RAC1/PAK1/p38/MMP2 Pathway (Homo sapiens)

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1NucleusRS1ProteasomedegradationFN1MAPK11MAPK12EGFRNCK1KRASNOS1MAPK8SHP2PIK3RRELAANG1NRASPXNMAPK14IKBKGRegulation of Actin CytoskeletonEIF4EBP1MAPK1GRB14PIP2AKTCASP7ERK2ABIN-2DOKRTP53ERK1MAPK14ABIN-1SOS1PAK1SRCMSH2MYCMapkYAP1VaculogenesisIKBJNKPck(s)GRB7RAC1IKK1CTNNB1IKK2ERBB2TEKANG4PIP3BAXCell migration,survival and cell-cell interactionANG3PI3K/p110FKHRANG2CASP9NFKB1ABIN-3BADIntegrinMAPK13RasGAPSTMN1SAPKPIK3/p85STAT3TIE1HRASSurvivinSTAT5ARAD51ERK1ERK2PPPGRB2PCRKPAK1STAT5BNFKB1IKBPFAKNOS2Angiogenesis


Description

Interplay of RAC1, p38 MAPK, PAK1 and MMP2 in cell signaling pathways downstream of TEK receptor activity related to tumor growth, angiogenesis, and cell proliferation. These processes are reduced in RAC1 inactivated models of ovarian cancer. Gonzalez-Villasana, et al. Clin Cancer Res, 2015.

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Ontology Terms

 

Bibliography

  1. Gonzalez-Villasana V, Fuentes-Mattei E, Ivan C, Dalton HJ, Rodriguez-Aguayo C, Fernandez-de Thomas RJ, Aslan B, Del C Monroig P, Velazquez-Torres G, Previs RA, Pradeep S, Kahraman N, Wang H, Kanlikilicer P, Ozpolat B, Calin G, Sood AK, Lopez-Berestein G; ''Rac1/Pak1/p38/MMP-2 Axis Regulates Angiogenesis in Ovarian Cancer.''; Clin Cancer Res, 2015 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
108160view10:43, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106501view21:46, 4 September 2019KhanspersModified description
106169view12:06, 16 August 2019MaintBotHMDB identifier normalization
105800view22:49, 15 August 2019KhanspersModified description
96971view01:57, 24 April 2018AlexanderPicoadded MMP2 and bolded main axis
96970view01:53, 24 April 2018AlexanderPicoOntology Term : 'ovarian cancer' added !
96969view01:53, 24 April 2018AlexanderPicoModified title
96968view01:52, 24 April 2018AlexanderPicoModified description
94281view18:48, 30 August 2017KhanspersOntology Term : 'signaling pathway' added !
94280view18:48, 30 August 2017KhanspersModified description
94279view18:47, 30 August 2017Khanspersminor layout change
87628view08:54, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
83781view15:34, 4 December 2015SusanChanged ID and name of NEMO
81655view21:21, 21 August 2015Khanspers
81652view19:12, 21 August 2015MaintBotModified description
81307view23:49, 17 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
ABIN-1GeneProductENSG00000145901 (Ensembl)
ABIN-2GeneProductENSG00000168884 (Ensembl)
ABIN-3GeneProductENSG00000050730 (Ensembl)
AKTGeneProductENSG00000142208 (Ensembl)
ANG1GeneProductENSG00000154188 (Ensembl)
ANG2GeneProductENSG00000091879 (Ensembl)
ANG3GeneProductENSG00000116194 (Ensembl)
ANG4GeneProductENSG00000101280 (Ensembl)
AngiogenesisPathwayWP1539 (WikiPathways)
BADGeneProductENSG00000002330 (Ensembl)
BAXGeneProductENSG00000087088 (Ensembl)
CASP7GeneProductENSG00000165806 (Ensembl)
CASP9GeneProductENSG00000132906 (Ensembl)
CRKGeneProductENSG00000167193 (Ensembl)
CTNNB1GeneProductENSG00000168036 (Ensembl)
Cell migration,

survival and

cell-cell interaction
Pathway
DOKRGeneProductENSG00000147443 (Ensembl)
EGFRGeneProductENSG00000146648 (Ensembl)
EIF4EBP1GeneProductENSG00000187840 (Ensembl)
ERBB2GeneProductENSG00000141736 (Ensembl)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
FKHRGeneProductENSG00000150907 (Ensembl)
FN1GeneProductENSG00000115414 (Ensembl)
GRB14GeneProductENSG00000115290 (Ensembl)
GRB2GeneProductENSG00000177885 (Ensembl)
GRB7GeneProductENSG00000141738 (Ensembl)
HRASGeneProductENSG00000174775 (Ensembl)
IKBGeneProductENSG00000100906 (Ensembl)
IKBKGGeneProductENSG00000269335 (Ensembl)
IKK1GeneProductENSG00000213341 (Ensembl)
IKK2GeneProductENSG00000104365 (Ensembl)
IntegrinGeneProductENSG00000150093 (Ensembl)
JNKGeneProductENSG00000107643 (Ensembl)
KRASGeneProductENSG00000133703 (Ensembl)
MAPK11GeneProductENSG00000185386 (Ensembl)
MAPK12GeneProductENSG00000188130 (Ensembl)
MAPK13GeneProductENSG00000156711 (Ensembl)
MAPK14GeneProductENSG00000112062 (Ensembl)
MAPK1GeneProductENSG00000100030 (Ensembl)
MAPK8GeneProductENSG00000107643 (Ensembl)
MSH2GeneProductENSG00000095002 (Ensembl)
MYCGeneProductENSG00000136997 (Ensembl)
MapkGeneProduct
NCK1GeneProductENSG00000158092 (Ensembl)
NFKB1GeneProductENSG00000109320 (Ensembl)
NOS1GeneProductENSG00000089250 (Ensembl)
NOS2GeneProductENSG00000007171 (Ensembl)
NRASGeneProductENSG00000213281 (Ensembl)
PAK1GeneProductENSG00000149269 (Ensembl)
PI3K/p110GeneProductENSG00000121879 (Ensembl)
PIK3/p85GeneProductENSG00000145675 (Ensembl)
PIK3RGeneProductENSG00000145675 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PIP3MetaboliteHMDB04249 (HMDB)
PXNGeneProductENSG00000089159 (Ensembl)
Pck(s)GeneProduct
Proteasome degradationPathwayWP183 (WikiPathways)
RAC1GeneProductENSG00000136238 (Ensembl)
RAD51GeneProductENSG00000051180 (Ensembl)
RELAGeneProductENSG00000173039 (Ensembl)
RS1GeneProductENSG00000102104 (Ensembl)
RasGAPGeneProductENSG00000145715 (Ensembl)
Regulation of Actin CytoskeletonPathwayWP51 (WikiPathways)
SAPKGeneProduct5601 (Entrez Gene)
SHP2GeneProductENSG00000179295 (Ensembl)
SOS1GeneProductENSG00000115904 (Ensembl)
SRCGeneProductENSG00000197122 (Ensembl)
STAT3GeneProductENSG00000168610 (Ensembl)
STAT5AGeneProductENSG00000126561 (Ensembl)
STAT5BGeneProductENSG00000173757 (Ensembl)
STMN1GeneProductENSG00000117632 (Ensembl)
SurvivinGeneProductENSG00000089685 (Ensembl)
TEKGeneProductENSG00000120156 (Ensembl)
TIE1GeneProductENSG00000066056 (Ensembl)
TP53GeneProductENSG00000141510 (Ensembl)
VaculogenesisPathway
YAP1GeneProductENSG00000137693 (Ensembl)

Annotated Interactions

No annotated interactions

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