Selenoamino acid metabolism (Homo sapiens)

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174, 7, 166, 103111, 322821, 2952034, 7, 1621, 253393319, 2421, 292812, 273712, 353138, 2025, 3014, 18, 2223, 26, 34311351336cytosolRPL9 RPL18 AdoHcyRPS19 AHCYFAD RPS15A L-AlaRPL34 RPL19 RPS27 RPL26 RPS27A(77-156) RPSA RPS9 H2ORPL34 2OBUTASec-tRNA(Sec)RPL7 RPL18A SECISBP2 RPL41 RPL23A PAPSS2 Me2SeSeMet-tRNA(Met)RPL27 EEFSEC MeSeHRPS5 Met-tRNAi H2Oreduced acceptorPPiRPL30 RPL22 RPL36 ATPRPLP0 CTH Hist,NAM,GlyPAPSS1 GSR-2 RPL32 RPL32 RPL34 TNXRD1:FAD dimerRPL17 PXLP RPL37A RPL35 RPS15 TNXRD1:FAD dimerRPL13A RPS29 RPS8 RPLP2 H2SeO4RPL28 RPS13 H2OMg2+ RPS5 RPL28 RPS26 RPL10 RPSA AIMP1(1-312) PAPSeRRPL9 RPS25 RPL11 RPL15 RPL27 ATPRPS15A ADPRPL11 RPL17 PiRPL24 RPLP2 RPS27A(77-156) RPS24 RPS21 RPL37A RARS QARS EEFSEC RPL14 RPL23 H+RPL4 RPL37 RPS3 NADPHRPL13A RPL39 RPL21 CTH SeO3(2-)RPL22 LARS RPL12 RPL29 RPS20 RPS20 AIMP2 RPL36 RPL26L1 RPL35 RPS4Y1 RPL7 RPS28 RPL26 Sec-tRNA(Sec):EEFSEC:GTPRPL26L1 RPL19 GSHRPL13 H2SeRPS11 RPL38 MeSeO2Haminoacyl-tRNAsynthetasemultienzyme complexRPL7 H2ORPL22 RPS26 RPS3 NAM RPL31 CTH tetramer:PXLPRPS17 EPRS NADP+RPL31 EEFSEC ATPSCLY RPS7 GNMT FAU NADP+RPL14 GSHFAD RPL3L APSeRPL21 18S rRNA RPL10A SeMetRPLP1 H2O18S rRNA RPS18 GDP H2OPPiMeHist PAPRPS16 Gly GSHRPS3 RPL38 FAU H2ORPS17 RPL18A PPiAdoMetRPL35A Me3Se+RPL27A RPL12 Met-tRNAi RPL37 AdeSeHCysEEFSEC:GDPH2OSARS dimerSARS RPS15 PPiHNMT RPS8 RPL30 INMTRPS29 MAT1A multimersRPS2 RPL3 TXNRD1 RPL23A RPS11 RPS27 RPS3A RPS10 PXLP AdoHcyRPL36 L-SerSCLY dimer:PXLPRPS23 tRNA(Met)Ceruloplasmin mRNA 5S rRNA GTP RPL13 AdoMetNADPHRPS12 RPS21 Sec-tRNA(Sec) NADPHRPS21 RPS20 AdoSeMetRPL18 K+ Ade-RibbGalNAc derivativeGSSGheme GSSebGalNacRPS6 RPSA SECISBP25S rRNA RPL23A RPL40 RPS7 RPL39 RPL8 MeSecRPS29 bGalNAcMARS RPLP0 RPS12 RPS28 FAD RPL36A MeHist,N1MNA,MeGlyRPL8 SEPSECStetramer:PXLPPAPSS1 H2ORPS4X RPL40 RPS23 RPS24 RPLP2 RPS23 RPL37A RPS9 RPS3A AdoHcyRPL40 RPS5 IARS RPL10A tRNA(Sec)RPL10 RPL29 CBS tetramerRPLP1 ADPRPS26 RPL24 RPS19 RPL24 RPL35A Ser-tRNA(Sec)RPS3A RPS27 acceptorH2OH+MNA TXNRD1 MeOHTNXRD1:FAD dimerPAPSS1,2RPL13 5S rRNA RPL3L RPS15 H+RPS12 H2OPAPSS2 RPS13 RPL37 ATPSEPSECS RPS14 28S rRNA RPL5 SECISBP2 GTP RPL35A RPL23 RPL6 RPL12 SeHCys5.8S rRNA RPS15A RPS24 RPL31 RPL32 RPS18 GTP NNMT PXLP-CBS RPS16 RPL39 H3PO4RPL5 RPS7 PAPSS1,2SecGSR-2:FAD dimerH2OPSTK:Mg2+RPL7A ATPCTH tetramer:PXLPH+RPS8 Hist PiEEF1E1 RPS19 H3SePO380S:Met-tRNAi:mRNA:SECISBP2:SecEEFSEC:GTPRPL13A RPS18 RPL28 RPL15 5.8S rRNA RPS25 NADP+Sec MeSebGalNacNH3RPS6 Ceruloplasmin mRNA MetTrans(1)RPL18 RPS4X RPS4Y1 RPL9 RPL38 RPS13 Ceruloplasmin mRNA PXLP RPS11 MSDMPXLP KARS NADP+RPS10 H+RPL36A RPS14 28S rRNA RPS2 RPL41 RPL27 RPS17 RPL6 GSHAMPRPS14 MeSeOHRPS4Y1 RPL26 RPL11 RPL15 RPL4 RPL35 ATPRPL19 AMPRPL10A 80S:Met-tRNAi:mRNARPL8 PAPSePSTK RPL7A RPS25 Mg2+ H+H2OFAD RPS16 TXNRD1 RPL30 AdoHcy5.8S rRNA RPL23 RPL10 GSSGRPLP1 RPL41 RPL4 2-acetamidoglucalRPL27A SeCystaRPLP0 AdoMet2OBUTAFAU MAT1A RPL29 MeSeHMTL-SerHSeMTRPL5 RPS28 GSSeSGRPL36A 80S:Met-tRNAi:mRNA:SECISBP2:Sec-tRNA(Sec):EEFSEC:GTPRPL21 Met-tRNAi RPS9 RPL3L DARS RPS2 NH3NADP+RPL7A RPS6 RPL3 RPL27A 28S rRNA Sec-tRNA(Sec) RPL14 RPL26L1 NADPHRPS10 RPS4X SARC GSSeHNADPH18S rRNA RPL6 Sep-tRNA(Sec)RPS27A(77-156) RPL17 EEFSEC pyruvic acidRPL18A RPL3 15


Description

Selenium (Se) is a trace element essential for the normal function of the body. Selenoamino acids are defined as those amino acids where selenium has been substituted for sulphur. Selenium and sulphur share many chemical properties and so the substitution of normal amino acids with selenoamino acids has little effect on protein structure and function. Both inorganic (selenite, SeO3(2-); and selenate, SeO4(2-)) and organic (selenocysteine, Sec; and selenomethionine, SeMet) forms of selenium can be introduced in the diet where they are transformed into the intermediate selenide (Se(2-)) and then utilized for the de novo synthesis of Sec through a phosphorylated intermediate in a tRNA-dependent fashion. The final step of Sec formation is catalyzed by O-phosphoseryl-tRNA:selenocysteinyl-tRNA synthase (SEPSECS) that converts phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec).

All nutritional selenium is metabolised into selenide directly or through methylselenol (MeSeH). Sec liberated from selenoproteins is transformed to Se(2-) by selenocysteine lyase (SCLY). SeMet liberated from general proteins and from free SeMet sources is transformed into Se(2-) either through MeSeH by cystathionine gamma-lyase (CTH) followed by demethylation (SeMet to CH3SeH to H2Se), or through Sec by SCLY after the trans-selenation pathway (SeMet to Sec to H2Se). MeSec is hydrolysed into MeSeH by CTH. Methylseleninic acid (MeSeO2H) is reduced to methylselenol. MeSeH is demethylated to Se(2-) for further utilization for selenoprotein synthesis or oxidised to selenite (SeO3(2-)) for excretion in the form of selenosugar. Additionally, MeSeH is further methylated to dimethylselenide (Me2Se) and trimethylselenonium (Me3Se+) for excretion. View original pathway at:Reactome.

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Bibliography

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History

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CompareRevisionActionTimeUserComment
101347view11:23, 1 November 2018ReactomeTeamreactome version 66
100885view20:57, 31 October 2018ReactomeTeamreactome version 65
100426view19:31, 31 October 2018ReactomeTeamreactome version 64
99976view16:15, 31 October 2018ReactomeTeamreactome version 63
99530view14:51, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99168view12:42, 31 October 2018ReactomeTeamreactome version 62
93759view13:34, 16 August 2017ReactomeTeamreactome version 61
93281view11:19, 9 August 2017ReactomeTeamreactome version 61
87653view08:55, 25 July 2016LindarieswijkOntology Term : 'selenoamino acid metabolic pathway' added !
86360view09:16, 11 July 2016ReactomeTeamNew pathway

External references