MFAP5-mediated ovarian cancer cell motility and invasiveness (Homo sapiens)

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(HMDB identifier normalization)
(Modified description)
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Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al].
Based on figure 6c in [https://www.ncbi.nlm.nih.gov/pubmed/25277212 Leung et al].
-
This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal].</Comment>
+
Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3301 CPTAC Assay Portal]</Comment>
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Revision as of 21:02, 12 September 2019

1Troponin C interacts with F-actinCalcium selective/non-selectivecation channelIncrease cell motilityIncrease traction forceOvarian Cancer CellActivated JUN forms transcription complex with cofactorTranscription of Troponin CCofactorExtracellular calcium sourceMFAP5Ca2+FAKTroponin CPRKCQITGB3DAGPLCG1CREB1PIP2RYR3TNNC1ITPR3IP3JUNERK2ITGAVCancer-associated stromal fibroblasts(CAFs)PPCa2+Ca2+Ca2+Ca2+Ca2+ERIncreased cytoplasmicCa2+ concentrationFAKPPRKCQPPLCG1PTroponin CCofactorCREB1PTranscription of JunCREB1ERK2PCa2+Ca2+JUNERK1ERK1P


Description

A graphical summary of the molecular signaling events involved in MFAP5-mediated ovarian cancer cell motility and invasiveness.

Based on figure 6c in Leung et al.

This pathway is part the CPTAC Assay Portal.

Quality Tags

Ontology Terms

 

Bibliography

  1. Leung CS, Yeung TL, Yip KP, Pradeep S, Balasubramanian L, Liu J, Wong KK, Mangala LS, Armaiz-Pena GN, Lopez-Berestein G, Sood AK, Birrer MJ, Mok SC; ''Calcium-dependent FAK/CREB/TNNC1 signalling mediates the effect of stromal MFAP5 on ovarian cancer metastatic potential.''; Nat Commun, 2014 PubMed Europe PMC Scholia

History

View all...
CompareRevisionActionTimeUserComment
108104view10:16, 29 November 2019FehrhartOntology Term : 'cancer pathway' added !
106638view21:02, 12 September 2019KhanspersModified description
106199view12:09, 16 August 2019MaintBotHMDB identifier normalization
105459view05:09, 8 August 2019KhanspersModified description
103743view20:48, 2 April 2019KhanspersModified description
103742view20:47, 2 April 2019KhanspersModified description
97674view11:23, 1 June 2018AMTanOntology Term : 'ovarian cancer' added !
94277view18:09, 30 August 2017Khanspersphosphorylations, updated for clarity
87836view11:46, 25 July 2016ElisaOntology Term : 'disease of cellular proliferation' added !
87835view11:46, 25 July 2016ElisaOntology Term : 'disease pathway' added !
81279view04:54, 14 August 2015KhanspersModified description
81278view04:52, 14 August 2015KhanspersNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
CREB1GeneProductENSG00000118260 (Ensembl)
Ca2+MetaboliteHMDB0000464 (HMDB)
DAGMetaboliteHMDB0007098 (HMDB)
ERK1GeneProductENSG00000102882 (Ensembl)
ERK2GeneProductENSG00000100030 (Ensembl)
FAKGeneProductENSG00000169398 (Ensembl)
IP3Metabolite85166-31-0 (CAS)
ITGAVGeneProductENSG00000138448 (Ensembl)
ITGB3GeneProductENSG00000259207 (Ensembl)
ITPR3GeneProductENSG00000096433 (Ensembl)
JUNGeneProductENSG00000177606 (Ensembl)
MFAP5GeneProductENSG00000197614 (Ensembl)
PIP2Metabolite245126-95-8 (CAS)
PLCG1GeneProductENSG00000124181 (Ensembl)
PRKCQGeneProductENSG00000065675 (Ensembl)
RYR3GeneProductENSG00000198838 (Ensembl)
TNNC1GeneProductENSG00000114854 (Ensembl)
Troponin CGeneProductENSG00000114854 (Ensembl)

Annotated Interactions

No annotated interactions

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