MAPK Signaling Pathway (Homo sapiens)

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(HMDB identifier normalization)
(Modified description)
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Description reference: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
Description reference: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010
-
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP382 CPTAC Assay Portal].</Comment>
+
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP382 CPTAC Assay Portal]</Comment>
   <BiopaxRef>a74</BiopaxRef>
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   <BiopaxRef>f20</BiopaxRef>
Line 15: Line 15:
   <BiopaxRef>c2b</BiopaxRef>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="nfat2/4" />
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   <DataNode TextLabel="ARRB2" GraphId="a48" Type="GeneProduct" GroupRef="b6b45">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB2 | arrestin beta 2" />
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   <DataNode TextLabel="MAPT" GraphId="e9e" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPT | microtubule-associated protein tau" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPT | microtubule-associated protein tau"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RASGRP1 | RAS guanyl releasing protein 1 (calci..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAP1B | RAP1B member of RAS oncogene family" />
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   <DataNode TextLabel="CD14" GraphId="ae2" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CD14 | CD14 antigen" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CD14 | CD14 antigen"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKG | inhibitor of kappa light polypeptide ge..." />
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   <DataNode TextLabel="BDNF" GraphId="ee4" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDNF | brain-derived neurotrophic factor" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDNF | brain-derived neurotrophic factor"/>
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     <Xref Database="Entrez Gene" ID="627"/>
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   <DataNode TextLabel="DAXX" GraphId="e72" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="DAXX | death-associated protein 6" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="DAXX | death-associated protein 6"/>
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   <DataNode TextLabel="MAPK10" GraphId="d31" Type="GeneProduct" GroupRef="ae773">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10"/>
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     <Xref Database="Entrez Gene" ID="5602"/>
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   <DataNode TextLabel="TNF" GraphId="ac2" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNF | tumor necrosis factor (TNF superfamily m..." />
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     <Xref Database="Entrez Gene" ID="7124"/>
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   <DataNode TextLabel="ARAF" GraphId="ca1" Type="GeneProduct" GroupRef="ca16e">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MOS | v-mos Moloney murine sarcoma viral oncoge..." />
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     <Xref Database="Ensembl" ID="ENSG00000078061"/>
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   <DataNode TextLabel="STK4" GraphId="cde" Type="GeneProduct" GroupRef="acec2">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MINK1 | misshapen-like kinase 1 (zebrafish)" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MINK1 | misshapen-like kinase 1 (zebrafish)"/>
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   <DataNode TextLabel="MAPK14" GraphId="f0b" Type="GeneProduct" GroupRef="f0d84">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14 | mitogen-activated protein kinase 14" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14 | mitogen-activated protein kinase 14"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKB | inhibitor of kappa light polypeptide ge..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB1 | arrestin beta 1" />
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     <Xref Database="Ensembl" ID="ENSG00000188906"/>
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   <DataNode TextLabel="CASP3" GraphId="b28" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP3 | caspase 3 apoptosis-related cysteine p..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP3 | caspase 3 apoptosis-related cysteine p..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FLNA | filamin A alpha (actin binding protein ..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACA | protein kinase cAMP-dependent cataly..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPKAPK2 | mitogen-activated protein kinase-act..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD | protein kinase C delta" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K14 | mitogen-activated protein kinase kina..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HSPB1 | heat shock 27kDa protein 1" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ZAK | sterile alpha motif and leucine zipper co..." />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNA12 | guanine nucleotide binding protein (G p..." />
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     <Xref Database="Entrez Gene" ID="2768"/>
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   <DataNode TextLabel="FGF16" GraphId="c348c" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FGF4 | fibroblast growth factor 4 (heparin secr..." />
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     <Xref Database="Ensembl" ID="ENSG00000196468"/>
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   </DataNode>
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   <DataNode TextLabel="FGF19" GraphId="fa721" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FGF4 | fibroblast growth factor 4 (heparin secr..." />
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   </DataNode>
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   <DataNode TextLabel="PAK2" GraphId="dfb" Type="GeneProduct" GroupRef="a5f41">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK2 | p21 (CDKN1A)-activated kinase 2" />
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     <Xref Database="Entrez Gene" ID="5062" />
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     <Xref Database="Entrez Gene" ID="5062"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK1 | p21/Cdc42/Rac1-activated kinase 1 (STE20..." />
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     <Comment>Stathmin is a ubiquitous phsosphorylated protein</Comment>
     <Comment>Stathmin is a ubiquitous phsosphorylated protein</Comment>
     <Comment>https://en.wikipedia.org/wiki/Stathmin#Function</Comment>
     <Comment>https://en.wikipedia.org/wiki/Stathmin#Function</Comment>
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     <Comment>Presumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitory</Comment>
     <Comment>Presumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitory</Comment>
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     <Comment>https://en.wikipedia.org/wiki/I%CE%BAB_kinase#Regulation</Comment>
     <Comment>https://en.wikipedia.org/wiki/I%CE%BAB_kinase#Regulation</Comment>
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     <Comment>G2019S</Comment>
     <Comment>G2019S</Comment>
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   <Group GroupId="ef3d5" GraphId="f361d" Style="Group"/>
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   <Group GroupId="acec2" GraphId="fb7ca" Style="Group"/>
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   <Group GroupId="a610a" GraphId="fc65f" Style="Group" />
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   <Group GroupId="a610a" GraphId="fc65f" Style="Group"/>
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   <Group GroupId="ae5f3" GraphId="ffcce" Style="Group"/>
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   <InfoBox CenterX="0.0" CenterY="0.0" />
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   <InfoBox CenterX="0.0" CenterY="0.0"/>
   <Biopax>
   <Biopax>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c2b">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="c2b">

Revision as of 20:59, 12 September 2019