Synthesis and Degradation of Ketone Bodies (Homo sapiens)

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1(HMG-CoA cycle)* pathway-regulated enzymes: HMG-CoA synthase, mtHMGCS2Pyruvate metabolismAcetyl-CoAOXCT1AcetoacetateSterol biosynthesis3-Hydroxy-butyrateACAT1Fatty Acid metabolismFatty Acid beta-oxidation3-Hydroxy-3-methylglutaryl-CoAAcetoacetyl-CoAGlycolysisAcetyl-CoABDHHMGCL


Ketone bodies are three water-soluble compounds (acetoacetate, beta-hydroxybutyrate, and the spontaneous breakdown product of acetoacetate, acetone) that are produced as by-products when fatty acids are broken down for energy in the liver and kidney. They are used as a source of energy in the heart and brain. In the brain, they are a vital source of energy during fasting. Source: Wikipedia

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  1. Fukao T, Lopaschuk GD, Mitchell GA; ''''; , PubMed Europe PMC Scholia


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113992view09:35, 15 December 2020EgonwTwo more pathways clickable
111482view08:50, 19 August 2020EveloModified description
104983view19:16, 27 June 2019Khanspersremoved genmapp comments
68921view17:32, 8 July 2013MaintBotUpdated to 2013 gpml schema
67674view11:47, 26 June 2013DdiglesOntology Term : 'ketone bodies metabolic pathway' added !
61697view23:23, 16 April 2013MaintBotremoved data source without identifer
48248view06:21, 17 May 2012MaintBotUpdating PubChem xrefs
48220view05:29, 17 May 2012MaintBotAutomatic update of PubChem xrefs
45110view22:36, 6 October 2011KhanspersOntology Term : 'ketone bodies biosynthetic pathway' added !
45108view22:36, 6 October 2011KhanspersOntology Term : 'ketone bodies degradation pathway' added !
43510view09:33, 24 June 2011AdrienDefayadd database name + database ID
41068view23:19, 1 March 2011MaintBotRemoved redundant pathway information and comments
38846view17:47, 24 September 2010Khanspers
38738view21:54, 23 September 2010KhanspersChanged interactions
38736view21:52, 23 September 2010KhanspersAdded pathway links, Changed lines
38735view21:47, 23 September 2010KhanspersAdded pathway links
35389view09:33, 12 February 2010Thomasfixed connections
35359view09:09, 12 February 2010Thomasfixed reference
35355view09:07, 12 February 2010ThomasModified description
35354view09:07, 12 February 2010Thomasadded literature
34452view18:23, 10 December 2009MaintBotAutomatic update of empty xrefs
21335view11:31, 14 November 2008MaintBot[[Pathway:Homo sapiens:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:WP311]]: Moved to stable identifier
13530view10:05, 18 May 2008Thomasadded connectors
13123view11:17, 17 May 2008MaintBotautomated metabolite conversion
8420view13:46, 7 January 2008MaintBot[[Pathway:Human:Synthesis and Degradation of Ketone Bodies KEGG]] moved to [[Pathway:Homo sapiens:Synthesis and Degradation of Ketone Bodies KEGG]]: Renaming species
7827view16:20, 18 December 2007MaintBotfixed category names
7401view12:42, 4 November 2007MaintBotAdded categories to GPML
6395view22:18, 22 May 2007N.Reyesgpml file for [[Human:Synthesis_and_Degradation_of_Ketone_Bodies_KEGG]]

External references


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NameTypeDatabase referenceComment
3-Hydroxy-3-methylglutaryl-CoAMetabolite1553-55-5 (CAS)
3-Hydroxy-butyrateMetabolite441 (PubChem-compound)
ACAT1GeneProduct38 (Entrez Gene)
AcetoacetateMetabolite6971017 (PubChem-compound)
Acetoacetyl-CoAMetabolite1420-36-6 (CAS)
Acetyl-CoAMetabolite72-89-9 (CAS)
BDHGeneProduct622 (Entrez Gene)
Fatty Acid beta-oxidationPathwayWP143 (WikiPathways)
Fatty Acid metabolismPathway
GlycolysisPathwayWP534 (WikiPathways)
HMGCLGeneProduct3155 (Entrez Gene)
HMGCS2GeneProduct3158 (Entrez Gene)
OXCT1GeneProduct5019 (Entrez Gene)
Pyruvate metabolismPathway
Sterol biosynthesisPathway

Annotated Interactions

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