MAPK Signaling Pathway (Homo sapiens)

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(Modified description)
(HMDB identifier normalization)
Line 15: Line 15:
   <BiopaxRef>c2b</BiopaxRef>
   <BiopaxRef>c2b</BiopaxRef>
   <BiopaxRef>b12</BiopaxRef>
   <BiopaxRef>b12</BiopaxRef>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB2 | arrestin beta 2"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPT | microtubule-associated protein tau"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RASGRP1 | RAS guanyl releasing protein 1 (calci..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="RAP1B | RAP1B member of RAS oncogene family"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CD14 | CD14 antigen"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKG | inhibitor of kappa light polypeptide ge..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDNF | brain-derived neurotrophic factor"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="BDNF | brain-derived neurotrophic factor" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="DAXX | death-associated protein 6"/>
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     <Xref Database="Entrez Gene" ID="1616" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK10 | mitogen-activated protein kinase 10" />
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TNF | tumor necrosis factor (TNF superfamily m..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MOS | v-mos Moloney murine sarcoma viral oncoge..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MINK1 | misshapen-like kinase 1 (zebrafish)"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPK14 | mitogen-activated protein kinase 14"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="IKBKB | inhibitor of kappa light polypeptide ge..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ARRB1 | arrestin beta 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CASP3 | caspase 3 apoptosis-related cysteine p..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FLNA | filamin A alpha (actin binding protein ..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKACA | protein kinase cAMP-dependent cataly..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAPKAPK2 | mitogen-activated protein kinase-act..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PRKCD | protein kinase C delta"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="MAP3K14 | mitogen-activated protein kinase kina..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HSPB1 | heat shock 27kDa protein 1"/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ZAK | sterile alpha motif and leucine zipper co..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="GNA12 | guanine nucleotide binding protein (G p..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="TGFB1 | transforming growth factor beta 1 (Cam..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FGF4 | fibroblast growth factor 4 (heparin secr..."/>
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     <Xref Database="Ensembl" ID="ENSG00000196468"/>
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     <Xref Database="Ensembl" ID="ENSG00000196468" />
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   </DataNode>
   <DataNode TextLabel="FGF19" GraphId="fa721" Type="GeneProduct">
   <DataNode TextLabel="FGF19" GraphId="fa721" Type="GeneProduct">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="FGF4 | fibroblast growth factor 4 (heparin secr..."/>
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     <Xref Database="Ensembl" ID="ENSG00000162344" />
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   </DataNode>
   <DataNode TextLabel="PAK2" GraphId="dfb" Type="GeneProduct" GroupRef="a5f41">
   <DataNode TextLabel="PAK2" GraphId="dfb" Type="GeneProduct" GroupRef="a5f41">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK2 | p21 (CDKN1A)-activated kinase 2"/>
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     <Xref Database="Entrez Gene" ID="5062"/>
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     <Xref Database="Entrez Gene" ID="5062" />
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   </DataNode>
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   <DataNode TextLabel="PAK1" GraphId="eec" Type="GeneProduct" GroupRef="a5f41">
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PAK1 | p21/Cdc42/Rac1-activated kinase 1 (STE20..."/>
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     <Xref Database="Entrez Gene" ID="5058"/>
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     <Comment>Stathmin is a ubiquitous phsosphorylated protein</Comment>
     <Comment>Stathmin is a ubiquitous phsosphorylated protein</Comment>
     <Comment>https://en.wikipedia.org/wiki/Stathmin#Function</Comment>
     <Comment>https://en.wikipedia.org/wiki/Stathmin#Function</Comment>
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     <Comment>Presumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitory</Comment>
     <Comment>Presumably a deactivating phosphorylation event, since JNK phosphorylaiton is shown as inhibitory</Comment>
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     <Comment>https://en.wikipedia.org/wiki/I%CE%BAB_kinase#Regulation</Comment>
     <Comment>https://en.wikipedia.org/wiki/I%CE%BAB_kinase#Regulation</Comment>
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     <Comment>G2019S</Comment>
     <Comment>G2019S</Comment>
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Line 2,614: Line 2,623:
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Line 2,710: Line 2,658:
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      <bp:TITLE rdf:datatype="http://www.w3.org/2001/XMLSchema#string">MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.</bp:TITLE>
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</Pathway>
</Pathway>

Revision as of 12:07, 16 August 2019

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Pathway history

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CompareRevisionActionTimeUserComment
107148view14:23, 17 September 2019MaintBotChEBI identifier normalization
106635view20:59, 12 September 2019KhanspersModified description
106182view12:07, 16 August 2019MaintBotHMDB identifier normalization
105440view04:52, 8 August 2019KhanspersModified description
105253view22:42, 24 July 2019Khanspersupdated phosphosites
105246view00:02, 24 July 2019Khanspersminor update
105245view23:50, 23 July 2019Khanspersupdating phosphosites
105244view23:47, 23 July 2019Khanspersupdating phosphosites
105243view23:41, 23 July 2019Khanspersupdating phospho sites
103466view19:21, 5 March 2019AlexanderPicoModified description
103464view19:19, 5 March 2019AlexanderPicoModified description
96995view21:30, 25 April 2018Khanspersadded phosphosites
96304view18:29, 7 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95114view14:52, 16 November 2017DeSlFIxed nested group.
94850view22:30, 9 October 2017Khanspersadded phosphorylation information as comments on states
94694view23:16, 4 October 2017Khanspersremoved old GenMAPP comments
94606view20:31, 29 September 2017Khanspersconnected lines and updated layout
94603view21:25, 28 September 2017Khanspersdefined FGF and calcium channels
94570view13:56, 28 September 2017DeSlChanged IDs of HMDB (removed 2 zero's, to use the primary ID).
94567view23:33, 27 September 2017Khanspersoverhaul in progress
94566view23:08, 27 September 2017Khanspersoverhaul in progress
94565view19:23, 27 September 2017Khanspersoverhaul - in progress
79951view11:12, 28 April 2015ZariChanged Entrez gene Id to Ensembl Id for MAP3K14
72103view21:47, 24 October 2013Mkutmonadded datasource for "Wnt signaling pathway", "Apoptosis" and "Cell cycle"
70631view00:25, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
70021view01:51, 12 July 2013AlexanderPicoModified title
68899view17:29, 8 July 2013MaintBotUpdated to 2013 gpml schema
67443view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
54211view22:33, 23 November 2012AlexanderPicoAdded Vemurafenib
54210view22:29, 23 November 2012AlexanderPicoAdded lrrk2
44890view10:14, 6 October 2011MartijnVanIerselOntology Term : 'MAPK signaling pathway' added !
41048view23:16, 1 March 2011MaintBotRemoved redundant pathway information and comments
38878view18:52, 24 September 2010KhanspersAdded pathway links and changed line types
38877view18:44, 24 September 2010Khanspers
37347view17:34, 28 May 2010KhanspersConnectors
35657view22:02, 12 February 2010