Serotonin Receptor 2 and ELK-SRF/GATA4 signaling (Bos taurus)

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18, 28, 55, 6954, 8925, 26, 35, 36, 45...22, 817684, 8633, 10620, 3212, 23, 38, 64, 66...8519, 51, 77, 97, 10015, 63601124, 93, 95, 10390, 9129, 59, 65, 68, 74...14, 5023, 17, 40, 53, 7830, 47, 48, 56, 62...1, 677, 10, 16, 31, 42...8, 714637, 619, 434, 6, 27, 34, 72...RASSRFELK4GATA4RASGRF11,4,5-Insp3KRASMAPK35HTR2BMAP2K1serotoninNRASELK1MAP2K2PLCGNAQCALCIUMHRASRASGRP1RAF1HTR2CITPR1MAPK1MAPKAPK2HTR2A44, 49, 52, 73, 835, 21, 39, 41, 58...13, 101


This pathway is courtesy of Ariadne Genomics Pathway Studio.


This pathway was inferred from Homo sapiens pathway WP732(80010) with a 85.0% conversion rate.

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  1. Uchida K, Miyauchi H, Furuichi T, Michikawa T, Mikoshiba K; ''Critical regions for activation gating of the inositol 1,4,5-trisphosphate receptor.''; J Biol Chem, 2003 PubMed Europe PMC
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  5. Rambaratsingh RA, Stone JC, Blumberg PM, Lorenzo PS; ''RasGRP1 represents a novel non-protein kinase C phorbol ester signaling pathway in mouse epidermal keratinocytes.''; J Biol Chem, 2003 PubMed Europe PMC
  6. Tanimura S, Nomura K, Ozaki K, Tsujimoto M, Kondo T, Kohno M; ''Prolonged nuclear retention of activated extracellular signal-regulated kinase 1/2 is required for hepatocyte growth factor-induced cell motility.''; J Biol Chem, 2002 PubMed Europe PMC
  7. Budnik LT, Brunswig-Spickenheier B, Mukhopadhyay AK; ''Lysophosphatidic acid signals through mitogen-activated protein kinase-extracellular signal regulated kinase in ovarian theca cells expressing the LPA1/edg2-receptor: involvement of a nonclassical pathway?''; Mol Endocrinol, 2003 PubMed Europe PMC
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  9. Raeder EM, Mansfield PJ, Hinkovska-Galcheva V, Kjeldsen L, Shayman JA, Boxer LA; ''Sphingosine blocks human polymorphonuclear leukocyte phagocytosis through inhibition of mitogen-activated protein kinase activation.''; Blood, 1999 PubMed Europe PMC
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  20. Ravanti L, Heino J, Lأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½pez-Otأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½n C, Kأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½hأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ri VM; ''Induction of collagenase-3 (MMP-13) expression in human skin fibroblasts by three-dimensional collagen is mediated by p38 mitogen-activated protein kinase.''; J Biol Chem, 1999 PubMed Europe PMC
  21. Zhong XP, Hainey EA, Olenchock BA, Zhao H, Topham MK, Koretzky GA; ''Regulation of T cell receptor-induced activation of the Ras-ERK pathway by diacylglycerol kinase zeta.''; J Biol Chem, 2002 PubMed Europe PMC
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  23. Yu YL, Chiang YJ, Chen YC, Papetti M, Juo CG, Skoultchi AI, Yen JJ; ''MAPK-mediated phosphorylation of GATA-1 promotes Bcl-XL expression and cell survival.''; J Biol Chem, 2005 PubMed Europe PMC
  24. Sharp AH, Nucifora FC Jr, Blondel O, Sheppard CA, Zhang C, Snyder SH, Russell JT, Ryugo DK, Ross CA; ''Differential cellular expression of isoforms of inositol 1,4,5-triphosphate receptors in neurons and glia in brain.''; J Comp Neurol, 1999 PubMed Europe PMC
  25. Imada-Shirakata Y, Kotera T, Ueda S, Okuma M; ''Serotonin activates electrolyte transport via 5-HT2A receptor in rat colonic crypt cells.''; Biochem Biophys Res Commun, 1997 PubMed Europe PMC
  26. Cox DA, Watts SW, Cohen ML; ''Neomycin selectively inhibits 5-hydroxytryptamine-induced contraction in the guinea pig trachea.''; J Pharmacol Exp Ther, 1996 PubMed Europe PMC
  27. Barry OP, Mullan B, Sheehan D, Kazanietz MG, Shanahan F, Collins JK, O'Sullivan GC; ''Constitutive ERK1/2 activation in esophagogastric rib bone marrow micrometastatic cells is MEK-independent.''; J Biol Chem, 2001 PubMed Europe PMC
  28. Waas WF, Dalby KN; ''Transient protein-protein interactions and a random-ordered kinetic mechanism for the phosphorylation of a transcription factor by extracellular-regulated protein kinase 2.''; J Biol Chem, 2002 PubMed Europe PMC
  29. Du JY, Ruan YC, Zuo WL, Yang ZH, Chen MH, Wu ZL, Xiang H, Zhou WL; ''Cellular mechanisms of carbachol-stimulated Cl- secretion in rat epididymal epithelium.''; Biol Reprod, 2006 PubMed Europe PMC
  30. Bandyopadhyay G, Sajan MP, Kanoh Y, Standaert ML, Quon MJ, Reed BC, Dikic I, Farese RV; ''Glucose activates protein kinase C-zeta /lambda through proline-rich tyrosine kinase-2, extracellular signal-regulated kinase, and phospholipase D: a novel mechanism for activating glucose transporter translocation.''; J Biol Chem, 2001 PubMed Europe PMC
  31. Soroka V, Kiryushko D, Novitskaya V, Ronn LC, Poulsen FM, Holm A, Bock E, Berezin V; ''Induction of neuronal differentiation by a peptide corresponding to the homophilic binding site of the second Ig module of the neural cell adhesion molecule.''; J Biol Chem, 2002 PubMed Europe PMC
  32. Venkatasubbarao K, Choudary A, Freeman JW; ''Farnesyl transferase inhibitor (R115777)-induced inhibition of STAT3(Tyr705) phosphorylation in human pancreatic cancer cell lines require extracellular signal-regulated kinases.''; Cancer Res, 2005 PubMed Europe PMC
  33. Bأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½camel C, Gavarini S, Chanrion B, Alonso G, Galأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½otti N, Dumuis A, Bockaert J, Marin P; ''The serotonin 5-HT2A and 5-HT2C receptors interact with specific sets of PDZ proteins.''; J Biol Chem, 2004 PubMed Europe PMC
  34. Yung Y, Yao Z, Aebersold DM, Hanoch T, Seger R; ''Altered regulation of ERK1b by MEK1 and PTP-SL and modified Elk1 phosphorylation by ERK1b are caused by abrogation of the regulatory C-terminal sequence of ERKs.''; J Biol Chem, 2001 PubMed Europe PMC
  35. Goppelt-Struebe M, Stroebel M; ''Mechanisms of serotonin-induced Ca2+ responses in mesangial cells.''; Naunyn Schmiedebergs Arch Pharmacol, 1997 PubMed Europe PMC
  36. Butts DA, Rokhsar DS; ''The information content of spontaneous retinal waves.''; J Neurosci, 2001 PubMed Europe PMC
  37. Hetman M, Hsuan SL, Habas A, Higgins MJ, Xia Z; ''ERK1/2 antagonizes glycogen synthase kinase-3beta-induced apoptosis in cortical neurons.''; J Biol Chem, 2002 PubMed Europe PMC
  38. Pikkarainen S, Tokola H, Kerkelأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ R, Majalahti-Palviainen T, Vuolteenaho O, Ruskoaho H; ''Endothelin-1-specific activation of B-type natriuretic peptide gene via p38 mitogen-activated protein kinase and nuclear ETS factors.''; J Biol Chem, 2003 PubMed Europe PMC
  39. Bai Y, Edamatsu H, Maeda S, Saito H, Suzuki N, Satoh T, Kataoka T; ''Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development.''; Cancer Res, 2004 PubMed Europe PMC
  40. Zhou B, Zhang ZY; ''The activity of the extracellular signal-regulated kinase 2 is regulated by differential phosphorylation in the activation loop.''; J Biol Chem, 2002 PubMed Europe PMC
  41. Guilbault B, Kay RJ; ''RasGRP1 sensitizes an immature B cell line to antigen receptor-induced apoptosis.''; J Biol Chem, 2004 PubMed Europe PMC
  42. Bakovic M, Waite K, Vance DE; ''Oncogenic Ha-Ras transformation modulates the transcription of the CTP:phosphocholine cytidylyltransferase alpha gene via p42/44MAPK and transcription factor Sp3.''; J Biol Chem, 2003 PubMed Europe PMC
  43. Nonner D, Barrett EF, Barrett JN; ''Brief exposure to neurotrophins produces a calcium-dependent increase in choline acetyltransferase activity in cultured rat septal neurons.''; J Neurochem, 2000 PubMed Europe PMC
  44. Zippel R, Orecchia S, Sturani E, Martegani E; ''The brain specific Ras exchange factor CDC25 Mm: modulation of its activity through Gi-protein-mediated signals.''; Oncogene, 1996 PubMed Europe PMC
  45. Piera MJ, Beaughard M, Michelin MT, Winslow E, Massingham R; ''Lack of efficacy of 5-HT2A receptor antagonists to reduce brain damage after 3 minutes of transient global cerebral ischaemia in gerbils.''; Fundam Clin Pharmacol, 1995 PubMed Europe PMC
  46. Yan C, Kim D, Aizawa T, Berk BC; ''Functional interplay between angiotensin II and nitric oxide: cyclic GMP as a key mediator.''; Arterioscler Thromb Vasc Biol, 2003 PubMed Europe PMC
  47. Ryder JW, Fahlman R, Wallberg-Henriksson H, Alessi DR, Krook A, Zierath JR; ''Effect of contraction on mitogen-activated protein kinase signal transduction in skeletal muscle. Involvement Of the mitogen- and stress-activated protein kinase 1.''; J Biol Chem, 2000 PubMed Europe PMC
  48. Ben-Levy R, Leighton IA, Doza YN, Attwood P, Morrice N, Marshall CJ, Cohen P; ''Identification of novel phosphorylation sites required for activation of MAPKAP kinase-2.''; EMBO J, 1995 PubMed Europe PMC
  49. Quilliam LA, Hisaka MM, Zhong S, Lowry A, Mosteller RD, Han J, Drugan JK, Broek D, Campbell SL, Der CJ; ''Involvement of the switch 2 domain of Ras in its interaction with guanine nucleotide exchange factors.''; J Biol Chem, 1996 PubMed Europe PMC
  50. Paine E, Palmantier R, Akiyama SK, Olden K, Roberts JD; ''Arachidonic acid activates mitogen-activated protein (MAP) kinase-activated protein kinase 2 and mediates adhesion of a human breast carcinoma cell line to collagen type IV through a p38 MAP kinase-dependent pathway.''; J Biol Chem, 2000 PubMed Europe PMC
  51. Deszo EL, Brake DK, Cengel KA, Kelley KW, Freund GG; ''CD45 negatively regulates monocytic cell differentiation by inhibiting phorbol 12-myristate 13-acetate-dependent activation and tyrosine phosphorylation of protein kinase Cdelta.''; J Biol Chem, 2001 PubMed Europe PMC
  52. Mattingly RR, Macara IG; ''Phosphorylation-dependent activation of the Ras-GRF/CDC25Mm exchange factor by muscarinic receptors and G-protein beta gamma subunits.''; Nature, 1996 PubMed Europe PMC
  53. Shi CS, Leonardi A, Kyriakis J, Siebenlist U, Kehrl JH; ''TNF-mediated activation of the stress-activated protein kinase pathway: TNF receptor-associated factor 2 recruits and activates germinal center kinase related.''; J Immunol, 1999 PubMed Europe PMC
  54. Chen DB, Westfall SD, Fong HW, Roberson MS, Davis JS; ''Prostaglandin F2alpha stimulates the Raf/MEK1/mitogen-activated protein kinase signaling cascade in bovine luteal cells.''; Endocrinology, 1998 PubMed Europe PMC
  55. Guha M, O'Connell MA, Pawlinski R, Hollis A, McGovern P, Yan SF, Stern D, Mackman N; ''Lipopolysaccharide activation of the MEK-ERK1/2 pathway in human monocytic cells mediates tissue factor and tumor necrosis factor alpha expression by inducing Elk-1 phosphorylation and Egr-1 expression.''; Blood, 2001 PubMed Europe PMC
  56. Krump E, Sanghera JS, Pelech SL, Furuya W, Grinstein S; ''Chemotactic peptide N-formyl-met-leu-phe activation of p38 mitogen-activated protein kinase (MAPK) and MAPK-activated protein kinase-2 in human neutrophils.''; J Biol Chem, 1997 PubMed Europe PMC
  57. Boyarsky BK, Haque W, Rouleau MR, Hirschfeld RM; ''Sexual functioning in depressed outpatients taking mirtazapine.''; Depress Anxiety, 1999 PubMed Europe PMC
  58. Ebinu JO, Stang SL, Teixeira C, Bottorff DA, Hooton J, Blumberg PM, Barry M, Bleakley RC, Ostergaard HL, Stone JC; ''RasGRP links T-cell receptor signaling to Ras.''; Blood, 2000 PubMed Europe PMC
  59. Paolucci L, Rozengurt E; ''Protein kinase D in small cell lung cancer cells: rapid activation through protein kinase C.''; Cancer Res, 1999 PubMed Europe PMC
  60. Chen JJ, Li Z, Pan H, Murphy DL, Tamir H, Koepsell H, Gershon MD; ''Maintenance of serotonin in the intestinal mucosa and ganglia of mice that lack the high-affinity serotonin transporter: Abnormal intestinal motility and the expression of cation transporters.''; J Neurosci, 2001 PubMed Europe PMC
  61. Gosmanov AR, Wong JA, Thomason DB; ''Duality of G protein-coupled mechanisms for beta-adrenergic activation of NKCC activity in skeletal muscle.''; Am J Physiol Cell Physiol, 2002 PubMed Europe PMC
  62. Chrestensen CA, Schroeder MJ, Shabanowitz J, Hunt DF, Pelo JW, Worthington MT, Sturgill TW; ''MAPKAP kinase 2 phosphorylates tristetraprolin on in vivo sites including Ser178, a site required for 14-3-3 binding.''; J Biol Chem, 2004 PubMed Europe PMC
  63. Heidenreich O, Neininger A, Schratt G, Zinck R, Cahill MA, Engel K, Kotlyarov A, Kraft R, Kostka S, Gaestel M, Nordheim A; ''MAPKAP kinase 2 phosphorylates serum response factor in vitro and in vivo.''; J Biol Chem, 1999 PubMed Europe PMC
  64. Kerkelأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ R, Pikkarainen S, Majalahti-Palviainen T, Tokola H, Ruskoaho H; ''Distinct roles of mitogen-activated protein kinase pathways in GATA-4 transcription factor-mediated regulation of B-type natriuretic peptide gene.''; J Biol Chem, 2002 PubMed Europe PMC
  65. Bayguinov O, Hagen B, Sanders KM; ''Muscarinic stimulation increases basal Ca(2+) and inhibits spontaneous Ca(2+) transients in murine colonic myocytes.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC
  66. Purcell NH, Darwis D, Bueno OF, Mأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ller JM, Schأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½le R, Molkentin JD; ''Extracellular signal-regulated kinase 2 interacts with and is negatively regulated by the LIM-only protein FHL2 in cardiomyocytes.''; Mol Cell Biol, 2004 PubMed Europe PMC
  67. Tao FC, Tolloczko B, Mitchell CA, Powell WS, Martin JG; ''Inositol (1,4,5)trisphosphate metabolism and enhanced calcium mobilization in airway smooth muscle of hyperresponsive rats.''; Am J Respir Cell Mol Biol, 2000 PubMed Europe PMC
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  69. Li QJ, Vaingankar S, Sladek FM, Martins-Green M; ''Novel nuclear target for thrombin: activation of the Elk1 transcription factor leads to chemokine gene expression.''; Blood, 2000 PubMed Europe PMC
  70. Coxon PY, Rane MJ, Uriarte S, Powell DW, Singh S, Butt W, Chen Q, McLeish KR; ''MAPK-activated protein kinase-2 participates in p38 MAPK-dependent and ERK-dependent functions in human neutrophils.''; Cell Signal, 2003 PubMed Europe PMC
  71. Nebigil CG, Jaffrأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ F, Messaddeq N, Hickel P, Monassier L, Launay JM, Maroteaux L; ''Overexpression of the serotonin 5-HT2B receptor in heart leads to abnormal mitochondrial function and cardiac hypertrophy.''; Circulation, 2003 PubMed Europe PMC
  72. Wall NR, Mohammad RM, Al-Katib AM; ''Mitogen-activated protein kinase is required for bryostatin 1-induced differentiation of the human acute lymphoblastic leukemia cell line Reh.''; Cell Growth Differ, 2001 PubMed Europe PMC
  73. Arozarena I, Matallanas D, Berciano MT, Sanz-Moreno V, Calvo F, Muأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½oz MT, Egea G, Lafarga M, Crespo P; ''Activation of H-Ras in the endoplasmic reticulum by the RasGRF family guanine nucleotide exchange factors.''; Mol Cell Biol, 2004 PubMed Europe PMC
  74. Haverstick DM, Heady TN, Macdonald TL, Gray LS; ''Inhibition of human prostate cancer proliferation in vitro and in a mouse model by a compound synthesized to block Ca2+ entry.''; Cancer Res, 2000 PubMed Europe PMC
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  76. Buchsbaum R, Telliez JB, Goonesekera S, Feig LA; ''The N-terminal pleckstrin, coiled-coil, and IQ domains of the exchange factor Ras-GRF act cooperatively to facilitate activation by calcium.''; Mol Cell Biol, 1996 PubMed Europe PMC
  77. Hأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½ser M, Luckett J, Chiloeches A, Mercer K, Iwobi M, Giblett S, Sun XM, Brown J, Marais R, Pritchard C; ''MEK kinase activity is not necessary for Raf-1 function.''; EMBO J, 2001 PubMed Europe PMC
  78. Lum H, Roebuck KA; ''Oxidant stress and endothelial cell dysfunction.''; Am J Physiol Cell Physiol, 2001 PubMed Europe PMC
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  80. Mochizuki N, Ohba Y, Kobayashi S, Otsuka N, Graybiel AM, Tanaka S, Matsuda M; ''Crk activation of JNK via C3G and R-Ras.''; J Biol Chem, 2000 PubMed Europe PMC
  81. Morimoto T, Hasegawa K, Kaburagi S, Kakita T, Wada H, Yanazume T, Sasayama S; ''Phosphorylation of GATA-4 is involved in alpha 1-adrenergic agonist-responsive transcription of the endothelin-1 gene in cardiac myocytes.''; J Biol Chem, 2000 PubMed Europe PMC
  82. Brunet A, Roux D, Lenormand P, Dowd S, Keyse S, Pouyssأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½gur J; ''Nuclear translocation of p42/p44 mitogen-activated protein kinase is required for growth factor-induced gene expression and cell cycle entry.''; EMBO J, 1999 PubMed Europe PMC
  83. Jacquet E, Vanoni M, Ferrari C, Alberghina L, Martegani E, Parmeggiani A; ''A mouse CDC25-like product enhances the formation of the active GTP complex of human ras p21 and Saccharomyces cerevisiae RAS2 proteins.''; J Biol Chem, 1992 PubMed Europe PMC
  84. Li Q, Muma NA, Battaglia G, Van de Kar LD; ''Fluoxetine gradually increases [125I]DOI-labelled 5-HT2A/2C receptors in the hypothalamus without changing the levels of Gq- and G11-proteins.''; Brain Res, 1997 PubMed Europe PMC
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  87. Lurtz MM, Louis CF; ''Calmodulin and protein kinase C regulate gap junctional coupling in lens epithelial cells.''; Am J Physiol Cell Physiol, 2003 PubMed Europe PMC
  88. Felix JA, Chaban VV, Woodruff ML, Dirksen ER; ''Mechanical stimulation initiates intercellular Ca2+ signaling in intact tracheal epithelium maintained under normal gravity and simulated microgravity.''; Am J Respir Cell Mol Biol, 1998 PubMed Europe PMC
  89. Sanna B, Bueno OF, Dai YS, Wilkins BJ, Molkentin JD; ''Direct and indirect interactions between calcineurin-NFAT and MEK1-extracellular signal-regulated kinase 1/2 signaling pathways regulate cardiac gene expression and cellular growth.''; Mol Cell Biol, 2005 PubMed Europe PMC
  90. Mo Y, Ho W, Johnston K, Marmorstein R; ''Crystal structure of a ternary SAP-1/SRF/c-fos SRE DNA complex.''; J Mol Biol, 2001 PubMed Europe PMC
  91. Hassler M, Richmond TJ; ''The B-box dominates SAP-1-SRF interactions in the structure of the ternary complex.''; EMBO J, 2001 PubMed Europe PMC
  92. Bأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½langer LF, Roy S, Tremblay M, Brott B, Steff AM, Mourad W, Hugo P, Erikson R, Charron J; ''Mek2 is dispensable for mouse growth and development.''; Mol Cell Biol, 2003 PubMed Europe PMC
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  95. Cameron AM, Steiner JP, Sabatini DM, Kaplin AI, Walensky LD, Snyder SH; ''Immunophilin FK506 binding protein associated with inositol 1,4,5-trisphosphate receptor modulates calcium flux.''; Proc Natl Acad Sci U S A, 1995 PubMed Europe PMC
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  99. Clarke LL, Harline MC, Otero MA, Glover GG, Garrad RC, Krugh B, Walker NM, Gonzأƒآƒأ‚آ¯أƒآ‚أ‚آ؟أƒآ‚أ‚آ½lez FA, Turner JT, Weisman GA; ''Desensitization of P2Y2 receptor-activated transepithelial anion secretion.''; Am J Physiol, 1999 PubMed Europe PMC
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  104. Puente LG, Stone JC, Ostergaard HL; ''Evidence for protein kinase C-dependent and -independent activation of mitogen-activated protein kinase in T cells: potential role of additional diacylglycerol binding proteins.''; J Immunol, 2000 PubMed Europe PMC
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  106. Nitsch RM, Deng M, Growdon JH, Wurtman RJ; ''Serotonin 5-HT2a and 5-HT2c receptors stimulate amyloid precursor protein ectodomain secretion.''; J Biol Chem, 1996 PubMed Europe PMC


101987view06:33, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
101983view20:37, 21 November 2018EgonwRemoved whitespace in PubMed identifiers.
80869view15:29, 30 June 2015MkutmonNew pathway

External references


View all...
NameTypeDatabase referenceComment
1,4,5-Insp3Metabolite85166-31-0 (CAS) 1,4,5-Insp3
5HTR2BGeneProductENSBTAG00000039772 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 2B
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3357
CALCIUMMetabolite7440-70-2 (CAS)
ELK1GeneProductENSBTAG00000015817 (Ensembl)
  • ELK1, member of ETS oncogene family
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2002
ELK4GeneProductENSBTAG00000004953 (Ensembl)
  • ETS domain-containing protein Elk-4 (SRF accessory protein 1)
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2005
GATA4GeneProductENSBTAG00000005425 (Ensembl)
  • GATA-binding protein 4/5/6
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2626
GNAQGeneProductENSBTAG00000009789 (Ensembl)
  • guanine nucleotide binding protein, alpha q polypeptide
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:2776
HRASGeneProductENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3265
HTR2AGeneProductENSBTAG00000013498 (Ensembl)
  • 5-hydroxytryptamine (serotonin) receptor 2A
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3356
HTR2CGeneProduct5-hydroxytryptamine (serotonin) receptor 2C
ITPR1GeneProductENSBTAG00000020455 (Ensembl)
  • inositol 1,4,5-triphosphate receptor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3708
MAP2K1GeneProductENSBTAG00000033983 (Ensembl)
  • mitogen activated protein kinase kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5604
MAP2K2GeneProductENSBTAG00000024450 (Ensembl)
  • mitogen activated protein kinase kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5605
MAPK1GeneProductENSBTAG00000010312 (Ensembl)
  • mitogen activated protein kinase 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = H:MAPK1
MAPK3GeneProductENSBTAG00000016156 (Ensembl)
  • mitogen activated protein kinase 3
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5595
MAPKAPK2GeneProductENSBTAG00000038107 (Ensembl)
  • MAP kinase-activated protein kinase 2
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:9261
NRASGeneProductENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:4893
PLCProteinphospholipase C group
RAF1GeneProductENSBTAG00000045748 (Ensembl)
  • v-raf-leukemia viral oncogene 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5894
RASGRF1GeneProductENSBTAG00000019940 (Ensembl)
  • RAS protein-specific guanine nucleotide-releasing factor 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5923
RASGRP1GeneProductENSBTAG00000021872 (Ensembl)
  • RAS guanyl releasing protein 1
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:10125
SRFGeneProductENSBTAG00000012777 (Ensembl)
  • serum response factor
  • HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6722
serotoninMetabolite50-67-9 (CAS)

Annotated Interactions

No annotated interactions
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