Mitochondrial LC-Fatty Acid Beta-Oxidation (Homo sapiens)

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(Modified description)
Current revision (14:23, 17 September 2019) (view source)
(ChEBI identifier normalization)
 
Line 3: Line 3:
   <Comment Source="WikiPathways-category">Metabolic Process</Comment>
   <Comment Source="WikiPathways-category">Metabolic Process</Comment>
   <Comment Source="WikiPathways-description">Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP368 CPTAC Assay Portal]</Comment>
   <Comment Source="WikiPathways-description">Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP368 CPTAC Assay Portal]</Comment>
-
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   <Graphics BoardWidth="817.0" BoardHeight="918.0" />
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   <DataNode TextLabel="ACADL" GraphId="d0f" Type="GeneProduct" GroupRef="a30d6">
+
   <DataNode TextLabel="ACSL4" GraphId="a3a" Type="GeneProduct" GroupRef="cde96">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADL | acyl-Coenzyme A dehydrogenase long cha..."/>
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACSL4 | acyl-CoA synthetase long-chain family m..." />
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     <Graphics CenterX="484.0" CenterY="130.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
-
     <Xref Database="Entrez Gene" ID="33"/>
+
    <Xref Database="Entrez Gene" ID="2182" />
 +
  </DataNode>
 +
  <DataNode TextLabel="SCP2" GraphId="a3e" Type="GeneProduct">
 +
    <Comment Source="GenMAPP remarks"></Comment>
 +
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SCP2 | sterol carrier protein 2" />
 +
    <Graphics CenterX="412.6666666666667" CenterY="685.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Entrez Gene" ID="6342" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CPT2" GraphId="a42" Type="GeneProduct">
   <DataNode TextLabel="CPT2" GraphId="a42" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CPT2 | carnitine palmitoyltransferase II"/>
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CPT2 | carnitine palmitoyltransferase II" />
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     <Graphics CenterX="473.0" CenterY="338.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Entrez Gene" ID="1376"/>
+
     <Xref Database="Entrez Gene" ID="1376" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="ACADM" GraphId="d6a" Type="GeneProduct" GroupRef="a30d6">
+
   <DataNode TextLabel="Long chain Acyl-CoA" GraphId="a4a4c" Type="Metabolite">
-
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADM | acyl-Coenzyme A dehydrogenase C-4 to C..."/>
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     <Xref Database="ChEBI" ID="CHEBI:83139" />
-
     <Xref Database="Entrez Gene" ID="34"/>
+
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="ACSL2" GraphId="c72" Type="GeneProduct" GroupRef="cde96">
+
   <DataNode TextLabel="3-Ketoacyl-CoA" GraphId="a8cba" Type="Metabolite">
-
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="Fatty Acid CoA Ligase 2"/>
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     <Xref Database="ChEBI" ID="CHEBI:57347" />
-
     <Xref Database="Entrez Gene" ID="80221"/>
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   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="PECR" GraphId="fc8" Type="GeneProduct">
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   <DataNode TextLabel="EHHADH" GraphId="ba9" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="PECR | peroxisomal trans-2-enoyl-CoA reductase"/>
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     <Xref Database="Entrez Gene" ID="55825"/>
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    <Xref Database="Entrez Gene" ID="1962" />
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  </DataNode>
 +
  <DataNode TextLabel="ACSL1" GraphId="bac" Type="GeneProduct" GroupRef="cde96">
 +
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     <Xref Database="Entrez Gene" ID="2180" />
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   </DataNode>
   <DataNode TextLabel="DCI" GraphId="bb1" Type="GeneProduct">
   <DataNode TextLabel="DCI" GraphId="bb1" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="DCI | dodecenoyl-Coenzyme A delta isomerase (3..."/>
+
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     <Xref Database="Entrez Gene" ID="1632"/>
+
     <Xref Database="Entrez Gene" ID="1632" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="SCP2" GraphId="a3e" Type="GeneProduct">
+
   <DataNode TextLabel="cis-D3-Enoyl-CoA" GraphId="bbe3a" Type="Metabolite">
-
    <Comment Source="GenMAPP remarks"/>
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    <Attribute Key="org.pathvisio.model.BackpageHead" Value="SCP2 | sterol carrier protein 2"/>
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    <Xref Database="Entrez Gene" ID="6342"/>
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-
  </DataNode>
+
-
  <DataNode TextLabel="EHHADH" GraphId="ba9" Type="GeneProduct">
+
-
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="EHHADH | enoyl-Coenzyme A hydratase/3-hydroxya..."/>
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     <Xref Database="Entrez Gene" ID="1962"/>
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   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACADS" GraphId="bd1" Type="GeneProduct" GroupRef="a30d6">
   <DataNode TextLabel="ACADS" GraphId="bd1" Type="GeneProduct" GroupRef="a30d6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADS | acyl-Coenzyme A dehydrogenase C-2 to C..."/>
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     <Xref Database="Entrez Gene" ID="35"/>
+
     <Xref Database="Entrez Gene" ID="35" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="ACADVL" GraphId="dd6" Type="GeneProduct" GroupRef="a30d6">
+
   <DataNode TextLabel="HADHA" GraphId="bd8" Type="GeneProduct" GroupRef="c87b1">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADVL | acyl-Coenzyme A dehydrogenase very lo..."/>
+
    <Comment Source="GenMAPP remarks">similiar to: ECHA RAT</Comment>
-
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HADHA | hydroxyacyl-Coenzyme A dehydrogenase/3-..." />
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     <Xref Database="Entrez Gene" ID="37"/>
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     <Xref Database="Entrez Gene" ID="3030" />
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  </DataNode>
 +
  <DataNode TextLabel="Long chain Acyl-CoA" GraphId="c239f" Type="Metabolite">
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    <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CPT1A" GraphId="c56" Type="GeneProduct">
   <DataNode TextLabel="CPT1A" GraphId="c56" Type="GeneProduct">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CPT1A | carnitine palmitoyltransferase 1A (live..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="CPT1A | carnitine palmitoyltransferase 1A (live..." />
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     <Xref Database="Entrez Gene" ID="1374"/>
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     <Xref Database="Entrez Gene" ID="1374" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="HADHSC" GraphId="df2" Type="GeneProduct" GroupRef="c87b1">
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   <DataNode TextLabel="ACSL2" GraphId="c72" Type="GeneProduct" GroupRef="cde96">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="HADHSC | L-3-hydroxyacyl-Coenzyme A dehydrogena..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="Fatty Acid CoA Ligase 2" />
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     <Graphics CenterX="484.0" CenterY="90.0" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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    <Xref Database="Entrez Gene" ID="3033"/>
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     <Xref Database="Entrez Gene" ID="80221" />
-
  </DataNode>
+
-
  <DataNode TextLabel="HADHA" GraphId="bd8" Type="GeneProduct" GroupRef="c87b1">
+
-
    <Comment Source="GenMAPP remarks">similiar to: ECHA RAT</Comment>
+
-
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HADHA | hydroxyacyl-Coenzyme A dehydrogenase/3-..."/>
+
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     <Xref Database="Entrez Gene" ID="3030"/>
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   </DataNode>
   </DataNode>
   <DataNode TextLabel="ACSL3" GraphId="c85" Type="GeneProduct" GroupRef="cde96">
   <DataNode TextLabel="ACSL3" GraphId="c85" Type="GeneProduct" GroupRef="cde96">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACSL3 | acyl-CoA synthetase long-chain family m..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACSL3 | acyl-CoA synthetase long-chain family m..." />
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     <Xref Database="Entrez Gene" ID="2181" />
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   </DataNode>
-
   <DataNode TextLabel="ACSL4" GraphId="a3a" Type="GeneProduct" GroupRef="cde96">
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   <DataNode TextLabel="Long chain acyl-carnitine" GraphId="ceed1" Type="Metabolite">
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    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACSL4 | acyl-CoA synthetase long-chain family m..."/>
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     <Xref Database="" ID="" />
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     <Xref Database="Entrez Gene" ID="2182"/>
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   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="SLC25A20" GraphId="e4f" Type="GeneProduct">
+
   <DataNode TextLabel="ACADL" GraphId="d0f" Type="GeneProduct" GroupRef="a30d6">
-
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SLC25A20 | solute carrier family 25 (carnitine/..."/>
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     <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADL | acyl-Coenzyme A dehydrogenase long cha..." />
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     <Xref Database="Entrez Gene" ID="788"/>
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     <Xref Database="Entrez Gene" ID="33" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="ACSL1" GraphId="bac" Type="GeneProduct" GroupRef="cde96">
+
   <DataNode TextLabel="Long chain acyl-carnitine" GraphId="d19e3" Type="Metabolite">
-
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACSL1 | acyl-CoA synthetase long-chain family m..."/>
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     <Xref Database="" ID="" />
-
     <Xref Database="Entrez Gene" ID="2180"/>
+
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Acyl-CoA (n-2)" GraphId="fad" Type="Metabolite">
+
   <DataNode TextLabel="ACADM" GraphId="d6a" Type="GeneProduct" GroupRef="a30d6">
-
     <Graphics CenterX="131.33333333333331" CenterY="651.0" Width="114.33333333333333" Height="19.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADM | acyl-Coenzyme A dehydrogenase C-4 to C..." />
-
     <Xref Database="CAS" ID="9029-97-4"/>
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    <Xref Database="Entrez Gene" ID="34" />
 +
  </DataNode>
 +
  <DataNode TextLabel="ACADVL" GraphId="dd6" Type="GeneProduct" GroupRef="a30d6">
 +
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="ACADVL | acyl-Coenzyme A dehydrogenase very lo..." />
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    <Graphics CenterX="461.0" CenterY="419.3333333333333" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
 +
     <Xref Database="Entrez Gene" ID="37" />
 +
  </DataNode>
 +
  <DataNode TextLabel="HADHSC" GraphId="df2" Type="GeneProduct" GroupRef="c87b1">
 +
    <Attribute Key="org.pathvisio.model.BackpageHead" Value="HADHSC | L-3-hydroxyacyl-Coenzyme A dehydrogena..." />
 +
    <Graphics CenterX="682.3333333333334" CenterY="634.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
 +
    <Xref Database="Entrez Gene" ID="3033" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Acetyl-CoA" GraphId="e27" Type="Metabolite">
   <DataNode TextLabel="Acetyl-CoA" GraphId="e27" Type="Metabolite">
-
     <Graphics CenterX="196.66666666666666" CenterY="677.0" Width="74.33333333333333" Height="16.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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-
     <Xref Database="CAS" ID="72-89-9"/>
+
     <Xref Database="CAS" ID="72-89-9" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="2,4 Dienoyl-CoA" GraphId="fd93b" Type="Metabolite">
+
   <DataNode TextLabel="SLC25A20" GraphId="e4f" Type="GeneProduct">
-
     <Comment>Type your comment here</Comment>
+
     <Attribute Key="org.pathvisio.model.BackpageHead" Value="SLC25A20 | solute carrier family 25 (carnitine/..." />
-
     <Graphics CenterX="230.0" CenterY="546.0" Width="104.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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     <Xref Database="" ID=""/>
+
     <Xref Database="Entrez Gene" ID="788" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Long chain Acyl-CoA" GraphId="a4a4c" Type="Metabolite">
+
   <DataNode TextLabel="3-L-Hydroxyacyl-CoA" GraphId="eba97" Type="Metabolite">
-
     <Graphics CenterX="406.5" CenterY="167.0" Width="115.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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     <Graphics CenterX="620.0" CenterY="610.0" Width="128.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
-
     <Xref Database="ChEBI" ID="CHEBI:83139"/>
+
     <Xref Database="" ID="" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Long Chain Fatty Acid" GraphId="f129e" Type="Metabolite">
   <DataNode TextLabel="Long Chain Fatty Acid" GraphId="f129e" Type="Metabolite">
-
     <Graphics CenterX="406.5" CenterY="35.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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     <Graphics CenterX="406.5" CenterY="35.0" Width="129.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
-
     <Xref Database="ChEBI" ID="CHEBI:15904"/>
+
     <Xref Database="ChEBI" ID="CHEBI:15904" />
   </DataNode>
   </DataNode>
   <DataNode TextLabel="trans-D2-Enoyl-CoA" GraphId="f6680" Type="Metabolite">
   <DataNode TextLabel="trans-D2-Enoyl-CoA" GraphId="f6680" Type="Metabolite">
-
     <Graphics CenterX="620.0" CenterY="546.0" Width="124.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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     <Graphics CenterX="620.0" CenterY="546.0" Width="124.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
-
     <Xref Database="ChEBI" ID="10723"/>
+
     <Xref Database="ChEBI" ID="CHEBI:10723" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Long chain acyl-carnitine" GraphId="ceed1" Type="Metabolite">
+
   <DataNode TextLabel="Acyl-CoA (n-2)" GraphId="fad" Type="Metabolite">
-
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-
     <Xref Database="" ID=""/>
+
     <Xref Database="CAS" ID="9029-97-4" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Long chain acyl-carnitine" GraphId="d19e3" Type="Metabolite">
+
   <DataNode TextLabel="PECR" GraphId="fc8" Type="GeneProduct">
-
     <Graphics CenterX="406.0" CenterY="310.0" Width="146.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
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    <Attribute Key="org.pathvisio.model.BackpageHead" Value="PECR | peroxisomal trans-2-enoyl-CoA reductase" />
-
     <Xref Database="" ID=""/>
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     <Graphics CenterX="174.66666666666666" CenterY="593.6666666666666" Width="60.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
 +
     <Xref Database="Entrez Gene" ID="55825" />
   </DataNode>
   </DataNode>
-
   <DataNode TextLabel="Long chain Acyl-CoA" GraphId="c239f" Type="Metabolite">
+
   <DataNode TextLabel="2,4 Dienoyl-CoA" GraphId="fd93b" Type="Metabolite">
-
     <Graphics CenterX="406.5" CenterY="376.0" Width="115.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
+
    <Comment>Type your comment here</Comment>
-
     <Xref Database="" ID=""/>
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Line 355: Line 360:
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
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</Pathway>

Current revision

cytosolmitochondrial matrixsaturatedAcyl-CoA dehydrogenases:unsaturatedLong chain acyl-carnitine3-L-Hydroxyacyl-CoASLC25A203-Ketoacyl-CoAHADHSCACADSACADLDCISCP2PECRLong chain acyl-carnitineLong chain Acyl-CoALong chain Acyl-CoAHADHAACADVLACSL3cis-D3-Enoyl-CoAACSL2ACSL4CPT2Long Chain Fatty Acidtrans-D2-Enoyl-CoAAcyl-CoA (n-2)2,4 Dienoyl-CoAACADMEHHADHAcetyl-CoAACSL1CPT1A


Description

Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

Quality Tags

Ontology Terms

 

Bibliography

No bibliography


History

View all...
CompareRevisionActionTimeUserComment
107146view14:23, 17 September 2019MaintBotChEBI identifier normalization
106650view21:12, 12 September 2019KhanspersModified description
105651view05:12, 10 August 2019KhanspersModified description
97834view06:36, 10 June 2018EgonwUndo revision 97739 by [[Special:Contributions/IreneHemel|IreneHemel]] ([[User talk:IreneHemel|Talk]])
97739view13:01, 7 June 2018IreneHemelModified description
94199view14:47, 25 August 2017Mkutmonadded some metabolite identifiers
88910view09:26, 17 August 2016MirellaKalafatiOntology Term : 'classic metabolic pathway' added !
79271view21:09, 19 March 2015Zariadded Identifier for ACSL2
71383view18:40, 17 October 2013MaintBotAutomated update of data sources
68980view17:42, 8 July 2013MaintBotUpdated to 2013 gpml schema
67479view11:07, 26 June 2013DdiglesOntology Term : 'fatty acid beta degradation pathway' added !
59768view17:43, 7 March 2013EgonwAdded the ChEBI id for 'long chain fatty acid'.
45141view01:08, 7 October 2011AlexanderPico
44911view10:35, 6 October 2011MartijnVanIerselOntology Term : 'fatty acid beta oxidation pathway' added !
41157view23:41, 1 March 2011MaintBotRemoved redundant pathway information and comments
38875view18:39, 24 September 2010KhanspersChanged line types
38874view18:32, 24 September 2010Khanspers
38832view12:01, 24 September 2010Jildaumitochondrion
34439view18:17, 10 December 2009MaintBotAutomatic update of empty xrefs
32067view13:35, 14 August 2009MaintBotFixed group labels
21451view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Mitochondrial fatty acid betaoxidation]] moved to [[Pathway:WP368]]: Moved to stable identifier
16606view20:38, 23 June 2008KhanspersPeriodical save, work in progress
13520view09:46, 18 May 2008Thomasadded connectors & converted labels to metabolites
13084view11:14, 17 May 2008MaintBotautomated metabolite conversion
8260view13:46, 7 January 2008MaintBot[[Pathway:Human:Mitochondrial fatty acid betaoxidation]] moved to [[Pathway:Homo sapiens:Mitochondrial fatty acid betaoxidation]]: Renaming species
7750view16:15, 18 December 2007MaintBotfixed category names
7378view12:42, 4 November 2007MaintBotAdded categories to GPML
6352view22:18, 22 May 2007N.Reyesgpml file for [[Human:Mitochondrial_fatty_acid_betaoxidation]]

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2,4 Dienoyl-CoAMetaboliteType your comment here
3-Ketoacyl-CoAMetaboliteCHEBI:57347 (ChEBI)
3-L-Hydroxyacyl-CoAMetabolite
ACADLGeneProduct33 (Entrez Gene)
ACADMGeneProduct34 (Entrez Gene)
ACADSGeneProduct35 (Entrez Gene)
ACADVLGeneProduct37 (Entrez Gene)
ACSL1GeneProduct2180 (Entrez Gene)
ACSL2GeneProduct80221 (Entrez Gene)
ACSL3GeneProduct2181 (Entrez Gene)
ACSL4GeneProduct2182 (Entrez Gene)
Acetyl-CoAMetabolite72-89-9 (CAS)
Acyl-CoA (n-2)Metabolite9029-97-4 (CAS)
CPT1AGeneProduct1374 (Entrez Gene)
CPT2GeneProduct1376 (Entrez Gene)
DCIGeneProduct1632 (Entrez Gene)
EHHADHGeneProduct1962 (Entrez Gene)
HADHAGeneProduct3030 (Entrez Gene) similiar to: ECHA RAT
HADHSCGeneProduct3033 (Entrez Gene)
Long Chain Fatty AcidMetaboliteCHEBI:15904 (ChEBI)
Long chain Acyl-CoAMetabolite
Long chain Acyl-CoAMetaboliteCHEBI:83139 (ChEBI)
Long chain acyl-carnitineMetabolite
PECRGeneProduct55825 (Entrez Gene)
SCP2GeneProduct6342 (Entrez Gene)
SLC25A20GeneProduct788 (Entrez Gene)
cis-D3-Enoyl-CoAMetabolite
trans-D2-Enoyl-CoAMetabolite10723 (ChEBI)

Annotated Interactions

No annotated interactions

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