Histidine, lysine, phenylalanine, tyrosine, proline and tryptophan catabolism (Homo sapiens)

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2, 2723, 53226521, 6237439, 39, 52, 7114, 30, 38, 51, 5823, 5357452632, 34, 54384432, 38196164251, 33, 501524, 26685, 671335, 5914, 30, 51, 5832, 34, 544217, 18, 494838363, 314, 63, 69, 7011, 28766296, 40, 415616, 465655, 6025, 4710128mitochondrial matrixcytosolmitochondrial intermembrane spaceperoxisomal matrixmitochondrial matrixFAH dimerFAD KYNU dimerPIPOXBH4I3LACT, I3PROPAL-Leu PiFADkPPVPXLP IDO1FUMAIDO2L-Phe GTPheme L-PheNAD+L-Val KYNAGluNADPHALDH7A1 H2O3HAAHGD H+H2OCRYMH2OCARNS1HALheme PCBD1 Glub-AlaAnserineNH3KYNAO2AdoMetHDC dimerHDC FTCD THFL-Leu H+L-Ile PXLP-AADAT CARNMeHistL-KYNPYRAMDHD1PXLP-TAT PiL-Alaligands of SLC7A5H2OL-Tyr FADH2TDO2 AP-DOBuAdoMetH2O2L-HisPYRHYKKPXLP-KYAT1 dimerL-Trp KMONicotinatemetabolism4aOH-BH4Fe2+ heme O2AADAT dimerAASS AASS tetramerPXLP-KYAT1 dimerO2L-Trpaspartame2AMPAH PHYKPL tetramerlipo-aKGDHACMSD dimerUCANADPHO2SLC3A2 CO2SACNNAD+L-Glu5SNAD+ 2OGNADP+2OGHistGluFe2+ PXLP-AADAT PXLP-KYNU 2OGH+L-Phe APDBANAD+FITHFFAH L-Trp HPRO2OGPXLP-CCBL2 H2OCO2OGDH PHYKPL FADNADHFe2+ L-His 5PHLO2L-TrpPRODH2H2OCoA-SHPAH tetramerH2OFTCD octamerH2ONADHPXLP-KYAT1 HGD hexamer2AMASL-Met 2AMALIPAM TDO2 tetramerH+GCDH tetramerALDH4A1 H2OL-AspH2OGSH L-AlaNH4+ADPL-KYN2OGIL4I1 NADHGSTZ1 dimerHNMTFADH2PXLP-KYAT1 CARNMT1H2OL-Val CO2UROC1:NAD+AADAT dimerAM-SHDHL-LysP6CH+CCBL2 dimerATPL-TyrH2OaKADAHPD dimerNADHHGTAH+ACMSD ASRGL1(168-308) 3HKYNNAD+NADP+H2OI3PROPA DLD H2OAdoHcySLC36A42OGTDP crotonyl-CoAIL4I1:FADH2O2GCDH O2Lipo-K110-DLST L-PheUROC1 H2OCO2NADP+L-ProaKADA3IN-PYRANH3H+L-Tyr L-Ile L-Glu1PYR-5COOHGSTZ1 FAD GL-CoAH+P2CFe2+ ASRGL1(1-167) H+FAD L-AlaACSASRGL1 heterodimerHAAOO2NAD+H+PPCATAT dimer4I-5PROAAdoHcyI3LACT IDO1 CO2MeOHHAAO O2GluL-Phe4FAAHPD NADPHHCOOHSLC7A5 QDPR dimerligands of SLC7A5AFMIDALDH4A1 dimerNADHPRODH(1-?)5HLYSALDH7A1 tetramerACANAD+QDPR H2ONF-GluIDO2 L-GluPCBD1 tetramer4MAAL-His L-Met 2AMAGDPSLC25A21NFKHPPYRAPXLP NADHqDHBSLC7A5:SLC3A232, 5432, 5411, 2830, 586839, 525562231, 3330, 51, 5837130, 5829123632, 5443281620594630, 51, 5832, 54


The catabolic pathways of histidine, lysine, phenylalanine, tyrosine, proline and tryptophan are described in this section (Berg et al. 2002). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 6788656
Reactome version: 61
Reactome Author 
Reactome Author: Jassal, Bijay

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  26. Rossi F, Han Q, Li J, Li J, Rizzi M.; ''Crystal structure of human kynurenine aminotransferase I.''; PubMed Europe PMC Scholia
  27. Pabarcus MK, Casida JE.; ''Kynurenine formamidase: determination of primary structure and modeling-based prediction of tertiary structure and catalytic triad.''; PubMed Europe PMC Scholia
  28. Yu P, Li Z, Zhang L, Tagle DA, Cai T.; ''Characterization of kynurenine aminotransferase III, a novel member of a phylogenetically conserved KAT family.''; PubMed Europe PMC Scholia
  29. Hallen A, Cooper AJ, Jamie JF, Karuso P.; ''Insights into Enzyme Catalysis and Thyroid Hormone Regulation of Cerebral Ketimine Reductase/μ-Crystallin Under Physiological Conditions.''; PubMed Europe PMC Scholia
  30. Comings DE, Muhleman D, Dietz G, Sherman M, Forest GL.; ''Sequence of human tryptophan 2,3-dioxygenase (TDO2): presence of a glucocorticoid response-like element composed of a GTT repeat and an intronic CCCCT repeat.''; PubMed Europe PMC Scholia
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  33. Veiga-da-Cunha M, Hadi F, Balligand T, Stroobant V, Van Schaftingen E.; ''Molecular identification of hydroxylysine kinase and of ammoniophospholyases acting on 5-phosphohydroxy-L-lysine and phosphoethanolamine.''; PubMed Europe PMC Scholia
  34. Drozak J, Piecuch M, Poleszak O, Kozlowski P, Chrobok L, Baelde HJ, de Heer E.; ''UPF0586 Protein C9orf41 Homolog Is Anserine-producing Methyltransferase.''; PubMed Europe PMC Scholia
  35. Wong JW, Chan CL, Tang WK, Cheng CH, Fong WP.; ''Is antiquitin a mitochondrial Enzyme?''; PubMed Europe PMC Scholia
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101379view11:26, 1 November 2018ReactomeTeamreactome version 66
100917view21:01, 31 October 2018ReactomeTeamreactome version 65
100458view19:36, 31 October 2018ReactomeTeamreactome version 64
100005view16:20, 31 October 2018ReactomeTeamreactome version 63
99558view14:54, 31 October 2018ReactomeTeamreactome version 62 (2nd attempt)
99187view12:42, 31 October 2018ReactomeTeamreactome version 62
93949view13:47, 16 August 2017ReactomeTeamreactome version 61
93542view11:26, 9 August 2017ReactomeTeamreactome version 61
87466view14:13, 22 July 2016MkutmonOntology Term : 'amino acid metabolic pathway' added !
86643view09:22, 11 July 2016ReactomeTeamreactome version 56
83463view12:29, 18 November 2015ReactomeTeamNew pathway

External references


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NameTypeDatabase referenceComment
1PYR-5COOHMetaboliteCHEBI:17388 (ChEBI)
2AMAMetaboliteCHEBI:15745 (ChEBI)
2AMAMetaboliteCHEBI:17082 (ChEBI)
2AMASMetaboliteCHEBI:17917 (ChEBI)
2AMMetaboliteCHEBI:16886 (ChEBI)
2OGMetaboliteCHEBI:30915 (ChEBI)
3HAAMetaboliteCHEBI:15793 (ChEBI)
3HKYNMetaboliteCHEBI:17380 (ChEBI)
3IN-PYRAMetaboliteCHEBI:29750 (ChEBI)
4FAAMetaboliteCHEBI:18034 (ChEBI)
4I-5PROAMetaboliteCHEBI:27384 (ChEBI)
4MAAMetaboliteCHEBI:17105 (ChEBI)
4aOH-BH4MetaboliteCHEBI:15374 (ChEBI)
5HLYSMetaboliteCHEBI:60175 (ChEBI)
5PHLMetaboliteCHEBI:16752 (ChEBI)
AADAT dimerComplexR-HSA-508545 (Reactome)
AASS ProteinQ9UDR5 (Uniprot-TrEMBL)
AASS tetramerComplexR-HSA-70925 (Reactome)
ACAMetaboliteCHEBI:13705 (ChEBI)
ACMSD ProteinQ8TDX5 (Uniprot-TrEMBL)
ACMSD dimerComplexR-HSA-71221 (Reactome)
ACSMetaboliteCHEBI:29044 (ChEBI)
ADPMetaboliteCHEBI:16761 (ChEBI)
AFMIDProteinQ63HM1 (Uniprot-TrEMBL)
ALDH4A1 ProteinP30038 (Uniprot-TrEMBL)
ALDH4A1 dimerComplexR-HSA-70674 (Reactome)
ALDH7A1 ProteinP49419 (Uniprot-TrEMBL)
ALDH7A1 tetramerComplexR-HSA-508564 (Reactome)
AM-SHDHR-HSA-71237 (Reactome)
AMDHD1ProteinQ96NU7 (Uniprot-TrEMBL)
AP-DOBuMetaboliteCHEBI:17442 (ChEBI)
APDBAMetaboliteCHEBI:17442 (ChEBI)
ASRGL1 heterodimerComplexR-HSA-5696373 (Reactome)
ASRGL1(1-167) ProteinQ7L266 (Uniprot-TrEMBL)
ASRGL1(168-308) ProteinQ7L266 (Uniprot-TrEMBL)
ATPMetaboliteCHEBI:15422 (ChEBI)
AdoHcyMetaboliteCHEBI:16680 (ChEBI)
AdoMetMetaboliteCHEBI:15414 (ChEBI)
AnserineMetaboliteCHEBI:18323 (ChEBI)
BH4MetaboliteCHEBI:15372 (ChEBI)
CARNMetaboliteCHEBI:15727 (ChEBI)
CARNMT1ProteinQ8N4J0 (Uniprot-TrEMBL)
CARNS1ProteinA5YM72 (Uniprot-TrEMBL)
CCBL2 dimerComplexR-HSA-901094 (Reactome)
CO2MetaboliteCHEBI:16526 (ChEBI)
CRYMProteinQ14894 (Uniprot-TrEMBL)
CoA-SHMetaboliteCHEBI:15346 (ChEBI)
DLD ProteinP09622 (Uniprot-TrEMBL)
FAD MetaboliteCHEBI:16238 (ChEBI)
FADMetaboliteCHEBI:16238 (ChEBI)
FADH2MetaboliteCHEBI:17877 (ChEBI)
FAH ProteinP16930 (Uniprot-TrEMBL)
FAH dimerComplexR-HSA-71175 (Reactome)
FITHFMetaboliteCHEBI:15639 (ChEBI)
FTCD ProteinO95954 (Uniprot-TrEMBL)
FTCD octamerComplexR-HSA-70908 (Reactome)
FUMAMetaboliteCHEBI:37154 (ChEBI)
Fe2+ MetaboliteCHEBI:18248 (ChEBI)
GCDH ProteinQ92947 (Uniprot-TrEMBL)
GCDH tetramerComplexR-HSA-71040 (Reactome)
GDPMetaboliteCHEBI:17552 (ChEBI)
GL-CoAMetaboliteCHEBI:15524 (ChEBI)
GSH MetaboliteCHEBI:16856 (ChEBI)
GSTZ1 ProteinO43708 (Uniprot-TrEMBL)
GSTZ1 dimerComplexR-HSA-71166 (Reactome)
GTPMetaboliteCHEBI:15996 (ChEBI)
GluMetaboliteCHEBI:29985 (ChEBI)
H+MetaboliteCHEBI:15378 (ChEBI)
H2O2MetaboliteCHEBI:16240 (ChEBI)
H2OMetaboliteCHEBI:15377 (ChEBI)
HAAO ProteinP46952 (Uniprot-TrEMBL)
HAAOComplexR-HSA-71086 (Reactome)
HALProteinP42357 (Uniprot-TrEMBL)
HCOOHMetaboliteCHEBI:30751 (ChEBI)
HDC ProteinP19113 (Uniprot-TrEMBL)
HDC dimerComplexR-HSA-977300 (Reactome)