MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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(HMDB identifier normalization)
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal].</Comment>
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal].</Comment>
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     <Graphics CenterX="109.0" CenterY="320.5" Width="148.0" Height="27.0" ZOrder="32776" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle"/>
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     <Graphics CenterX="109.0" CenterY="320.5" Width="148.0" Height="27.0" ZOrder="32776" FillColor="ffffff" FontWeight="Bold" FontSize="12" Valign="Middle" />
   </Label>
   </Label>
   <Label TextLabel="Cofactor" GraphId="a937f" GroupRef="ad16b">
   <Label TextLabel="Cofactor" GraphId="a937f" GroupRef="ad16b">
-
     <Graphics CenterX="109.5" CenterY="599.0" Width="57.0" Height="20.0" ZOrder="32792" FillColor="cccccc" FontSize="10" Valign="Middle" ShapeType="Oval"/>
+
     <Graphics CenterX="109.5" CenterY="599.0" Width="57.0" Height="20.0" ZOrder="32792" FillColor="cccccc" FontSize="10" Valign="Middle" ShapeType="Oval" />
   </Label>
   </Label>
   <Label TextLabel="Transcription of Jun" GraphId="a8b4b">
   <Label TextLabel="Transcription of Jun" GraphId="a8b4b">
-
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   </Label>
   </Label>
   <Shape GraphId="aba9a">
   <Shape GraphId="aba9a">
-
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum"/>
+
     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Endoplasmic Reticulum" />
-
     <Graphics CenterX="358.89219101761563" CenterY="291.15478475817355" Width="256.0" Height="215.24468093154042" ZOrder="16384" FillColor="edeaea" FontSize="10" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="2.0" Color="c0c0c0" Rotation="0.6968727446734324"/>
+
     <Graphics CenterX="358.89219101761563" CenterY="291.15478475817355" Width="256.0" Height="215.24468093154042" ZOrder="16384" FillColor="edeaea" FontSize="10" Valign="Middle" ShapeType="Endoplasmic Reticulum" LineThickness="2.0" Color="c0c0c0" Rotation="0.6968727446734324" />
   </Shape>
   </Shape>
   <Shape GraphId="ef470">
   <Shape GraphId="ef470">
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     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus"/>
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     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Nucleus" />
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     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/>
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     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
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   </Shape>
   </Shape>
   <Shape GraphId="f85d7">
   <Shape GraphId="f85d7">
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     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell"/>
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     <Attribute Key="org.pathvisio.CellularComponentProperty" Value="Cell" />
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     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double"/>
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     <Attribute Key="org.pathvisio.DoubleLineProperty" Value="Double" />
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   </Shape>
-
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+
   <Group GroupId="a1d2b" GraphId="b2dde" Style="Group" />
-
   <Group GroupId="f6235" GraphId="c981f" Style="Group"/>
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   <Group GroupId="f6235" GraphId="c981f" Style="Group" />
-
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+
   <Group GroupId="ad16b" GraphId="ce904" Style="Group" />
-
   <Group GroupId="b680b" GraphId="d046d" Style="Complex"/>
+
   <Group GroupId="b680b" GraphId="d046d" Style="Complex" />
-
   <Group GroupId="b1e44" GraphId="e0815" Style="Group"/>
+
   <Group GroupId="b1e44" GraphId="e0815" Style="Group" />
-
   <Group GroupId="b25b4" GraphId="e7e86" Style="Group"/>
+
   <Group GroupId="b25b4" GraphId="e7e86" Style="Group" />
-
   <Group GroupId="d348f" GraphId="f3b2d" Style="Group"/>
+
   <Group GroupId="d348f" GraphId="f3b2d" Style="Group" />
-
   <Group GroupId="a9c7c" GraphId="fe0f2" Style="Group"/>
+
   <Group GroupId="a9c7c" GraphId="fe0f2" Style="Group" />
-
   <InfoBox CenterX="0.0" CenterY="0.0"/>
+
   <InfoBox CenterX="0.0" CenterY="0.0" />
   <Biopax>
   <Biopax>
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
     <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
-
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease of cellular proliferation</bp:TERM>
+
       <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">ovarian cancer</bp:TERM>
-
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:14566</bp:ID>
+
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:2394</bp:ID>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
Line 515: Line 515:
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
       <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">PW:0000013</bp:ID>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
       <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Pathway Ontology</bp:Ontology>
 +
    </bp:openControlledVocabulary>
 +
    <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#">
 +
      <bp:TERM xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">disease of cellular proliferation</bp:TERM>
 +
      <bp:ID xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">DOID:14566</bp:ID>
 +
      <bp:Ontology xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Disease</bp:Ontology>
     </bp:openControlledVocabulary>
     </bp:openControlledVocabulary>
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0f">
     <bp:PublicationXref xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#" xmlns:rdf="http://www.w3.org/1999/02/22-rdf-syntax-ns#" rdf:id="a0f">
Line 536: Line 541:
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mok SC</bp:AUTHORS>
       <bp:AUTHORS rdf:datatype="http://www.w3.org/2001/XMLSchema#string">Mok SC</bp:AUTHORS>
     </bp:PublicationXref>
     </bp:PublicationXref>
-
   <bp:openControlledVocabulary xmlns:bp="http://www.biopax.org/release/biopax-level3.owl#"><bp:TERM>ovarian cancer</bp:TERM><bp:ID>DOID:2394</bp:ID><bp:Ontology>Disease</bp:Ontology></bp:openControlledVocabulary></Biopax>
+
   </Biopax>
</Pathway>
</Pathway>

Revision as of 12:09, 16 August 2019

1Ovarian Cancer CellCalcium selective/non-selectivecation channelActivated JUN forms transcription complex with cofactorIncrease cell motilityCofactorTranscription of Troponin CIncrease traction forceExtracellular calcium sourceTroponin C interacts with F-actinTNNC1ITPR3IP3JUNRYR3PIP2FAKMFAP5PRKCQPLCG1Ca2+DAGITGAVCREB1ITGB3ERK2Troponin CPCancer-associated stromal fibroblasts(CAFs)PCa2+Ca2+Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationFAKPPRKCQPPLCG1PTroponin CCofactorCREB1PTranscription of JunCREB1ERK2PCa2+Ca2+JUNERK1ERK1P


Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in Leung et al.

This pathway is part the CPTAC Assay Portal.

Quality Tags

Ontology Terms

 

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC

History

View all...
CompareRevisionActionTimeUserComment
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteHMDB0007098 (HMDB)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
TNNC1GeneProductENSG00000114854 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

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