CenterY="342.0" Width="45.0" Height="22.0" ZOrder="32777" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="753.5" CenterY="342.0" Width="45.0" Height="22.0" ZOrder="32777" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000136238" />
+
     <Xref Database="Ensembl" ID="ENSG00000136238"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAC2" GraphId="b10c6" Type="GeneProduct" GroupRef="d3138">
   <DataNode TextLabel="RAC2" GraphId="b10c6" Type="GeneProduct" GroupRef="d3138">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment>
-
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     <Graphics CenterX="753.5" CenterY="364.0" Width="45.0" Height="22.0" ZOrder="32778" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000128340" />
+
     <Xref Database="Ensembl" ID="ENSG00000128340"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="RAC3" GraphId="fb211" Type="GeneProduct" GroupRef="d3138">
   <DataNode TextLabel="RAC3" GraphId="fb211" Type="GeneProduct" GroupRef="d3138">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment>
-
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-
     <Xref Database="Ensembl" ID="ENSG00000169750" />
+
     <Xref Database="Ensembl" ID="ENSG00000169750"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VAV1" GraphId="d0362" Type="GeneProduct" GroupRef="b1008">
   <DataNode TextLabel="VAV1" GraphId="d0362" Type="GeneProduct" GroupRef="b1008">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000034116</Comment>
-
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     <Graphics CenterX="753.5" CenterY="224.0" Width="45.0" Height="20.0" ZOrder="32780" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000141968" />
+
     <Xref Database="Ensembl" ID="ENSG00000141968"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VAV2" GraphId="af215" Type="GeneProduct" GroupRef="b1008">
   <DataNode TextLabel="VAV2" GraphId="af215" Type="GeneProduct" GroupRef="b1008">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000009621</Comment>
-
     <Graphics CenterX="753.5" CenterY="244.0" Width="45.0" Height="20.0" ZOrder="32781" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="753.5" CenterY="244.0" Width="45.0" Height="20.0" ZOrder="32781" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000160293" />
+
     <Xref Database="Ensembl" ID="ENSG00000160293"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="VAV3" GraphId="c016f" Type="GeneProduct" GroupRef="b1008">
   <DataNode TextLabel="VAV3" GraphId="c016f" Type="GeneProduct" GroupRef="b1008">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033721</Comment>
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   <DataNode TextLabel="NCKAP1L" GraphId="e2518" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000022488</Comment>
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   <DataNode TextLabel="ARPC1B" GraphId="dd45f" Type="GeneProduct">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000029622</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000130429"/>
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   <DataNode TextLabel="NCF4" GraphId="c53ff" Type="GeneProduct" GroupRef="c50e8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000100365"/>
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   <DataNode TextLabel="NCF2" GraphId="fc72f" Type="GeneProduct" GroupRef="c50e8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000116701"/>
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   <DataNode TextLabel="NCF1" GraphId="a5899" Type="GeneProduct" GroupRef="c50e8">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment>
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     <Xref Database="Ensembl" ID="ENSG00000158517"/>
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   <DataNode TextLabel="CYBB" GraphId="b1743" Type="GeneProduct" GroupRef="b1453">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment>
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   <DataNode TextLabel="CYBA" GraphId="b86eb" Type="GeneProduct" GroupRef="b1453">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment>
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   <DataNode TextLabel="NCF1" GraphId="bd8a4" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015950</Comment>
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   <DataNode TextLabel="NCF4" GraphId="f5c7f" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000071715</Comment>
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   <DataNode TextLabel="NCF2" GraphId="c8e62" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000026480</Comment>
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   <DataNode TextLabel="RAC1" GraphId="c7ed8" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000001847</Comment>
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   <DataNode TextLabel="RAC2" GraphId="da134" Type="GeneProduct" GroupRef="ca49c">
   <DataNode TextLabel="RAC2" GraphId="da134" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033220</Comment>
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   <DataNode TextLabel="RAC3" GraphId="f3951" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000018012</Comment>
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   <DataNode TextLabel="CYBB" GraphId="bee15" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000015340</Comment>
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   <DataNode TextLabel="CYBA" GraphId="b99bf" Type="GeneProduct" GroupRef="ca49c">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000006519</Comment>
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   <DataNode TextLabel="C1QB" GraphId="fe05b" Type="GeneProduct" GroupRef="f05af">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036905</Comment>
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   <DataNode TextLabel="C1QC" GraphId="cba5d" Type="GeneProduct" GroupRef="f05af">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000036896</Comment>
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   <DataNode TextLabel="PIK3CG" GraphId="f18be" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000020573</Comment>
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   <DataNode TextLabel="PIK3CA" GraphId="ccea2" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000027665</Comment>
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   <DataNode TextLabel="PIK3CD" GraphId="ac5ec" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000039936</Comment>
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   <DataNode TextLabel="PIK3CB" GraphId="e411c" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000032462</Comment>
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   <DataNode TextLabel="PIK3R2" GraphId="db275" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000031834</Comment>
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   <DataNode TextLabel="PIK3C3" GraphId="a87de" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000033628</Comment>
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   <DataNode TextLabel="PIK3C2A" GraphId="ed399" Type="GeneProduct" GroupRef="bbc2b">
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660</Comment>
     <Comment Source="HomologyMapper">Homology Mapping from Mus musculus to Homo sapiens: Original ID = En:ENSMUSG00000030660</Comment>
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   <Biopax>
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Current revision

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
106647view21:08, 12 September 2019KhanspersModified description
106184view12:08, 16 August 2019MaintBotHMDB identifier normalization
105650view05:12, 10 August 2019KhanspersModified description
94208view21:18, 25 August 2017DeSlAdded ID for PIP2
90777view01:24, 14 December 2016KhanspersOntology Term : 'innate immune response pathway' added !
90776view01:24, 14 December 2016KhanspersOntology Term : 'Alzheimer disease pathway' added !
90775view01:23, 14 December 2016KhanspersOntology Term : 'microglial cell' added !
90774view01:23, 14 December 2016KhanspersNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/7/7e/WP3937_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/7/7e/WP3937_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106647)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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