MAPK Signaling Pathway (Rattus norvegicus)

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Scaffold1-3, 6-1145LegendCalcium channelsActivating mutationCalcium channelsHeteromeric G-proteinProliferation, differentiationJNK & p38 MAP kinase pathwayERK5 pathwayClassical MAP kinase PathwayMKPProliferation, differentiation,inflammationSerum, cytotoxic drugs, irradiation,heatshock, reactive oxy speciesLPS and other stressProliferation, inflammation, anti-apoptosisp38Proliferation, differentiationSerum, EGF,reactive oxygen species.or Srk tyrokinase downstreamDNA damagePTPJNKTraf6Mef2cPSrfRps6ka3PMap2k3PElk4PRap1aPCrkIl1aPdgfbAkt3EcsitMap3k13Rasgrp4LOC100910771PMapk9PGrb2Mknk1PDusp1Stmn1PElk1PPPEgfrPpp3cbPpp3ccMap4k1Nfatc1PArrb2MaptPRasgrp1Rap1bPCd14IkbkgBdnfDaxxMapk10PLOC103694380MosStk4Mapk14PIkbkbPPArrb1Lrrk2Casp3FlnaPRKACAMapkapk2PTnfrsf1aMap3k14Hspb1PMap3k20Gna12Tgfb1LOC100912399PMap3k2PMaxPDusp10RASGRF2Map4k4PdgfrbTab1Map3k4Gadd45aWnt signaling pathwayMap2k5Cdc25bPIl1r1Rac2PrkcdPpp5cMap2k1PPRac1Ptpn7Il1r2Tab2Tgfbr1Mapk1PPPtprrPtpn5Pla2g4dPBrafNtrk1Atf2PMap2k4PLPSFosPrkcgMycSos2Tgfb2Elk1PLOC100912585PDusp4Cacng3ApoptosisHspa8Mapk12PMapk8ip1IP3Ppm1aCa2+VemurafenibIl1bElk4PTraf2Mapk13PTaok1Map2k6PDusp8Akt2Mapkapk5PRasa2Dusp7Ppp3r2Fgfr1Tgfb3Ppp3caEgfDdit3PMap3k6Map3k8NgfLOC100911248Taok2cAMPMapk3PPMapk8PNr4a1PCell cyclePrkcaAtf4PNtf4PdgfaAtf4PNtrk2FaslgPdgfrbPpm1bFgfr2Cdc42Fgfr3Lamtor3Fgfr4JunPPJundSos1PRrasHrasPPRps6ka5PMap3k12Tp53PRras2PNfkb1Gng12Pla2g4cPNf1Rasgrp2Akt1p53 signaling pathwayRasgrp3Rasgrp4Rasa1Rasgrf1HSPA6Ca2+Ntf3Rapgef2Phosphatidylinositolsignaling systemPrkacbHspa1aPrkacaStk3Dusp3Map4k3ChukPTgfbr2Nfkb2Map4k2RelaMap2k7PRelbPPP3R1Dusp9NlkPDusp2DAGDusp16FasMknk2PPla2g4aPNfatc3PMap3k5PMap3k11PTaok3Dusp6Map2k2PPPPP5D1Mapk11PRps6ka4PMapkapk3PRac3Mapk8ip2Mapk8ip3FlnbFlncHspa1aHspa1lHspa2MrasPNrasPKrasPRaf1PPla2g4fPPla2g4bPla2g4ePPCacng2Cacng5Cacng4Cacna2d3Cacng8Cacng7Cacng6Cacna1aCacna1bCacna1cCacna1dCacna1eCacna1fCacna1sCacna2d1Cacnb1Cacnb2Cacnb3Cacnb4Cacng1CACNA1ICacna1hCacna1gCacna2d2Cacna2d4Fgf4Fgf1Fgf2Fgf3Fgf4Fgf5Fgf6Fgf7Fgf8Fgf9Fgf10Fgf11Fgf12Fgf13Fgf14Fgf20Fgf21Fgf22Fgf23Fgf18Fgf17Fgf16Fgf19Fibroblast growth factorsFibroblast growthfactorsPak2Pak1


Description

The mitogen-activated protein kinase (MAPK) cascade is a highly conserved module that is involved in various cellular functions, including cell proliferation, differentiation and migration. Mammals express at least four distinctly regulated groups of MAPKs, extracellular signal-related kinases (ERK)-1/2, Jun amino-terminal kinases (JNK1/2/3), p38 proteins (p38alpha/beta/gamma/delta) and ERK5, that are activated by specific MAPKKs: MEK1/2 for ERK1/2, MKK3/6 for the p38, MKK4/7 (JNKK1/2) for the JNKs, and MEK5 for ERK5. Each MAPKK, however, can be activated by more than one MAPKKK, increasing the complexity and diversity of MAPK signalling. Presumably each MAPKKK confers responsiveness to distinct stimuli. For example, activation of ERK1/2 by growth factors depends on the MAPKKK c-Raf, but other MAPKKKs may activate ERK1/2 in response to pro-inflammatory stimuli. Source: KEGG http://www.genome.jp/dbget-bin/www_bget?pathway:map04010

Comments

HomologyMapper 
This pathway was inferred from Homo sapiens pathway WP382 (r95114) with a 98.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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  1. Yang SH, Sharrocks AD, Whitmarsh AJ; ''Transcriptional regulation by the MAP kinase signaling cascades.''; Gene, 2003 PubMed Europe PMC
  2. Huang EJ, Reichardt LF; ''Trk receptors: roles in neuronal signal transduction.''; Annu Rev Biochem, 2003 PubMed Europe PMC
  3. Chen Z, Gibson TB, Robinson F, Silvestro L, Pearson G, Xu B, Wright A, Vanderbilt C, Cobb MH; ''MAP kinases.''; Chem Rev, 2001 PubMed Europe PMC
  4. Takeda K, Ichijo H; ''Neuronal p38 MAPK signalling: an emerging regulator of cell fate and function in the nervous system.''; Genes Cells, 2002 PubMed Europe PMC
  5. Dent P, Yacoub A, Fisher PB, Hagan MP, Grant S; ''MAPK pathways in radiation responses.''; Oncogene, 2003 PubMed Europe PMC
  6. Harper SJ, LoGrasso P; ''Signalling for survival and death in neurones: the role of stress-activated kinases, JNK and p38.''; Cell Signal, 2001 PubMed Europe PMC
  7. Tanoue T, Nishida E; ''Docking interactions in the mitogen-activated protein kinase cascades.''; Pharmacol Ther, 2002 PubMed Europe PMC
  8. Abell AN, Granger DA, Johnson GL; ''MEKK4 stimulation of p38 and JNK activity is negatively regulated by GSK3beta.''; J Biol Chem, 2007 PubMed Europe PMC
  9. Zhu X, Lee HG, Raina AK, Perry G, Smith MA; ''The role of mitogen-activated protein kinase pathways in Alzheimer's disease.''; Neurosignals, 2002 PubMed Europe PMC
  10. Cho H, Lee J, Kwak NJ, Lee KH, Rha S, Kim YH, Cho YY, Yang KH, Kim K, Lim Y; ''Silica induces nuclear factor-kappaB activation through TAK1 and NIK in Rat2 cell line.''; Toxicol Lett, 2003 PubMed Europe PMC
  11. Chen CY, Weng YH, Chien KY, Lin KJ, Yeh TH, Cheng YP, Lu CS, Wang HL; ''(G2019S) LRRK2 activates MKK4-JNK pathway and causes degeneration of SN dopaminergic neurons in a transgenic mouse model of PD.''; Cell Death Differ, 2012 PubMed Europe PMC

History

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CompareRevisionActionTimeUserComment
106982view13:44, 17 September 2019MaintBotHMDB identifier normalization
105688view20:58, 13 August 2019Khanspersremoved human-specific drug targeting and mutation
96398view10:11, 12 March 2018EgonwReplaced secondary ChEBI identifiers with primary identifiers.
95780view14:33, 19 January 2018MkutmonHomology conversion update
95213view12:05, 24 November 2017Mkutmonadded homology converter comment source
83027view01:58, 18 November 2015MkutmonFix outdated identifiers
69374view18:55, 8 July 2013MaintBotUpdated to 2013 gpml schema
67442view11:02, 26 June 2013DdiglesOntology Term : 'mitogen activated protein kinase signaling pathway' added !
47771view05:31, 6 April 2012Khanspersupdated xref
41688view02:36, 2 March 2011MaintBotRemoved redundant pathway information and comments
35661view22:13, 12 February 2010KhanspersAdded Description and LIt Refs
34074view19:11, 9 December 2009MaintBotAutomatic update of empty xrefs
32409view17:04, 15 August 2009MaintBotFixed text labels
32065view13:35, 14 August 2009MaintBotFixed group labels
31440view21:05, 13 August 2009MaintBotFixed text labels
30944view00:41, 30 July 2009MaintBotConverted from Homo sapiens
21429view11:31, 14 November 2008MaintBot[[Pathway:Rattus norvegicus:MAPK signaling pathway KEGG]] moved to [[Pathway:WP358]]: Moved to stable identifier
8252view13:46, 7 January 2008MaintBot[[Pathway:Rat:MAPK signaling pathway KEGG]] moved to [[Pathway:Rattus norvegicus:MAPK signaling pathway KEGG]]: Renaming species
7746view16:15, 18 December 2007MaintBotfixed category names
7279view12:41, 4 November 2007MaintBotAdded categories to GPML
6574view22:20, 22 May 2007S.Burelgpml file for [[Rat:MAPK_signaling_pathway_ KEGG]]

External references

DataNodes

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NameTypeDatabase referenceComment
Akt1GeneProductENSRNOG00000028629 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:207
Akt2GeneProductENSRNOG00000018677 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:208
Akt3GeneProductENSRNOG00000021497 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:10000
ApoptosisPathwayWP254 (WikiPathways)
Arrb1GeneProductENSRNOG00000030404 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:408
Arrb2GeneProductENSRNOG00000019308 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:409
Atf2GeneProductENSRNOG00000001597 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1386
Atf4GeneProductENSRNOG00000017801 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:468
BdnfGeneProductENSRNOG00000047466 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:627
BrafGeneProductENSRNOG00000010957 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:673
CACNA1IGeneProductNo homologues found for original id En:ENSG00000100346
Ca2+MetaboliteHMDB00464 (HMDB)
Cacna1aGeneProductENSRNOG00000052707 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000141837
Cacna1bGeneProductENSRNOG00000004560 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000148408
Cacna1cGeneProductENSRNOG00000007090 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151067
Cacna1dGeneProductENSRNOG00000013147 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157388
Cacna1eGeneProductENSRNOG00000002863 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000198216
Cacna1fGeneProductENSRNOG00000010348 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000102001
Cacna1gGeneProductENSRNOG00000060528 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000006283
Cacna1hGeneProductENSRNOG00000033893 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000196557
Cacna1sGeneProductENSRNOG00000046231 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000081248
Cacna2d1GeneProductENSRNOG00000033531 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000153956
Cacna2d2GeneProductENSRNOG00000015835 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000007402
Cacna2d3GeneProductENSRNOG00000031287 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000157445
Cacna2d4GeneProductENSRNOG00000008031 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000151062
Cacnb1GeneProductENSRNOG00000004518 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000067191
Cacnb2GeneProductENSRNOG00000018378 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000165995
Cacnb3GeneProductENSRNOG00000054274 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000167535
Cacnb4GeneProductENSRNOG00000007666 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000182389
Cacng1GeneProductENSRNOG00000003245 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108878
Cacng2GeneProductENSRNOG00000006226 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000166862
Cacng3GeneProductENSRNOG00000012362 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = H:CACNG3
Cacng4GeneProductENSRNOG00000003262 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075461
Cacng5GeneProductENSRNOG00000003288 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000075429
Cacng6GeneProductENSRNOG00000057852 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000130433
Cacng7GeneProductENSRNOG00000056257 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000105605
Cacng8GeneProductENSRNOG00000057848 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000142408
Casp3GeneProductENSRNOG00000010475 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:836
Cd14GeneProductENSRNOG00000017819 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:929
Cdc25bGeneProductENSRNOG00000021248 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:994
Cdc42GeneProductENSRNOG00000013536 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:998
Cell cyclePathwayWP179 (WikiPathways)
ChukGeneProductENSRNOG00000022485 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000213341
CrkGeneProductENSRNOG00000025792 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1398
DAGMetaboliteCHEBI:4481 (ChEBI)
DaxxGeneProductENSRNOG00000000477 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1616
Ddit3GeneProductENSRNOG00000006789 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1649
Dusp10GeneProductENSRNOG00000004003 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:11221
Dusp16GeneProductENSRNOG00000006628 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000111266
Dusp1GeneProductENSRNOG00000003977 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1843
Dusp2GeneProductENSRNOG00000013862 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000158050
Dusp3GeneProductENSRNOG00000036798 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = En:ENSG00000108861
Dusp4GeneProductENSRNOG00000011921 (Ensembl) Homology Mapping from Homo sapiens to Rattus norvegicus: Original ID = L:1846