Nanoparticle-mediated activation of receptor signaling (Bos taurus)

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1NP-induced extracellular ROS productionIntegrinAutocrine loopReceptor-mediated NP uptakeCOL1A1ITGA1AREGEGFRApoptosisHRASFN1ROSNRASKRASRAF1MAP2K1MAP2K2MAPK1MAPK8MAPK9MAPK10MAPK12MAPK13MAPK14MAPK11ITGB1TLN1PXNSRCPTK2SOS1GRB2PIK3CDAKT3ProliferationInflammationMigrationAngiogenesisDifferentiationROSEndocytosis of NP


Description

Nanoparticle-mediated activation of receptor signaling. Several NP formulations were shown to interact with cellular receptors such as the EGFR and integrins, inducing cellular phenotypes such as proliferation, apoptosis, differentiation, and migration. In lung epithelial cells, NPs interact with both EGFR and integrins, leading to cell proliferation via activation of PI3K and AKT. NPs were shown to activate the EGFR, leading in parallel to apoptosis and proliferation, and oncogenic Ras mutations might influence these effects. Interestingly, while integrin-mediated activation of ERK was instrumental for proliferation, apoptosis was mediated via activation of JNK. In addition, NPs (PM2.5) are able to bind the EGFR to activate the MAPK signaling cascade. Activation of ERK leads to the expression and secretion of the epidermal growth factor amphiregulin, thus forming an autocrine loop, which might be instrumental for sustained inflammatory responses. Nanoparticles are depicted as red circles.

Comments

HomologyConvert 
This pathway was inferred from Homo sapiens pathway WP2643(74251) with a 96.0% conversion rate.

Quality Tags

Ontology Terms

 

Bibliography

  1. Rauch J, Kolch W, Laurent S, Mahmoudi M; ''Big signals from small particles: regulation of cell signaling pathways by nanoparticles.''; Chem Rev, 2013 PubMed Europe PMC

History

CompareRevisionActionTimeUserComment
107063view14:15, 17 September 2019MaintBotChEBI identifier normalization
102085view21:22, 28 November 2018EgonwReplaced Wikipedia with Wikidata and ChEBI identifiers.
87900view12:54, 25 July 2016ElisaOntology Term : 'signaling pathway' added !
80760view15:24, 30 June 2015MkutmonNew pathway

External references

DataNodes

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NameTypeDatabase referenceComment
AKT3ProteinENSBTAG00000017788 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y243
AREGProteinENSBTAG00000018134 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P15514
AngiogenesisAngiogenesis (Wikipedia)
ApoptosisApoptosis (Wikipedia)
COL1A1ProteinENSBTAG00000013103 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P02452
DifferentiationCellular differentiation (Wikipedia)
EGFRProteinENSBTAG00000011628 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P00533
FN1ProteinENSBTAG00000008300 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P02751
GRB2ProteinENSBTAG00000004736 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P62993
HRASProteinENSBTAG00000046644 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01112
ITGA1ProteinENSBTAG00000016525 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P56199
ITGB1ProteinENSBTAG00000015910 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P05556
InflammationInflammation (Wikipedia)
KRASProtein
MAP2K1ProteinENSBTAG00000033983 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q02750
MAP2K2ProteinENSBTAG00000024450 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P36507
MAPK10ProteinENSBTAG00000020048 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53779
MAPK11ProteinENSBTAG00000030182 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q15759
MAPK12ProteinENSBTAG00000019574 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P53778
MAPK13ProteinENSBTAG00000010007 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O15264
MAPK14ProteinENSBTAG00000020783 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q16539
MAPK1ProteinENSBTAG00000010312 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P28482
MAPK8ProteinENSBTAG00000007876 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45983
MAPK9ProteinENSBTAG00000004709 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P45984
MigrationCell migration (Wikipedia)
NRASProteinENSBTAG00000046797 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P01111
PIK3CDProteinENSBTAG00000018984 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:O00329
PTK2ProteinENSBTAG00000009578 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q05397
PXNProteinENSBTAG00000018108 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P49023
ProliferationCell proliferation (Wikipedia)
RAF1ProteinENSBTAG00000045748 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P04049
ROSReactive oxygen species (Wikipedia)
SOS1ProteinENSBTAG00000011643 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q07889
SRCProteinENSBTAG00000008938 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:P12931
TLN1ProteinENSBTAG00000025868 (Ensembl) HomologyConvert: Homo sapiens to Bos taurus: Original ID = S:Q9Y490

Annotated Interactions

No annotated interactions
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