Ergosterol Biosynthesis (Saccharomyces cerevisiae)

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1-3mevalonate-5-PPCO2O2O2trans, trans-farnesyl diphosphatedimethylallyl-pyrophosphate4-methyl-8,24-cholestadienol5,7,24(28)-ergostatrienolNADPgeranyl-PPacceptormevalonateNADPfecosterol2 NADPNADPNADPmevalonate-5Pdelta3-isopentenyl-PPepisterol5,7,22,24(28)-ergostatetraenol4,4-dimethyl-8,24-cholestadienoldelta3-isopentenyl-PPlanosterol4,4-dimethyl-cholestra-8,12,24-trienolO2O2H2OS-adenosyl-L-methionine3-hydroxy-3-methyl-glutaryl-CoAS-adenosyl-homocysteineNADPreduced acceptorH2ONADPHHMG1ERG102 acetyl-CoAacetoacetyl-CoANADPHERG24ERG5acetyl-CoAADP(S)-2,3-epoxysqualeneERG12pyrophosphateERG9zymosterolpyrophosphateERG8squaleneERG1ATPERG2ADPCoenzyme AATPERG25ERG3NADPHHMG2ERG6ATPpyrophosphateERG20NADPHERG13NADPHERG4ERG7MVD1ADPERG20ergosterolCoenzyme A2 NADPHIDI1phosphateCoenzyme AERG11


Description

The ergosterol biosynthesis pathway is required for generation of a major constituent of the fungal plasma membrane, ergosterol (CITS: [Paltauf])(CITS: [8561481]). This pathway is fungal-specific; plasma membranes of other organisms are composed predominantly of other types of sterol. However, the pathway is not universally present in fungi; for example, Pneumocystis carinii plasma membranes lack ergosterol (CITS: [12531182]). In S. cerevisiae, some steps in the pathway are dispensible while others are essential for viability (CITS: [8277826]). The ergosterol biosynthesis pathway has been the subject of intensive investigation as a target of antifungal drugs (CITS: [11815273]). The major target of azole antifungal drugs is lanosterol 14-alpha demethylase, a member of the cytochrome P450 family known as Erg11 protein in many fungal species. Squalene epoxidase (Erg1p in S. cerevisiae) is the specific target of allylamine drugs such as terbinafine (CITS: [14638499]). Mutations in the genes encoding these enzymes and others in the pathway, as well as alterations in the expression levels of the pathway constituents, can lead to antifungal drug resistance (CITS: [11815273]). SOURCE: SGD pathways, http://pathway.yeastgenome.org/server.html

Comments

GenMAPP remarks 
Based on http://pathway.yeastgenome.org/biocyc/

Quality Tags

Ontology Terms

 

Bibliography

  1. Parks LW, Casey WM; ''Physiological implications of sterol biosynthesis in yeast.''; Annu Rev Microbiol, 1995 PubMed Europe PMC
  2. Mo C, Valachovic M, Randall SK, Nickels JT, Bard M; ''Protein-protein interactions among C-4 demethylation enzymes involved in yeast sterol biosynthesis.''; Proc Natl Acad Sci U S A, 2002 PubMed Europe PMC
  3. Bard M, Bruner DA, Pierson CA, Lees ND, Biermann B, Frye L, Koegel C, Barbuch R; ''Cloning and characterization of ERG25, the Saccharomyces cerevisiae gene encoding C-4 sterol methyl oxidase.''; Proc Natl Acad Sci U S A, 1996 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
101816view09:45, 10 November 2018EgonwReplaced a wrong CAS number of with right ChEBI identifier.
90093view07:53, 13 October 2016EgonwReplace the CAS numbers of the salt with that of just the metabolite.
88005view13:27, 25 July 2016SusanOntology Term : 'classic metabolic pathway' added !
78318view11:05, 30 December 2014Santosh.kodgireSpecify description
69857view17:16, 11 July 2013EgonwMarked a few DataNodes with CAS registry numbers as metabolites.
69624view20:35, 8 July 2013MaintBotUpdated to 2013 gpml schema
41859view04:51, 2 March 2011MaintBotRemoved redundant pathway information and comments
36620view22:32, 9 April 2010MaintBotDescription and bibliography added from SGD
21399view11:31, 14 November 2008MaintBot[[Pathway:Saccharomyces cerevisiae:Ergosterol Biosynthesis]] moved to [[Pathway:WP343]]: Moved to stable identifier
12694view07:58, 17 May 2008MaintBotautomated metabolite conversion
8699view14:07, 7 January 2008MaintBotAdded to category $category
8697view14:06, 7 January 2008M.BraymerUploaded new pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
(S)-2,3-epoxysqualene9029-62-3 (CAS)
2 NADPH2646-71-1 (CAS)
2 acetyl-CoA72-89-9 (CAS)
ADP58-64-0 (CAS)
ATP1927-31-7 (CAS)
Coenzyme A64885-97-8 (CAS)
ERG10GeneProductS000005949 (SGD)
ERG11GeneProductS000001049 (SGD)
ERG12GeneProductS000004821 (SGD)
ERG13GeneProductS000004595 (SGD)
ERG1GeneProductS000003407 (SGD)
ERG20GeneProductS000003703 (SGD)
ERG24GeneProductS000005224 (SGD)
ERG25GeneProductS000005224 (SGD)
ERG2GeneProductS000004815 (SGD)
ERG3GeneProductS000004046 (SGD)
ERG4GeneProductS000002980 (SGD)
ERG5GeneProductS000004617 (SGD)
ERG6GeneProductS000004467 (SGD)
ERG7GeneProductS000001114 (SGD)
ERG8GeneProductS000004833 (SGD)
ERG9GeneProductS000001233 (SGD)
HMG1GeneProductS000004540 (SGD)
HMG2GeneProductS000004442 (SGD)
IDI1GeneProductS000006038 (SGD)
MVD1GeneProductS000005326 (SGD)
NADPH2646-71-1 (CAS)
acetoacetyl-CoA1420-36-6 (CAS)
acetyl-CoA72-89-9 (CAS)
ergosterol57-87-4 (CAS)
phosphate14265-44-2 (CAS)
pyrophosphate2466-09-3 (CAS)
squalene111-02-4 (CAS)
zymosterol128-33-6 (CAS)

Annotated Interactions

No annotated interactions
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