Hexoses metabolism in proximal tubules (Rattus norvegicus)

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CytosolMitochondrionFatty AcidSynthesisGlucoseSlc2a4AldocPyruvatePgk2Pentose Phosphate PathwayDihydroxyacetone-PSlc2a2Slc2a5Pdha1PkmPyruvateSlc2a1PdhbPgam1LactatePdp11,3BP-GlyceratePgk1Fructose-1,6BPP-enolpyruvateGlyceraldehyde 3PGlucoseFructose 6PPklr3P-GlycerateGapdhTpi1PdhxHk1DlatGpiSlc2a32P-GlycerateGlucose-6PMpc1Pdp2AldobGlycogen MetabolismPdha2AldoaAcetyl-CoADldmpc2Pdk1Pdk3Pdk2Pdk4Fbp2Fbp1OxalacetatePcMalateMalateOxalacetateAspartateCitrateAspartateCitrateAcetyl-CoAAclyPfklPfkpPfkmTkfcSordFructoseKhkSorbitolFructose-1-PGlyderaldehydeAldobAkr1b1Polyol Pathwayspecific stepsSlc5a10Slc2a5Slc5a9Slc2a2FructoseG6pcHk1Low affinityfor fructoseRate limitingstepNeutral lipidSynthesisLipid DropletsPgam2Eno1Eno3Eno2ExtracellularPck1Got1Got2Mdh2Mdh1CsDiacylglycerolSynthesisLdhbLdha


This pathway is a based on Glycolysis and Gluconeogenesis (Mus musculus) [1]

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Ontology Terms



  1. Fukuzawa T, Fukazawa M, Ueda O, Shimada H, Kito A, Kakefuda M, Kawase Y, Wada NA, Goto C, Fukushima N, Jishage K, Honda K, King GL, Kawabe Y; ''SGLT5 reabsorbs fructose in the kidney but its deficiency paradoxically exacerbates hepatic steatosis induced by fructose.''; PLoS One, 2013 PubMed Europe PMC Scholia
  2. Tazawa S, Yamato T, Fujikura H, Hiratochi M, Itoh F, Tomae M, Takemura Y, Maruyama H, Sugiyama T, Wakamatsu A, Isogai T, Isaji M; ''SLC5A9/SGLT4, a new Na+-dependent glucose transporter, is an essential transporter for mannose, 1,5-anhydro-D-glucitol, and fructose.''; Life Sci., 2005 PubMed Europe PMC Scholia
  3. Gonzalez-Vicente A, Garvin JL, Hopfer U; ''Transcriptome signature for dietary fructose-specific changes in rat renal cortex: A quantitative approach to physiological relevance.''; PLoS One, 2018 PubMed Europe PMC Scholia
  4. Grempler R, Augustin R, Froehner S, Hildebrandt T, Simon E, Mark M, Eickelmann P; ''Functional characterisation of human SGLT-5 as a novel kidney-specific sodium-dependent sugar transporter''; FEBS Lett., 2012 PubMed Europe PMC Scholia
  5. Gonzalez-Vicente A, Cabral PD, Hong NJ, Asirwatham J, Saez F, Garvin JL; ''Fructose reabsorption by rat proximal tubules: role of Na+-linked cotransporters and the effect of dietary fructose.''; Am J Physiol Renal Physiol, 2019 PubMed Europe PMC Scholia


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108295view17:36, 4 December 2019AgustinGVAdd new reference
106989view13:44, 17 September 2019MaintBotHMDB identifier normalization
98350view22:42, 23 August 2018AlexanderPicoUpdated datasource for apopotosis pathway node
98346view20:44, 23 August 2018Elisson nlFatty Acid Reference
98289view13:36, 16 August 2018DeSlRemoved licence number
98288view13:35, 16 August 2018DeSlSmall changes to layout for readability.
98211view12:32, 9 August 2018AgustinGVRefs added
91332view18:22, 2 February 2017Khanspersconnected interaction
90672view21:56, 5 December 2016MaintBotFixed confusion between HMDB datasource but CAS identifier
90642view18:37, 4 December 2016AlexanderPicoManually fixed lit refs
90641view18:27, 4 December 2016AlexanderPicoUpdated lit refs, cell compartments, groups and metabolite colors
90640view18:13, 4 December 2016AlexanderPicoModified description
90525view19:19, 21 November 2016AgustinGVSpecify description
90524view19:16, 21 November 2016AgustinGVUpdate tissue specific glucose transporters
90494view21:24, 17 November 2016AgustinGVSpecify description
90493view21:18, 17 November 2016AgustinGVOntology Term : 'PW:0000041' removed !
90492view21:18, 17 November 2016AgustinGVOntology Term : 'epithelial cell of proximal tubule' added !
90491view21:17, 17 November 2016AgustinGVOntology Term : 'inherited metabolic disorder' added !
90490view21:17, 17 November 2016AgustinGVOntology Term : 'acquired metabolic disease' added !
90489view21:16, 17 November 2016AgustinGVOntology Term : 'disease of metabolism' added !
90488view21:16, 17 November 2016AgustinGVOntology Term : 'fructose and mannose metabolic pathway' added !
90487view21:16, 17 November 2016AgustinGVOntology Term : 'glycolysis/gluconeogenesis pathway' added !
90486view21:16, 17 November 2016AgustinGVOntology Term : 'classic metabolic pathway' added !
90485view21:15, 17 November 2016AgustinGVOntology Term : 'carbohydrate metabolic pathway' added !
90484view21:15, 17 November 2016AgustinGVSpecify description
90483view20:29, 17 November 2016AgustinGVSpecify description
90482view20:27, 17 November 2016AgustinGVSpecify description
90481view20:27, 17 November 2016AgustinGVAdd Ldh a/b
90480view20:09, 17 November 2016AgustinGVFix wrong interaction
90479view19:44, 17 November 2016AgustinGVSpecify description
90478view19:29, 17 November 2016AgustinGVSpecify description
90477view19:28, 17 November 2016AgustinGVSpecify description
90476view19:23, 17 November 2016AgustinGVSpecify description
90475view19:20, 17 November 2016AgustinGVPeriodical save, work in progress
90474view19:14, 17 November 2016AgustinGVSpecify description
90473view18:58, 17 November 2016AgustinGVSpecify description
90472view18:57, 17 November 2016AgustinGVPeriodical save, work in progress
90471view18:51, 17 November 2016AgustinGVSpecify description
90470view18:50, 17 November 2016AgustinGVSpecify description
90469view18:44, 17 November 2016AgustinGVModified title
90468view18:43, 17 November 2016AgustinGVNew pathway

External references


View all...
NameTypeDatabase referenceComment
1,3BP-GlycerateMetaboliteHMDB01270 (HMDB)
2P-GlycerateMetaboliteHMDB00362 (HMDB)
3P-GlycerateMetaboliteHMDB00807 (HMDB)
Acetyl-CoAMetabolite72-89-9 (CAS)
AclyGeneProduct24159 (Entrez Gene)
Akr1b1GeneProduct24192 (Entrez Gene)
AldoaGeneProduct24189 (Entrez Gene)
AldobGeneProduct24190 (Entrez Gene)
AldocGeneProduct24191 (Entrez Gene)
AspartateMetabolite6915-15-7 (CAS)
CitrateMetabolite6915-15-7 (CAS)
CsGeneProduct170587 (Entrez Gene)
Diacylglycerol SynthesisPathway
Dihydroxyacetone-PMetaboliteHMDB01473 (HMDB)
DlatGeneProduct81654 (Entrez Gene)
DldGeneProduct298942 (Entrez Gene)
Eno1GeneProduct24333 (Entrez Gene)
Eno2GeneProduct24334 (Entrez Gene)
Eno3GeneProduct25438 (Entrez Gene)
Fatty Acid SynthesisPathway
Fbp1Protein24362 (Entrez Gene)
Fbp2Protein114508 (Entrez Gene)
Fructose 6PMetaboliteHMDB00124 (HMDB)
Fructose-1,6BPMetaboliteHMDB01058 (HMDB)
Fructose-1-PMetaboliteHMDB01076 (HMDB)
FructoseMetaboliteHMDB00660 (HMDB)
G6pcGeneProduct25634 (Entrez Gene)
GapdhGeneProduct24383 (Entrez Gene)
Glucose-6PMetaboliteHMDB01401 (HMDB)
GlucoseMetaboliteHMDB00122 (HMDB)
Glyceraldehyde 3PMetaboliteHMDB01112 (HMDB)
Glycogen MetabolismPathway
GlyderaldehydeMetaboliteHMDB01051 (HMDB)
Got1GeneProduct24401 (Entrez Gene)
Got2GeneProduct25721 (Entrez Gene)
GpiGeneProduct292804 (Entrez Gene)
Hk1GeneProduct25058 (Entrez Gene)
KhkGeneProduct25659 (Entrez Gene)
LactateMetabolite79-33-4 (CAS)
LdhaGeneProduct24533 (Entrez Gene) Make sure to differentiate between M1 and M2 isoform
LdhbGeneProduct24534 (Entrez Gene) 2 Isoforms: L Liver and R red cells
MalateMetabolite6915-15-7 (CAS)
Mdh1GeneProduct24551 (Entrez Gene)
Mdh2GeneProduct81829 (Entrez Gene)
Mpc1GeneProduct171087 (Entrez Gene)
Neutral lipid


Lipid Droplets
Pathwaywp (WikiPathways)
OxalacetateMetabolite328-42-7 (HMDB)
P-enolpyruvateMetaboliteHMDB00263 (HMDB)
PcGeneProduct25104 (Entrez Gene)
Pck1GeneProduct362282 (Entrez Gene)
Pdha1GeneProduct29554 (Entrez Gene)
Pdha2GeneProduct117098 (Entrez Gene)
PdhbGeneProduct289950 (Entrez Gene)
PdhxGeneProduct311254 (Entrez Gene)
Pdk1GeneProduct116551 (Entrez Gene)
Pdk2GeneProduct81530 (Entrez Gene)
Pdk3GeneProduct296849 (Entrez Gene)
Pdk4GeneProduct89813 (Entrez Gene)
Pdp1GeneProduct54705 (Entrez Gene)
Pdp2GeneProduct246311 (Entrez Gene)
Pentose Phosphate PathwayPathway
PfklGeneProduct25741 (Entrez Gene)
PfkmGeneProduct65152 (Entrez Gene)
PfkpGeneProduct60416 (Entrez Gene)
Pgam1GeneProduct24642 (Entrez Gene)
Pgam2GeneProduct24959 (Entrez Gene)
Pgk1GeneProduct24644 (Entrez Gene)
Pgk2GeneProduct316265 (Entrez Gene)
PklrGeneProduct24651 (Entrez Gene) Make sure to differentiate between M1 and M2 isoform
PkmGeneProduct25630 (Entrez Gene) 2 Isoforms: L Liver and R red cells
PyruvateMetaboliteHMDB00243 (HMDB)
Slc2a1GeneProduct24778 (Entrez Gene)
Slc2a2GeneProduct25351 (Entrez Gene)
Slc2a3GeneProduct25551 (Entrez Gene)
Slc2a4GeneProduct25139 (Entrez Gene)
Slc2a5GeneProduct65197 (Entrez Gene)
Slc5a10GeneProduct303205 (Entrez Gene)
Slc5a9GeneProduct366441 (Entrez Gene)
SorbitolMetaboliteHMDB00247 (HMDB)
SordGeneProduct24788 (Entrez Gene)
TkfcGeneProduct361730 (Entrez Gene)
Tpi1GeneProduct24849 (Entrez Gene)
mpc2GeneProduct100359982 (Entrez Gene)

Annotated Interactions

No annotated interactions

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