GPCRs, class B secretin-like (Homo sapiens)

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Class B orphan/otherSecretinGrowth hormone-releasing hormoneCorticotropin releasing factorGastric inhibitory peptideCalcitoninVasoactive intestinal polypeptideParathyroid hormoneDiuretic hormoneEMR1LatrophilinGlucagonPACAPGLP2RADCYAP1R1LPHN1CD97GLP1RSCTRPTHR2LPHN3EMR2GIPRCRHR1PTHR1VIPR1CALCRGHRHRVIPR2CRHR2EMR1GPR64GCGRELTD1CD97CALCRLLPHN2


This pathway was created using the GPCRDB (Horn et al., 1998), (originally at The groupings are based on the GPCR phylogenetic tree available from the GPCRDB and the training sets used by Karchin et al. (Bioinformatics, 2002, pg. 147-159). The labels indicate children and grandchildren of the various classes of GPCRs as described by these references.

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Ontology Terms



  1. Karchin R, Karplus K, Haussler D; ''Classifying G-protein coupled receptors with support vector machines.''; Bioinformatics, 2002 PubMed Europe PMC Scholia
  2. Horn F, Weare J, Beukers MW, Hörsch S, Bairoch A, Chen W, Edvardsen O, Campagne F, Vriend G; ''GPCRDB: an information system for G protein-coupled receptors.''; Nucleic Acids Res, 1998 PubMed Europe PMC Scholia


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117741view12:44, 22 May 2021EweitzModified title
79716view08:40, 6 April 2015EgonwAdded the two references cited in the Description.
79713view08:33, 6 April 2015EgonwModified description
63204view20:56, 8 May 2013MaintBotUpdating gpml version
45339view20:22, 7 October 2011AlexanderPicoOntology Term : 'G protein mediated signaling pathway' added !
41173view23:42, 1 March 2011MaintBotRemoved redundant pathway information and comments
38916view20:52, 24 September 2010Khanspers
34572view22:03, 21 December 2009KhanspersModified description
34532view18:52, 21 December 2009KhanspersModified description
34531view18:51, 21 December 2009KhanspersMoved comment to Description
34530view18:50, 21 December 2009KhanspersModified description
34527view18:13, 21 December 2009Khanspersremoved label
34516view20:05, 18 December 2009KhanspersChanges to label
34515view20:03, 18 December 2009Khanspersminor layout change
34514view20:00, 18 December 2009KhanspersAdded label
32401view17:02, 15 August 2009MaintBotFixed text labels
32053view13:31, 14 August 2009MaintBotFixed group labels
21381view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:GPCRDB Class B Secretin-like]] moved to [[Pathway:WP334]]: Moved to stable identifier
14201view01:03, 22 May 2008AlexanderPicoFixed labels
14199view01:03, 22 May 2008AlexanderPicoGrouped by class
12993view11:00, 17 May 2008MaintBotSticky edges patch by Sjoerd
8108view13:46, 7 January 2008MaintBot[[Pathway:Human:GPCRDB Class B Secretin-like]] moved to [[Pathway:Homo sapiens:GPCRDB Class B Secretin-like]]: Renaming species
7675view16:09, 18 December 2007MaintBotfixed category names
7419view12:42, 4 November 2007MaintBotAdded categories to GPML
19487view22:17, 22 May 2007BruceConklingpml file for [[Human:GPCRDB_Class_B_Secretin-like]]
6322view22:17, 22 May 2007Nsalomonisgpml file for [[Human:GPCRDB_Class_B_Secretin-like]]

External references


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NameTypeDatabase referenceComment
ADCYAP1R1GeneProduct117 (Entrez Gene)
CALCRGeneProduct799 (Entrez Gene)
CALCRLGeneProduct10203 (Entrez Gene)
CD97GeneProduct976 (Entrez Gene)
CRHR1GeneProduct1394 (Entrez Gene)
CRHR2GeneProduct1395 (Entrez Gene)
ELTD1GeneProduct64123 (Entrez Gene)
EMR1GeneProduct2015 (Entrez Gene)
EMR2GeneProduct30817 (Entrez Gene)
GCGRGeneProduct2642 (Entrez Gene)
GHRHRGeneProduct2692 (Entrez Gene)
GIPRGeneProduct2696 (Entrez Gene)
GLP1RGeneProduct2740 (Entrez Gene)
GLP2RGeneProduct9340 (Entrez Gene)
GPR64GeneProduct10149 (Entrez Gene)
LPHN1GeneProduct22859 (Entrez Gene)
LPHN2GeneProduct23266 (Entrez Gene)
LPHN3GeneProduct23284 (Entrez Gene)
PTHR1GeneProduct5745 (Entrez Gene)
PTHR2GeneProduct5746 (Entrez Gene)
SCTRGeneProduct6344 (Entrez Gene)
VIPR1GeneProduct7433 (Entrez Gene)
VIPR2GeneProduct7434 (Entrez Gene)

Annotated Interactions

No annotated interactions

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