Wnt Signaling Pathway (Homo sapiens)

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ActivationDCY->PMInhibitionEndoplasmic reticulumMolecule in the pathwayPMControlDDCY->PMENPhosphorylationCY->NUDemethylationNucleusDAutophosphorylationDMTDReaction through unknowm mechanisms/moleculesCYCY->PMDephosphorylationCY->PMRecruitmentPM->CYMolecular AssociationGolgi apparatusDeubiquitinationCY->NUMethylationTranslocationMitochondrionDDAccession Number: NetPath_8; cellmap:8Gene SymbolECCytoplasmEndosomeCY->NUEnzyme ComplexPlasma membraneReceptorNUDGOProteolytic cleavagePalmitoylationComplex formationDeacetylationProteins in a complex interactionSumoylationLigandAcetylationExtracellularERCY->NUNU->CYUbiquitinationCY->NUGlycosylation(Protein-protein interaction)DesumoylationMAP3K7CXXC4AXIN1ARRB1AXIN2LRP1PPP2CACDH1MAP1BAXIN1LRP5FRAT2CCND1DVL3MAGI3WNT4DVL1FZD2SKP1APRKCB1SF1WNT3NLKLEF1RAC1CSNK2A1CUL1PRKCACDC2AKT1WNT4CSNK1A1FZD4CAMK2BBTRCTAX1BP3MARK2BCL9CTNNB1FZD1MYBSMAD4PIAS4WNT1RUNX2ARRB2CSNK1DDKK1WNT9BTCF3DVL2SOX9TCF4LEF1CAMK2ACSNK2A2CAMK2GWNT1VANGL2DVL1AXIN1DLG1WNT9APRKCGMAPK8APCCSNK1EGSK3BJUNWNT2APCCTBP1RUVBL1SOX1EP300DAAM1MAPK1WNT1SENP2TBPANKRD6NKD1PIN1AP2DVL2FZD7LRP6CTNNBIP1FZD4CDC2CAMK2DSMAD3UBL1PAX2FZD1APCFZD8CDC25CGSK3BAPCFZD5FRAT1FZD9ROR2FHL2SFRP1WNT2CRYBB2WNT1AKT1MAPK9JUPFZD1BTRCHIPK2FZD6SALL1LRP6CSNK2A2MAPK3WNT3AMAPK8IP1WNT5ASMT3H2BRD7CSNK2A1DLG2FZD1CTBP2APCCTNNB1DVL1SFRP2ARRB2WNT3ACSNK2BRHOAWNT7AWNT1MAP3K7CTNNB1DAB2DLG4RAF1


Wnt family of proteins are a large family of cysteine-rich secreted glycoproteins that regulate cell-cell interactions. They bind to members of the Frizzled family of 7 transmembrane receptors. Binding of Wnt to its receptors leads to activation of at least 3 distinct pathways: i) the canonical beta catenin pathway, ii) the planar cell polarity pathway, and, iii) the calcium pathway. In the canonical beta catenin pathway, binding of Wnt to its receptors leads to stabilization of beta catenin in the cytosol followed by its translocation into the nucleus where it activates the transcription factor Tcf/Lef leading to upregulation of target genes. The non canonical planar cell polarity pathway involves activation of Dishevelled, small G proteins (Rho/Rac) and JNK. The non canonical calcium pathway involves activation of calcium sensitive kinases, PKC and CAMKII by Dishevelled. The Wnt signaling pathway is similar to the Hedgehog pathway in many respects. Abnormalities in the Wnt signaling pathway are associated with a large variety of human malignancies including tumors of breast, colon, pancreas, liver and bone.

Source: NethPath

Additional comments:

This cancer signaling pathway is available at Cancer Cell Map (http://cancer.cellmap.org) and NetPath (http://www.netpath.org) and is part of a collaborative project between the Computational Biology Center at Memorial Sloan-Kettering Cancer Center (http://cbio.mskcc.org), PandeyLab at Johns Hopkins University (http://pandeylab.igm.jhmi.edu) and Institute of Bioinformatics (http://www.ibioinformatics.org). If you use this pathway, you must cite the Cancer Cell Map and NetPath websites until the pathway is published.

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Ontology Terms



  1. Kandasamy K, Mohan SS, Raju R, Keerthikumar S, Kumar GS, Venugopal AK, Telikicherla D, Navarro JD, Mathivanan S, Pecquet C, Gollapudi SK, Tattikota SG, Mohan S, Padhukasahasram H, Subbannayya Y, Goel R, Jacob HK, Zhong J, Sekhar R, Nanjappa V, Balakrishnan L, Subbaiah R, Ramachandra YL, Rahiman BA, Prasad TS, Lin JX, Houtman JC, Desiderio S, Renauld JC, Constantinescu SN, Ohara O, Hirano T, Kubo M, Singh S, Khatri P, Draghici S, Bader GD, Sander C, Leonard WJ, Pandey A; ''''; , PubMed Europe PMC


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97637view13:39, 31 May 2018Lorasimonsconnect line
97562view07:24, 25 May 2018Fehrhartadded citation
97561view07:22, 25 May 2018Fehrhartfixed lines
94887view18:04, 11 October 2017KhanspersModified title
78571view14:50, 7 January 2015MaintBotadded missing graphIds
70630view00:23, 20 August 2013MaintBotUpdated xrefs by Anatoly Urisman
70108view19:00, 12 July 2013MaintBotupdated to 2013 schema
68007view06:28, 29 June 2013EgonwAdded missing "Entrez Gene" data sources to Proteins with an identifier (ID confirmed via Entrez Gene)
67750view11:58, 26 June 2013DdiglesOntology Term : 'canonical Wnt signaling pathway' added !
62949view11:52, 5 May 2013MaintBotModified title
47977view14:34, 23 April 2012NetPathModified description
47854view17:27, 13 April 2012Sham.ukPeriodical save, work in progress
47851view17:17, 13 April 2012Sham.ukPeriodical save, work in progress
47850view17:07, 13 April 2012Sham.ukPeriodical save, work in progress
47849view16:57, 13 April 2012Sham.ukPeriodical save, work in progress
45009view17:40, 6 October 2011KhanspersOntology Term : 'Wnt signaling pathway' added !
44607view21:23, 21 September 2011KhanspersUpdating content to NetSlim
44606view21:22, 21 September 2011KhanspersUpdating content to NetSlim
44605view21:21, 21 September 2011KhanspersUpdating content to NetSlim
44121view20:51, 24 August 2011KhanspersReverted to version '23:40, 1 March 2011' by Khanspers
44016view22:39, 22 August 2011Khanspers
44010view22:11, 22 August 2011KhanspersModified description
44005view21:51, 22 August 2011KhanspersAdded category
44004view21:47, 22 August 2011KhanspersModified description
44003view21:40, 22 August 2011KhanspersModified description
44002view21:38, 22 August 2011Khanspersremoved GenMAPP comment
44001view21:37, 22 August 2011KhanspersModified description
44000view21:30, 22 August 2011KhanspersUpdating pathway from NetSlim
41151view23:40, 1 March 2011MaintBotRemoved redundant pathway information and comments
38067view20:10, 6 August 2010AlexanderPicoadded wnt9b and connected to database
38019view02:40, 30 July 2010ElgavishReverted to version '02:33, 30 July 2010' by Elgavish
38018view02:39, 30 July 2010ElgavishSpecify description
38017view02:33, 30 July 2010ElgavishPCP pathway
38016view02:27, 30 July 2010ElgavishPeriodical save, work in progress
35029view09:17, 11 February 2010Thomasremoved old genmapp comments (moved to description)
35021view09:11, 11 February 2010ThomasModified description
28127view19:35, 27 January 2009KhanspersReverted to version '13:36, 14 November 2008' by Khanspers
28125view19:12, 27 January 2009KhanspersRemoved Netpath suffix from name
22584view13:36, 14 November 2008Thomaschanged title (was duplicate of WP428)
21439view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Wnt NetPath 8]] moved to [[Pathway:WP363]]: Moved to stable identifier
14174view22:56, 21 May 2008AlexanderPicoModified categories
11945view23:29, 12 May 2008KhanspersNew pathway

External references


View all...
NameTypeDatabase referenceComment
AKT1GeneProduct207 (Entrez Gene)
ANKRD6GeneProduct22881 (Entrez Gene)
AP2GeneProduct7020 (Entrez Gene)
APCGeneProduct324 (Entrez Gene)
ARRB1GeneProduct408 (Entrez Gene)
ARRB2GeneProduct409 (Entrez Gene)
AXIN1GeneProduct8312 (Entrez Gene)
AXIN2GeneProduct8313 (Entrez Gene)
BCL9GeneProduct607 (Entrez Gene)
BRD7GeneProduct29117 (Entrez Gene)
BTRCGeneProduct8945 (Entrez Gene)
CAMK2AGeneProduct815 (Entrez Gene)
CAMK2BGeneProduct816 (Entrez Gene)
CAMK2DGeneProduct817 (Entrez Gene)
CAMK2GGeneProduct818 (Entrez Gene)
CCND1GeneProduct595 (Entrez Gene)
CDC25CGeneProduct995 (Entrez Gene)
CDC2GeneProduct983 (Entrez Gene)
CDH1GeneProduct999 (Entrez Gene)
CRYBB2GeneProduct1415 (Entrez Gene)
CSNK1A1GeneProduct1452 (Entrez Gene)
CSNK1DGeneProduct1453 (Entrez Gene)
CSNK1EGeneProduct1454 (Entrez Gene)
CSNK2A1GeneProduct1457 (Entrez Gene)
CSNK2A2GeneProduct1459 (Entrez Gene)
CSNK2BGeneProduct1460 (Entrez Gene)
CTBP1GeneProduct1487 (Entrez Gene)
CTBP2GeneProduct1488 (Entrez Gene)
CTNNB1GeneProduct1499 (Entrez Gene)
CTNNBIP1GeneProduct56998 (Entrez Gene)
CUL1GeneProduct8454 (Entrez Gene)
CXXC4GeneProduct80319 (Entrez Gene)
DAAM1GeneProduct23002 (Entrez Gene)
DAB2GeneProduct1601 (Entrez Gene)
DKK1GeneProduct22943 (Entrez Gene)
DLG1GeneProduct1739 (Entrez Gene)
DLG2GeneProduct1740 (Entrez Gene)
DLG4GeneProduct1742 (Entrez Gene)
DVL1GeneProduct1855 (Entrez Gene)
DVL2GeneProduct1856 (Entrez Gene)
DVL3GeneProduct1857 (Entrez Gene)
EP300GeneProduct2033 (Entrez Gene)
FHL2GeneProduct2274 (Entrez Gene)
FRAT1GeneProduct10023 (Entrez Gene)
FRAT2GeneProduct23401 (Entrez Gene)
FZD1GeneProduct8321 (Entrez Gene)
FZD2GeneProduct2535 (Entrez Gene)
FZD4GeneProduct8322 (Entrez Gene)
FZD5GeneProduct7855 (Entrez Gene)
FZD6GeneProduct8323 (Entrez Gene)
FZD7GeneProduct8324 (Entrez Gene)
FZD8GeneProduct8325 (Entrez Gene)
FZD9GeneProduct8326 (Entrez Gene)
GSK3BGeneProduct2932 (Entrez Gene)
HIPK2GeneProduct28996 (Entrez Gene)
JUNGeneProduct3725 (Entrez Gene)
JUPGeneProduct3728 (Entrez Gene)
LEF1GeneProduct51176 (Entrez Gene)
LRP1GeneProduct4035 (Entrez Gene)
LRP5GeneProduct4041 (Entrez Gene)
LRP6GeneProduct4040 (Entrez Gene)
MAGI3GeneProduct260425 (Entrez Gene)
MAP1BGeneProduct4131 (Entrez Gene)
MAP3K7GeneProduct6885 (Entrez Gene)
MAPK1GeneProduct5594 (Entrez Gene)
MAPK3GeneProduct5595 (Entrez Gene)
MAPK8GeneProduct5599 (Entrez Gene)
MAPK8IP1GeneProduct9479 (Entrez Gene)
MAPK9GeneProduct5601 (Entrez Gene)
MARK2GeneProduct2011 (Entrez Gene)
MYBGeneProduct4602 (Entrez Gene)
NKD1GeneProduct85407 (Entrez Gene)
NLKGeneProduct51701 (Entrez Gene)
PAX2GeneProduct5076 (Entrez Gene)
PIAS4GeneProduct51588 (Entrez Gene)
PIN1GeneProduct5300 (Entrez Gene)
PPP2CAGeneProduct5515 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
RAC1GeneProduct5879 (Entrez Gene)
RAF1GeneProduct5894 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
ROR2GeneProduct4920 (Entrez Gene)
RUNX2GeneProduct860 (Entrez Gene)
RUVBL1GeneProduct8607 (Entrez Gene)
SALL1GeneProduct6299 (Entrez Gene)
SENP2GeneProduct59343 (Entrez Gene)
SF1GeneProduct2516 (Entrez Gene)
SFRP1GeneProduct6422 (Entrez Gene)
SFRP2GeneProduct6423 (Entrez Gene)
SKP1AGeneProduct6500 (Entrez Gene)
SMAD3GeneProduct4088 (Entrez Gene)
SMAD4GeneProduct4089 (Entrez Gene)
SMT3H2GeneProduct6613 (Entrez Gene)
SOX1GeneProduct6656 (Entrez Gene)
SOX9GeneProduct6662 (Entrez Gene)
TAX1BP3GeneProduct30851 (Entrez Gene)
TBPGeneProduct6908 (Entrez Gene)
TCF3GeneProduct6929 (Entrez Gene)
TCF4GeneProduct6925 (Entrez Gene)
UBL1GeneProduct7341 (Entrez Gene)
VANGL2GeneProduct57216 (Entrez Gene)
WNT1GeneProduct7471 (Entrez Gene)
WNT2GeneProduct7472 (Entrez Gene)
WNT3GeneProduct7473 (Entrez Gene)
WNT3AGeneProduct89780 (Entrez Gene)
WNT4GeneProduct54361 (Entrez Gene)
WNT5AGeneProduct7474 (Entrez Gene)
WNT7AGeneProduct7476 (Entrez Gene)
WNT9AGeneProduct7483 (Entrez Gene)
WNT9BGeneProduct7484 (Entrez Gene)

Annotated Interactions

No annotated interactions

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