Fatty acid biosynthesis (Homo sapiens)

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CytosolPalmitateMalonyl-ACPAcetyl-synthaseCrotonoyl-ACPOxaloacetateFatty acyl CoAbeta-hydroxybutyrylMitochondrion3-ketoacyl-CoAAcetyl-ACPtrans-delta2-enoyl-CoApyruvateTCA Cycle6 iterationsButyryl-ACPPalmitoyl-ACPless than 6 iterationsLong-Chain fatty acidCitrate3-L-Hydroxyacyl-CoAAcetoacetyl-ACPACSL1FASNACAA2ACSL3MECRTriacylglyceride Synthesis pathwayACSL5ECH1ACLYACACBFASNFASNACSL4ACACAFASNFASNAcyl-CoA (n+2)Malonyl-CoAECHDC1ECHS1ACSL6Acetyl-CoAECHDC2FASNFASNDECR1ECHDC3ACAS2SCDFASNPCPECRHADHSC111111111


Fatty acid synthesis is the creation of fatty acids from acetyl-CoA and NADPH through the action of enzymes called fatty acid synthases. This process takes place in the cytoplasm of the cell. Most of the acetyl-CoA which is converted into fatty acids is derived from carbohydrates via the glycolytic pathway. Source: Wikipedia Proteins on this pathway have targeted assays available via the CPTAC Assay Portal

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  1. Weiss L, Hoffmann GE, Schreiber R, Andres H, Fuchs E, Körber E, Kolb HJ; ''Fatty-acid biosynthesis in man, a pathway of minor importance. Purification, optimal assay conditions, and organ distribution of fatty-acid synthase.''; Biol Chem Hoppe Seyler, 1986 PubMed Europe PMC Scholia


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121828view07:30, 7 March 2022EgonwMade a pathway clickable
117722view12:34, 22 May 2021EweitzModified title
114302view12:16, 6 January 2021DeSlAnnotated Acetly-ACP, converted Acetyl-synthase to Protein DataNode.
114301view12:13, 6 January 2021DeSlUpdate description
114300view12:12, 6 January 2021DeSlAdded isotope tracer info for malonyl-CoA
114299view12:10, 6 January 2021DeSlAdded lit. ref for FASN
114297view11:58, 6 January 2021DeSlAnnotation of 3-L-hydroxyacyl-CoA
114296view11:49, 6 January 2021DeSlStarted annotating missing IDs.
110772view21:30, 3 June 2020Khanspersremoved stray gene
106416view21:59, 28 August 2019KhanspersModified description
105595view04:47, 10 August 2019KhanspersModified description
98551view18:05, 16 September 2018AlexanderPicoupdated outdated chebi
98530view20:27, 14 September 2018Khanspersoverall update
98529view20:06, 14 September 2018KhanspersModified description
98528view20:05, 14 September 2018Khanspersremoved GenMAPP comments
98527view20:04, 14 September 2018KhanspersModified description
98526view20:04, 14 September 2018KhanspersModified description
98056view06:36, 13 July 2018Fehrhartadded ID for ACSS2 (Acetyl-(CoA) synthase)
94197view14:43, 25 August 2017Mkutmonadded some metabolite identifiers
85181view07:04, 23 April 2016EgonwConverted the remaining metabolite labels into Metabolite DataNodes.
70641view10:21, 20 August 2013EgonwAdded a ChEBI id for 'long chain fatty acid'.
70640view10:18, 20 August 2013EgonwConverted a IUPAC-named Label into a Chemspider-backed Metabolite DataNode.
69014view17:47, 8 July 2013MaintBotUpdated to 2013 gpml schema
45261view18:44, 7 October 2011AlexanderPicoOntology Term : 'fatty acid biosynthetic pathway' added !
41186view23:43, 1 March 2011MaintBotRemoved redundant pathway information and comments
39781view14:51, 18 January 2011MartijnVanIerselpathway link added
38814view08:58, 24 September 2010Jildaucompartment
38673view15:08, 23 September 2010BassetfrogAdded link to Triacylglyceride Synthesis pathway
32875view22:22, 16 September 2009MaintBotchanged type for metabolites
32064view13:34, 14 August 2009MaintBotFixed group labels
30271view20:19, 25 July 2009AlexanderPicofixed unsupported characters in Comment Source "GenMAPP notes"
21427view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:WP357]]: Moved to stable identifier
14593view06:32, 23 May 2008AlexanderPicoupdated pathway reference
14144view14:59, 21 May 2008MichielConnected genes to reaction arrows
14142view14:54, 21 May 2008MichielPeriodical save, work in progress
14138view14:40, 21 May 2008MichielConnected arrows
14136view14:30, 21 May 2008Michiel
14134view14:30, 21 May 2008MichielCreated groups of genes
13068view11:13, 17 May 2008MaintBotautomated metabolite conversion
8052view13:46, 7 January 2008MaintBot[[Pathway:Human:Fatty Acid Synthesis BiGCaT]] moved to [[Pathway:Homo sapiens:Fatty Acid Synthesis BiGCaT]]: Renaming species
7648view16:07, 18 December 2007MaintBotfixed category names
7357view12:42, 4 November 2007MaintBotAdded categories to GPML
19460view22:17, 22 May 2007Evelogpml file for [[Human:Fatty_Acid_Synthesis_BiGCaT]]
6318view22:17, 22 May 2007Kdahlquistgpml file for [[Human:Fatty_Acid_Synthesis_BiGCaT]]

External references


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NameTypeDatabase referenceComment
3-L-Hydroxyacyl-CoAMetaboliteCHEBI:57318 (ChEBI)
3-ketoacyl-CoAMetaboliteCHEBI:57347 (ChEBI) aka 3-oxo-fatty acyl-CoA(4−)
ACAA2GeneProduct10449 (Entrez Gene)
ACACAGeneProduct31 (Entrez Gene)
ACACBGeneProduct32 (Entrez Gene)
ACAS2GeneProduct55902 (Entrez Gene)
ACLYGeneProduct47 (Entrez Gene)
ACSL1GeneProduct2180 (Entrez Gene)
ACSL3GeneProduct2181 (Entrez Gene)
ACSL4GeneProduct2182 (Entrez Gene)
ACSL5GeneProduct51703 (Entrez Gene)
ACSL6GeneProduct23305 (Entrez Gene)
Acetoacetyl-ACPMetaboliteCHEBI:2393 (ChEBI)
Acetyl-ACPMetaboliteQ59811305 (Wikidata)
Acetyl-CoAMetaboliteCHEBI:15351 (ChEBI)
Acetyl-synthaseProteinENSG00000131069 (Ensembl)
Acyl-CoA (n+2)Metabolite9029-97-4 (CAS)
Butyryl-ACPMetaboliteCHEBI:3247 (ChEBI)
CitrateMetabolite29081 (Chemspider)
Crotonoyl-ACPMetaboliteC04618 (KEGG Compound) aka (3R)-3-Hydroxybutanoyl-[acyl-carrier protein]
DECR1GeneProduct1666 (Entrez Gene)
ECH1GeneProduct1891 (Entrez Gene)
ECHDC1GeneProduct55862 (Entrez Gene)
ECHDC2GeneProduct55268 (Entrez Gene)
ECHDC3GeneProduct79746 (Entrez Gene)
ECHS1GeneProduct1892 (Entrez Gene)
FASNGeneProduct2194 (Entrez Gene)
Fatty acyl CoAMetabolite
HADHSCGeneProduct3033 (Entrez Gene)
Long-Chain fatty acidMetaboliteCHEBI:15904 (ChEBI)
MECRGeneProduct51102 (Entrez Gene)
Malonyl-ACPMetaboliteC01209 (KEGG Compound)
Malonyl-CoAMetabolite524-14-1 (CAS) Used in small tissue samples as [14C] isotope tracer to improve sensiticity of FASN activity. [https://doi.org/10.1515/bchm3.1986.367.2.905]
OxaloacetateMetaboliteCHEBI:30744 (ChEBI)
PCGeneProduct5091 (Entrez Gene)
PECRGeneProduct55825 (Entrez Gene)
PalmitateMetabolite440215 (Chemspider)
Palmitoyl-ACPMetaboliteC16520 (KEGG Compound)
SCDGeneProduct6319 (Entrez Gene)
TCA CyclePathwayWP78 (WikiPathways)
Triacylglyceride Synthesis pathwayPathwayWP325 (WikiPathways)
pyruvateMetaboliteCHEBI:15361 (ChEBI)

Annotated Interactions

SourceTargetTypeDatabase referenceComment
3-ketoacyl-CoA3-L-Hydroxyacyl-CoAmim-conversion22434 (Rhea)
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