IL-6 signaling pathway (Homo sapiens)

From WikiPathways

Revision as of 23:40, 1 March 2011 by MaintBot (Talk | contribs)
Jump to: navigation, search
DTranslocationInhibitionGolgi apparatusLigandMitochondrionCY->NUCY->NUGODephosphorylationDDNucleus(Protein-Protein interaction)Accession Number: NetPath 18ExtracellularProteolytic cleavageDReceptorDemethylationDMTECGlycosylationControlEnzyme complexCY->NUCY->NUCYMethylationDCytoplasmDDEREndosomeEndoplasmic reticulumDDDesumoylationMolecular associationAutophosphorylationSumoylationReactions through unknown mechanisms/moleculesDDActivationDeacetylationENComplex formationPMAcetylationMolecule in the pathwayNURecruitmentProteins in a complex interactionCY->NUCY->NUCY->ENDeubiquitinationPhosphorylationUbiquitinationEarly EndosomesDDGene SymbolPlasma membranePalmitoylationPTK2STAT3PPP2R1BFYNJAK2GAB2PPP2R2BSTAT5BPPP2R5DCASP9PPP2R3AMAPTPPP2R3BSOS1FESNFKB1EP300IL6VAV1PTPN11SHC1PTK2BARPPP2R5CDAXXRAF1STAT3PPP2R1ASGKPPP2CBGRB2STAT3TECMAPK3PPP2R2CJUNSTAT3MAP3K7FOXO1ANFKB1IL6RSOCS3FOXO3ASTAT3TYK2RAC1MAP3K4FGRCEBPBPPP2R5AHDAC1BADSTAT1MAP2K1PPP2R5ESTAT5AFOSPXNMAP3K7PRKCDPPP2R5BMAP2K6EIF2ARPS6KB1JAK1TCF1IL6SGKPLCG1INPP5DNCOA1HSP90AA1MAPK1STAT3MAPKAPK2CEBPBRB1HCKPPP2R4LYNSTAT1IL6STMAPK8NLKSTAT1MAP2K2INPPL1EIF4EBP1EIF4ECREBBPCD40MAPK14RPS6KA2ERBB3MAPK14BMXGSK3BBTKIL6RHSPB1GAB1ERBB2CASP3HRASIL6STSTAT3PIK3R2STAT3STAT1MLLT7PPP2R2ACDK5CDK9MAP2K4AKT1PPP2CACDK5R1PIK3R1


Interleukin-6 belongs to a family of cytokines which includes IL-11, ciliary neurotrophic factor (CNTF), cardiotropin-1, cardiotrophin-like cytokine, leukemia inhibitory factor (LIF) and Oncostatin M. IL-6 signals through a ternary receptor complex consisting of IL-6 receptor alpha (IL6RA) and a homodimer of the signal transducing receptor gp130. IL-6 stimulates the association of IL6RA to gp130, which then activates the Jak/STAT, Ras/Raf/MAPK and PI 3-kinase signaling modules. Source: NetPath


GenMAPP notes 
NetPath 18 - IL-6 signaling pathway. NetPath ( is a collaborative project between PandeyLab at Johns Hopkins University ( and the Institute of Bioinformatics ( If you use this pathway, you must cite the NetPath website until the pathway is published.
GenMAPP remarks

Quality Tags

Ontology Terms



  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''NetPath: a public resource of curated signal transduction pathways.''; Genome Biol, 2010 PubMed Europe PMC Scholia


View all...
115943view08:20, 21 March 2021EgonwCopied the NetPath paper into the literature list
115929view08:07, 21 March 2021EgonwModified description
108327view21:09, 6 December 2019L DupuisConverted interactions to graphical lines in legend
106597view19:35, 10 September 2019KhanspersModified description
105508view06:00, 8 August 2019KhanspersModified description
89832view12:08, 6 October 2016MkutmonModified description
83783view15:44, 4 December 2015SusanChange ID of A2M
79962view13:38, 28 April 2015Zariannotated MAP3K7 gene
78561view10:31, 7 January 2015MaintBotadded missing graphIds
73871view14:01, 26 February 2014Joppe014connected lines; created complexes
73870view13:55, 26 February 2014Joppe014Periodical save, work in progress
73869view13:45, 26 February 2014Joppe014Periodical save, work in progress
73868view13:35, 26 February 2014Joppe014Periodical save, work in progress
73867view13:09, 26 February 2014Joppe014Periodical save, work in progress
73866view12:58, 26 February 2014Joppe014Periodical save, work in progress
72134view08:05, 25 October 2013Mkutmonadded datasource for "GAB1" and "IL6ST"
67384view10:45, 26 June 2013Christine ChichesterOntology Term : 'interleukin-6 signaling pathway' added !
63213view20:59, 8 May 2013MaintBotUpdating gpml version
48439view14:40, 24 May 2012NetPathModified description
44848view09:47, 6 October 2011MartijnVanIerselOntology Term : 'Interleukin mediated signaling pathway' added !
44627view18:07, 22 September 2011KhanspersUpdating content to NetSlim
44109view20:32, 24 August 2011KhanspersReverted to version '23:40, 1 March 2011' by Khanspers
44050view23:52, 22 August 2011KhanspersModified description
44049view23:51, 22 August 2011KhanspersUpdating pathway from NetSlim
41147view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
35645view21:35, 12 February 2010KhanspersModified description
28142view23:57, 27 January 2009KhanspersChanged name
21441view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:IL-6 NetPath 18]] moved to [[Pathway:WP364]]: Moved to stable identifier
8188view13:46, 7 January 2008MaintBot[[Pathway:Human:IL-6 NetPath 18]] moved to [[Pathway:Homo sapiens:IL-6 NetPath 18]]: Renaming species
7714view16:12, 18 December 2007MaintBotfixed category names
7253view12:41, 4 November 2007MaintBotAdded categories to GPML
6339view22:18, 22 May 2007A.Pandeygpml file for [[Human:IL-6_NetPath_18]]

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ARGeneProduct367 (Entrez Gene)
BADGeneProduct572 (Entrez Gene)
BMXGeneProduct660 (Entrez Gene)
BTKGeneProduct695 (Entrez Gene)
CASP3GeneProduct836 (Entrez Gene)
CASP9GeneProduct842 (Entrez Gene)
CD40GeneProduct958 (Entrez Gene)
CDK5GeneProduct1020 (Entrez Gene)
CDK5R1GeneProduct8851 (Entrez Gene)
CDK9GeneProduct1025 (Entrez Gene)
CEBPBGeneProduct1051 (Entrez Gene)
CREBBPGeneProduct1387 (Entrez Gene)
DAXXGeneProduct1616 (Entrez Gene)
EIF2AGeneProduct83939 (Entrez Gene)
EIF4EGeneProduct1977 (Entrez Gene)
EIF4EBP1GeneProduct1978 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
ERBB2GeneProduct2064 (Entrez Gene)
ERBB3GeneProduct2065 (Entrez Gene)
FESGeneProduct2242 (Entrez Gene)
FGRGeneProduct2268 (Entrez Gene)
FOSGeneProduct2353 (Entrez Gene)
FOXO1AGeneProduct2308 (Entrez Gene)
FOXO3AGeneProduct2309 (Entrez Gene)
FYNGeneProduct2534 (Entrez Gene)
GAB1GeneProduct2549 (Entrez Gene)
GAB2GeneProduct9846 (Entrez Gene)
GRB2GeneProduct2885 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HCKGeneProduct3055 (Entrez Gene)
HDAC1GeneProduct3065 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
HSP90AA1GeneProduct3320 (Entrez Gene)
HSPB1GeneProduct3315 (Entrez Gene)
IL6GeneProduct3569 (Entrez Gene)
IL6RGeneProduct3570 (Entrez Gene)
IL6STGeneProduct3572 (Entrez Gene)
INPP5DGeneProduct3635 (Entrez Gene)
INPPL1GeneProduct3636 (Entrez Gene)
JAK1GeneProduct3716 (Entrez Gene)
JAK2GeneProduct3717 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
LYNGeneProduct4067 (Entrez Gene)
MAP2K1GeneProduct5604 (Entrez Gene)
MAP2K2GeneProduct5605 (Entrez Gene)
MAP2K4GeneProduct6416 (Entrez Gene)
MAP2K6GeneProduct5608 (Entrez Gene)
MAP3K4GeneProduct4216 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAPK14GeneProduct1432 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPKAPK2GeneProduct9261 (Entrez Gene)
MAPTGeneProduct4137 (Entrez Gene)
MLLT7GeneProduct4303 (Entrez Gene)
NCOA1GeneProduct8648 (Entrez Gene)
NFKB1GeneProduct4790 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
PIK3R1GeneProduct5295 (Entrez Gene)
PIK3R2GeneProduct5296 (Entrez Gene)
PLCG1GeneProduct5335 (Entrez Gene)
PPP2CAGeneProduct5515 (Entrez Gene)
PPP2CBGeneProduct5516 (Entrez Gene)
PPP2R1AGeneProduct5518 (Entrez Gene)
PPP2R1BGeneProduct5519 (Entrez Gene)
PPP2R2AGeneProduct5520 (Entrez Gene)
PPP2R2BGeneProduct5521 (Entrez Gene)
PPP2R2CGeneProduct5522 (Entrez Gene)
PPP2R3AGeneProduct5523 (Entrez Gene)
PPP2R3BGeneProduct28227 (Entrez Gene)
PPP2R4GeneProduct5524 (Entrez Gene)
PPP2R5AGeneProduct5525 (Entrez Gene)
PPP2R5BGeneProduct5526 (Entrez Gene)
PPP2R5CGeneProduct5527 (Entrez Gene)
PPP2R5DGeneProduct5528 (Entrez Gene)
PPP2R5EGeneProduct5529 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PTK2GeneProduct5747 (Entrez Gene)
PTK2BGeneProduct2185 (Entrez Gene)
PTPN11GeneProduct5781 (Entrez Gene)
PXNGeneProduct5829 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RB1GeneProduct5925 (Entrez Gene)
RPS6KA2GeneProduct6196 (Entrez Gene)
RPS6KB1GeneProduct6198 (Entrez Gene)
SGKGeneProduct6446 (Entrez Gene)
SHC1GeneProduct6464 (Entrez Gene)
SOCS3GeneProduct9021 (Entrez Gene)
SOS1GeneProduct6654 (Entrez Gene)
STAT1GeneProduct6772 (Entrez Gene)
STAT3GeneProduct6774 (Entrez Gene)
STAT5AGeneProductSTAT5A (Entrez Gene)
STAT5BGeneProductSTAT5B (Entrez Gene)
TCF1GeneProduct6927 (Entrez Gene)
TECGeneProduct7006 (Entrez Gene)
TYK2GeneProduct7297 (Entrez Gene)
VAV1GeneProduct7409 (Entrez Gene)

Annotated Interactions

No annotated interactions
Personal tools