G Protein Signaling Pathways (Homo sapiens)

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G proteins, short for guanine nucleotide-binding proteins, are a family of proteins involved in second messenger cascades.

G proteins are so called because they function as "molecular switches". They alternate from 'inactive' guanosine diphosphate (GDP) to 'active' guanosine triphosphate (GTP), which is a binding state, and which proceeds to regulate downstream cell processes.

Source: Wikipedia

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Ontology Terms



  1. Stryer L, Bourne HR; ''G proteins: a family of signal transducers.''; Annu Rev Cell Biol, 1986 PubMed Europe PMC Scholia
  2. Neves SR, Ram PT, Iyengar R; ''G protein pathways.''; Science, 2002 PubMed Europe PMC Scholia


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106737view13:22, 17 September 2019MaintBotHMDB identifier normalization
106428view23:20, 28 August 2019KhanspersModified description
105604view04:51, 10 August 2019KhanspersModified description
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79952view11:32, 28 April 2015Zarichanded Id for IP3 metabolite
71252view20:48, 16 October 2013MaintBotAutomated update of data sources
63188view20:49, 8 May 2013MaintBotUpdating gpml version
45294view19:16, 7 October 2011AlexanderPicoOntology Term : 'PW:0000227' removed !
45292view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
45291view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphas family' added !
45290view19:15, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphaq family' added !
45289view19:14, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galphai family' added !
45287view19:14, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway via Galpha12/Galpha13 family' added !
45286view19:13, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
43862view21:35, 9 August 2011Samuel SklarPeriodical save, work in progress
41095view23:21, 1 March 2011MaintBotRemoved redundant pathway information and comments
35311view08:13, 12 February 2010ThomasModified description
35310view08:12, 12 February 2010Thomasadded literature
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20751view11:29, 14 November 2008MaintBot[[Pathway:Homo sapiens:G Protein Signaling]] moved to [[Pathway:WP35]]: Moved to stable identifier
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External references


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NameTypeDatabase referenceComment
ADCY1GeneProduct107 (Entrez Gene)
ADCY2GeneProduct108 (Entrez Gene)
ADCY3GeneProduct109 (Entrez Gene)
ADCY4GeneProduct196883 (Entrez Gene)
ADCY5GeneProduct111 (Entrez Gene)
ADCY6GeneProduct112 (Entrez Gene)
ADCY7GeneProduct113 (Entrez Gene)
ADCY8GeneProduct114 (Entrez Gene)
ADCY9GeneProduct115 (Entrez Gene)
AKAP10GeneProduct11216 (Entrez Gene)
AKAP11GeneProduct11215 (Entrez Gene)
AKAP12GeneProduct9590 (Entrez Gene)
AKAP13GeneProduct11214 (Entrez Gene)
AKAP1GeneProduct8165 (Entrez Gene)
AKAP2GeneProduct11217 (Entrez Gene)
AKAP3GeneProduct10566 (Entrez Gene)
AKAP4GeneProduct8852 (Entrez Gene)
AKAP5GeneProduct9495 (Entrez Gene)
AKAP6GeneProduct9472 (Entrez Gene)
AKAP7GeneProduct9465 (Entrez Gene)
AKAP8GeneProduct10270 (Entrez Gene)
AKAP9GeneProduct10142 (Entrez Gene)
ARHGEF1GeneProduct9138 (Entrez Gene)
CALM1GeneProduct801 (Entrez Gene)
Ca2+MetaboliteHMDB00464 (HMDB)
DAGMetaboliteC00165 (Kegg Compound)
GNA11GeneProduct2767 (Entrez Gene)
GNA12GeneProduct2768 (Entrez Gene)
GNA13GeneProduct10672 (Entrez Gene)
GNA14GeneProduct9630 (Entrez Gene)
GNA15GeneProduct2769 (Entrez Gene)
GNAI1GeneProduct2770 (Entrez Gene)
GNAI2GeneProduct2771 (Entrez Gene)
GNAI3GeneProduct2773 (Entrez Gene)
GNALGeneProduct2774 (Entrez Gene)
GNAO1GeneProduct2775 (Entrez Gene)
GNAQGeneProduct2776 (Entrez Gene)
GNASGeneProduct2778 (Entrez Gene)
GNAZGeneProduct2781 (Entrez Gene)
GNB1GeneProduct2782 (Entrez Gene)
GNB2GeneProduct2783 (Entrez Gene)
GNB3GeneProduct2784 (Entrez Gene)
GNB5GeneProduct10681 (Entrez Gene)
GNG10GeneProduct2790 (Entrez Gene)
GNG11GeneProduct2791 (Entrez Gene)
GNG12GeneProduct55970 (Entrez Gene)
GNG13GeneProduct51764 (Entrez Gene)
GNG3GeneProduct2785 (Entrez Gene)
GNG4GeneProduct2786 (Entrez Gene)
GNG5GeneProduct2787 (Entrez Gene)
GNG7GeneProduct2788 (Entrez Gene)
GNG8GeneProduct94235 (Entrez Gene)
GNGT1GeneProduct2792 (Entrez Gene)
GNGT2GeneProduct2793 (Entrez Gene)
HRASGeneProduct3265 (Entrez Gene)
IP3MetaboliteHMDB01143 (HMDB)
ITPR1GeneProduct3708 (Entrez Gene)
KCNJ3GeneProduct3760 (Entrez Gene)
KRASGeneProduct3845 (Entrez Gene)
NRASGeneProduct4893 (Entrez Gene)
PDE1AGeneProduct5136 (Entrez Gene)
PDE1BGeneProduct5153 (Entrez Gene)
PDE1CGeneProduct5137 (Entrez Gene)
PDE4AGeneProduct5141 (Entrez Gene)
PDE4BGeneProduct5142 (Entrez Gene)
PDE4CGeneProduct5143 (Entrez Gene)
PDE4DGeneProduct5144 (Entrez Gene)
PDE7AGeneProduct5150 (Entrez Gene)
PDE7BGeneProduct27115 (Entrez Gene)
PDE8AGeneProduct5151 (Entrez Gene)
PDE8BGeneProduct8622 (Entrez Gene)
PLCB3GeneProduct5331 (Entrez Gene)
PPP3CAGeneProduct5530 (Entrez Gene)
PPP3CCGeneProduct5533 (Entrez Gene)
PRKACAGeneProduct5566 (Entrez Gene)
PRKACBGeneProduct5567 (Entrez Gene)
PRKACGGeneProduct5568 (Entrez Gene)
PRKAR1AGeneProduct5573 (Entrez Gene)
PRKAR1BGeneProduct5575 (Entrez Gene)
PRKAR2AGeneProduct5576 (Entrez Gene)
PRKAR2BGeneProduct5577 (Entrez Gene)
PRKCAGeneProduct5578 (Entrez Gene)
PRKCB1GeneProduct5579 (Entrez Gene)
PRKCDGeneProduct5580 (Entrez Gene)
PRKCEGeneProduct5581 (Entrez Gene)
PRKCGGeneProduct5582 (Entrez Gene)
PRKCHGeneProduct5583 (Entrez Gene)
PRKCIGeneProduct5584 (Entrez Gene)
PRKCQGeneProduct5588 (Entrez Gene)
PRKCZGeneProduct5590 (Entrez Gene)
PRKD1GeneProduct5587 (Entrez Gene)
PRKD3GeneProduct23683 (Entrez Gene)
RHOAGeneProduct387 (Entrez Gene)
RRASGeneProduct6237 (Entrez Gene)
SLC9A1GeneProduct6548 (Entrez Gene)
cAMPMetaboliteHMDB00058 (HMDB)

Annotated Interactions

No annotated interactions

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