MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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1Increase cell motilityActivated JUN forms transcription complex with cofactorTNNC1 geneIncrease traction forceCofactorTroponin C mRNACAF-derived MFAP5Transcription of Troponin CExtracellular calcium sourceTroponin C interacts with F-actinCalcium selective/non-selectivecation channelOvarian Cancer CellITPR3ERKITGB3CREB5PRKCQPIP2IP3ITGAVTroponin CCa2+DAGPLCG1FAKRYR3JUNMFAP5Cancer-associated stromal fibroblasts(CAFs)PPCa2+Ca2+Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationFAKPPRKCQPPLCG1PTroponin CJUN geneCofactorCREB5PTranscription of JunCREB5ERKPCa2+Ca2+Troponin C mRNA


A graphical summary of the molecular signalling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

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Ontology Terms



  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia


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108104view10:16, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references


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NameTypeDatabase referenceComment
CREB5GeneProductENSG00000146592 (Ensembl)
Ca2+MetaboliteHMDB00464 (HMDB)
DAGMetaboliteHMDB07098 (HMDB)
ERKGeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

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