Eukaryotic Transcription Initiation (Danio rerio)

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Steps 2) Association of TIFs and RNA polymeraseTranscription Initiation Factors (TIFs)TFIIDTFIIFRNA polymerase IIIRNA polymerase I35(large ribosomal RNAs)TFIIESteps 3) DNA melting by association with TFIIHGene Regulatory ProteinsRNA pol II5TFIIF(mRNA, snRNPs)3TATA(small stable RNAs)5Steps 4) Transcription elongation by NTPsTFIIATFIID5TFIIF3TATAcell growth35TATATFIIATATA Box bindingTFIIETFIIB(recognize surface DNA geometry)TFIIH53Primary RNA transcript5TFIIB33HOMOLOGY MAPP5TFIIH3proteindsDNASteps 1) TBP binds TATA boxRNA polymerase II5Steps 5) RNA elongation with CDT phosphorylation35POLR1BPOLR2Btaf12ercc3POLR2ATAF9zgc:110289zgc:92774POLR1DTAF13polr2cGTF2E1tbpgtf2e2gtf2bgtf2h2POLR2Kzgc:56407RPC2zgc:92790gtf2h3TAF7zgc:92878Polr1eTAF5zgc:110584zgc:101098ILKpolr2glzgc:85821zgc:77721zgc:114132zgc:86775zgc:103515POLR1Azgc:92126zgc:101599zgc:110005zgc:55592zgc:92160ERCC2


Description

In eukaryotes, RNA polymerase, and therefore the initiation of transcription, requires the presence of a core promoter sequence in the DNA. RNA polymerase is able to bind to core promoters in the presence of various specific transcription factors. The most common type of core promoter in eukaryotes is a short DNA sequence known as a TATA box. The TATA box, as a core promoter, is the binding site for a transcription factor known as TATA binding protein (TBP), which is itself a subunit of another transcription factor, called Transcription Factor II D (TFIID). After TFIID binds to the TATA box via the TBP, five more transcription factors and RNA polymerase combine around the TATA box in a series of stages to form a preinitiation complex. One transcription factor, DNA helicase, has helicase activity and so is involved in the separating of opposing strands of double-stranded DNA to provide access to a single-stranded DNA template. However, only a low, or basal, rate of transcription is driven by the preinitiation complex alone. Other proteins known as activators and repressors, along with any associated coactivators or corepressors, are responsible for modulating transcription rate. Source: Wikipedia

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Reference: http://www.web-books.com/MoBio/Free/Ch4E.htm
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Bibliography

  1. Lee TI, Young RA; ''Regulation of gene expression by TBP-associated proteins.''; Genes Dev, 1998 PubMed Europe PMC Scholia
  2. Lemon B, Tjian R; ''Orchestrated response: a symphony of transcription factors for gene control.''; Genes Dev, 2000 PubMed Europe PMC Scholia

History

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CompareRevisionActionTimeUserComment
91985view10:04, 11 April 2017LWackersUpdated annotations
68688view05:49, 6 July 2013MaintBotUpdated to 2013 gpml schema
67212view10:21, 26 June 2013Christine ChichesterOntology Term : 'transcription pathway' added !
40863view22:20, 1 March 2011MaintBotRemoved redundant pathway information and comments
35528view13:58, 12 February 2010Thomasadded literature
35517view13:52, 12 February 2010ThomasModified description
34243view21:42, 9 December 2009MaintBotAutomatic update of empty xrefs
21401view11:31, 14 November 2008MaintBot[[Pathway:Danio rerio:RNA transcription Reactome]] moved to [[Pathway:WP344]]: Moved to stable identifier
12020view08:44, 15 May 2008MaintBotAdded to category $category
12018view08:44, 15 May 2008NsalomonisUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ERCC2GeneProduct393900 (Entrez Gene)
GTF2E1GeneProduct
ILKGeneProduct393543 (Entrez Gene)
POLR1AGeneProduct327078 (Entrez Gene)
POLR1BGeneProduct
POLR1DGeneProduct
POLR2AGeneProduct553347 (Entrez Gene)
POLR2BGeneProduct100149268 (Entrez Gene)
POLR2KGeneProduct
Polr1eGeneProduct553733 (Entrez Gene)
RPC2GeneProduct
TAF13GeneProduct324153 (Entrez Gene)
TAF5GeneProduct641491 (Entrez Gene)
TAF7GeneProduct100002261 (Entrez Gene)
TAF9GeneProduct321485 (Entrez Gene)
ercc3GeneProduct324323 (Entrez Gene)
gtf2bGeneProduct324823 (Entrez Gene)
gtf2e2GeneProduct334854 (Entrez Gene)
gtf2h2GeneProduct323239 (Entrez Gene)
gtf2h3GeneProduct436837 (Entrez Gene)
polr2cGeneProduct334669 (Entrez Gene)
polr2glGeneProduct324088 (Entrez Gene)
taf12GeneProduct386637 (Entrez Gene)
tbpGeneProduct368882 (Entrez Gene)
zgc:101098GeneProduct445170 (Entrez Gene)
zgc:101599GeneProduct450080 (Entrez Gene)
zgc:103515GeneProduct449992 (Entrez Gene)
zgc:110005GeneProduct554099 (Entrez Gene)
zgc:110289GeneProduct550263 (Entrez Gene)
zgc:110584GeneProduct553632 (Entrez Gene)
zgc:114132GeneProduct541325 (Entrez Gene)
zgc:55592GeneProduct336518 (Entrez Gene)
zgc:56407GeneProduct393257 (Entrez Gene)
zgc:77721GeneProduct334839 (Entrez Gene)
zgc:85821GeneProduct405897 (Entrez Gene)
zgc:86775GeneProduct415217 (Entrez Gene)
zgc:92126GeneProduct447857 (Entrez Gene)
zgc:92160GeneProduct447818 (Entrez Gene)
zgc:92774GeneProduct436826 (Entrez Gene)
zgc:92790GeneProduct436817 (Entrez Gene)
zgc:92878GeneProduct436749 (Entrez Gene)

Annotated Interactions

No annotated interactions
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