Renin - Angiotensin System (Rattus norvegicus)

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DNACellular Proliferation,Cell membraneand Induction of ApoptosisHypertrophy, fibrosisEndoplasmatic ReticulumAldosterone, MyocardialDNAJNK isoformsIPR3 isoformsPAK isoformsVasadiconstriction,Hypersecration ofCell nucleusDNADNAVasodilation, Inhibationand Renal damageof Cellular Proliferation AceItpr2NOSTAT3PpgbCeramideTYKPrkcqRac1Mapk10Angiotensin IIRasPKAMKK4GalfaQ/11cAMPPYK2ROSMEKK1Grb2Ace2Raf1IP3AngiotensinogenDAGc-FosAceFAKAngiotensin IIIPIP2Plcb1IkbkgAngiotensin IVTYKPAK6PI3KCTSGCMA1ATF2PAK1Mapk9STAT1NF-KBERK1Mapk8Mas1Anpepp38Jak2SOSAngiotensin (1-7)PtgIRJNKPAK3PAKAce2SHCAngiotensinogenThop1MKK7AC2/3Itpr1EnpepAngiotensin (1-9)Cpa3NlnPAK2CA2+Mapk3Angiotensin 1LnpepAngiotensin (1-5)Agtr1aMmeReninc-JunItpr3Agtr2AcePAK7IkbkbMEKK1IP3RPPtaseElk1MmePAK475, 17222, 58, 66, 69, 70, 103...2130, 105, 12718, 27, 28, 56, 59...15, 2026, 32, 40, 65, 71...108, 116, 1268337, 48, 17452, 7114, 24, 29, 34, 62...13014539, 42, 45, 51, 64...10, 11, 35, 63, 80...1, 5, 17, 29, 79...17, 31, 46, 78, 90...13, 72, 13147, 601, 5, 17, 29, 79...65, 9449, 76, 84, 93, 100...91, 129, 1406, 7, 41, 43, 54...3, 22, 23, 73, 81...144, 1598312, 22, 49, 53, 88...96, 102, 11019, 2571, 124209, 952, 8, 51, 82, 97...3, 22, 23, 73, 81...122, 167113, 114, 13022, 58, 66, 69, 70, 103...21, 3857, 101, 16113836, 504, 11, 16, 33, 46...92, 106, 16344, 55, 14667, 12161, 67837465, 1373, 22, 23, 73, 81...


This pathway is based on the KEGG pathway of renin-angiotensin and the Ambion pathway of renin-angiotensin

The different colors used in the pathway stand for:

  • Darkblue: gene product.
  • Green: protein.
  • Red: metabolite.
  • Lightblue: protein which occurs in the human, but we don't know if this protein also occurs in the rat.

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107611view14:06, 24 October 2019DeSlAdded last missing ID.
107610view14:05, 24 October 2019DeSlUpdated secondary ChEBI ID, added missing IDs to some proteins+metabolites.
107543view19:06, 18 October 2019KhanspersModified description
107542view19:05, 18 October 2019Khanspersadditional cleanup, added legend
107541view18:27, 18 October 2019Khanspersupdated layout, added xrefs
107242view14:34, 17 September 2019MaintBotChEBI identifier normalization
106984view13:44, 17 September 2019MaintBotHMDB identifier normalization
105411view16:06, 7 August 2019DeSlModified description
105410view16:05, 7 August 2019DeSlChanged colours to WPs scheme.
105409view16:02, 7 August 2019DeSlConnected unconnected lines (to groups)
105288view11:40, 28 July 2019EgonwAdded some interaction typing and missing identifiers.
101984view21:12, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
89602view16:08, 19 September 2016AgustinGVOntology Term : 'renal hypertension' added !
89601view16:08, 19 September 2016AgustinGVOntology Term : 'hypertension' added !
89042view19:57, 18 August 2016AgustinGVUpdate available metabolites annotations
88865view17:22, 16 August 2016AgustinGVSpecify description
88864view17:21, 16 August 2016AgustinGVSpecify description
88863view17:17, 16 August 2016AgustinGVUpdate AGT
88862view17:07, 16 August 2016AgustinGVUpdate AGT as protein
88861view17:04, 16 August 2016AgustinGVUpdate AGT Gene ID
88860view16:24, 16 August 2016AgustinGVQuick edit to datanode annotation or property
83030view02:21, 18 November 2015Mkutmonfix issues in reference list
83029view02:07, 18 November 2015Mkutmonfix outdated identifiers
70120view19:23, 12 July 2013MaintBotupdated to 2013 schema
67626view11:35, 26 June 2013DdiglesOntology Term : 'renin-angiotensin cascade pathway' added !
41750view02:40, 2 March 2011MaintBotRemoved redundant pathway information and comments
34121view19:26, 9 December 2009MaintBotAutomatic update of empty xrefs
32412view17:06, 15 August 2009MaintBotFixed text labels
32069view13:36, 14 August 2009MaintBotFixed group labels
29243view07:40, 18 April 2009EveloSome annotations
21469view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:Renin - Angiotensin System]] moved to [[Pathway:WP376]]: Moved to stable identifier
15828view08:19, 5 June 2008Thomaschanged type of Reactive oxygen species (ROS) to metabolite
11563view07:25, 11 April 2008Thomas
11553view17:09, 10 April 2008MarkRenin - Angiotensin System
11548view10:17, 10 April 2008Thomas
11535view07:42, 8 April 2008Markrenin-angiontensin system
11500view09:42, 3 April 2008Thomasremoved special characters from literature references
11491view18:05, 2 April 2008ThomasModified description
11490view17:22, 2 April 2008Mark
11488view13:29, 2 April 2008ThomasReverted edits by [[Special:Contributions/Mark|Mark]] ([[User_talk:Mark|Talk]]); changed back to last version by [[User:Thomas|Thomas]]
11487view13:24, 2 April 2008MarkRenin - Angiotensin System
11486view11:09, 2 April 2008MarkModified description
11476view15:20, 1 April 2008Thomascosmetic changes
11475view15:16, 1 April 2008Thomaschanged green to darker shade (more easy to read)
11468view12:35, 1 April 2008Thomasfixed anchor links
11459view09:58, 1 April 2008RishiaachaibersingRenin - Angiotensin System
11458view08:35, 1 April 2008MarkRenin - Angiotensin System
11454view07:24, 1 April 2008Mark
11277view14:14, 26 March 2008MarkRenin - Angiotensin System
11272view13:32, 26 March 2008MarkRenin - Angiotensin System

External references


View all...
NameTypeDatabase referenceComment
AC2/3Protein2036 (RGD)
ATF2Protein81647 (Entrez Gene)
AceProtein2493 (RGD)
Ace2Protein728890 (RGD)
Agtr1aProtein2070 (RGD)
Agtr2Protein2072 (RGD)
Angiotensin (1-5)Metabolite
Angiotensin (1-7)Metabolite
Angiotensin (1-9)Metabolite
Angiotensin 1Metabolite
Angiotensin IIMetaboliteHMDB01035 (HMDB)
Angiotensin IIIMetaboliteHMDB01036 (HMDB)
Angiotensin IVMetaboliteHMDB01038 (HMDB)
AngiotensinogenProtein2069 (RGD)
AnpepProtein2991 (RGD)
CMA1Protein2365 (RGD)
CTSGProtein1307681 (RGD)
Cpa3Protein2390 (RGD)
ERK1Protein70500 (RGD)
Elk1Protein1598663 (RGD)
EnpepProtein621228 (RGD)
FAKProtein3443 (RGD)
Grb2Protein81504 (Entrez Gene)
IkbkbProtein621375 (RGD)
IkbkgProteinENSRNOG00000060936 (Ensembl)
Itpr1Protein2933 (RGD)
Itpr2Protein69649 (RGD)
Itpr3Protein2934 (RGD)
Jak2ProteinENSRNOG00000059968 (Ensembl)
LnpepProtein621752 (RGD)
MEKK1Protein620966 (RGD)
MKK4Protein1307040 (RGD)
MKK7Protein1560043 (RGD)
Mapk10Protein3663 (RGD)
Mapk3ProteinENSRNOG00000053583 (Ensembl)
Mapk8Protein621506 (RGD)
Mapk9Protein628847 (RGD)
Mas1Protein3049 (RGD)
MmeProtein3098 (RGD)
NF-KBProtein727889 (RGD)
NlnProtein621518 (RGD)
PAK1Protein3250 (RGD)
PAK2Protein61953 (RGD)
PAK3Protein3251 (RGD)
PAK4Protein1307705 (RGD)
PAK6Protein1306213 (RGD)
PAK7Protein1312009 (RGD)
PKAProtein3389 (RGD)
PPtaseProtein62018 (RGD)
PYK2Protein628758 (RGD)
Plcb1Protein3344 (RGD)
PpgbProtein1309070 (RGD)
PrkcqProtein620968 (RGD)
PtgIRProtein292661 (Entrez Gene)
Rac1Protein619755 (RGD)
Raf1Protein24703 (Entrez Gene)
RasProtein2981 (RGD)
ReninProtein3554 (RGD)
STAT1Protein3771 (RGD)
STAT3Protein3772 (RGD)
Thop1Protein68330 (RGD)
c-JunProtein2943 (RGD)
p38Protein3045 (RGD)

Annotated Interactions

No annotated interactions

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