Eukaryotic Transcription Initiation (Danio rerio)

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1, 2TFIIHPrimary RNA transcriptcell growthTFIIB3TATA33Steps 3) DNA melting by association with TFIIHTFIIETFIIATFIIHSteps 2) Association of TIFs and RNA polymeraseSteps 5) RNA elongation with CDT phosphorylationRNA polymerase IIIGene Regulatory Proteins5RNA pol IITFIIE5TATA Box binding(mRNA, snRNPs)3TATA3TFIIF3TFIIF5TFIIATFIIFRNA polymerase II5proteinTranscription Initiation Factors (TIFs)(large ribosomal RNAs)55RNA polymerase ISteps 1) TBP binds TATA boxSteps 4) Transcription elongation by NTPs5HOMOLOGY MAPPTATA3535(small stable RNAs)(recognize surface DNA geometry)5TFIIBTFIID3TFIIDdsDNApolr2ebTAF5polr3htaf6taf12TAF9polr3kgtf2f2agtf2h3polr2igtf2h1gtf2e2ercc3POLR2Bpolr3dccnhPOLR1Agtf2bPOLR2KTAF13mnat1RPC2polr2jgtf2a2ILKpolr2glpolr3ePOLR1Bgtf2h2polr2fGTF2E1cdk7POLR2Apolr2hERCC2gtf2h4tbpPolr1epolr2cTAF7POLR1D


In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia


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  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia


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91985view10:04, 11 April 2017LWackersUpdated annotations
68688view05:49, 6 July 2013MaintBotUpdated to 2013 gpml schema
67212view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
40863view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
35528view13:58, 12 February 2010Thomasadded literature
35517view13:52, 12 February 2010ThomasModified description
34243view21:42, 9 December 2009MaintBotAutomatic update of empty xrefs
21401view11:31, 14 November 2008MaintBot[[Pathway:Danio rerio:RNA transcription Reactome]] moved to [[Pathway:WP344]]: Moved to stable identifier
12020view08:44, 15 May 2008MaintBotAdded to category $category
12018view08:44, 15 May 2008NsalomonisUploaded new pathway

External references


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NameTypeDatabase referenceComment
ERCC2GeneProduct393900 (Entrez Gene)
GTF2E1GeneProductENSDARG00000000542 (Ensembl)
ILKGeneProduct393543 (Entrez Gene)
POLR1AGeneProduct327078 (Entrez Gene)
POLR1BGeneProductENSDARG00000077469 (Ensembl)
POLR1DGeneProductENSDARG00000037570 (Ensembl)
POLR2AGeneProduct553347 (Entrez Gene)
POLR2BGeneProduct100149268 (Entrez Gene)
POLR2KGeneProductENSDARG00000075616 (Ensembl)
Polr1eGeneProduct553733 (Entrez Gene)
RPC2GeneProductENSDARG00000062915 (Ensembl) polr3b is zebrafish ortholog of human POLR3B (Alias RPC2)
TAF13GeneProduct324153 (Entrez Gene)
TAF5GeneProduct641491 (Entrez Gene)
TAF7GeneProduct100002261 (Entrez Gene)
TAF9GeneProduct321485 (Entrez Gene)
ccnhGeneProduct541325 (Entrez Gene)
cdk7GeneProduct405897 (Entrez Gene)
ercc3GeneProduct324323 (Entrez Gene)
gtf2a2GeneProduct798997 (Entrez Gene)
gtf2bGeneProduct324823 (Entrez Gene)
gtf2e2GeneProduct334854 (Entrez Gene)
gtf2f2aGeneProduct415217 (Entrez Gene)
gtf2h1GeneProduct447857 (Entrez Gene)
gtf2h2GeneProduct323239 (Entrez Gene)
gtf2h3GeneProduct436837 (Entrez Gene)
gtf2h4GeneProduct334839 (Entrez Gene)
mnat1GeneProduct450080 (Entrez Gene)
polr2cGeneProduct334669 (Entrez Gene)
polr2ebGeneProduct445170 (Entrez Gene)
polr2fGeneProduct436817 (Entrez Gene)
polr2glGeneProduct324088 (Entrez Gene)
polr2hGeneProduct550263 (Entrez Gene)
polr2iGeneProduct449992 (Entrez Gene)
polr2jGeneProduct554099 (Entrez Gene)
polr3dGeneProduct393257 (Entrez Gene)
polr3eGeneProduct336518 (Entrez Gene)
polr3hGeneProduct436749 (Entrez Gene)
polr3kGeneProduct436826 (Entrez Gene)
taf12GeneProduct386637 (Entrez Gene)
taf6GeneProduct447818 (Entrez Gene)
tbpGeneProduct368882 (Entrez Gene)

Annotated Interactions

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