Hfe effect on hepcidin production (Mus musculus)

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1ALabelHampSmad7Id1Tmprss6HfeHjv (hemojuvelin)Bmp6HfeHfeBC


Hfe, the mouse equivalent of the human hemochromatosis gene, is known to promote expression of hepcidin, a gene product that inhibits iron absorption, but it is not fully clear how it does this, or at which point Hfe interacts with the cycle(Hfe could be acting on the interaction at points A,B, or C). Hfe, as well as Tmprss6, another gene product, are used in the regulation of systemic iron homeostasis. Evidence obtained from gene testing on mice seems to indicate that Hfe inhibits Tmprss6, which is known to be an inhibitor of Hjv, a gene product that augments BMP/SMAD signaling for the production of hepcidin. Alternatively, Hfe may promote Bmp/Smad signaling by HJV, or by promoting signaling at a point past where Tmprss6 inhibits HJV.

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Ontology Terms



  1. Karin E. Finberg, Rebecca L. Wittlesey, Nancy C. Andrews; ''Tmprss6 is a genetic modifier of the Hfe-hemochromatosis phenotype in mice''; NIH, 2011 PubMed Europe PMC Scholia


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90722view22:21, 13 December 2016Khanspersupdated xref
87409view11:23, 22 July 2016Mkutmonfix publication reference
87062view23:52, 17 July 2016AlexanderPicoOntology Term : 'regulatory pathway' added !
87061view23:52, 17 July 2016AlexanderPicoOntology Term : 'PW:0000003' removed !
87060view23:52, 17 July 2016AlexanderPicoOntology Term : 'iron homeostasis pathway' added !
87059view23:46, 17 July 2016AlexanderPicoOntology Term : 'signaling pathway' added !
87058view23:44, 17 July 2016AlexanderPicoUpdated interactions and hypothetical labels
86275view12:59, 9 July 2016AAR&CoModified description
86274view12:58, 9 July 2016AAR&CoModified description
86273view12:56, 9 July 2016AAR&CoUpdate Source
86125view12:44, 1 July 2016AAR&CoModified description
86124view12:42, 1 July 2016AAR&CoNew pathway

External references


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NameTypeDatabase referenceComment
Bmp6GeneProductENSMUSG00000039004 (Ensembl)
HampGeneProductENSMUSG00000050440 (Ensembl) Hepcidin. Inhibits iron absorbtion
HfeGeneProductENSMUSG00000006611 (Ensembl)
Hjv (hemojuvelin)GeneProductENSMUST00000049208 (Ensembl)
Id1GeneProductENSMUSG00000042745 (Ensembl)
Smad7GeneProductENSMUSG00000025880 (Ensembl)
Tmprss6GeneProductENSMUSG00000016942 (Ensembl)

Annotated Interactions

No annotated interactions

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