Melatonin metabolism and effects (Homo sapiens)

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   <Comment Source="WikiPathways-description">Melatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptophan which is catalyzed to serotonin. AANAT and ASMT catalyze the reaction to N-acetylserotonin and melatonin, respectively. Melatonin is mainly discarded by the liver enzyme CYP1A2 but other enzymes from the cytochrome family are also known to metabolize melatonin. Recent investigation show e.g. that melatonin plays an important role in colon cancer growth.  
   <Comment Source="WikiPathways-description">Melatonin is an important regulator of circadian rythmus and influences also insulin secretion, immune function, retinal function and neuroprotection. The synthesis starts with the amino acid tryptophan which is catalyzed to serotonin. AANAT and ASMT catalyze the reaction to N-acetylserotonin and melatonin, respectively. Melatonin is mainly discarded by the liver enzyme CYP1A2 but other enzymes from the cytochrome family are also known to metabolize melatonin. Recent investigation show e.g. that melatonin plays an important role in colon cancer growth.  
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This pathway is part the [https://assays.cancer.gov/available_assays?wp_id=WP3298 CPTAC Assay Portal].</Comment>
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Proteins on this pathway have targeted assays available via the [https://assays.cancer.gov/available_assays?wp_id=WP3298 CPTAC Assay Portal]</Comment>
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     <Graphics CenterX="202.0" CenterY="313.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="9900cc" />
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     <Graphics CenterX="202.0" CenterY="313.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="9900cc"/>
-
     <Xref Database="miRBase Sequence" ID="MI0000477" />
+
     <Xref Database="miRBase Sequence" ID="MI0000477"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="MTNR1A" GraphId="c468a" Type="GeneProduct" GroupRef="b0209">
   <DataNode TextLabel="MTNR1A" GraphId="c468a" Type="GeneProduct" GroupRef="b0209">
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     <Graphics CenterX="335.0840336134451" CenterY="496.93277310924424" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="335.0840336134451" CenterY="496.93277310924424" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000168412" />
+
     <Xref Database="Ensembl" ID="ENSG00000168412"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Melatonin" GraphId="c491a" Type="Metabolite">
   <DataNode TextLabel="Melatonin" GraphId="c491a" Type="Metabolite">
-
     <Graphics CenterX="496.11181640625" CenterY="387.95000000000016" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="496.11181640625" CenterY="387.95000000000016" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:16796" />
+
     <Xref Database="ChEBI" ID="CHEBI:16796"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CLOCK" GraphId="c4db5" Type="GeneProduct" GroupRef="a9a98">
   <DataNode TextLabel="CLOCK" GraphId="c4db5" Type="GeneProduct" GroupRef="a9a98">
-
     <Graphics CenterX="107.0" CenterY="533.9327731092442" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="107.0" CenterY="533.9327731092442" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000134852" />
+
     <Xref Database="Ensembl" ID="ENSG00000134852"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="cyclic 6-hydroxymelatonin" GraphId="c8d1e" Type="Metabolite" GroupRef="c3b50">
   <DataNode TextLabel="cyclic 6-hydroxymelatonin" GraphId="c8d1e" Type="Metabolite" GroupRef="c3b50">
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     <Graphics CenterX="656.0" CenterY="549.0" Width="136.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="656.0" CenterY="549.0" Width="136.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="HMDB" ID="HMDB0060810" />
+
     <Xref Database="HMDB" ID="HMDB0060810"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Per" GraphId="c9385" Type="Protein" GroupRef="c475c">
   <DataNode TextLabel="Per" GraphId="c9385" Type="Protein" GroupRef="c475c">
-
     <Graphics CenterX="197.25" CenterY="695.0336134453764" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="197.25" CenterY="695.0336134453764" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSP00000314420" />
+
     <Xref Database="Ensembl" ID="ENSP00000314420"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PKC" GraphId="cbb47" Type="GeneProduct">
   <DataNode TextLabel="PKC" GraphId="cbb47" Type="GeneProduct">
     <Comment>PCK - alpha (literature does not give the exact subclass of PCK)</Comment>
     <Comment>PCK - alpha (literature does not give the exact subclass of PCK)</Comment>
-
     <Graphics CenterX="334.0840336134452" CenterY="430.7899159663858" Width="62.05882352941179" Height="18.40336134453787" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Xref Database="Ensembl" ID="ENSG00000154229" />
+
     <Xref Database="Ensembl" ID="ENSG00000154229"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Ethinhyloestradiol" GraphId="cc012" Type="Metabolite">
   <DataNode TextLabel="Ethinhyloestradiol" GraphId="cc012" Type="Metabolite">
     <BiopaxRef>ed3</BiopaxRef>
     <BiopaxRef>ed3</BiopaxRef>
-
     <Graphics CenterX="643.0" CenterY="592.0" Width="91.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="643.0" CenterY="592.0" Width="91.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="PubChem-compound" ID="5991" />
+
     <Xref Database="PubChem-compound" ID="5991"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="6-Sulfatoxymelatonin" GraphId="cfd8f" Type="Metabolite">
   <DataNode TextLabel="6-Sulfatoxymelatonin" GraphId="cfd8f" Type="Metabolite">
-
     <Graphics CenterX="495.11181640625" CenterY="662.25" Width="106.25" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="495.11181640625" CenterY="662.25" Width="106.25" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="HMDB" ID="HMDB0041815" />
+
     <Xref Database="HMDB" ID="HMDB0041815"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="AANAT" GraphId="d1d9a" Type="GeneProduct">
   <DataNode TextLabel="AANAT" GraphId="d1d9a" Type="GeneProduct">
-
     <Graphics CenterX="643.0" CenterY="230.34999999999982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="643.0" CenterY="230.34999999999982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000129673" />
+
     <Xref Database="Ensembl" ID="ENSG00000129673"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="cAMP" GraphId="d310c" Type="Metabolite" GroupRef="d823e">
   <DataNode TextLabel="cAMP" GraphId="d310c" Type="Metabolite" GroupRef="d823e">
-
     <Graphics CenterX="357.0" CenterY="210.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
+
     <Graphics CenterX="357.0" CenterY="210.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:17489" />
+
     <Xref Database="ChEBI" ID="CHEBI:17489"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="GSK3B" GraphId="d3633" Type="GeneProduct" GroupRef="abe33">
   <DataNode TextLabel="GSK3B" GraphId="d3633" Type="GeneProduct" GroupRef="abe33">
-
     <Graphics CenterX="129.25" CenterY="793.0336134453764" Width="92.5" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="129.25" CenterY="793.0336134453764" Width="92.5" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000082701" />
+
     <Xref Database="Ensembl" ID="ENSG00000082701"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="N,N-Dimethyltryptamine" GraphId="d3915" Type="Metabolite" GroupRef="a0c63">
   <DataNode TextLabel="N,N-Dimethyltryptamine" GraphId="d3915" Type="Metabolite" GroupRef="a0c63">
-
     <Graphics CenterX="851.0" CenterY="499.0" Width="127.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="851.0" CenterY="499.0" Width="127.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:28969" />
+
     <Xref Database="ChEBI" ID="CHEBI:28969"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CSNK1E" GraphId="d4669" Type="Protein" GroupRef="abe33">
   <DataNode TextLabel="CSNK1E" GraphId="d4669" Type="Protein" GroupRef="abe33">
-
     <Graphics CenterX="129.25" CenterY="756.0336134453764" Width="92.5" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="129.25" CenterY="756.0336134453764" Width="92.5" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000213923" />
+
     <Xref Database="Ensembl" ID="ENSG00000213923"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="SIRT1" GraphId="da834" Type="GeneProduct">
   <DataNode TextLabel="SIRT1" GraphId="da834" Type="GeneProduct">
     <BiopaxRef>c50</BiopaxRef>
     <BiopaxRef>c50</BiopaxRef>
-
     <Graphics CenterX="312.0" CenterY="356.0" Width="46.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="312.0" CenterY="356.0" Width="46.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000096717" />
+
     <Xref Database="Ensembl" ID="ENSG00000096717"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="5-methoxypsoralen" GraphId="dd287" Type="Metabolite">
   <DataNode TextLabel="5-methoxypsoralen" GraphId="dd287" Type="Metabolite">
     <BiopaxRef>ed3</BiopaxRef>
     <BiopaxRef>ed3</BiopaxRef>
-
     <Graphics CenterX="845.1500000000023" CenterY="380.0500000000005" Width="106.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="845.1500000000023" CenterY="380.0500000000005" Width="106.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="PubChem-compound" ID="2355" />
+
     <Xref Database="PubChem-compound" ID="2355"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ADRB" GraphId="df496" Type="GeneProduct">
   <DataNode TextLabel="ADRB" GraphId="df496" Type="GeneProduct">
-
     <Graphics CenterX="823.7125" CenterY="271.55000000000007" Width="49.17500000000046" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="823.7125" CenterY="271.55000000000007" Width="49.17500000000046" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000043591" />
+
     <Xref Database="Ensembl" ID="ENSG00000043591"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Nf-kb" GraphId="dfb08" Type="GeneProduct" GroupRef="d6d84">
   <DataNode TextLabel="Nf-kb" GraphId="dfb08" Type="GeneProduct" GroupRef="d6d84">
-
     <Graphics CenterX="238.0" CenterY="190.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="238.0" CenterY="190.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000109320" />
+
     <Xref Database="Ensembl" ID="ENSG00000109320"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="FOXO1" GraphId="dfb19" Type="GeneProduct" GroupRef="d6d84">
   <DataNode TextLabel="FOXO1" GraphId="dfb19" Type="GeneProduct" GroupRef="d6d84">
-
     <Graphics CenterX="238.0" CenterY="210.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
+
     <Graphics CenterX="238.0" CenterY="210.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000150907" />
+
     <Xref Database="Ensembl" ID="ENSG00000150907"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CYP1A1" GraphId="e054d" Type="GeneProduct" GroupRef="beeaf">
   <DataNode TextLabel="CYP1A1" GraphId="e054d" Type="GeneProduct" GroupRef="beeaf">
     <BiopaxRef>db4</BiopaxRef>
     <BiopaxRef>db4</BiopaxRef>
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     <Graphics CenterX="643.0" CenterY="371.09999999999974" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="643.0" CenterY="371.09999999999974" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000140465" />
+
     <Xref Database="Ensembl" ID="ENSG00000140465"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PKA" GraphId="e3a4e" Type="Protein">
   <DataNode TextLabel="PKA" GraphId="e3a4e" Type="Protein">
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     <Graphics CenterX="741.0250000000004" CenterY="271.55000000000007" Width="53.649999999999736" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="741.0250000000004" CenterY="271.55000000000007" Width="53.649999999999736" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PER3" GraphId="e544f" Type="GeneProduct" GroupRef="c1fff">
   <DataNode TextLabel="PER3" GraphId="e544f" Type="GeneProduct" GroupRef="c1fff">
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     <Graphics CenterX="316.0" CenterY="640.0336134453781" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="316.0" CenterY="640.0336134453781" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000049246" />
+
     <Xref Database="Ensembl" ID="ENSG00000049246"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Cancer growth" GraphId="e5647" Type="Pathway">
   <DataNode TextLabel="Cancer growth" GraphId="e5647" Type="Pathway">
-
     <Graphics CenterX="102.0" CenterY="149.15966386554632" Width="104.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e" />
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     <Graphics CenterX="102.0" CenterY="149.15966386554632" Width="104.0" Height="20.0" ZOrder="32768" FontWeight="Bold" FontSize="12" Valign="Middle" ShapeType="None" Color="14961e"/>
-
     <Xref Database="" ID="" />
+
     <Xref Database="" ID=""/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ECE-1" GraphId="e8221" Type="GeneProduct">
   <DataNode TextLabel="ECE-1" GraphId="e8221" Type="GeneProduct">
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     <Graphics CenterX="357.0" CenterY="238.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="357.0" CenterY="238.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000117298" />
+
     <Xref Database="Ensembl" ID="ENSG00000117298"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Noradrenaline" GraphId="f1c98" Type="Metabolite">
   <DataNode TextLabel="Noradrenaline" GraphId="f1c98" Type="Metabolite">
     <BiopaxRef>b4b</BiopaxRef>
     <BiopaxRef>b4b</BiopaxRef>
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     <Graphics CenterX="927.649999999999" CenterY="230.34999999999982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="927.649999999999" CenterY="230.34999999999982" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="33569" />
+
     <Xref Database="ChEBI" ID="33569"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="6-Hydroxymelatonin" GraphId="f2242" Type="Metabolite">
   <DataNode TextLabel="6-Hydroxymelatonin" GraphId="f2242" Type="Metabolite">
-
     <Graphics CenterX="494.11181640625" CenterY="567.0" Width="101.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="494.11181640625" CenterY="567.0" Width="101.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:2198" />
+
     <Xref Database="ChEBI" ID="CHEBI:2198"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ApoE" GraphId="f386c" Type="GeneProduct">
   <DataNode TextLabel="ApoE" GraphId="f386c" Type="GeneProduct">
     <BiopaxRef>afb</BiopaxRef>
     <BiopaxRef>afb</BiopaxRef>
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     <Graphics CenterX="754.0" CenterY="153.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="754.0" CenterY="153.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Uniprot-TrEMBL" ID="P02649" />
+
     <Xref Database="Uniprot-TrEMBL" ID="P02649"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="PER1" GraphId="f42ed" Type="GeneProduct" GroupRef="c1fff">
   <DataNode TextLabel="PER1" GraphId="f42ed" Type="GeneProduct" GroupRef="c1fff">
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     <Graphics CenterX="316.0" CenterY="601.7836134453787" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" />
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-
     <Xref Database="Ensembl" ID="ENSG00000179094" />
+
     <Xref Database="Ensembl" ID="ENSG00000179094"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CYP1A2" GraphId="f957c" Type="GeneProduct" GroupRef="beeaf">
   <DataNode TextLabel="CYP1A2" GraphId="f957c" Type="GeneProduct" GroupRef="beeaf">
Line 262: Line 263:
     <BiopaxRef>c05</BiopaxRef>
     <BiopaxRef>c05</BiopaxRef>
     <BiopaxRef>db4</BiopaxRef>
     <BiopaxRef>db4</BiopaxRef>
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     <Graphics CenterX="643.0" CenterY="352.95000000000033" Width="79.99999999999994" Height="19.999999999999986" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000140505" />
+
     <Xref Database="Ensembl" ID="ENSG00000140505"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="Bufotenin" GraphId="f9a55" Type="Metabolite" GroupRef="a0c63">
   <DataNode TextLabel="Bufotenin" GraphId="f9a55" Type="Metabolite" GroupRef="a0c63">
-
     <Graphics CenterX="852.0" CenterY="480.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff" />
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     <Graphics CenterX="852.0" CenterY="480.0" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle" Color="0000ff"/>
-
     <Xref Database="ChEBI" ID="CHEBI:3210" />
+
     <Xref Database="ChEBI" ID="CHEBI:3210"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="ASMT" GraphId="fc1a3" Type="GeneProduct">
   <DataNode TextLabel="ASMT" GraphId="fc1a3" Type="GeneProduct">
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     <Graphics CenterX="643.0" CenterY="307.4500000000001" Width="80.0" Height="20.0" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000196433" />
+
     <Xref Database="Ensembl" ID="ENSG00000196433"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CYP2C19" GraphId="fea23" Type="GeneProduct" GroupRef="beeaf">
   <DataNode TextLabel="CYP2C19" GraphId="fea23" Type="GeneProduct" GroupRef="beeaf">
     <BiopaxRef>db4</BiopaxRef>
     <BiopaxRef>db4</BiopaxRef>
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     <Graphics CenterX="643.0" CenterY="389.85000000000014" Width="79.99999999999994" Height="19.999999999999986" ZOrder="32768" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="643.0" CenterY="389.85000000000014" Width="79.99999999999994" Height="19.999999999999986" ZOrder="32768" FontSize="10" Valign="Middle"/>
-
     <Xref Database="Ensembl" ID="ENSG00000165841" />
+
     <Xref Database="Ensembl" ID="ENSG00000165841"/>
   </DataNode>
   </DataNode>
   <DataNode TextLabel="CRY2" GraphId="bb2b5" Type="GeneProduct" GroupRef="c1fff">
   <DataNode TextLabel="CRY2" GraphId="bb2b5" Type="GeneProduct" GroupRef="c1fff">
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     <Graphics CenterX="405.00042016806725" CenterY="624.0840336134456" Width="80.0" Height="20.0" ZOrder="32777" FontSize="10" Valign="Middle" />
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     <Graphics CenterX="405.00042016806725" CenterY="624.0840336134456" Width="80.0" Height="20.0" ZOrder="32777" FontSize="10" Valign="Middle"/>
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     <Xref Database="Ensembl" ID="ENSG00000121671" />
+
     <Xref Database="Ensembl" ID="ENSG00000121671"/>
   </DataNode>
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Revision as of 21:03, 12 September 2019

Error rendering pathway page

This revision of the pathway probably contains invalid GPML code. If this happens to the most recent revision, try reverting the pathway using the pathway history displayed below or contact the site administrators (see WikiPathways:About) to resolve this problem.

Pathway history

View all...
CompareRevisionActionTimeUserComment
107142view14:22, 17 September 2019MaintBotChEBI identifier normalization
106641view21:03, 12 September 2019KhanspersModified description
106153view12:05, 16 August 2019MaintBotHMDB identifier normalization
105644view05:09, 10 August 2019KhanspersModified description
91618view12:20, 23 March 2017Mkutmonfix references
91561view20:01, 13 March 2017Khanspersfixed literature refs
91550view13:10, 10 March 2017FehrhartID update
91549view13:03, 10 March 2017FehrhartID correction of MTNR1B and A
91533view08:14, 9 March 2017Marvin M2Reverted to version '21:59, 15 December 2016' by Marvin M2
91516view08:15, 8 March 2017JustgerrardzModified description
90887view21:59, 15 December 2016Khanspersfixed bad format lit refs
90688view15:22, 8 December 2016FehrhartUpdated IDs for cyclic hydroxymelatonins and sulfatoxymelatonin
88827view09:01, 15 August 2016Fehrhartfixed a line
88826view08:58, 15 August 2016FehrhartAdded melatonin effects on LPS induced inflammation pathways
84382view10:30, 18 February 2016FehrhartAdded AANAT breakdown
84381view10:10, 18 February 2016FehrhartUpgrade of melatonin-serotonin cycle
84145view16:04, 19 January 2016Fehrhartadded literature and details for noradrenaline pathway influencing melatonin synthesis
84143view13:41, 19 January 2016EgonwOntology Term : 'hormone signaling pathway' added !
84142view13:35, 19 January 2016EgonwOntology Term : 'cancer' added !
84141view13:35, 19 January 2016EgonwOntology Term : 'developmental disorder of mental health' added !
84140view13:33, 19 January 2016EgonwOntology Term : 'sleep disorder' added !
84139view13:27, 19 January 2016EgonwFixed the data source name.
84138view13:25, 19 January 2016EgonwAdded a extra identifiers.
83822view22:43, 11 December 2015AlexanderPicoClearing incomplete xref for PKA
82917view22:03, 12 November 2015Khanspersconnected interactions
82856view13:20, 10 November 2015FehrhartAdded dendrite formation pathway
82757view15:41, 30 October 2015Fehrhartfixed some ensembl identifiers
82738view15:35, 26 October 2015FehrhartAdded 3rd melatonin breakdown pathway via O-methylserotonin
81803view14:50, 30 August 2015EgonwFixed weird characters in a paper title.
81802view14:49, 30 August 2015EgonwFixed weird characters in autors names.
81801view13:52, 30 August 2015EgonwAdded a ChEBI ID for 'free radical'.
81796view11:19, 28 August 2015FehrhartSome more literature
81795view10:29, 28 August 2015FehrhartModified description
81794view10:26, 28 August 2015FehrhartMelatonin breakdown pathways
81784view14:24, 27 August 2015FehrhartLiver location of CYP and light dependant noradrenaline stimulation of melatonin production
81783view13:28, 27 August 2015FehrhartAdded backpage annotations
81782view10:47, 27 August 2015FehrhartAdded circadian regulation of clock genes by melatonin
81661view16:06, 22 August 2015MaintBotModified title
81212view15:47, 4 August 2015FehrhartSome more MIM stuff and addition of MAOA
81209view15:18, 4 August 2015Mkutmonfixed literature reference
81208view15:10, 4 August 2015EveloSome MIM stuff
81206view13:01, 4 August 2015FehrhartConnecting lines and added tryptophan pathway
81205view12:37, 4 August 2015FehrhartModified description
81204view12:28, 4 August 2015FehrhartConnection to biogenic amine synthesis pathway
81203view12:25, 4 August 2015FehrhartNew pathway

Error details

exception 'Exception' with message 'Unable to convert to /var/www/wikipathways/images/e/ed/WP3298_prev.svg:
<BR>Status:1
<BR>Message:Exception in thread "main" java.lang.NullPointerException
	at org.pathvisio.core.Engine.getPathwayImporters(Unknown Source)
	at org.pathvisio.core.Engine.importPathway(Unknown Source)
	at org.pathvisio.core.util.Converter.main(Unknown Source)

<BR>Command:java -Xmx1024M -jar /var/www/wikipathways/wpi/bin/pathvisio_core.jar "/var/www/wikipathways" "/var/www/wikipathways/images/e/ed/WP3298_prev.svg" 2>&1<BR>' in /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php:1255
Stack trace:
#0 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1227): Pathway::convertWithPathVisio(false, '/var/www/wikipa...')
#1 /var/www/wikipathways/wpi/extensions/Pathways/Pathway.php(1137): Pathway->saveConvertedByPathVisioCache('svg')
#2 /var/www/wikipathways/wpi/extensions/Pathways/PathwayPage.php(21): Pathway->updateCache('svg')
#3 [internal function]: renderPathwayPage(Object(Parser), '<?xml version="...', Object(StripState))
#4 /var/www/wikipathways/includes/Hooks.php(125): call_user_func_array('renderPathwayPa...', Array)
#5 /var/www/wikipathways/includes/parser/Parser.php(318): wfRunHooks('ParserBeforeStr...', Array)
#6 /var/www/wikipathways/includes/OutputPage.php(405): Parser->parse('<?xml version="...', Object(Title), Object(ParserOptions), true, true, 106641)
#7 /var/www/wikipathways/includes/OutputPage.php(391): OutputPage->addWikiTextTitle('<?xml version="...', Object(Title), true, true)
#8 /var/www/wikipathways/includes/OutputPage.php(500): OutputPage->addWikiTextTitleTidy('<?xml version="...', Object(Title), true)
#9 /var/www/wikipathways/includes/DifferenceEngine.php(313): OutputPage->addWikiTextTidy('<?xml version="...')
#10 /var/www/wikipathways/includes/DifferenceEngine.php(271): DifferenceEngine->renderNewRevision()
#11 /var/www/wikipathways/includes/Article.php(729): DifferenceEngine->showDiffPage(false)
#12 /var/www/wikipathways/includes/Wiki.php(437): Article->view()
#13 /var/www/wikipathways/includes/Wiki.php(59): MediaWiki->performAction(Object(OutputPage), Object(Article), Object(Title), Object(User), Object(WebRequest))
#14 /var/www/wikipathways/index.php(93): MediaWiki->initialize(Object(Title), Object(Article), Object(OutputPage), Object(User), Object(WebRequest))
#15 {main}
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