Activated PKN1 stimulates transcription of AR (androgen receptor) regulated genes KLK2 and KLK3 (Homo sapiens)

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18, 20, 2121208, 202018, 20218, 20202118, 2020cytosolnucleoplasmH2AFX p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12,Me3K-10-H3AR DHTEST H2AFZ HIST1H2AB HIST1H2BO RHO GTPases activatePKNsH2AFX HIST3H2BB HIST2H2AC p-T774-PKN1 androst-4-en-3,17-dione KLK2 Gene HIST2H2BE H2BFS DHTEST HIST1H2BB 6-Dehydrotestosterone KDM4C6-Dehydrotestosterone H2AFB1 p-T12,MeK-10-HIST1H3A HIST3H2BB KDM4C p-T774-PKN1 p-T12, Me2K-10-HIST2H3A HIST3H2BB H2AFV HIST1H2AD HIST1H2AD HIST1H2AC DHTEST HIST1H2BN KLK2 Gene AR DHTEST H2AFV TEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-H3p-T774-PKN1 HIST1H2BM H2AFZ HIST1H2AB HIST1H2AJ p-T774-PKN1androst-4-en-3,17-dione HIST1H2BK Me3K-10-HIST1H3A HIST1H2BB p-T12, Me2K-10-HIST1H3A HIST1H2AJ H2BFS 6-Dehydrotestosterone HIST2H2AC H2AFZ androst-4-en-3,17-dione p-T12, Me3K-10-HIST2H3A 6-Dehydrotestosterone H2BFS HIST2H2BE O2HIST1H2BD 6-Dehydrotestosterone HIST1H2BH AR H2AFB1 HIST1H2AC p-T12, Me2K-10-HIST2H3A HIST1H2BO p-T12-HIST2H3A HIST1H2BM KLK3 Gene H2AFX HIST1H2BC HIST2H2AA3 p-T774-PKN1 HIST1H2BC HIST1H2BB HIST1H2BN Me3K-10-HIST2H3A androst-4-en-3,17-dione KDM1AH2AFB1 HIST2H2AC AR HIST1H2BA HIST2H2AA3 6-Dehydrotestosterone 6-Dehydrotestosterone H2BFS NCOA2 HIST1H4 H2AFZ KLK2 Gene HIST1H2BJ HIST1H2AD HIST1H2BK KLK3 Gene AR DHTEST HIST2H2BE H2AFJ HIST3H2BB HIST1H2BD HIST1H2BL HIST1H2AJ TEST p-T12, Me2K-10-H3F3A SUCCAHIST1H2BC H2AFJ HIST1H2AC HIST1H2BM androst-4-en-3,17-dione H2AFX HIST1H2BN HIST1H2BK p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,MeK-10-H3:KDM1Aandrost-4-en-3,17-dione O2KLK3 Gene androst-4-en-3,17-dione H2AFB1 HIST1H2BK p-T12,MeK-HIST2H3A HIST1H2BJ TEST HIST1H2BL CH2OKLK3 Gene TEST HIST1H2BL HIST2H2AA3 KDM1A HIST2H2AA3 p-T12-HIST1H3A KLK2 Gene 2OGKLK3 Gene HIST1H2AB HIST2H2BE KLK3 Gene HIST1H2AJ Me3K-10-H3F3A HIST1H2BN HIST2H2AA3 H2AFV KLK3 Gene HIST2H2AC p-T774-PKN1 HIST1H2BK HIST1H2AB HIST1H2BJ AR androst-4-en-3,17-dione HIST1H2BB H2AFZ Me3K-10-HIST2H3A KLK3 HIST2H2AC HIST1H2AC TEST NCOA2HIST1H2BD HIST2H2AC AR 2OGKLK2 Gene HIST1H2BA HIST3H2BB DHTEST H2AFJ p-T12,Me3K-10-H3F3A H2BFS HIST1H4 H2AFB1 6-Dehydrotestosterone H2AFV HIST1H2BH HIST1H2AB HIST1H2BK H2AFJ HIST2H2BE androst-4-en-3,17-dione HIST1H2AJ p-T12, Me2K-10-H3F3A HIST1H2BB HIST1H2BD KLK2,KLK3H2AFX AR HIST1H2BA HIST3H2BB HIST1H2AJ HIST1H4 p-T12, Me3K-10-HIST1H3A H2AFZ SUCCAHIST1H4 androst-4-en-3,17-dione HIST1H2BN HIST1H2BJ HIST1H2AD H2AFV HIST1H2AB HIST1H2BL KLK2 Gene HIST1H2BJ HIST1H2BC H2AFJ HIST1H2BM TEST CO2HIST1H2BH HIST1H4 p-T12, Me3K-10-HIST2H3A HIST1H2AD H2AFB1 KLK2 Gene HIST1H2BA p-T774-PKN1:AR:Androgen6-Dehydrotestosterone AR:AndrogenKLK2 Gene HIST1H2AB HIST1H2BC HIST1H2BO H2AFV TEST H2AFZ HIST1H2BM HIST2H2AA3 p-T12, Me3K-10-HIST1H3A 2OGp-T774-PKN1 KLK2,3Gene:Nucleosomewith Me3K-10-H3KLK2 Gene Me3K-10-HIST1H3A HIST1H2BA HIST3H2BB HIST1H2BO HIST1H2BN HIST1H2BD HIST1H2BM HIST2H2AC androst-4-en-3,17-dione HIST2H2AA3 DHTEST DHTEST HIST1H2BK DHTEST AR H2AFZ p-T774-PKN1 HIST1H2BL HIST1H2AC H2BFS HIST1H2BO HIST1H2BA HIST1H2BB HIST2H2AC HIST1H2BM KLK3 Gene p-T12-H3F3A H2BFS p-T12,Me3K-10-H3F3A HIST1H2BH HIST1H2AD 6-Dehydrotestosterone AR ADPHIST1H2BH TEST p-T774-PKN1:AR:Androgen:KLK2,KLK3 Gene:Nucleosome with p-T12,Me2K-10-H3:KDM1ACH2O6-Dehydrotestosterone HIST2H2BE p-T774-PKN1:AR:AndrogenH2AFV HIST2H2BE p-T774-PKN1 HIST1H2BL H2BFS CO2HIST1H2BH H2AFB1 SUCCAKDM1A DHTEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with Me3K-10-H3HIST1H2BH HIST1H2BJ H2AFX p-T774-PKN1 HIST1H2BN HIST1H2BD Me3K-10-H3F3A O2HIST1H2BN HIST1H2BC AR HIST1H2BO HIST1H4 TEST KLK2 HIST1H4 KLK2,3 genesp-T12, Me2K-10-HIST1H3A HIST1H4 HIST1H2AD HIST1H2BD HIST1H2BC HIST1H2BO H2AFJ HIST1H2AC HIST1H2BD p-T12,MeK-H3F3A CH2OHIST2H2AA3 HIST1H2BL HIST1H2BM HIST1H2AJ HIST1H2AB HIST1H2BJ H2AFB1 HIST1H2AD KLK3 Gene HIST1H2BJ HIST1H2BA HIST1H2AC DHTEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12-Me2K-10-H3H2AFJ HIST1H2BC p-T774-PKN1:AR:Androgen:NCOA2TEST H2AFX HIST1H2BA H2AFJ H2AFV HIST1H2BK HIST1H2AC HIST1H2BH TEST p-T774-PKN1:AR:Androgen:KLK2,3 Gene:Nucleosome with p-T12, Me3K-10-H3:KDM4CHIST1H2BL CO2HIST1H2BO HIST3H2BB HIST1H2BB HIST2H2BE HIST1H2AJ HIST1H2BB H2AFX ATPp-T774-PKN1 20212020212021201-7, 9-17, 192020


PKN1, activated by phosphorylation at threonine T774, binds activated AR (androgen receptor) and promotes transcription from AR-regulated promoters. On one hand, phosphorylated PKN1 promotes the formation of a functional complex of AR with the transcriptional coactivator NCOA2 (TIF2) (Metzger et al. 2003). On the other hand, binding of phosphorylated PKN1, in complex with the activated AR, to androgen-reponsive promoters of KLK2 and KLK3 (PSA) genes, leads to PKN1-mediated histone phosphorylation. PKN1-phosphorylated histones recruit histone demethylases KDM4C (JMJD2C) and KDM1A (LSD1), and the ensuing demethylation of histones associated with the promoter regions of KLK2 and KLK3 genes increases their transcription (Metzger et al. 2005, Metzger et al. 2008). View original pathway at:Reactome.


Pathway is converted from Reactome ID: 5625886
Reactome version: 61
Reactome Author 
Reactome Author: Orlic-Milacic, Marija

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