TGF-beta signaling pathway (Homo sapiens)

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The Transforming growth factor beta (TGFβ) signaling pathway is involved in many cellular processes in both the adult organism and the developing embryo including cell growth, cell differentiation, apoptosis, cellular homeostasis and other cellular functions. In spite of the wide range of cellular processes that the TGFβ signaling pathway regulates, the process is relatively simple. TGFβ superfamily ligands bind to a type II receptor, which recruits and phosphorylates a type I receptor. The type I receptor then phosphorylates receptor-regulated SMADs (R-SMADs) which can now bind the coSMAD SMAD4. R-SMAD/coSMAD complexes accumulate in the nucleus where they act as transcription factors and participate in the regulation of target gene expression. (source: WikiPedia). Also see: TGF-beta receptor signaling at the NCI-Nature pathway interaction database.


GenMAPP remarks 
edited by: Nathan Salomonis

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Ontology Terms



  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


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117839view15:12, 22 May 2021EweitzModified title
116028view07:23, 31 March 2021EgonwCopied the NetPath paper to the literature list.
116027view07:19, 31 March 2021Egonw
116026view07:14, 31 March 2021EgonwReverted to version '05:40, 8 August 2019' by Egonw
116025view07:13, 31 March 2021EgonwReverted to version '11:39, 7 December 2019' by Egonw
116011view07:30, 29 March 2021DeSlReverted to version '05:40, 8 August 2019' by DeSl
115984view18:11, 23 March 2021EgonwModified description
108333view11:39, 7 December 2019L DupuisConverted interactions to graphical lines in legend
105483view05:40, 8 August 2019KhanspersModified description
105454view05:05, 8 August 2019KhanspersModified description
90028view19:37, 8 October 2016AlexanderPicoModified description
87408view11:09, 22 July 2016MkutmonModified description
87394view11:05, 22 July 2016MaintBotadded missing graphids
86819view18:55, 11 July 2016KhanspersQuick edit to datanode annotation or property
84196view23:15, 28 January 2016KhanspersRemoved redundant legend
84195view23:11, 28 January 2016KhanspersRemoved redundant legend and random extra arc
83869view00:52, 18 December 2015AlexanderPicoModified title
79966view15:00, 28 April 2015Zariannotated COL1A2
79341view13:12, 21 March 2015EgonwRandom change to trigger update to the GPML 2013a schema.
79340view13:08, 21 March 2015EgonwReverted to version '04:16, 17 April 2013' by Egonw
69026view17:49, 8 July 2013MaintBotUpdated to 2013 gpml schema
61702view04:16, 17 April 2013MaintBotfixed missing xrefs
61682view21:49, 16 April 2013MaintBotfixed xrefs
61678view21:41, 16 April 2013MaintBot
47976view14:31, 23 April 2012NetPathModified description
45152view01:34, 7 October 2011AlexanderPicofixed db ref
45088view20:58, 6 October 2011KhanspersOntology Term : 'transforming growth factor-beta superfamily mediated signaling pathway' added !
44604view21:19, 21 September 2011KhanspersUpdating content to NetSlim
44119view20:49, 24 August 2011KhanspersReverted to version '23:44, 1 March 2011' by Khanspers
44048view23:45, 22 August 2011KhanspersModified description
44047view23:43, 22 August 2011KhanspersUpdating pathway from NetSlim
41205view23:44, 1 March 2011MaintBotRemoved redundant pathway information and comments
35302view23:29, 11 February 2010NsalomonisModified description
35301view23:26, 11 February 2010NsalomonisModified description
21445view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:WP366]]: Moved to stable identifier
8434view13:46, 7 January 2008MaintBot[[Pathway:Human:TGF-beta-Receptor NetPath 7]] moved to [[Pathway:Homo sapiens:TGF-beta-Receptor NetPath 7]]: Renaming species
7833view16:21, 18 December 2007MaintBotfixed category names
7304view12:42, 4 November 2007MaintBotAdded categories to GPML
6397view22:18, 22 May 2007A.Pandeygpml file for [[Human:TGF-beta-Receptor_NetPath_7]]

External references


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NameTypeDatabase referenceComment
BAMBIGeneProduct25805 (Entrez Gene)
BMP4GeneProduct652 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
EGFGeneProduct1950 (Entrez Gene)
ENGGeneProduct2022 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FKBP1AGeneProduct2280 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXH1GeneProduct8928 (Entrez Gene)
FSTGeneProduct10468 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IFNGGeneProduct3458 (Entrez Gene)
INHBAGeneProduct3624 (Entrez Gene)
ITGB6GeneProduct3694 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LEFTY1GeneProduct10637 (Entrez Gene)
LEFTY2GeneProduct7044 (Entrez Gene)
LIFGeneProduct3976 (Entrez Gene)
LTBP1GeneProduct4052 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MIR302AGeneProductENSG00000207927 (Ensembl)
NFKB1GeneProduct4790 (Entrez Gene)
NOGGeneProduct9241 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUNX3GeneProduct864 (Entrez Gene)
SERPINE1GeneProduct5054 (Entrez Gene)
SKIGeneProduct6497 (Entrez Gene)
SKILGeneProduct6498 (Entrez Gene)
SMAD1GeneProduct4086 (Entrez Gene)
SMAD2GeneProduct4087 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMAD5GeneProduct4090 (Entrez Gene)
SMAD6GeneProduct4091 (Entrez Gene)
SMAD7GeneProduct4092 (Entrez Gene)
SMAD9GeneProduct4093 (Entrez Gene)
SPP1GeneProduct6696 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TFE3GeneProduct7030 (Entrez Gene)
TGFB1GeneProduct7040 (Entrez Gene)
TGFBR1GeneProduct7046 (Entrez Gene)
TGFBR2GeneProduct7048 (Entrez Gene)
TGFBR3GeneProduct7049 (Entrez Gene)
TGIFGeneProduct7050 (Entrez Gene)
THBS1GeneProduct7057 (Entrez Gene) there are 5 types of tsp
TNFGeneProduct7124 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
ZFHX1BGeneProduct9839 (Entrez Gene)
ZFYVE9GeneProduct9372 (Entrez Gene)
ZNF423GeneProduct23090 (Entrez Gene)

Annotated Interactions

No annotated interactions
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