IL-6 signaling pathway (Homo sapiens)

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IL-6 Signal Transduction PathwayEnzyme complexInhibitionAuto catalysisTransportPositive regulation of gene expressionLeads to through unknown mechanismNegative regulation of gene expressionTranslocation UbiquitinationDeubiquitinationSumoylationInduced catalysisProtein-protein interactionAcetylationDephosphorylationLEGENDPhosphorylationProteinmRNAProteinReceptorLigandDeacetylationGolgi apparatusEndosomeNucleusMitochondrionDesumoylationMethylationDemethylationPalmitoylationCytoplasmECPlasma membraneMTEndoplasmic reticulumCYPMGONUExtracellularERENProteolytic cleavage101, 321253, 38918, 59, 101, 170, 224...18, 10818, 1082, 3644, 345, 44154, 206, 345, 44154, 200, 2462, 3618, 1082, 364200, 24679, 115115, 34310818, 120, 128, 246240, 34330, 78, 152, 171, 184...82, 340108, 287, 340108, 340MAP2K1PIL6115, 192STAT3GRB2MAPK3P33, 137, 186, 273, 292...STAT1SOS1P59MAP2K2PMAP2K4PPRKCD192GAB1P2, 364MAPK1240, 389P387, 389PRPS6KB133, 137, 186, 273, 292...HCKPAKT166, 387PIK3R1PRAC146, 192GTPGSK3B2, 36SHC1IL6RSTAT3P28, 29, 46, 136, 137, 154...VAV1IL6STPJAK136, 79PIK3R2JAK2SOCS3STAT1PBADTYK2150, 279, 350, 395PTPN113893666, 36859, 170, 307, 38746, 42430, 78, 152, 171, 184...IL6RIL6IL6ST92STAT regulated geneexpressionPRDM1STAT1MAP3K7STAT3STAT3IRF1BCL2L1STAT1STAT1CREBBPVIPSTAT3STAT1A2MCRPJUNBSTAT3HDAC1TIMP1STAT3NLKNCOA1STAT1EP300IL6STSTAT1AGTSTAT3NUCYNUCYNUCYMAP3K7177177177183, 194


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108327view21:09, 6 December 2019L DupuisConverted interactions to graphical lines in legend
106597view19:35, 10 September 2019KhanspersModified description
105508view06:00, 8 August 2019KhanspersModified description
89832view12:08, 6 October 2016MkutmonModified description
83783view15:44, 4 December 2015SusanChange ID of A2M
79962view13:38, 28 April 2015Zariannotated MAP3K7 gene
78561view10:31, 7 January 2015MaintBotadded missing graphIds
73871view14:01, 26 February 2014Joppe014connected lines; created complexes
73870view13:55, 26 February 2014Joppe014Periodical save, work in progress
73869view13:45, 26 February 2014Joppe014Periodical save, work in progress
73868view13:35, 26 February 2014Joppe014Periodical save, work in progress
73867view13:09, 26 February 2014Joppe014Periodical save, work in progress
73866view12:58, 26 February 2014Joppe014Periodical save, work in progress
72134view08:05, 25 October 2013Mkutmonadded datasource for "GAB1" and "IL6ST"
67384view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-6 signaling pathway' added !
63213view20:59, 8 May 2013MaintBotUpdating gpml version
48439view14:40, 24 May 2012NetPathModified description
44848view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44627view18:07, 22 September 2011KhanspersUpdating content to NetSlim
44109view20:32, 24 August 2011KhanspersReverted to version '23:40, 1 March 2011' by Khanspers
44050view23:52, 22 August 2011KhanspersModified description
44049view23:51, 22 August 2011KhanspersUpdating pathway from NetSlim
41147view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
35645view21:35, 12 February 2010KhanspersModified description
28142view23:57, 27 January 2009KhanspersChanged name
21441view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-6 NetPath 18]] moved to [[Pathway:WP364]]: Moved to stable identifier
8188view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-6 NetPath 18]] moved to [[Pathway:Homo sapiens:IL-6 NetPath 18]]: Renaming species
7714view16:12, 18 December 2007MaintBotfixed category names
7253view12:41, 4 November 2007MaintBotAdded categories to GPML
6339view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-6_NetPath_18]]

External references


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NameTypeDatabase referenceComment
A2MRna2 (Entrez Gene)
AGTRna183 (Entrez Gene)
AKT1GeneProduct207 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BCL2L1GeneProduct598 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
CRPGeneProduct1401 (Entrez Gene)
EP300GeneProduct2063 (Entrez Gene)
GAB1GeneProduct2549IL-6 stimulates the tyrosine phosphorylation of Gab1. Gab1 further forms a complex with SHP-2 and the p85 subunit of PI3 kinase in HepG2 cells.
GRB2GeneProduct2885 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
IL6STGeneProduct3572[pubmed:15786731] has shown that IL6 induced dephosphorylation of phospho-Serine-782 in gp130 in HepG2 cells.
IL6STGeneProduct3572 (Entrez Gene)
IRF1GeneProduct3659 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNBGeneProduct3726 (Entrez Gene)
LigandGeneProduct7040 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PRDM1GeneProduct639 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
ProteinProtein5894 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
ReceptorGeneProduct7040 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
TIMP1GeneProduct7076 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)
VIPGeneProduct7432 (Entrez Gene)

Annotated Interactions

No annotated interactions

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