Signaling by FGFR4 (Homo sapiens)

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6, 32, 44, 46, 80...85, 9235, 78751, 84, 90, 917410, 38, 82, 87749, 58, 7156, 63, 704, 8674939, 15, 33, 718, 30, 35, 787514, 35, 376927, 30, 35, 5454, 58, 7830, 4640, 526934, 7031, 43, 83, 895921, 25, 27, 646936, 535, 13, 26, 28, 7921, 27, 6412, 328, 1917, 3630, 4614, 19, 48, 5030, 4618, 22, 55, 60, 72...798, 21, 30, 47, 88408, 35, 8821, 25, 27, 6531, 43, 83, 84, 89...4, 49, 5274364, 63, 863, 76cytosolPPP2R1A FGF9 FGF20 SHC1-2 FGF16 UBC(381-456) PPP2CB p5Y-FGFR4 Y367C mutant PPA2A(A:C):S112/S115p-SPRY2FGF18 ActivatedFGFR4:p-FRS2:p-PPTN11:p-CBL:GRB2PPP2R1A FGF4 FGF17-1 HS FGFR4-binding FGFsp-6Y-FRS2 FGF18 PI(3,4,5)P3 ATPUBA52(1-76) FGF1 GalNAc-T178-FGF23(25-251) PIP3 activates AKTsignalingKLB FGF1 PPP2CA FGF19 FGF16 GalNAc-T178-FGF23(25-251) S111/S120p-SPRY2:B-RAFFGF9 PPP2R1A FGF1 GRB2-1 FGF17-1 UBC(229-304) FGF2(10-155) FGF4 KLB ATPp-5Y-FGFR4 p-5Y-FGFR4 UBB(1-76) GRB2-1 SPRY2 PPP2R1A FGF8-1 FGF18 FGF2(10-155) ADPFGF2(10-155) p-5Y-FGFR4 N535K CBL FGF1 FGFR4:HS:KLB:FGF19FGF8-1 p-Y55,Y227-SPRY2 FGF17-1 GalNAc-T178-FGF23(25-251) FGF17-1 FGF6 UBC(77-152) GRB2-1 p-5Y-FGFR4 FGF20 KLB FGF17-1 UBB(77-152) FGF18 FGF1 KLB GalNAc-T178-FGF23(25-251) FGFR4 N535K Y55/Y227-pSPRY2:CBLFGF20 p-5Y-FGFR4 UBB(1-76) KLB FGF17-1 PPA2A (A:C):Y55/Y227p-SPRY2:GRB2Activated FGFR4mutants:p-4Y-PLCG1KLB ATPFGF17-1 FGF16 FGF8-1 GRB2-1:SOS1FGF1 PPP2CA ActivatedFGFR4:p-FRS2:GRB2:SOS1FGF9 HS UBC(1-76) FGF2(10-155) FGF17-1 FGF8-1 Activated FGFR4mutants:PLCG1PiGalNAc-T178-FGF23(25-251) FGF16 UBB(1-76) FGF17-1 GalNAc-T178-FGF23(25-251) p5Y-FGFR4 Y367C mutant ADPp-6Y-FRS2 FGF20 UBC(1-76) SHC1-3 KLB FGF9 FGFR4 Y367C mutantdimerGalNAc-T178-FGF23(25-251) HRAS FGF20 FGF1 FGF8-1 ActivatedFGFR4:p-FRS2:p-PTPN11PPP2CA FGF4 p-5Y-FGFR4 FGF16 p-6Y-FRS2 FGF16 FGF9 FGF8-1 FGF4 RPS27A(1-76) FGFR4 N535D PP2A(A:C):SPRY2PIK3R1 PLCG1PPP2CA p-5Y-FGFR4 FGF6 p-Y371-CBL FGF18 p-T185,Y187-MAPK1 ADPp-5Y-FGFR4 Activated FGFR4enhanced kinasemutantsPIK3R1 FGFR4FGF8-1 p-4Y-PLCG1 SPRY2:B-RAFp-4Y-PLCG1 FGF17-1 FGF6 HS p-S111,S120-SPRY2FGF16 UBA52(1-76) FGF1 FGF8-1 FGF19 FGF19 FGFR4 mutant dimerswith enhancedkinaseactivity:PD173074PP2A (A:C)p-5Y-FGFR4 p-Y546,Y584-PTPN11 KLB KLBHS FGF18 FGF19 PIK3R1 GalNAc-T178-FGF23(25-251) FGFR4 V550L FGF6 FGF1 GRB2-1 FGF18 ATPFGF6 p-Y371-CBL:GRB2FGF16 UBC(609-684) GalNAc-T178-FGF23(25-251) UBC(533-608) NRAS UBB(1-76) HS GalNAc-T178-FGF23(25-251) UbUBC(1-76) FGF16 FGF8-1 Activated FGFR4:SHC1ATPp-6Y-FRS2 ActivatedFGFR4:p-FRS:p-PTPN11FGF19 KLB FGF19KLB FGF6 FGF20 p-6Y-FRS2 FGF20 FGF16 UBC(305-380) FGF9 FGF19 KLB FGF19 p-Y546,Y584-PTPN11 UBA52(1-76) GAB1 FGF18 KLB SPRY2 UBC(457-532) NRAS FGF20 activatedFGFR4:p-4Y-PLCG1GRB2-1 PPP2CB SOS1 FGF19 HS GalNAc-T178-FGF23(25-251) FGF9 Activated FGFR4HSFGF19 GDPFGF20 FGF4 FGF9 UBB(153-228) FGFR4 V550L FGF17-1 FGF1 ADPKLB UBC(153-228) FGF6 HS Ub-Activated FGFR4complex:Ub-p-FRS2FGFR4 enhancedkinase mutantsHS HS UBC(533-608) PPA2A(A:C):SPRY2FGF18 FGFR4 FGF18 FGF2(10-155) UBC(153-228) RPS27A(1-76) FGF20 FGF8-1 FGF1 FGF20 FGF4 ADPFGF2(10-155) p-5Y-FGFR4 FGF16 p-6Y-FRS2 GalNAc-T178-FGF23(25-251) activatedFGFR4:PLCG1p-5Y-FGFR4 KLB FGF20 p-6Y-FRS2 HS FGF4 UBB(77-152) PPP2CA FGF1 RAF/MAP kinasecascadep-Y55,Y227-SPRY2 p-8T-FRS2 FRS2UBC(533-608) HS FGF18 PD173074 GAB1 FGF1 FGF16 p-T,Y MAPK dimersATPFGF20 FGFR4 GalNAc-T178-FGF23(25-251) UBC(609-684) GAB1 FGF17-1 PLCG1 Activated FGFR4 enhanced kinase mutants FGF8-1 ATPFGF19 ATPFGF19 UBC(229-304) FGF2(10-155) HS FGF8-1 FGF2(10-155) UBC(381-456) FGF19 UBC(1-76) GalNAc-T178-FGF23(25-251) FGF17-1 FGF2(10-155) HS PIK3CA FGF20 ActivatedFGFR4:p-FRS3FGF18 UBC(305-380) ADPFGF9 FGF6 CBLp-S112,S121-SPRY2 FGF6 Ub-(Y55/Y227)p-SPRY2ActivatedFGFR4:pY-SHC1:GRB2:SOS1PIK3R1 PPP2R1A GRB2-1FGF20 PPP2CB UBB(1-76) GRB2-1 FGF18 HS FGF8-1 FGFR4 enhancedkinase mutantdimersFGF17-1 GTP PTPN11 PPP2CA DAG and IP3signalingFGF4 GRB2-1 RPS27A(1-76) FGF20 GRB2:GAB1ActivatedFGFR4:p-FRS:PTPN11p-Y546,Y584-PTPN11 KLB HS PI(3,4,5)P3FGF16 FGF8-1 p-5Y-FGFR4 V550L p-5Y-FGFR4 PPP2R1A GAB1 ActivatedFGFR4:p-FRS2HS FGF18 ActivatedFGFR4:pY-SHC1FGF6 GRB2-1 FGF6 FGFR4 N535D FGF19 KLB p-S112,S115-SPRY2 FGF6 FRS2 FGF2(10-155) FGFR4 V550L FGF4 UBC(609-684) UBC(305-380) p-Y371-CBL FGF1 FGF20 UBB(153-228) PPP2CA FGF17-1 FGF1 FGF19 GalNAc-T178-FGF23(25-251) FGF9 p-Y546,Y584-PTPN11 p21 RAS:GDPUBC(229-304) Activated FGFR4 enhanced kinase mutants GRB2:GAB1:PIK3R1FGF19 FGF4 FGF9 FGF17-1 Activated FGFR4 enhanced kinase mutants FGF1 UBB(77-152) FGF6 p-6Y-FRS2 HS UBC(533-608) UbFGFR4 V550E KRAS p5Y-FGFR4 Y367C mutant p-5Y-FGFR4 GalNAc-T178-FGF23(25-251) PPP2CB KLB GalNAc-T178-FGF23(25-251) p-5Y-FGFR4 FGF2(10-155) FGF4 FGF4 ADPp-5Y-FGFR4 FGF6 FGF1 CBL FGF8-1 FGF6 FGF16 GalNAc-T178-FGF23(25-251) FGF1 ActivatedFGFR4:p-FRS2:GRB2:GAB1:PI3KFGF2(10-155) ADPHS FGF9 p-Y546,Y584-PTPN11 Activated FGFR4Y367C mutantBRAF UBC(229-304) FGF9 FGF8-1 FGF6 FGF20 FGFR4 Y367CHS HS p-5Y-FGFR4 p-Y239,Y240,Y317-SHC1-2 FGF16 PIK3R1HS FGF2(10-155) UBB(153-228) FGF19 ATPFGF8-1 FGF6 GRB2-1 p-Y239,Y240,Y317-SHC1-2 FGF6 UBC(153-228) FGF2(10-155) Activated FGFR4bound toFGF19:BetaKlothoUBC(457-532) ATPFGF4 SOS1 FGF18 FGF6 p-T250,T255,T385,S437-MKNK1FGF1 HRAS FGF16 FGF18 FGF18 ADPp-5Y-FRS3 UBB(153-228) ATPRPS27A(1-76) p-5Y-FRS3 UBC(1-76) FGF20 PI(3,4,5)P3 KLB FGF16 FGF18 GAB1 SHC1-2 FGF6 FGF17-1 KLB Activated FGFR4:FRS3p21 RAS:GTPFGF17-1 HS FGF19 FGF17-1 HS FGF19 UBC(533-608) UBC(77-152) FGF17-1 FGF17-1 PPP2CB FGF2(10-155) Activated FGFR4:FRS2FGF20 p-5Y-FGFR4 GalNAc-T178-FGF23(25-251) FGF19 GalNAc-T178-FGF23(25-251) FGF9 FGF8-1 p-5Y-FGFR4 FGF18 KLB FGF1 FGF2(10-155) FRS3UBA52(1-76) ADPFGF2(10-155) BRAFActivatedFGFR4:p-FRSUBC(77-152) FGF6 Activated FGFR4mutantsp-5Y-FRS3 FGF6 KRAS GAB1 p-6Y-FRS2 FGF19 FGF20 FGF9 FGF1 p-Y55,Y227-SPRY2 FGF9 FGF17-1 FGF19 ActivatedFGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PI3Kp-5Y-FGFR4 p-4Y-PLCG1GalNAc-T178-FGF23(25-251) PPP2CB FGF20 GalNAc-T178-FGF23(25-251) FRS3 SPRY2 FGF18 FGF8-1 p-6Y-FRS2 FGF16 ActivatedFGFR4:p-FRS2:GRB2:GAB1:PIK3R1p-5Y-FGFR4 V550E HSFGF18 FGF8-1 UBC(381-456) SHC1-2,SHC1-3ADPUBC(609-684) FGF16 GRB2-1 GalNAc-T178-FGF23(25-251) HS FGF2(10-155) FGF18 p-S111,S120-SPRY2 FGFR4 homodimerbound to FGFFGF6 FGF19 p-5Y-FRS3 PIK3R1 p-5Y-FGFR4 FGF4 GalNAc-T178-FGF23(25-251) FGF16 UBC(153-228) FGF9 p-5Y-FGFR4 PP2A(A:C):Y55/Y227-pSPRY2p-5Y-FGFR4 FGF9 p-5Y-FRS3 FGF16 FGF4 PTPN11UBC(609-684) GRB2-1 PI(3,4,5)P3FGF9 FGF18 UBB(77-152) FGFR4 V550E UBC(457-532) p-6Y-FRS2 FGF4 FGF9 UBB(153-228) PD173074FGF16 FGF19 UBC(457-532) FGF1 FGF20 UBC(381-456) p-Y546,Y584-PTPN11 FGF4 FGF9 p-5Y-FGFR4 FGF16 FGF9 HS KLB UBA52(1-76) KLB GRB2-1 UBC(229-304) UBC(77-152) KLB FGF9 FGF8-1 PI(4,5)P2Activated FGFR4homodimerFGFR4 N535K UBC(381-456) FGF9 FGF16 SOS1 FGF18 FGF20 UBC(77-152) FGF4 FGF2(10-155) FGF2(10-155) p5Y-FGFR4 Y367C mutant FGFR4 N535K PIK3CA GRB2-1 FGF19 UBC(305-380) FGF1 UBC(153-228) FGF19 FGF4 p-5Y-FGFR4 FGF20 Ub:Y55/Y227-pSPRY2:CBLFGF17-1 FGF6 FGFR4 N535D FGF4 ActivatedFGFR4:p-8T-FRS2FGF2(10-155) p-5Y-FGFR4 N535D KLB FGF6 FGF4 SHC1-3 FGF1 FGF1 p-5Y-FGFR4 FGF4 FGF2(10-155) PPP2R1A UBC(457-532) FGF19 BRAF FGF4 FGF16 p-Y55,Y227-SPRY2 PP2A(A:C):S112/S121-pSPRY2p-Y194,Y195,Y272-SHC1-3 RPS27A(1-76) FGF2(10-155) UBB(77-152) FGF2(10-155) GTPFGF8-1 p-6Y-FRS2 ActivatedFGFR4:p-FRS2:p-PTPN11:GRB2:GAB1:PIK3R1FGFR4 V550E PIK3CAp-Y194,Y195,Y272-SHC1-3 UBC(305-380) ADPp-Y371-CBL GalNAc-T178-FGF23(25-251) GDP PLCG1 FGF2(10-155) p-Y55,Y227-SPRY2 SRC-1FGF4 FGFR4 Y367C FGF8-1 FGF8-1 FGF4 ATPPPP2CB FGF19 FGF17-1 FGF8-1 FGF18 p-T202,Y204-MAPK3 FGF17-1 FGF9 403669361911, 16, 20, 23, 24, 42...3669696969366979696931, 43, 83, 896969797, 29, 39, 5141696969697, 29, 39, 51692, 75696957