Spinal Cord Injury (Bos taurus)

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2722PTPRZ1MIFCSPG4TNFSF13CDC42CD47PDYNTNFSF13BAIF1LTBPLXNA2NONGFRLTB4FECHP1C1QBLGALS3AQP1APEX1OBLTB4R3047244344313425343381819Motor NeuronOligodendrocyteAstroctyeSpinal Cord InjuryTimePro-InflammatoryFactorsZFP36FCGR2CPRB1PTPRAIL1BZFP36INOSTNFNR4A128IL4BTG2BTG2FBRCDK2NOS1IL2TNFIL6TLR4FOSIL1BTGFB1TLR4TNFEGR1FOSMMP12IFNGGlial ScarAstrocyte GliosisSwelling/EdemaMBPAntigens ReleasedRTN4C5GRO1Neutrophil ChemoattractantsCXCL837, 40NeurtrophilsMonocytesAQP4TT10LegendTT:Therapeutic Target (increase)TTTTTT:Therapeutic Target (decrease)T-CellsB-CellsB Cell Stimulating2Activated Microglia/Macrophages(Transient)RepairIL1BINOSTNFARG1TOXIC FERROUSIRONFocal Adensions45, 51EPHA4TTEFNB2TTTTTTTTCXCL10Neuro protectionAntibody ReleaseNeuronalInjuryResponseAstrocyteInjuryResponseG1-S Cell Cycle Re-entry (TT)50CCNG1MicrogliaMicrogliaActivationAxonal RetractionRecruitmentRecruitmentMMP917TTChondroitin Sulfate ProteoglycansNCAN14SLIT1Axon RetractionSLIT214SLIT3NTN1RGMATTTTTTTTTTMMP9MMP91717MMP917TTTTTTCCR2IL1R1TT37ECM BreakdownECM BreakdownIL1AGRO1Monocyte Chemoattractants37, 40GRO1CCL2OligodendrocyteInjury ResponsePLA2G6PLA2G5PLA2G2AmelittinInflammationDemyelinationANXA1TT9TTTTTTRed Blood CellsMyelinEndothelial LeukocyteAdehsion Factors20ICAM1SELPTTTTPlasticityKLK823TTMicrogliaActivated Microglia/MacrophagesActivated Microglia/MacrophagesGFAP17TTIntermediateFillament26CDK4NK1RE2F5RB1PRKCAE2F1MAPK1CCND1MYCGADD45AMAPK3TTTTTTAstroctyeNeuron & OligodendrocyteApoptosis/NecrosisMicrogliaProliferationTP53CytotoxicCytotoxicCHST11VCANCOL4A1XYLT1COL2A1ACANBCANGlial Scar FromationSOX9Axonal GrowthInhibition26IgG, IgMTP5333TTTTTTGRIN125VIMTT16T Cell StimulatingFK50621PPP3CATTFK506FK50688GAP43TTFK5068Axonal RegenerationFKBP1AIL2C3 ToxinC1Q and Fc receptive cellsMAGRTN4RHOARHOCRHOBROCK2OMGRTN4RLILRB311MyelinInjury ResponseArachidonic acidPGH2PGHS-246TT39ROS1NOX4bta-mir-23bOlomoucine52CDK1GDNF29TTSEMA6ATT44Axonal GrowthInhibitionGJA148ATP-ReleaseTTBDNFTTImmediate Response Genes502-Methoxyestradiol30TTRAC1TTTTAstroctyeFOXO3TT13CDKN1BTT13N2 Glial Precursor12EGFRPD 1683936TT34CASP3TTTT


Description

This pathway provides an overview of cell types, therapeutic targets, drugs, new proposed targets and pathways implicated in spinal cord injury. Spinal cord injury is a complex multistep process that involves the regulation of gene expression and signaling in motor neurons, oligodentrocytes, microglia, and astrocytes that trigger immediate immune responses lasting several weeks. Within 24 hours, chemoattractants and cytokines released from the site of injury activate neutrophils which further recruit B and T cells or recruit monocytes that ultimately result in infiltration and activation by microglia and macrophages. These immune responses result in inflammation, excitotoxicity, cell death, formation of glial scar, and suppression of axonal regeneration. An increase in the expression of cell cycle genes further results in proliferation of astrocytes and microglia that leads to apoptosis and necrosis of oligodentrocytes and neurons. An example therapy is the administration of the immunosuppressant FK506, also used in transplantation to offer neuroprotection.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2431(80343) with a 97.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

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History

CompareRevisionActionTimeUserComment
101996view19:52, 22 November 2018EgonwRemoved whitespace in PubMed identifiers.
87681view08:55, 25 July 2016LindarieswijkOntology Term : 'disease pathway' added !
80768view15:25, 30 June 2015MkutmonNew pathway

External references

DataNodes

View all...
NameTypeDatabase referenceComment
2-MethoxyestradiolMetabolite66414 (PubChem-compound)
ACANGeneProductENSBTAG00000016158 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000157766
AIF1GeneProductENSBTAG00000020554 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:199
ANXA1GeneProductENSBTAG00000015978 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135046
APEX1GeneProductENSBTAG00000002745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100823
AQP1GeneProductENSBTAG00000000745 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240583
AQP4GeneProductENSBTAG00000019037 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171885
ARG1GeneProductENSBTAG00000012403 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118520
Arachidonic acidMetaboliteHMDB01043 (HMDB)
BCANGeneProductENSBTAG00000015789 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132692
BDNFGeneProductENSBTAG00000008134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176697
BTG2GeneProductENSBTAG00000015711 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000159388
C1QBGeneProductENSBTAG00000011196 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173369
C5GeneProductENSBTAG00000012210 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106804
CASP3GeneProductENSBTAG00000015874 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000164305
CCL2GeneProductENSBTAG00000037811 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000108691
CCND1GeneProductENSBTAG00000017514 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000110092
CCNG1GeneProductENSBTAG00000006607 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113328
CCR2GeneProductENSBTAG00000013586 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000121807
CD47GeneProductENSBTAG00000003585 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000196776
CDC42GeneProductENSBTAG00000001700 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000070831
CDK1GeneProductENSBTAG00000010109 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170312
CDK2GeneProductENSBTAG00000004021 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123374
CDK4GeneProductENSBTAG00000046091 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000135446
CDKN1BGeneProductENSBTAG00000018254 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111276
CHST11GeneProductENSBTAG00000010644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000171310
COL2A1GeneProductENSBTAG00000013155 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139219
COL4A1GeneProductENSBTAG00000012849 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187498
CSPG4GeneProductENSBTAG00000012219 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000173546
CXCL10GeneProductENSBTAG00000001725 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169245
CXCL8GeneProductENSBTAG00000019716 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000169429
E2F1GeneProductENSBTAG00000003971 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101412
E2F5GeneProductENSBTAG00000009378 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000133740
EFNB2GeneProductENSBTAG00000016991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125266
EGFRGeneProductENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000146648
EGR1GeneProductENSBTAG00000010069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000120738
EPHA4GeneProductENSBTAG00000010030 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116106
FBRGeneProduct
FCGR2CGeneProductENSBTAG00000038124 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143226
FECHP1GeneProduct
FK506Metabolite104987-11-3 (CAS)
FKBP1AGeneProductENSBTAG00000032651 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000088832
FOSGeneProductENSBTAG00000004322 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000170345
FOXO3GeneProductENSBTAG00000011234 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000118689
GADD45AGeneProductENSBTAG00000013860 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000116717
GAP43GeneProductENSBTAG00000006451 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000172020
GDNFGeneProductENSBTAG00000005176 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000168621
GFAPGeneProductENSBTAG00000013534 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131095
GJA1GeneProductENSBTAG00000001835 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000152661
GRIN1GeneProductENSBTAG00000047202 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000176884
GRO1GeneProductENSBTAG00000037558 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000081041
ICAM1GeneProductENSBTAG00000010303 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000090339
IFNGGeneProductENSBTAG00000012529 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000111537
IL1AGeneProductENSBTAG00000010349 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:3552
IL1BGeneProductENSBTAG00000001321 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125538
IL1R1GeneProductENSBTAG00000005273 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115594
IL2GeneProductENSBTAG00000020883 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000109471
IL4GeneProductENSBTAG00000015957 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000113520
IL6GeneProductENSBTAG00000014921 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136244
INOSGeneProductENSBTAG00000006894 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000007171
KLK8GeneProductENSBTAG00000015128 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000129455
LGALS3GeneProductENSBTAG00000002326 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000131981
LILRB3GeneProductENSBTAG00000039932 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000204577
LTB4Metabolite169 (PubChem-compound)
LTB4RGeneProductENSBTAG00000010238 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000213903
LTBGeneProductENSBTAG00000020674 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000227507
MAGGeneProductENSBTAG00000017044 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105695
MAPK1GeneProductENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100030
MAPK3GeneProductENSBTAG00000016156 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102882
MBPGeneProductENSBTAG00000022890 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000197971
MIFGeneProductENSBTAG00000007375 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000240972
MMP12GeneProduct
MMP9GeneProductENSBTAG00000020676 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000100985
MYCGeneProductENSBTAG00000008409 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136997
NCANGeneProductENSBTAG00000001764 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000130287
NGFRGeneProductENSBTAG00000020979 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000064300
NK1RGeneProductENSBTAG00000015575 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115353
NOMetabolite145068 (PubChem-compound)
NOS1GeneProductENSBTAG00000002023 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000089250
NOX4GeneProductENSBTAG00000018540 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000086991
NR4A1GeneProductENSBTAG00000000507 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000123358
NTN1GeneProductENSBTAG00000012137 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000065320
OBGeneProductENSBTAG00000014911 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174697
OMGGeneProductENSBTAG00000025213 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000126861
OlomoucineMetaboliteHMDB35233 (HMDB)
PD 168393Metabolite4708 (PubChem-compound)
PDYNGeneProductENSBTAG00000045520 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000101327
PGH2MetaboliteHMDB01381 (HMDB)
PGHS-2GeneProductENSBTAG00000014127 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:5743
PLA2G2AGeneProductENSBTAG00000005759 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000188257
PLA2G5GeneProductENSBTAG00000039122 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000127472
PLA2G6GeneProductENSBTAG00000014015 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184381
PLXNA2GeneProductENSBTAG00000001173 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000076356
PPP3CAGeneProductENSBTAG00000016005 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000138814
PRB1GeneProduct
PRKCAGeneProductENSBTAG00000001061 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000154229
PTPRAGeneProductENSBTAG00000011425 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000132670
PTPRZ1GeneProductENSBTAG00000012119 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000106278
RAC1GeneProductENSBTAG00000009233 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136238
RB1GeneProductENSBTAG00000006640 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000139687
RGMAGeneProductENSBTAG00000018603 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000182175
RHOAGeneProductENSBTAG00000004279 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000067560
RHOBGeneProductENSBTAG00000046054 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000143878
RHOCGeneProductENSBTAG00000014299 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000155366
ROCK2GeneProductENSBTAG00000005847 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000134318
ROS1GeneProductENSBTAG00000047600 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = L:6098
RTN4GeneProductENSBTAG00000011104 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000115310
RTN4RGeneProductENSBTAG00000046677 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000040608
SELPGeneProductENSBTAG00000020755 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000174175
SEMA6AGeneProductENSBTAG00000020489 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000092421
SLIT1GeneProductENSBTAG00000043991 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000187122
SLIT2GeneProductENSBTAG00000005108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000145147
SLIT3GeneProductENSBTAG00000017746 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000184347
SOX9GeneProductENSBTAG00000045824 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000125398
TGFB1GeneProductENSBTAG00000020457 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000105329
TLR4GeneProductENSBTAG00000006240 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000136869
TNFGeneProductENSBTAG00000025471 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000232810
TNFSF13BGeneProductENSBTAG00000045907 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000102524
TNFSF13GeneProductENSBTAG00000000130 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000161955
TP53GeneProductENSBTAG00000001069 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000141510
VCANGeneProductENSBTAG00000014906 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000038427
VIMGeneProductENSBTAG00000018463 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000026025
XYLT1GeneProductENSBTAG00000005523 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000103489
ZFP36GeneProductENSBTAG00000008573 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000128016
bta-mir-23bRnaENSBTAG00000029989 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = En:ENSG00000207563
melittinMetabolite16133648 (PubChem-compound)

Annotated Interactions

No annotated interactions
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