Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)

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18, 20, 21208, 20212121208, 2018, 2018, 202020cytosolnucleoplasmHIST3H2BB HIST1H2BH KLK2 Gene p-T12,MeK-HIST2H3A KLK3 Gene TEST 6-Dehydrotestosterone HIST1H2BK DHTEST HIST1H2BO HIST1H2BL p-T12, Me3K-10-HIST2H3A CH2ODHTEST KLK3 Gene HIST2H2BE KLK2 Gene HIST1H2AD HIST2H2AC HIST1H2AD HIST1H2AJ TEST AR androst-4-en-3,17-dione H2AFV HIST3H2BB H2AFB1 HIST1H2BK AR Me3K-10-HIST2H3A HIST1H2BK p-T774-PKN1 DHTEST HIST1H2BO p-T12-H3F3A 6-Dehydrotestosterone HIST1H2AB CH2ODHTEST androst-4-en-3,17-dione HIST1H2BO HIST1H2BM HIST1H2AC DHTEST H2AFJ H2AFV H2AFX KLK3 Gene CO2p-T774-PKN1HIST2H2BE HIST1H2BM HIST1H2AB AR H2AFV p-T12,Me3K-10-H3F3A HIST3H2BB H2AFB1 HIST1H4 HIST2H2AC HIST1H2AD HIST1H2AD p-T12,Me3K-10-H3F3A p-T12, Me2K-10-H3F3A HIST1H2BD HIST3H2BB HIST1H2BA HIST2H2AA3 HIST1H2BK HIST1H2AJ HIST1H2BK HIST1H2BD HIST1H2BC NCOA2 KLK2 Gene KDM1A HIST1H2BN p-T774-PKN1 androst-4-en-3,17-dione androst-4-en-3,17-dione H2BFS HIST1H2AJ HIST1H2BJ TEST p-T12, Me2K-10-HIST1H3A HIST1H2BH HIST1H4 HIST1H2AJ HIST1H2AJ HIST2H2AA3 HIST1H2BO HIST1H2BD TEST HIST2H2BE KLK2 Gene 6-Dehydrotestosterone HIST1H2BB HIST1H2BN HIST1H2BA HIST1H4 HIST1H2BO HIST1H2BA HIST1H2BM HIST1H2BB p-T12, Me2K-10-HIST2H3A HIST1H2AJ TEST HIST1H2BO androst-4-en-3,17-dione HIST1H2AD HIST1H2BL p-T12-HIST2H3A HIST1H2BB p-T774-PKN1:AR:AndrogenHIST1H2BN Me3K-10-HIST1H3A KLK3 Gene p-T12, Me3K-10-HIST1H3A HIST1H2BD HIST1H2AC HIST1H2BB O26-Dehydrotestosterone H2BFS H2AFX TEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3H2AFJ Me3K-10-HIST1H3A ADPHIST1H2AC HIST1H2BL H2AFZ androst-4-en-3,17-dione HIST1H2BL HIST1H2BM HIST1H4 HIST1H2BC HIST1H2BC Me3K-10-HIST2H3A HIST1H2BJ HIST1H2AD H2AFZ HIST1H2BA KLK3 Gene H2AFB1 H2BFS HIST2H2AA3 H2AFB1 HIST1H2BB KLK2 Gene HIST1H2BO H2AFJ HIST1H2BO androst-4-en-3,17-dione HIST2H2BE KLK2,KLK3p-T12, Me3K-10-HIST1H3A DHTEST 6-Dehydrotestosterone H2AFJ p-T12-HIST1H3A H2AFJ 6-Dehydrotestosterone HIST1H2BJ HIST2H2BE HIST1H2BH 2OGHIST1H2AB HIST1H2AC HIST2H2AC H2AFX TEST p-T774-PKN1 p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4CHIST1H2BL HIST1H2BC H2AFB1 KLK3 Gene HIST1H2AD HIST1H2BA 6-Dehydrotestosterone H2BFS HIST1H2AC H2AFX p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H36-Dehydrotestosterone p-T12,MeK-10-HIST1H3A 6-Dehydrotestosterone HIST3H2BB TEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3androst-4-en-3,17-dione HIST1H2AB HIST1H2BJ HIST2H2BE HIST1H2AC SUCCAKLK2 Gene HIST1H2BK H2AFV HIST1H2AB HIST1H2BD HIST1H2BB HIST1H2BD HIST1H2BD O2HIST1H2AC HIST3H2BB androst-4-en-3,17-dione p-T12, Me3K-10-HIST2H3A HIST1H2BM H2AFJ KLK2 AR KLK2,3Gene:Nucleosomewith Me3K-10-H3Me3K-10-H3F3A androst-4-en-3,17-dione SUCCAH2AFJ HIST1H2BM HIST2H2AC SUCCAKLK3 Gene H2BFS AR HIST2H2AA3 AR KLK3 Gene H2AFB1 p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1AHIST1H2AB HIST1H2BN HIST1H2BB H2AFV HIST1H2BA HIST1H2BM H2AFB1 HIST1H2BA p-T12, Me2K-10-HIST1H3A HIST1H2AJ p-T12, Me2K-10-HIST2H3A DHTEST HIST1H2BN HIST1H4 p-T12,MeK-H3F3A H2AFV HIST2H2AA3 H2AFZ p-T774-PKN1 ATPHIST1H4 HIST1H2BJ CH2OH2AFZ HIST1H2AB H2AFX p-T774-PKN1 H2BFS H2AFV HIST1H2BC H2AFX TEST HIST1H2BN H2AFZ H2AFB1 HIST3H2BB H2AFX HIST1H2BH p-T774-PKN1 HIST1H2AJ 6-Dehydrotestosterone DHTEST HIST1H2BL p-T12, Me2K-10-H3F3A HIST2H2BE HIST1H2BN HIST2H2AC HIST1H4 p-T774-PKN1 CO2AR AR HIST1H2BH HIST2H2AA3 AR:AndrogenHIST1H2BH AR H2AFV HIST1H2BH HIST1H2BC HIST1H2AD DHTEST H2AFX H2AFJ HIST1H2AB KDM1AHIST1H2BD H2BFS KLK3 Gene p-T774-PKN1 p-T774-PKN1 HIST1H2BC KDM4CHIST2H2AC p-T774-PKN1 HIST1H2BL 2OGKLK2 Gene HIST1H2BC HIST1H2BB 2OGKDM1A HIST1H2BH HIST1H2BK TEST H2BFS HIST1H2BK p-T774-PKN1:AR:Androgenp-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3AR RHO GTPases activatePKNsHIST1H2BL O2CO2HIST1H2BJ KDM4C KLK3 KLK2 Gene HIST1H2AC H2AFZ androst-4-en-3,17-dione KLK2,3 genesp-T774-PKN1:AR:Androgen:NCOA2HIST1H2BJ HIST3H2BB DHTEST H2AFZ NCOA2KLK2 Gene HIST1H2BN HIST2H2AC HIST1H2BJ HIST1H4 H2AFZ HIST2H2AC HIST2H2AA3 TEST HIST2H2BE AR HIST1H2BM DHTEST HIST1H2BA 6-Dehydrotestosterone Me3K-10-H3F3A HIST2H2AA3 p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1A211-7, 9-17, 19202020212120202020


PKN1, activated by phosphorylation at threonine T774, binds activated AR (androgen receptor) and promotes transcription from AR-regulated promoters. On one hand, phosphorylated PKN1 promotes the formation of a functional complex of AR with the transcriptional coactivator NCOA2 (TIF2) (Metzger et al. 2003). On the other hand, binding of phosphorylated PKN1, in complex with the activated AR, to androgen-reponsive promoters of KLK2 and KLK3 (PSA) genes, leads to PKN1-mediated histone phosphorylation. PKN1-phosphorylated histones recruit histone demethylases KDM4C (JMJD2C) and KDM1A (LSD1), and the ensuing demethylation of histones associated with the promoter regions of KLK2 and KLK3 genes increases their transcription (Metzger et al. 2005, Metzger et al. 2008). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 5625886
Reactome version: 61
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

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  1. Palmer RH, Dekker LV, Woscholski R, Le Good JA, Gigg R, Parker PJ.; ''Activation of PRK1 by phosphatidylinositol 4,5-bisphosphate and phosphatidylinositol 3,4,5-trisphosphate. A comparison with protein kinase C isotypes.''; PubMed Europe PMC Scholia
  2. Metzger E, Wissmann M, Yin N, Müller JM, Schneider R, Peters AH, Günther T, Buettner R, Schüle R.; ''LSD1 demethylates repressive histone marks to promote androgen-receptor-dependent transcription.''; PubMed Europe PMC Scholia
  3. Maesaki R, Ihara K, Shimizu T, Kuroda S, Kaibuchi K, Hakoshima T.; ''The structural basis of Rho effector recognition revealed by the crystal structure of human RhoA complexed with the effector domain of PKN/PRK1.''; PubMed Europe PMC Scholia
  4. Kato T, Gotoh Y, Hoffmann A, Ono Y.; ''Negative regulation of constitutive NF-kappaB and JNK signaling by PKN1-mediated phosphorylation of TRAF1.''; PubMed Europe PMC Scholia
  5. Hamaguchi T, Ito M, Feng J, Seko T, Koyama M, Machida H, Takase K, Amano M, Kaibuchi K, Hartshorne DJ, Nakano T.; ''Phosphorylation of CPI-17, an inhibitor of myosin phosphatase, by protein kinase N.''; PubMed Europe PMC Scholia
  6. Flynn P, Mellor H, Casamassima A, Parker PJ.; ''Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase.''; PubMed Europe PMC Scholia
  7. Collazos A, Michael N, Whelan RD, Kelly G, Mellor H, Pang LC, Totty N, Parker PJ.; ''Site recognition and substrate screens for PKN family proteins.''; PubMed Europe PMC Scholia
  8. Mukai H, Toshimori M, Shibata H, Takanaga H, Kitagawa M, Miyahara M, Shimakawa M, Ono Y.; ''Interaction of PKN with alpha-actinin.''; PubMed Europe PMC Scholia
  9. Zong H, Raman N, Mickelson-Young LA, Atkinson SJ, Quilliam LA.; ''Loop 6 of RhoA confers specificity for effector binding, stress fiber formation, and cellular transformation.''; PubMed Europe PMC Scholia
  10. Matsuzawa K, Kosako H, Inagaki N, Shibata H, Mukai H, Ono Y, Amano M, Kaibuchi K, Matsuura Y, Azuma I, Inagaki M.; ''Domain-specific phosphorylation of vimentin and glial fibrillary acidic protein by PKN.''; PubMed Europe PMC Scholia
  11. Misaki K, Mukai H, Yoshinaga C, Oishi K, Isagawa T, Takahashi M, Ohsumi K, Kishimoto T, Ono Y.; ''PKN delays mitotic timing by inhibition of Cdc25C: possible involvement of PKN in the regulation of cell division.''; PubMed Europe PMC Scholia
  12. Metzger E, Yin N, Wissmann M, Kunowska N, Fischer K, Friedrichs N, Patnaik D, Higgins JM, Potier N, Scheidtmann KH, Buettner R, Schüle R.; ''Phosphorylation of histone H3 at threonine 11 establishes a novel chromatin mark for transcriptional regulation.''; PubMed Europe PMC Scholia